Hyun Lee

发表

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

Debbie C. Mulhearn, Michael E. Johnson, A. Mittal, 2013, Bioorganic & Medicinal Chemistry.

Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/HLA-A2 interactions.

Nikita R. Dsouza, Michael E. Johnson, H. Deng, 2018, Bioorganic & medicinal chemistry letters.

Ca-asp bound X-ray structure and inhibition of Bacillus anthracis dihydroorotase (DHOase).

Michael E. Johnson, B. Santarsiero, Hyun Lee, 2016, Bioorganic & medicinal chemistry.

Inhibitor Recognition Specificity of MERS-CoV Papain-like Protease May Differ from That of SARS-CoV

Arun K. Ghosh, Shuyi Cao, Michael E. Johnson, 2015, ACS chemical biology.

Probing the structural requirements of non-electrophilic naphthalene-based Nrf2 activators.

Laura J. Kingsley, A. Mesecar, J. Luciano, 2015, European journal of medicinal chemistry.

Structural characterization of Porphyromonas gingivalis enoyl-ACP reductase II (FabK).

Michael E. Johnson, K. Hevener, B. Santarsiero, 2018, Acta crystallographica. Section F, Structural biology communications.

Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets

Michael E. Johnson, A. Mittal, Rima Chaudhuri, 2012, Analytical Biochemistry.

Allosteric inhibitors of the main protease of SARS-CoV-2

Khaled M. Elokely, Xuping Xie, P. Shi, 2022, Antiviral Research.

Identification of B. anthracis N(5)-carboxyaminoimidazole ribonucleotide mutase (PurE) active site binding compounds via fragment library screening.

Tian Zhu, Michael E. Johnson, L. Fung, 2016, Bioorganic & medicinal chemistry.

Insights into substrate promiscuity of human seryl-tRNA synthetase

K. M. Holman, Hyun Lee, M. Simonović, 2017, RNA.

Over-expression, purification, and confirmation of Bacillus anthracis transcriptional regulator NprR.

Michael E. Johnson, Hyunwoo Lee, Jerry K K Woo, 2016, Protein expression and purification.

Antimycobacterial Rufomycin Analogues from Streptomyces atratus Strain MJM3502.

C. Abad-Zapatero, B. Santarsiero, J. Suh, 2020, Journal of natural products.

Rufomycins or Ilamycins: Naming Clarifications and Definitive Structural Assignments.

J. Suh, S. Franzblau, J. McAlpine, 2021, Journal of natural products.

High-Resolution Structure of ClpC1-Rufomycin and Ligand Binding Studies Provide a Framework to Design and Optimize Anti-Tuberculosis Leads.

C. Abad-Zapatero, Wei-Lin Gao, B. Santarsiero, 2019, ACS infectious diseases.

Limonoids and other triterpenoids from Entandrophragma angolense.

J. Burdette, C. Che, Hyun Lee, 2021, Fitoterapia.

Identification of Small Molecules Exhibiting Oxacillin Synergy through a Novel Assay for Inhibition of vraTSR Expression in Methicillin-Resistant Staphylococcus aureus

Tian Zhu, Michael E. Johnson, K. Hevener, 2019, Antimicrobial Agents and Chemotherapy.

Rufomycin Targets ClpC1 Proteolysis in Mycobacterium tuberculosis and M. abscessus

Wei-Lin Gao, J. Suh, S. Franzblau, 2019, Antimicrobial Agents and Chemotherapy.

Ginkgolic acid and anacardic acid are specific covalent inhibitors of SARS-CoV-2 cysteine proteases

Lijun Rong, Ruikun Du, Q. Cui, 2021, Cell & Bioscience.

The Role of Membrane-Type 1 Matrix Metalloproteinase–Substrate Interactions in Pathogenesis

D. Azar, Hyun Lee, Kyu-Yeon Han, 2023, International journal of molecular sciences.

Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

E. Saphire, G. Thatcher, Lijun Rong, 2021, PLoS pathogens.

Exploring small molecules with pan-genotypic inhibitory activities against hepatitis C virus NS3/4A serine protease.

Maulik R. Patel, Michael E. Johnson, Hyun Lee, 2019, Bioorganic & medicinal chemistry letters.

A Family of Small Intrinsically Disordered Proteins Involved in Flagellum-Dependent Motility in Salmonella enterica

Yixin Shi, Jiyoung Lee, Hyunyoung Jeong, 2018, Journal of bacteriology.

Hit-to-Lead: Hit Validation and Assessment.

Hyun Lee, Kirk E Hevener, Russell Pesavento, 2018, Methods in enzymology.

Identification of Quorum-Sensing Inhibitors Disrupting Signaling between Rgg and Short Hydrophobic Peptides in Streptococci

G. Chlipala, M. Federle, K. Ratia, 2015, mBio.

Identification of the inhibitory mechanism of ecumicin and rufomycin 4-7 on the proteolytic activity of Mycobacterium tuberculosis ClpC1/ClpP1/ClpP2 complex.

J. Suh, Cherlhyun Jeong, Hanki Lee, 2022, Tuberculosis.

Fragment-Based Drug Discovery Using a Multidomain, Parallel MD-MM/PBSA Screening Protocol

Kirk E. Hevener, Michael E. Johnson, Hyun Lee, 2013, J. Chem. Inf. Model..

Discovery of chebulagic acid and punicalagin as novel allosteric inhibitors of SARS-CoV-2 3CLpro

Lijun Rong, Ruikun Du, Q. Cui, 2021, Antiviral Research.

α-Mangostin Promotes In Vitro and In Vivo Degradation of Androgen Receptor and AR-V7 Splice Variant in Prostate Cancer Cells

B. Vemu, J. Johnson, M. Sverdlov, 2023, Cancers.

Potent, Novel SARS-CoV-2 PLpro Inhibitors Block Viral Replication in Monkey and Human Cell Cultures

G. Thatcher, Lijun Rong, K. Ratia, 2021, bioRxiv.

Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

G. Thatcher, Lijun Rong, K. Ratia, 2021, Journal of medicinal chemistry.

Synergistic Inhibitor Binding to the Papain‐Like Protease of Human SARS Coronavirus: Mechanistic and Inhibitor Design Implications

Arun K. Ghosh, Shuyi Cao, Michael E. Johnson, 2013, ChemMedChem.

Targeting SARS‐CoV‐2 viral proteases as a therapeutic strategy to treat COVID‐19

Lijun Rong, Han Cheng, Hyun Lee, 2021, Journal of medical virology.