N. Kaila

发表

N. Kaila, B. Thomas, 2003 .

Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.

J. Telliez, J. Cuozzo, Lih-Ling Lin, 2006, Bioorganic & medicinal chemistry letters.

Diazine indole acetic acids as potent, selective, and orally bioavailable antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2012, Journal of medicinal chemistry.

Prophylactic P-selectin inhibition with PSI-421 promotes resolution of venous thrombosis without anticoagulation

T. Wakefield, R. Schaub, F. Londy, 2008, Thrombosis and Haemostasis.

Resolution of venous thrombosis using a novel oral small-molecule inhibitor of P-selectin (PSI-697) without anticoagulation

T. Wakefield, R. Schaub, F. Londy, 2007, Thrombosis and Haemostasis.

A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model

P. Tummino, I. Waddell, D. Ciccone, 2020, European Journal of Cancer.

Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.

A. Moretto, G. Shaw, L. Di, 2010, Journal of medicinal chemistry.

New spleen tyrosine kinase inhibitors: patent applications published during 2011-2013.

A. Thorarensen, N. Kaila, 2014, Pharmaceutical patent analyst.

Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

B. Molitoris, Liping Huang, K. Beaumont, 2022, Frontiers in Medicine.

Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.

J. Telliez, Lih-Ling Lin, Junjun Wu, 2009, Bioorganic & medicinal chemistry letters.

Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.

J. Telliez, D. Powell, J. Cuozzo, 2007, Bioorganic & medicinal chemistry.

Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships.

J. Telliez, A. Gopalsamy, G. Ciszewski, 2005, Bioorganic & medicinal chemistry letters.

Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.

Mark J. Mitton-Fry, J. D. Clark, M. Hegen, 2018, Journal of medicinal chemistry.

Selectin inhibitors: a patent review

N. Kaila, Patricia W. Bedard, 2010, Expert opinion on therapeutic patents.

CRTH2 is Critical to the Development of Colitis Induced by Dextran Sodium Sulfate (DSS)

H. Ma, E. Saiah, Z. Radi, 2012 .

Bromodecarboxylation of quinoline salicylic acids: increasing the diversity of accessible substituted quinolines.

N. Kaila, Kristin Janz, 2009, The Journal of organic chemistry.

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.

R. Kurumbail, K. Geoghegan, L. R. Hoth, 2016, Acta crystallographica. Section F, Structural biology communications.

Decreased venous thrombosis with an oral inhibitor of P selectin.

T. Wakefield, G. Shaw, R. Schaub, 2005, Journal of vascular surgery.

Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis.

T. Wakefield, G. Shaw, R. Schaub, 2006, Journal of vascular surgery.

N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1

V. Marathias, E. Saiah, N. Papaioannou, 2011 .

Design and synthesis of sialyl Lewisx mimics as E‐ and P‐selectin inhibitors

N. Kaila, B. Thomas, Bert E. Thomas IV, 2002, Medicinal research reviews.

Discovery of isoquinolinone indole acetic acids as antagonists of chemoattractant receptor homologous molecule expressed on Th2 cells (CRTH2) for the treatment of allergic inflammatory diseases.

A. Moretto, T. Mansour, C. Hubeau, 2014, Journal of medicinal chemistry.

Arylbis(arylthio)sulfonium salts as reagents for the synthesis of 2-deoxy-.beta.-glycosides

Gurmit S. Grewal, N. Kaila, R. Franck, 1992 .

A molecular orbital study of diastereofacial selectivity in the Diels-Alder reaction

J. Dannenberg, N. Kaila, R. Franck, 1989 .

Synthesis of the C'D' disaccharide of aureolic acid.

N. Kaila, R. Franck, 1993, Carbohydrate research.

Polarized-.pi. frontier molecular orbital (PPFMO) and experimental studies of facial selectivity in electrophilic attacks on substituted alkenes

J. Dannenberg, N. Kaila, R. Franck, 1993 .

Face selectivity of the protonation of glycals

N. Kaila, R. Franck, M. Blumenstein, 1992 .

Aureolic acid antibiotics: a simple method for 2-deoxy-.beta.-glycosidation

Gurmit S. Grewal, N. Kaila, R. Franck, 1990 .

Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.

Adam Shilling, J. Keith, A. Shilling, 2007, