S. Tong

A. Lindquist, R. Hiscock, S. Tong, 2019, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

E. Lim, A. Horne, N. Hannan, 2018, EBioMedicine.

Explorer Vinorelbine Potently Induces Placental Cell Death , Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

E. Lim, W. Horne, N. Hannan, 2018 .

Circulating mRNAs are differentially expressed in pregnancies with severe placental insufficiency and at high risk of stillbirth

S. Kane, A. David, L. Gordon, 2020, BMC Medicine.

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

S. Walker, N. Hannan, S. Tong, 2015, Hypertension.

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2014, Placenta.

Nanoparticles in pregnancy: the next frontier in reproductive therapeutics.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2020, Human reproduction update.

Risk of major labour-related complications for pregnancies progressing to 42 weeks or beyond

S. Walker, A. Lindquist, R. Hiscock, 2021, BMC Medicine.

Enoxaparin for the prevention of preeclampsia and intrauterine growth restriction in women with a history: a randomized trial

S. Kane, Arier C. Lee, S. Middeldorp, 2017, American journal of obstetrics and gynecology.

Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight

L. Hui, S. Walker, R. Hiscock, 2020, BMC Medicine.

Circulating Growth Differentiation Factor 15 Is Increased Preceding Preeclampsia Diagnosis: Implications as a Disease Biomarker

Tuong-Vi Nguyen, J. Myers, L. Bergman, 2021, Journal of the American Heart Association.

Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage

D. Brown, S. Breit, E. Wallace, 2004, The Lancet.

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2019, Placenta.

Estimation of neonatal body fat percentage predicts neonatal hypothermia better than birthweight centile

S. Walker, T. MacDonald, S. Tong, 2022, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Using a decline in serum hCG between days 0–4 to predict ectopic pregnancy treatment success after single-dose methotrexate: a retrospective cohort study

P. Dutton, W. C. Duncan, A. Horne, 2013, BMC Pregnancy and Childbirth.

The incidence of hypertensive disorders of pregnancy following sperm donation in IVF: an Australian state-wide retrospective cohort study.

B. Vollenhoven, S. Walker, A. Lindquist, 2019, Human reproduction.

Placental HtrA3 is regulated by oxygen tension and serum levels are altered during early pregnancy in women destined to develop preeclampsia.

E. Wallace, L. Salamonsen, G. Nie, 2010, The Journal of clinical endocrinology and metabolism.

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage.

C. Cuman, E. Dimitriadis, E. Menkhorst, 2014, Placenta.

Predicting Perinatal Outcome Through Changes in Umbilical Artery Doppler Studies After Antenatal Corticosteroids in the Growth-Restricted Fetus

V. Yu, E. Wallace, S. Tong, 2009, Obstetrics and gynecology.

LOX-1 expression is reduced in placenta from pregnancies complicated by preeclampsia and in hypoxic cytotrophoblast.

S. Kane, S. Walker, N. Hannan, 2021, Pregnancy hypertension.

Corin, an enzyme with a putative role in spiral artery remodeling, is up-regulated in late secretory endometrium and first trimester decidua.

P. Rogers, J. Bulmer, N. Hannan, 2013, Human reproduction.

First trimester levels of inhibins and activin A in normal and failing pregnancies

E. Wallace, S. Tong, B. Marjono, 2004, Clinical endocrinology.

Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia

J. Galaz, M. Varas-Godoy, S. Illanes, 2017, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Stability of absolute copy number of housekeeping genes in preeclamptic and normal placentas, as measured by digital PCR.

N. Hannan, R. Hiscock, S. Tong, 2014, Placenta.

Severe early-onset preeclampsia is not associated with a change in placental catechol O-methyltransferase (COMT) expression.

M. Lappas, C. Whitehead, S. Tong, 2011, The American journal of pathology.

MMP-15 Is Upregulated in Preeclampsia, but Does Not Cleave Endoglin to Produce Soluble Endoglin

S. Tong, T. Kaitu'u-Lino, L. Tuohey, 2012, PloS one.

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)–Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms–Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction: Potential Therapeutic for Preeclampsia

N. Hannan, S. Tong, N. Binder, 2015, Hypertension.

Preventable stillbirths in the Solomon Islands – A hidden tragedy

S. Walker, A. Lindquist, S. Tong, 2020, The Lancet regional health. Western Pacific.

Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage.

S. Tong, T. Kaitu'u-Lino, L. Tuohey, 2012, Journal of reproductive immunology.

Adjusting growth standards for fetal sex improves correlation of small babies with stillbirth and adverse perinatal outcomes: A state-wide population study

S. Walker, A. Lindquist, S. Tong, 2021, PloS one.

Placental SEMA3B expression is not altered in severe early onset preeclampsia.

N. Hannan, S. Tong, N. Binder, 2014, Placenta.

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2015, Molecular and Cellular Endocrinology.

Cerebral biomarkers in neurologic complications of preeclampsia

K. Blennow, H. Zetterberg, L. Bergman, 2022 .

Plasma MIC-1 and PAPP-A Levels Are Decreased among Women Presenting to an Early Pregnancy Assessment Unit, Have Fetal Viability Confirmed but Later Miscarry

R. Hiscock, S. Tong, J. Konje, 2013, PloS one.

Diagnostic Accuracy of Maternal Serum Macrophage Inhibitory Cytokine-1 and Pregnancy-Associated Plasma Protein-A at 6–10 Weeks of Gestation to Predict Miscarriage

M. Lappas, M. Permezel, S. Walker, 2012, Obstetrics and gynecology.

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

L. Parry, N. Hannan, Sevvandi N. Senadheera, 2019, EBioMedicine.

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

L. Gordon, S. Walker, C. Whitehead, 2015, Reproductive Sciences.

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2016, Pregnancy hypertension.

Preventing preeclampsia with aspirin: does dose or timing matter?

B. Mol, S. Walker, S. Tong, 2017, American journal of obstetrics and gynecology.

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia.

C. Whitehead, N. Hannan, S. Tong, 2018, Pregnancy hypertension.

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia.

P. Fuller, C. Whitehead, N. Hannan, 2016, Placenta.

Clinical tools and biomarkers to predict preeclampsia

S. Walker, N. Hannan, T. MacDonald, 2021, EBioMedicine.

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2020, Pregnancy hypertension.

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia.

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2020, Placenta.

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2018, Pregnancy hypertension.

Melatonin enhances antioxidant molecules in the placenta, reduces secretion of soluble fms-like tyrosine kinase 1 (sFLT) from primary trophoblast but does not rescue endothelial dysfunction: An evaluation of its potential to treat preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, PloS one.

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta.

N. Hannan, M. Deo, S. Tong, 2016, Placenta.

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2016, BMC Pregnancy and Childbirth.

Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery

S. Tong, F. Brownfoot, Samantha S Mooney, 2016, The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

C. Whitehead, N. Hannan, S. Tong, 2015, Hypertension.

Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol

B. Mol, C. Cluver, S. Walker, 2015, BMJ Open.

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin.

N. Hannan, S. Tong, Sally Beard, 2014, Pregnancy hypertension.

PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia.

S. Tong, L. Tuohey, L. Ye, 2013, Placenta.

MMP-14 is expressed in preeclamptic placentas and mediates release of soluble endoglin.

M. Lappas, E. Williams, C. Whitehead, 2012, The American journal of pathology.

Is Fetal Growth Restriction Associated with a More Severe Maternal Phenotype in the Setting of Early Onset Pre-Eclampsia? A Retrospective Study

S. Tong, K. Palmer, Jane M Weiler, 2011, PloS one.

Placental expression of a novel primate‐specific splice variant of sFlt‐1 is upregulated in pregnancies complicated by severe early onset pre‐eclampsia

M. Lappas, C. Whitehead, S. Tong, 2011, BJOG : an international journal of obstetrics and gynaecology.

Serum Collected from Preeclamptic Pregnancies Drives Vasoconstriction of Human Omental Arteries—A Novel Ex Vivo Model of Preeclampsia for Therapeutic Development

N. Hannan, S. Tong, N. Binder, 2022, International journal of molecular sciences.

Associations Between Soluble fms‐Like Tyrosine Kinase‐1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia

L. Bergman, C. Cluver, S. Walker, 2022, Journal of the American Heart Association.

Placental DAAM2 is unaltered in preeclampsia, but upregulated by treatment with proton pump inhibitors.

