Y. Freund

发表

Prophylactic clarithromycin to treat mycobacterium avium in HIV patients receiving zidovudine may significantly increase mortality by suppressing lymphopoiesis and hematopoiesis.

N. Mohagheghpour, Y. Freund, L. Dousman, 2002, International immunopharmacology.

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

A. Hoerauf, S. Ward, Mark J. Taylor, 2020, PLoS neglected tropical diseases.

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Malina A. Bakowski, A. Hoerauf, Laura J. Myhill, 2019, Journal of medicinal chemistry.

Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation

J. Derisi, P. Rosenthal, J. Legac, 2020, mBio.

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

J. McKerrow, S. Lustigman, J. Plattner, 2019, ACS infectious diseases.

Host-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles

Mark C. Field, Isabel M. Vincent, K. Read, 2018, PLoS pathogens.

Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.

K. R. Maples, S. Baker, Huchen Zhou, 2009, Bioorganic & medicinal chemistry letters.

TNF-α differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines

T. Wynn, Y. Freund, D. Paulnock, 1992 .

Veterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs

Mark C. Field, Isabel M. Vincent, K. Read, 2020, PLoS pathogens.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Mark C. Field, I. Gilbert, D. Horn, 2018, Proceedings of the National Academy of Sciences.

Case History: AN5568 (SCYX-7158)

Yong-Kang Zhang, Y. Freund, R. Jacobs, 2017 .

Inhibition of Toll-Like Receptor-Mediated Inflammation In Vitro and In Vivo by a Novel Benzoxaborole

K. Jarnagin, A. Gertrudes, T. Akama, 2013, Journal of Pharmacology and Experimental Therapeutics.

Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.

K. Jarnagin, M. Orr, J. Plattner, 2013, Bioorganic & medicinal chemistry letters.

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

F. Gamo, Laura M Sanz, Huchen Zhou, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents.

J. Gut, P. Rosenthal, F. Gamo, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application.

S. Baker, J. Plattner, Yong-Kang Zhang, 2010, Bioorganic & medicinal chemistry letters.

Discovery of Novel Orally Bioavailable Oxaborole 6-Carboxamides That Demonstrate Cure in a Murine Model of Late-Stage Central Nervous System African Trypanosomiasis

K. Jarnagin, B. Nare, R. Brun, 2010, Antimicrobial Agents and Chemotherapy.

Discovery of novel benzoxaborole-based potent antitrypanosomal agents.

Yaxue Zhao, B. Nare, J. McKerrow, 2010, ACS medicinal chemistry letters.

Coordinate induction of Ia alpha, beta, and Ii mRNA in a macrophage cell line.

J. Parnes, P. P. Jones, Y. Freund, 1985, Journal of immunology.

Interferon-γ: Receptors and Effects on MHC Antigen Expression

G. Pavlath, R. Aiyer, Patricia P. Jones, 1986 .

In Vitro Investigation of Host Resistance toToxoplasma gondii Infection in Microglia of BALB/c and CBA/Ca Mice

H. Javitz, Y. Freund, N. Zaveri, 2001, Infection and Immunity.

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

R. Tarleton, S. Hamer, J. Halladay, 2022, Nature Microbiology.

Synergistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models: mechanism of toxicity.

J. T. Macgregor, C. Tyson, J. Dabbs, 2002, Toxicology and applied pharmacology.

Immunohematotoxicity studies with combinations of dapsone and zidovudine.

J. T. Macgregor, N. Mohagheghpour, Y. Freund, 2001, International immunopharmacology.

Oral treatment with trimethoprim-sulfamethoxazole and zidovudine suppresses murine accessory cell-dependent immune responses.

J. T. Macgregor, N. Mohagheghpour, Y. Freund, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

SCYX-7158, an Orally-Active Benzoxaborole for the Treatment of Stage 2 Human African Trypanosomiasis

B. Nare, Jennifer L Owens, R. Brun, 2011, PLoS neglected tropical diseases.

Pyrimethamine impairs host resistance to infection with Listeria monocytogenes in BALB/c mice.

J. T. Macgregor, S. Phillips, Y. Freund, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis

J. Gut, C. Huston, J. Plattner, 2019, Nature Communications.

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)

B. Nare, M. Witty, R. Brun, 2018, Bioorganic & medicinal chemistry letters.

The trypanocidal benzoxaborole AN7973 inhibits trypanosome mRNA processing

Isabel M. Vincent, M. Barrett, C. Clayton, 2018, bioRxiv.

