M. Jung

发表

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

B. Metcalf, M. Jung, 1975 .

THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

A. Sjoerdsma, P. Schechter, B. Metcalf, 1977 .

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE 1

P. Schechter, B. Metcalf, P. Böhlen, 1977, Journal of neurochemistry.

1 – Inhibition of Basic Amino Acid Decarboxylases Involved in Polyamine Biosynthesis

C. Danzin, M. Jung, P. Bey, 1987 .

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues.

C. Danzin, M. Jung, P. Bey, 1979, Life sciences.

Audiogenic seizure protection by elevated brain GABA concentration in mice: Effects of γ-acetylenic GABA and γ-vinyl GABA, two irreversible GABA-T inhibitors

P. Schechter, P. Böhlen, M. Jung, 1977 .

Effects of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats.

A. Sjoerdsma, J. Koch-weser, C. Danzin, 1979, The Biochemical journal.

GABA-Transaminase Inhibitors and Neuronal Function

M. Jung, 1982 .

Audiogenic seizure protection by elevated brain GABA concentration in mice: effects of gamma-acetylenic gaba and gamma-vinyl GABA, two irreversible GABA-T inhibitors.

P. Schechter, P. Böhlen, M. Jung, 1977, European journal of pharmacology.

Guanidinium and amidinium fungicides: a new class of carbocation mimetic ergosterol biosynthesis inhibitors

M. Jung, J. Liebeschuetz, M. Arnold, 1995 .

4-amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain.

B. Metcalf, P. Casara, M. Jung, 1977, European journal of biochemistry.

Synthesis and evaluation of mono-, di-, and trifluoroethenyl-GABA derivatives as GABA-T inhibitors.

M. Jung, M. Kolb, J. Barth, 1987, Journal of medicinal chemistry.

New insight for fluoroquinophenoxazine derivatives as possibly new potent topoisomerase I inhibitor.

Y. Na, Youngjoo Kwon, Y. Jahng, 2008, Bioorganic & medicinal chemistry letters.

Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors.

Y. Na, Youngjoo Kwon, M. Jung, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, biological evaluation, and molecular docking study of 3-(3'-heteroatom substituted-2'-hydroxy-1'-propyloxy) xanthone analogues as novel topoisomerase IIα catalytic inhibitor.

Y. Na, Youngjoo Kwon, Kyu-Yeon Jun, 2011, European journal of medicinal chemistry.

New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.

Y. Na, Youngjoo Kwon, M. Jung, 2010, Bioorganic & medicinal chemistry.

Synthesis and biological properties of alpha-mono- and alpha-difluoromethyl derivatives of tryptophan and 5-hydroxytryptophan.

D. Schirlin, M. Jung, J. Wagner, 1988, Journal of medicinal chemistry.

Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.

Y. Na, W. Cho, Youngjoo Kwon, 2010, Bioorganic & medicinal chemistry.

Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.

A. Sjoerdsma, P. Schechter, M. Jung, 1977, The Journal of pharmacology and experimental therapeutics.

Stereospecific synthesis of (2R,5R)-hept-6-yne-2,5-diamine: a potent and selective enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC)

C. Darwin, B. Metcalf, P. Casara, 1985 .

Enzyme Inhibition by Amino Acids and their Derivatives

M. Jung, 1985 .

Irreversible Inhibition of Gaba-T by Halogenated Analogues of βAlanine

D. Schirlin, S. Baltzer, M. Jung, 1987 .

Synthesis of (E)-β-fluoromethyleneglutamic acid

M. Palfreyman, I. McDonald, M. Jung, 1985 .

2,2-dimethyl-2H-pyran-derived alkaloids I. Practical synthesis of acronycine and benzo[b]acronycine and their biological properties

Seung Ho Lee, Youngjoo Kwon, Y. Jahng, 2008, Archives of pharmacal research.

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

B. Metcalf, C. Danzin, P. Casara, 1978 .

Inhibition of monoamine synthesis by irreversible blockade of aromatic aminoacid decarboxylase with alpha-monofluoromethyldopa.

J. Koch-weser, M. Palfreyman, M. Jung, 1979, Life sciences.

Stereospecific irreversible inhibition of mammalian (S)-ornithine decarboxylase by (R)-(–)-hex-5-yne-1,4-diamine

B. Metcalf, C. Danzin, P. Casara, 1982 .

2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.

Y. Na, Youngjoo Kwon, Y. Jahng, 2010, Bioorganic & medicinal chemistry.

UNUSUAL POLING BEHAVIOR OF POLY(P-PHENYLENE TEREPHTHALATES) WITH A NONLINEAR OPTICAL SIDEGROUP

I. Jeon, M. Jung, Seunghee Lee, 1997 .

Stereocontrolled Synthesis of Fluorosqualenes and Fluoroepoxysqualenes as Inhibitors of Squalene Epoxidase and 2,3-Oxidosqualene Cyclase.

F. Viola, P. Milla, L. Cattel, 1995 .

Preparation of 3‐chloroacetylpyridine adenine dinucleotide: An alkylating analogue of NAD+

G. Branlant, J. Biellmann, B. Foucaud, 1974, FEBS letters.

Biochemical consequences of reactions catalyzed by GAD and GABA-T

B. Metcalf, M. Jung, B. Lippert, 1980, Brain Research Bulletin.

Stereochemistry of reactions catalysed by mammalian-brain L-glutamate 1-carboxy-lyase and 4-aminobutyrate: 2-oxoglutarate aminotransferase.