N. Hannan, S. Tong, N. Binder, 2022, Pregnancy hypertension.

Circulating SPINT1 Is Reduced in a Preeclamptic Cohort with Co-Existing Fetal Growth Restriction

C. Cluver, S. Walker, N. Hannan, 2022, Journal of clinical medicine.

PROVE—Pre-Eclampsia Obstetric Adverse Events: Establishment of a Biobank and Database for Pre-Eclampsia

M. Belfort, L. Bergman, C. Cluver, 2021, Cells.

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction.

N. Hannan, S. Tong, N. Binder, 2020, Pregnancy hypertension.

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

B. Mol, C. Cluver, S. Walker, 2019, BMJ Open.

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm preeclampsia (PI2 Trial): study protocol

C. Cluver, R. Hiscock, S. Tong, 2019 .

Esomeprazole to treat women with preterm preeclampsia: a randomized placebo controlled trial

P. Schubert, B. Mol, G. Theron, 2018, American journal of obstetrics and gynecology.

Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

A. Shub, T. Johns, N. Hannan, 2015, Hypertension.

Treatment of Early-Onset Preeclampsia With Continuous Positive Airway Pressure

M. Howard, S. Walker, C. Whitehead, 2015, Obstetrics and gynecology.

Thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation

K. Sikaris, E. Wallace, E. Hamilton, 2009, Clinical endocrinology.

Nicotinamide and its effects on endothelial dysfunction and secretion of antiangiogenic factors by primary human placental cells and tissues.

N. Hannan, S. Tong, N. Binder, 2021, Placenta.

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia.

Tuong-Vi Nguyen, J. Myers, S. Walker, 2021, Placenta.

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction – implications as a preeclampsia treatment

Tuong-Vi Nguyen, N. Hannan, M. Deo, 2017, Scientific Reports.

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

M. Ikawa, L. Parry, Masanaga Muto, 2017, Hypertension.

Transcription factors E2F1 and E2F3 are expressed in placenta but do not regulate MMP14.

H. Nguyen, N. Hannan, S. Tong, 2015, Placenta.

Peptides do not prevent cleavage of endoglin to produce soluble endoglin.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2014, Pregnancy hypertension.

PAPPA2 is increased in severe early onset pre-eclampsia and upregulated with hypoxia.

M. Gantier, S. Tong, T. Kaitu'u-Lino, 2014, Reproduction, fertility, and development.

PSG7 and 9 (Pregnancy‐Specific β‐1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia

J. Myers, L. Bergman, C. Cluver, 2022, Journal of the American Heart Association.

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Scientific Reports.

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2018, Pregnancy hypertension.

Key players of the necroptosis pathway RIPK1 and SIRT2 are altered in placenta from preeclampsia and fetal growth restriction.

Qi Chen, N. Hannan, S. Tong, 2017, Placenta.

Aurora kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction.

K. Schindler, N. Hannan, S. Tong, 2020, Placenta.

Placental galectin-3 is reduced in early-onset preeclampsia

N. Hannan, T. MacDonald, S. Tong, 2022, Frontiers in Physiology.

Systematic evaluation of the pre-eclampsia drugs, dietary supplements and biologicals pipeline using target product profiles

J. Vogel, A. M. Gülmezoglu, Joshua P. Vogel, 2022, BMC Medicine.

An estriol-eluting pessary to treat pelvic organ prolapse

A. Seyfoddin, S. Tong, Ghada Zidan, 2022, Scientific Reports.

Prediction of adverse maternal outcomes in preeclampsia at term.