Inhibition of Toll-Like Receptor-Mediated Inflammation in vitro and in vivo by a Novel Benzoxaborole

K. Jarnagin, A. Gertrudes, T. Akama, 2012 .

Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors

K. Jarnagin, F. Rock, Yong-Kang Zhang, 2013, The Journal of Pharmacology and Experimental Therapeutics.

cis-acting sequences required for class II gene regulation by interferon gamma and tumor necrosis factor alpha in a murine macrophage cell line

Y. Freund, R. Dedrick, P. Jones, 1990, The Journal of experimental medicine.

cis-acting sequences required for class II gene regulation by interferon gamma and tumor necrosis factor alpha in a murine macrophage cell line

Patricia P. Jones, Y. Freund, R. Dedrick, 1990, The Journal of experimental medicine.

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei

Mark C. Field, Isabel M. Vincent, M. Barrett, 2018, PLoS neglected tropical diseases.

Interactions of bovine thrombin and plasma albumin with low-energy surfaces.

D. F. Waugh, Y. Freund, J. Lippe, 1978, Journal of biomedical materials research.

Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.

K. Jarnagin, V. Ciaravino, T. Akama, 2012, Journal of pharmaceutical and biomedical analysis.

Depression of natural killer activity and mitogen responsiveness in mice treated with pristane.

Y. Freund, P. Blair, 1982, Journal of immunology.

Vaccination with a recombinant vaccinia vaccine containing the B7‐1 co‐stimulatory molecule causes no significant toxicity and enhances T cell–mediated cytotoxicity

J. Schlom, C. Tyson, J. Kantor, 2000, International journal of cancer.

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

Patrick G. Schupp, J. Derisi, J. Gut, 2017, Nature Communications.

Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis

P. Rosenthal, A. Bougdour, S. Cusack, 2017, EMBO molecular medicine.

Immune response gene expression increases in the aging murine hippocampus

Stephen R. Morairty, B. P. Eynon, A. Apte-Deshpande, 2002, Journal of Neuroimmunology.

Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.

B. Nare, N. Yarlett, M. Orr, 2011, Future medicinal chemistry.

Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase

J. Derisi, J. Gut, P. Rosenthal, 2016, Antimicrobial Agents and Chemotherapy.

Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.

K. Jarnagin, J. Nieman, Rajeshwar Singh, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013, Antimicrobial Agents and Chemotherapy.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

V. Ciaravino, P. Rosenthal, F. Gamo, 2017, Journal of medicinal chemistry.

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

P. Rosenthal, F. Gamo, J. Plattner, 2015, Journal of Medicinal Chemistry.

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

I. Gilbert, V. Yardley, B. Nare, 2021, Journal of medicinal chemistry.

Polymorphisms in the tumor necrosis factor alpha (TNF-alpha) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-alpha mRNA in infected brain tissue

C. Jacob, Y. Suzuki, J. Remington, 1992, Journal of Experimental Medicine.

Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase

J. Gut, P. Rosenthal, A. Bougdour, 2016, Antimicrobial Agents and Chemotherapy.

Stephen R. Morairty, A. Apte-Deshpande, T. Kilduff, 2002, Neuroscience Letters.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

cis-ACTING SEQUENCES REQUIRED FOR CLASS II GENE REGULATION BY INTERFERON y AND TUMOR NECROSIS FACTOR a IN A MURINE MACROPHAGE CELL LINE

Patricia P. Jones, Y. Freund, R. Dedrick, 2003 .

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Mark C. Field, I. Gilbert, D. Horn, 2018, Proceedings of the National Academy of Sciences.

with Activity against Gram-negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013 .

TNF-alpha differentially regulates Ia antigen expression and macrophage tumoricidal activity in two murine macrophage cell lines.

T. Wynn, Y. Freund, D. Paulnock, 1992, Cellular Immunology.

Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors

K. Jarnagin, F. Rock, Yong-Kang Zhang, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Is TNF beneficial or deleterious in resistance to toxoplasmic encephalitis? Reply

Yasuhiro Suzuki, J. Remington, Y. Freund, 1992 .