M. Jung, B. Lippert, M. Bouclier, 1979, European journal of biochemistry.

Enzyme-activated irreversible inhibitors of L-ornithine:2-oxoacid aminotransferase. Demonstration of mechanistic features of the inhibition of ornithine aminotransferase by 4-aminohex-5-ynoic acid and gabaculine and correlation with in vivo activity.

N. Seiler, M. Jung, 1978, The Journal of biological chemistry.

Substrates and inhibitors of aromatic amino acid decarboxylase

M. Jung, 1986 .

Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine beta-hydroxylase.

M. Palfreyman, J. Mccarthy, M. Jung, 1986, Journal of medicinal chemistry.

Chapter 26. Selective Enzyme Inhibitors in Medicinal Chemistry

M. Jung, 1978 .

Synthesis of isoquinolinone-based tetracycles as poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors.

M. Jung, Myung-Hwa Kim, H. Y. Choo, 2009, Bioorganic & medicinal chemistry.

(2R,5R)-6-heptyne-2,5-diamine, an extremely potent inhibitor of mammalian ornithine decarboxylase.

B. Metcalf, C. Danzin, P. Casara, 1983, Biochemical and biophysical research communications.

Syntheses of -2-fluoromethy--tyrosine and -2-difluoromethyl--tyrosine as potential inhibitors of tyrosine hydroxylase

I. McDonald, J. Sabol, M. Jung, 1991 .

ω‐Fluoromethyl Analogues of ω‐Amino Acids as Irreversible Inhibitors of 4‐Aminobutyrate: 2‐ Oxoglutarate Aminotransferase

D. Schirlin, P. Casara, M. Jung, 1981, Journal of neurochemistry.

Molecular basis for the irreversible inhibition of 4-aminobutyric acid:2-oxoglutarate and L-ornithine:2-oxoacid aminotransferases by 3-amino-1,5-cyclohexadienyl carboxylic acid (isogabaculline).

B. Metcalf, M. Jung, 1979, Molecular pharmacology.

The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gammma-ethynyl GABA) a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo.

A. Sjoerdsma, P. Schechter, B. Metcalf, 1977, Journal of neurochemistry.

ENZYME-ACTIVATED IRREVERSIBLE INHIBITION OF AROMATIC L-AMINO ACID DECARBOXYLASE (AADC) BY α-DIFLUOROMETHYL DOPA (DFMD, RMI 71.801) AND α-MONOFLUOROMETHYL DOPA (MFMD, RMI 71.963)

A. Sjoerdsma, M. Palfreyman, C. Danzin, 1979 .

Inhibition of histamine biosynthesis and gastric function in the rat: effect on pentagastrin-induced gastric acid secretion

M. Jung, M. Bouclier, F. Gerhart, 1983, Agents and Actions.

Decrease of polyamine levels in rat tissues by 5-hexyne-1,4-diamine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase.

B. Metcalf, C. Danzin, P. Casara, 1979, Biochemical pharmacology.

Rapid determination of trace methylmercury in natural crude medicine of animal origin

D. Kwon, Mi‐jeong Kim, Shin-Jung Kang, 2009 .

Histamine receptor blockade (H2) versus inhibition of histamine synthesis in stress ulceration in rats.

M. Jung, M. Bouclier, F. Gerhart, 1983, European journal of pharmacology.

α-Fluoromethyl histidine

M. Jung, M. Bouclier, F. Gerhart, 1983 .

Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations

M. Jung, M. Bouclier, F. Gerhart, 1983, Experientia.

Stereochemistry of the inactivation of 4-aminobutyrate: 2-oxoglutarate aminotransferase and L-glutamate 1-carboxylase by 4-aminohex-5-ynoic acid enantiomers.

C. Danzin, M. Jung, N. Claverie, 1984, Biochemical pharmacology.

Monamine-depleting properties of a new and very potent enzyme-activated irreversible inhibitor of aromatic aminoacid decarboxylase: alpha-monofluoromethyldopa [proceedings].

M. Palfreyman, M. Jung, J. Wagner, 1979, British Journal of Pharmacology.

Synthesis and inhibitory properties of α(chlorofluoromethyl)-α-amino acids, a novel class of irreversible inactivators of decarboxylases

A. Mitschler, D. Schirlin, A. Cian, 1992 .

Mechanism of the stereospectific irreversible inhibition of bacterial glutamic acid decarboxylase by (R)-(--)-4-aminohex-5-ynoic acid, an analogue of 4-aminobutyric acid.

B. Metcalf, P. Casara, M. Jung, 1978, Biochemistry.

Lack of stringent stereospecificity in the inactivation of pyridoxal phosphate-dependent enzymes by suicide-substrates.

C. Danzin, M. Jung, 1984, Progress in clinical and biological research.

Effect of 5-hexyne-1,4-diamine on brain 4-aminobutyric acid metabolism in rats and mice.

N. Seiler, B. Metcalf, C. Danzin, 1979, Biochemical Pharmacology.