J. Bujons

发表

Asymmetric assembly of aldose carbohydrates from formaldehyde and glycolaldehyde by tandem biocatalytic aldol reactions

J. Joglar, Xavier Garrabou, P. Clapés, 2015, Nature Chemistry.

Charge reversal of a critical active-site residue of cytochrome-c peroxidase: characterization of the Arg48-->Glu variant.

L. Banci, J. Ferrer, A. Mauk, 1997, European journal of biochemistry.

Chemoenzymatic Hydroxymethylation of Carboxylic Acids by Tandem Stereodivergent Biocatalytic Aldol Reaction and Chemical Decarboxylation

J. Joglar, P. Clapés, M. Bolte, 2019, ACS Catalysis.

Aldolases as Catalyst for the Synthesis of Carbohydrates and Analogs

J. Joglar, P. Clapés, J. Bujons, 2014 .

Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.

J. Joglar, P. Clapés, T. Parella, 2011, Chemical communications.

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase from E. Coli, YfaU

J. Joglar, P. Clapés, T. Parella, 2018 .

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli.

J. Joglar, P. Clapés, T. Parella, 2018, Angewandte Chemie.

EngineeredL-Serine Hydroxymethyltransferase fromStreptococcus thermophilusfor the Synthesis of α,α-Dialkyl-α-Amino Acids

J. Joglar, I. Usón, P. Clapés, 2015 .

Engineered L-serine hydroxymethyltransferase from Streptococcus thermophilus for the synthesis of α,α-dialkyl-α-amino acids.

J. Joglar, I. Usón, P. Clapés, 2015, Angewandte Chemie.

Structure-guided minimalist redesign of the L-fuculose-1-phosphate aldolase active site: expedient synthesis of novel polyhydroxylated pyrrolizidines and their inhibitory properties against glycosidases and intestinal disaccharidases.

J. Joglar, Xavier Garrabou, P. Clapés, 2010, Chemistry.

2‐Keto‐3‐Deoxy‐l‐Rhamnonate Aldolase (YfaU) as Catalyst in Aldol Additions of Pyruvate to Amino Aldehyde Derivatives

J. Joglar, P. Clapés, T. Parella, 2017 .

15N NMR spectroscopic and theoretical GIAO-DFT studies for the unambiguous characterization of disubstituted 1,2,3-triazoles.

A. Messeguer, I. Alfonso, J. Bujons, 2013, Organic & biomolecular chemistry.

Salt-induced adaptation of a dynamic combinatorial library of pseudopeptidic macrocycles: unraveling the electrostatic effects in mixed aqueous media.

A. Moure, I. Alfonso, Joan Atcher, 2015, Chemistry.

Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors.

A. Messeguer, A. Moure, I. Alfonso, 2016, Biophysical journal.

Dynamic Covalent Identification of an Efficient Heparin Ligand.

A. Messeguer, I. Alfonso, D. Carbajo, 2018, Angewandte Chemie.

Dynamic Covalent Identification of an Efficient Heparin Ligand

A. Messeguer, I. Alfonso, D. Carbajo, 2018, Angewandte Chemie.

Expedient synthesis of C-aryl carbohydrates by consecutive biocatalytic benzoin and aldol reactions.

J. Joglar, P. Clapés, M. Pohl, 2015, Chemistry.

Cytochrome c peroxidase-cytochrome c complex: locating the second binding domain on cytochrome c peroxidase with site-directed mutagenesis.

B. Hoffman, A. Mauk, J. Bujons, 2000, Biochemistry.

Studies on the inhibition of sphingosine-1-phosphate lyase by stabilized reaction intermediates and stereodefined azido phosphates.

J. Casas, J. Abad, J. Bujons, 2016, European journal of medicinal chemistry.

Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde.

J. Joglar, Xavier Garrabou, P. Clapés, 2014, Chemistry.

Biocatalytic Construction of Quaternary Centers by Aldol Addition of 3,3-Disubstituted 2-Oxoacid Derivatives to Aldehydes.

J. Joglar, P. Clapés, T. Parella, 2020, Journal of the American Chemical Society.

The organochlorine pesticides gamma-hexachlorocyclohexane (lindane), alpha-endosulfan and dieldrin differentially interact with GABA(A) and glycine-gated chloride channels in primary cultures of cerebellar granule cells.

C. Vale, A. Messeguer, C. Suñol, 2003, Neuroscience.

Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks

Xavier Garrabou, Pere Clapés, Jordi Bujons, 2014 .

Synthesis and evaluation of hydroxymethylaminocyclitols as glycosidase inhibitors.

A. Llebaria, A. Trapero, J. Bujons, 2015, The Journal of organic chemistry.

Efficient Synthesis of Conformationally Restricted Apoptosis Inhibitors Bearing a Triazole Moiety.

E. Pérez-Payá, A. Messeguer, I. Alfonso, 2015, Chemistry.

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols.

J. Joglar, Xavier Garrabou, P. Clapés, 2012, Organic & biomolecular chemistry.

Optimizing the control of apoptosis by amide/triazole isosteric substitution in a constrained peptoid.