R. Hiscock, S. Tong, F. Brownfoot, 2019, Pregnancy hypertension.

Assessing the sensitivity of placental growth factor and soluble fms-like tyrosine kinase 1 at 36 weeks’ gestation to predict small-for-gestational-age infants or late-onset preeclampsia: a prospective nested case-control study

S. Brennecke, L. Hui, S. Walker, 2018, BMC Pregnancy and Childbirth.

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production1

N. Hannan, S. Illanes, S. Tong, 2016, Biology of reproduction.

Serum Concentrations of Soluble Flt-1 Are Decreased among Women with a Viable Fetus and No Symptoms of Miscarriage Destined for Pregnancy Loss

M. Permezel, C. Whitehead, S. Tong, 2012, PloS one.

Accuracy of clinical suspicion of growth restriction at term despite a normal growth ultrasound: A retrospective cohort study.

L. Hui, S. Tong, F. Brownfoot, 2020, The Australian & New Zealand journal of obstetrics & gynaecology.

Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series

W. C. Duncan, T. Johns, A. Horne, 2014, Human reproduction.

A wash step at collection of placental biopsies from preeclamptic pregnancies does not adversely affect levels of sFlt-1 or endoglin.

N. Hannan, S. Tong, N. Binder, 2015, Pregnancy hypertension.

Endothelial protein C receptor is increased in preterm preeclampsia and fetal growth restriction

N. Hannan, T. MacDonald, S. Tong, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

School-age outcomes among IVF-conceived children: A population-wide cohort study

L. Gurrin, J. Cheong, B. Vollenhoven, 2023, PLoS medicine.

Circulating syndecan-1 is reduced in pregnancies with poor fetal growth and its secretion regulated by matrix metalloproteinases and the mitochondria

J. Myers, S. Walker, N. Hannan, 2021, Scientific Reports.

Measuring circulating miRNAs in early pregnancy could identify fetuses’ destined to undergrow and be at increased risk of stillbirth

S. Tong, T. Kaitu'u-Lino, 2020, EBioMedicine.

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

L. Hui, Tuong-Vi Nguyen, J. Myers, 2020, Nature Communications.

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin.

L. Hui, S. Walker, N. Hannan, 2020, Placenta.

Blood‐based biomarkers in the maternal circulation associated with fetal growth restriction

S. Walker, T. MacDonald, S. Tong, 2019, Prenatal diagnosis.

Cerebral–placental–uterine ratio as novel predictor of late fetal growth restriction: prospective cohort study

L. Hui, S. Walker, T. MacDonald, 2019, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

L. Hui, S. Walker, T. MacDonald, 2017, BMC Medicine.

Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.

Helen C McNamara, P. Fuller, S. Walker, 2016, American journal of obstetrics and gynecology.

Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol

J. Norman, J. Mollison, W. C. Duncan, 2013, BMJ Open.

Inhibins and activins: clinical advances in reproductive medicine

H. Burger, E. Wallace, S. Tong, 2003, Clinical endocrinology.

Molecular diagnostics and therapeutics for ectopic pregnancy.

A. Horne, S. Tong, M. Skubisz, 2015, Molecular human reproduction.

The untapped potential of placenta-enriched molecules for diagnostic and therapeutic development.

S. Walker, N. Hannan, T. MacDonald, 2019, Placenta.

Measuring circulating placental RNAs to non‐invasively assess the placental transcriptome and to predict pregnancy complications

S. Walker, C. Whitehead, S. Tong, 2016, Prenatal diagnosis.

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

N. Hannan, S. Seeho, K. Groom, 2021, Scientific Reports.

DAAM2 is elevated in the circulation and placenta in pregnancies complicated by fetal growth restriction and is regulated by hypoxia

S. Kane, L. Hui, S. Walker, 2021, Scientific reports.

The role of leukemia inhibitory factor in tubal ectopic pregnancy.