E. Pérez-Payá, A. Messeguer, I. Alfonso, 2013, European journal of medicinal chemistry.

Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives.

J. Joglar, P. Clapés, P. Cardona, 2013, Organic & biomolecular chemistry.

New glucocerebrosidase inhibitors by exploration of chemical diversity of N-substituted aminocyclitols using click chemistry and in situ screening.

A. Llebaria, J. Casas, J. Bujons, 2011, Journal of medicinal chemistry.

Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I.

J. Joglar, I. Usón, P. Clapés, 2017, Angewandte Chemie.

Chemoenzymatic Production of Enantiocomplementary 2-Substituted 3-Hydroxycarboxylic Acids from L-α-Amino Acids

J. Joglar, P. Clapés, J. Bujons, 2021, Advanced synthesis & catalysis.

Stereoselective aldol additions catalyzed by dihydroxyacetone phosphate-dependent aldolases in emulsion systems: preparation and structural characterization of linear and cyclic iminopolyols from aminoaldehydes.

C. Solans, J. Joglar, P. Clapés, 2003, Chemistry.

Live-Cell-Templated Dynamic Combinatorial Chemistry.

I. Alfonso, D. Carbajo, J. Bujons, 2020, Angewandte Chemie.

Entropy-driven homochiral self-sorting of a dynamic library.

I. Alfonso, Joan Atcher, J. Bujons, 2017, Chemical communications.

Dynamic Combinatorial Optimization of In Vitro and In Vivo Heparin Antidotes

M. Guerra-Rebollo, E. Prats, I. Alfonso, 2022, Journal of medicinal chemistry.

Synthesis of γ-Hydroxy-α-amino Acid Derivatives by Enzymatic Tandem Aldol Addition–Transamination Reactions

J. Joglar, P. Clapés, Carlos J. Moreno, 2021, ACS catalysis.

Allosteric positive interaction of thymol with the GABAA receptor in primary cultures of mouse cortical neurons

C. Vale, C. Suñol, J. Bujons, 2006, Neuropharmacology.

Aldolase‐Catalyzed Asymmetric Synthesis of N‐Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

W. Fessner, J. Joglar, P. Clapés, 2019, Advanced synthesis & catalysis.

The organochlorine pesticides γ-hexachlorocyclohexane (lindane), α-endosulfan and dieldrin differentially interact with GABAA and glycine-gated chloride channels in primary cultures of cerebellar granule cells

C. Vale, A. Messeguer, C. Suñol, 2003, Neuroscience.

Click chemistry approach to new N-substituted aminocyclitols as potential pharmacological chaperones for Gaucher disease.

A. Llebaria, J. Casas, J. Bujons, 2010, Journal of medicinal chemistry.

Selective chaperone effect of aminocyclitol derivatives on G202R and other mutant glucocerebrosidases causing Gaucher disease.

D. Grinberg, L. Vilageliu, J. Aerts, 2014, The international journal of biochemistry & cell biology.

Computational Prediction of Structure-Activity Relationships for the Binding of Aminocyclitols to β-Glucocerebrosidase

Johan Åqvist, Antonio Delgado, Hugo Gutiérrez-de-Terán, 2011, J. Chem. Inf. Model..

Dihydroxyacetone phosphate aldolase catalyzed synthesis of structurally diverse polyhydroxylated pyrrolidine derivatives and evaluation of their glycosidase inhibitory properties.

J. Joglar, J. Calveras, P. Clapés, 2009, Chemistry.

Aldol additions of dihydroxyacetone phosphate to N-Cbz-amino aldehydes catalyzed by L-fuculose-1-phosphate aldolase in emulsion systems: inversion of stereoselectivity as a function of the acceptor aldehyde.

J. Joglar, J. Calveras, P. Clapés, 2005, Chemistry.

Redesign of the Phosphate Binding Site of L-Rhamnulose- 1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase

R. Crehuet, J. Joglar, Xavier Garrabou, 2011 .

Influence of N-amino protecting group on aldolase-catalyzed aldol additions of dihydroxyacetone phosphate to amino aldehydes

R. Crehuet, J. Joglar, J. Calveras, 2006 .

Novel separation of bioactive catechin derivatives from complex plant mixtures by anion-exchange chromatography

J. Torres, J. Bujons, C. Lozano, 2008 .

Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II[S]

J. Casas, G. Fabriàs, J. Bujons, 2014, Journal of Lipid Research.

Allopregnanolone and pregnanolone analogues modified in the C ring: synthesis and activity.

C. Suñol, Z. Krištofíková, A. Kasal, 2013, Journal of medicinal chemistry.

Activity of B-nor analogues of neurosteroids on the GABA(A) receptor in primary neuronal cultures.

C. Suñol, Z. Krištofíková, A. Kasal, 2006, Journal of medicinal chemistry.

Bacterial versus human sphingosine-1-phosphate lyase (S1PL) in the design of potential S1PL inhibitors.

J. Casas, J. Abad, J. Bujons, 2016, Bioorganic & medicinal chemistry.

Identification of benzo[cd]indol-2(1H)-ones as novel Atg4B inhibitors via a structure-based virtual screening and a novel AlphaScreen assay.