N. Nicola, A. Horne, S. Sonderegger, 2013, Placenta.

The Evolution of Methotrexate as a Treatment for Ectopic Pregnancy and Gestational Trophoblastic Neoplasia: A Review

S. Tong, M. Skubisz, 2012, ISRN obstetrics and gynecology.

Transcriptomic analysis of patient plasma reveals circulating miR200c as a potential biomarker for high-grade serous ovarian cancer

P. Cohen, C. Whitehead, N. Hannan, 2021, Gynecologic oncology reports.

The circulating microRNA-200 family in whole blood are potential biomarkers for high-grade serous epithelial ovarian cancer.

C. Whitehead, N. Hannan, S. Tong, 2017, Biomedical reports.

Death associated protein kinase 1 (DAPK-1) is increased in preeclampsia.

S. Walker, N. Hannan, T. MacDonald, 2019, Placenta.

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2020, Scientific Reports.

Circulating GATA2 mRNA is decreased among women destined to develop preeclampsia and may be of endothelial origin

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Scientific Reports.

Measuring thyroid peroxidase antibodies on the day nulliparous women present for management of miscarriage: a descriptive cohort study

M. Lappas, M. Permezel, R. Hoermann, 2013, Reproductive Biology and Endocrinology.

Corpus luteum across the first trimester: size and laterality as observed by ultrasound.

B. Vollenhoven, S. Tong, M. Teoh, 2008, Fertility and sterility.

Miscarriage Risk for Asymptomatic Women After a Normal First-Trimester Prenatal Visit

M. Permezel, S. Walker, S. Tong, 2008, Obstetrics and gynecology.

Pravastatin, proton pump inhibitors, metformin, micronutrients and biologics: new horizons for the prevention or treatment of preeclampsia.

C. Cluver, N. Hannan, S. Tong, 2020, American journal of obstetrics and gynecology.

A disintegrin and metalloproteinase 12 (ADAM12) is reduced at 36 weeks' gestation in pregnancies destined to deliver small for gestational age infants.

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2021, Placenta.

Gefitinib and Methotrexate to Treat Ectopic Pregnancies with a Pre-Treatment Serum hCG 1000–10,000 IU/L: Phase II Open Label, Single Arm Multi-Centre Trial☆

J. Mollison, T. Johns, A. Horne, 2018, EBioMedicine.

Hysteroscopy under general anaesthesia, a near painless procedure

B. Vollenhoven, S. Tong, R. Zachariah, 2003, The Australian & New Zealand journal of obstetrics & gynaecology.

Delayed presentation of uterine perforation and haemorrhagic shock 10 days after surgical termination of pregnancy

B. Vollenhoven, S. Tong, R. Lopes, 2001, The Australian & New Zealand journal of obstetrics & gynaecology.

Effects of Maternal Obstructive Sleep Apnoea on Fetal Growth: A Prospective Cohort Study

M. Lappas, M. Howard, F. O'Donoghue, 2013, PloS one.

Risk of obstetric anal sphincter injury among women who birth vaginally after a prior caesarean section: A state‐wide cohort study

S. Walker, A. Lindquist, R. Hiscock, 2021, BJOG : an international journal of obstetrics and gynaecology.

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion

N. Hannan, S. Tong, Sally Beard, 2019, Hypertension.

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2017, Reproductive Sciences.

Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis

S. Tong, T. Kaitu'u-Lino, K. Palmer, 2016, Molecular human reproduction.

Abnormal plasma DNA profiles in early ovarian cancer using a non-invasive prenatal testing platform: implications for cancer screening

M. Pertile, L. Hui, P. Cohen, 2016, BMC Medicine.

Low levels of pregnancy-associated plasma protein-A in asymptomatic women destined for miscarriage.

E. Wallace, S. Tong, B. Marjono, 2004, Fertility and sterility.

NR4A2 expression is not altered in placentas from cases of growth restriction or preeclampsia, but is reduced in hypoxic cytotrophoblast

S. Kane, S. Walker, N. Hannan, 2021, Scientific Reports.

Fetal activin A: associations with labour, umbilical artery pH and neonatal outcome

E. Wallace, S. Tong, V. Egan, 2004, BJOG : an international journal of obstetrics and gynaecology.

Maternal and foetal activin A levels: associations with normal and abnormal labour.

M. Schneider-Kolsky, E. Wallace, S. Tong, 2002, Placenta.

Placental OLAH Levels Are Altered in Fetal Growth Restriction, Preeclampsia and Models of Placental Dysfunction

S. Kane, N. Hannan, S. Seeho, 2022, Antioxidants.

Placental specific mRNA in the maternal circulation are globally dysregulated in pregnancies complicated by fetal growth restriction.

Stephen Tong, M. Lappas, S. Walker, 2013, The Journal of clinical endocrinology and metabolism.

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction – implications for treating preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, PloS one.

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia

A. Dobierzewska, S. Illanes, S. Tong, 2016, PloS one.

Circulating trace elements for the prediction of preeclampsia and small for gestational age babies

A. Perkins, T. MacDonald, S. Tong, 2021, Metabolomics.

Maternal lithium use and the risk of adverse pregnancy and neonatal outcomes: a Swedish population-based cohort study

A. Wikström, L. Lindström, A. Lindquist, 2021, BMC Medicine.

Measurement of mRNA transcripts of very high placental expression in maternal blood as biomarkers of preeclampsia.

C. Whitehead, S. Tong, K. Palmer, 2011, The Journal of clinical endocrinology and metabolism.

Patients’ understanding of long-term cardiovascular risks and associated health-seeking behaviours after pre-eclampsia

A. Lindquist, S. Tong, A. Middleton, 2023, Open Heart.

Pre-Clinical Investigation of Cardioprotective Beta-Blockers as a Therapeutic Strategy for Preeclampsia

N. Hannan, T. MacDonald, S. Tong, 2021, Journal of clinical medicine.

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

S. Walker, A. Lindquist, S. Tong, 2019, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

Maternal mortality at the National Referral Hospital in Honiara, Solomon Islands over a five‐year period

A. Lindquist, S. Tong, L. Panisi, 2020, The Australian & New Zealand journal of obstetrics & gynaecology.

Human HtrA4 Expression Is Restricted to the Placenta, Is Significantly Up-Regulated in Early-Onset Preeclampsia, and High Levels of HtrA4 Cause Endothelial Dysfunction.

Y. Li, Mingzhi Zhao, G. Nie, 2015, The Journal of clinical endocrinology and metabolism.

Circulating adrenomedullin mRNA is decreased in women destined to develop term preeclampsia.

Tuong-Vi Nguyen, S. Walker, N. Hannan, 2019, Pregnancy hypertension.

Placental Insufficiency in Fetuses That Slow in Growth but Are Born Appropriate for Gestational Age: A Prospective Longitudinal Study

S. Walker, C. Whitehead, A. Ugoni, 2016, PloS one.

Maternal serum activin A and the prediction of intrauterine growth restriction

A. Edwards, E. Wallace, S. Tong, 2006, The Australian & New Zealand journal of obstetrics & gynaecology.

Decline in βhCG levels between days 0 and 4 after a single dose of methotrexate for ectopic pregnancy predicts treatment success: a retrospective cohort study

S. Tong, M. Skubisz, E. Wallace, 2011, BJOG : an international journal of obstetrics and gynaecology.

Time to resolution of tubal ectopic pregnancy following methotrexate treatment: A retrospective cohort study

A. Lindquist, S. Tong, F. Brownfoot, 2022, PloS one.

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction.

L. Parry, N. Hannan, Sevvandi N. Senadheera, 2016, American journal of obstetrics and gynecology.

Screening circulating proteins to identify biomarkers of fetal macrosomia

Tuong-Vi Nguyen, S. Walker, T. MacDonald, 2019, BMC Research Notes.

ELABELA/APELA Levels Are Not Decreased in the Maternal Circulation or Placenta among Women with Preeclampsia

D. Charnock-Jones, Sungsam Gong, Gordon C. S. Smith, 2018, The American journal of pathology.

Association Between Twin Discordance at 6–9 Weeks' of Gestation and Birthweight Complications

L. Rombauts, S. Tong, J. Onwude, 2010, Twin Research and Human Genetics.

Developmental Outcomes for Children After Elective Birth at 39 Weeks' Gestation.

L. Gurrin, J. Cheong, S. Walker, 2022, JAMA pediatrics.

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

A. Chand, C. Whitehead, N. Hannan, 2017, Hypertension.

A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension

C. Cluver, S. Walker, A. Lindquist, 2019, Open Journal of Obstetrics and Gynecology.

Analysis of a maternal health medicines pipeline database 2000–2021: New candidates for the prevention and treatment of fetal growth restriction

Joshua P. Vogel, S. Tong, R. Hastie, 2023, BJOG : an international journal of obstetrics and gynaecology.

ATF3 is a negative regulator of inflammation in human fetal membranes.

M. Lappas, R. Lim, S. Liong, 2016, Placenta.

A Bioplex Analysis of Cytokines and Chemokines in First Trimester Maternal Plasma to Screen for Predictors of Miscarriage

N. Hannan, S. Tong, J. Konje, 2014, PloS one.

Severe maternal morbidity in the Asia Pacific: a systematic review and meta-analysis

C. Cluver, S. Walker, A. Lindquist, 2021, The Lancet regional health. Western Pacific.

Incidence and causes of stillbirth in the only tertiary referral hospital in the Solomon Islands: a hospital-based retrospective cohort study

A. Lindquist, S. Tong, L. Panisi, 2022, BMJ Open.

Comparison of Maternal Labor-Related Complications and Neonatal Outcomes Following Elective Induction of Labor at 39 Weeks of Gestation vs Expectant Management

A. Lindquist, S. Tong, A. Middleton, 2023, JAMA network open.

Cerebral biomarkers in neurological complications of preeclampsia.

K. Blennow, H. Zetterberg, L. Bergman, 2022, American Journal of Obstetrics and Gynecology.

Improving Knowledge on Safety is Key to Enabling Drug Access for Pregnant and Breastfeeding Women

L. Chappell, S. Tong, 2021, Clinical pharmacology and therapeutics.

Activin A, hypoxia and the prediction of obstetric outcomes

S. Tong, 2006, The Australian & New Zealand journal of obstetrics & gynaecology.

Aspirin use during pregnancy and the risk of bleeding complications: A Swedish population-based cohort study.

L. Bergman, A. Wikström, A. Sandström, 2020, American journal of obstetrics and gynecology.

Placental growth factor is negatively regulated by epidermal growth factor receptor (EGFR) signaling.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2021, Placenta.

Use of metformin to prolong gestation in preterm pre-eclampsia: randomised, double blind, placebo controlled trial

C. Cluver, S. Walker, R. Hiscock, 2021, BMJ.

Maternal factors during pregnancy influencing maternal, fetal and childhood outcomes: Meet the Guest Editors

S. Ozanne, K. Benhalima, S. Tong, 2022, BMC Medicine.

Quantifying circulating hypoxia-induced RNA transcripts in maternal blood to determine in utero fetal hypoxic status

S. Walker, C. Whitehead, S. Tong, 2013, BMC Medicine.

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women: A Swedish Population Register–Based Cohort Study

A. Wikman, L. Bergman, C. Cluver, 2019, Hypertension.

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies.

T. Johns, A. Horne, J. Macdiarmid, 2013, Endocrinology.

Prevalence of Perinatal Depression in Low- and Middle-Income Countries

C. Homer, C. Cluver, A. Lindquist, 2023, JAMA psychiatry.

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study.

P. Gluckman, K. Godfrey, J. Eriksson, 2021, Placenta.

Maternal Serum Macrophage Inhibitory Cytokine-1 as a Biomarker for Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

A. Horne, S. Tong, T. Kaitu'u-Lino, 2013, PloS one.

A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol

C. Bottomley, B. Mol, A. Coomarasamy, 2018, Trials.

A multi-centre , double-blind , placebo-controlled , randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies ( GEM 3 )

C. Bottomley, B. Mol, A. Coomarasamy, 2018 .

Appropriate-for-gestational-age infants who exhibit reduced antenatal growth velocity display postnatal catch-up growth

L. Hui, S. Walker, R. Hiscock, 2020, PloS one.

Elevated Circulating and Placental SPINT2 Is Associated with Placental Dysfunction

Tuong-Vi Nguyen, J. Myers, S. Walker, 2021, International journal of molecular sciences.