Gemma Triola, J. Bujons, J. Comas-Barceló, 2019, European journal of medicinal chemistry.

Biosynthesis of 10,12-dienoic fatty acids by a bifunctional Delta11 desaturase in Spodoptera littoralis.

B. Piña, G. Fabriàs, J. Bujons, 2006, Insect biochemistry and molecular biology.

The first fluorogenic sensor for sphingosine-1-phosphate lyase activity in intact cells.

J. Casas, G. Fabriàs, J. Abad, 2017, Chemical communications.

Mutants That Alter the Covalent Structure of Catalase Hydroperoxidase II from Escherichia coli*

W. Ens, J. Bravo, M. Maté, 1999, The Journal of Biological Chemistry.

Use of dimethyldioxirane in the preparation of highly reactive compounds: First direct epoxidation of precocenes

A. Messeguer, J. Bujons, F. Camps, 1990 .

Use of Dimethyldioxirane in the Preparation of Highly Reactive Compounds: First Direct Epoxidation of Precocenes (I).

A. Messeguer, J. Bujons, F. Camps, 1991 .

Combining Aldolases and Transaminases for the Synthesis of 2‑Amino-4-hydroxybutanoic Acid

W. Fessner, P. D. D. María, J. Joglar, 2017 .

Triazine-based vanilloid 1 receptor open channel blockers: design, synthesis, evaluation, and SAR analysis.

J. González-Ros, A. Fernández-Carvajal, A. Ferrer-Montiel, 2011, Journal of medicinal chemistry.

A study of the interconversion between 3,4-dihydro-4-formyl-2-hydroxy-2H-benzopyran and 2,3,3a,8a-tetrahydro-2-hydroxyfuro[2,3-b]benzofuran moieties, and its application to a formal synthesis of (±)-aflatoxin B1

F. Sánchez-Baeza, A. Messeguer, J. Bujons, 1994 .

Structure-Guided Engineering of D-Fructose-6-Phosphate Aldolase for Improved Acceptor Tolerance in Biocatalytic Aldol Additions

J. Joglar, P. Clapés, T. Parella, 2015 .

Metabolism of R,S enantiomers of 3-phenylamino-1,2-propanediol, a compound associated with the toxic oil syndrome, in C57BL/6- and A/J-strain mice.

A. Messeguer, A. Morató, J. Bujons, 2001, Advances in experimental medicine and biology.

Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration

A. Messeguer, A. Moure, I. Alfonso, 2021, Pharmaceuticals.

Live‐Cell‐Templated Dynamic Combinatorial Chemistry

I. Alfonso, D. Carbajo, J. Bujons, 2020, Angewandte Chemie.

Chemical modulation of peptoids: synthesis and conformational studies on partially constrained derivatives.

E. Pérez-Payá, A. Messeguer, G. Sanclimens, 2011, Chemistry.

Positional Scanning Synthesis of a Peptoid Library Yields New Inducers of Apoptosis that Target Karyopherins and Tubulin

H. Waldmann, A. Messeguer, A. Brockmeyer, 2015, Chembiochem : a European journal of chemical biology.

Biotransformation and clearance of 3-(phenylamino)propane-1,2-diol, a compound present in samples related to toxic oil syndrome, in C57BL/6 and A/J mice.

A. Messeguer, A. Morató, J. Bujons, 1999, Chemical research in toxicology.

Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes

Israel Sánchez-Moreno, W. Fessner, J. Joglar, 2018, ACS catalysis.

Highly efficient aldol additions of DHA and DHAP to N-Cbz-amino aldehydes catalyzed by L-rhamnulose-1-phosphate and L-fuculose-1-phosphate aldolases in aqueous borate buffer.

J. Joglar, J. Calveras, Xavier Garrabou, 2011, Organic & biomolecular chemistry.

A convenient entry to the toxicophoric furo[2,3-b] benzofuran fragment present in aflatoxins

F. Sánchez-Baeza, A. Messeguer, J. Bujons, 1992 .

Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity

E. Pérez-Payá, A. Pineda-Lucena, A. Messeguer, 2014, PloS one.

Biocatalytic Synthesis of Homochiral 2-Hydroxy-4-butyrolactone Derivatives by Tandem Aldol Addition and Carbonyl Reduction

J. Joglar, P. Clapés, T. Parella, 2023, ACS catalysis.

Inhibition of Sema-3A Promotes Cell Migration, Axonal Growth, and Retinal Ganglion Cell Survival

A. Barzilai, A. Messeguer, M. Safrin, 2021, Translational vision science & technology.

Aflatoxin M1 8,9-epoxide: preparation and mutagenic activity.

A. Messeguer, N. Kado, D. Hsieh, 1995, Chemical research in toxicology.

Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I.

J. Joglar, I. Usón, P. Clapés, 2017, Angewandte Chemie.

N epsilon,N epsilon-dimethyl-lysine cytochrome c as an NMR probe for lysine involvement in protein-protein complex formation.

G. Moore, M. R. Mauk, F. Rosell, 1998, The Biochemical journal.

Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde.

J. Joglar, Xavier Garrabou, P. Clapés, 2014, Chemistry.