University of Birmingham A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3)

T. Bourne, C. Bottomley, A. Coomarasamy, 2018 .

Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia.

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2023, Placenta.

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women

A. Wikman, L. Bergman, C. Cluver, 2019 .

Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia

N. Hannan, S. Tong, T. Kaitu'u-Lino, 2023, Reproductive Biology and Endocrinology.

Assessment of the tocolytic nifedipine in preclinical primary models of preterm birth

A. Hayes, Danielle A. Debruin, N. Hannan, 2023, Scientific Reports.

Effects of Gefitinib, an Epidermal Growth Factor Receptor Inhibitor, on Human Placental Cell Growth

T. Johns, A. Horne, C. Whitehead, 2013, Obstetrics and gynecology.

Evaluation of ADAM-12 as a Diagnostic Biomarker of Ectopic Pregnancy in Women with a Pregnancy of Unknown Location

A. Horne, S. Tong, T. Kaitu'u-Lino, 2012, PloS one.

Combination methotrexate and gefitinib: A potential medical treatment for inoperable nontubal ectopic pregnancy

S. Tong, E. Readman, R. Hastie, 2019, The journal of obstetrics and gynaecology research.

Combination Gefitinib and Methotrexate Compared With Methotrexate Alone to Treat Ectopic Pregnancy

W. C. Duncan, T. Johns, H. Critchley, 2013, Obstetrics and gynecology.

Plasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant

B. Nijagal, T. MacDonald, S. Tong, 2023, EBioMedicine.

Measuring hypoxia-induced RNA in maternal blood: a new way to identify critically hypoxic fetuses in utero?

C. Whitehead, S. Tong, 2014, Expert review of molecular diagnostics.

Can single-cell and spatial omics unravel the pathophysiology of pre-eclampsia?

C. Gray, R. Dechend, L. Bergman, 2023, Journal of reproductive immunology.

293. Preclinical assessment of new generation antiplatelet therapies to prevent preeclampsia

Tuong-Vi Nguyen, N. Hannan, S. Tong, 2018, Pregnancy Hypertension.

The New Generation Antiplatelet Agent Prasugrel Represents an Exciting Novel Candidate Therapy for Preeclampsia.

N. Hannan, S. Tong, N. Binder, 2020 .

[261-POS]: Heme oxygenase-1 is not reduced in pre-eclampsia and does not regulate sFlt-1 or soluble endoglin production.

C. Cluver, C. Whitehead, N. Hannan, 2015 .

Maternal serum interleukin-33 and soluble ST2 across early pregnancy, and their association with miscarriage.

S. Tong, L. Tuohey, T. Kaitu’u-Lino, 2012, Journal of reproductive immunology.

A comparison of sample collection methods for quantifying cell-free fetal neurodevelopment transcripts in amniotic fluid

L. Hui, N. Hannan, S. Tong, 2016, BMC Research Notes.

Inconsistent detection of interleukin‐10 in the maternal serum

E. Wallace, S. Tong, B. Marjono, 2002, BJOG : an international journal of obstetrics and gynaecology.

Paternal obesity in a rodent model affects placental gene expression in a sex-specific manner.

D. Gardner, N. Hannan, S. Tong, 2015, Reproduction.

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage.

C. Cuman, Thilini Gamage, E. Dimitriadis, 2014, Placenta.

Screening circulating proteins to identify biomarkers of fetal macrosomia

T. MacDonald, S. Tong, K. Dane, 2019, BMC Research Notes.

Using the methylome to predict pre-eclampsia

S. Tong, Lucy A. Bartho, T. Kaitu’u-Lino, 2023, Nature Medicine.

Characterization of Symptoms Immediately Preceding Eclampsia

C. Whitehead, S. Tong, S. Cooray, 2011, Obstetrics and gynecology.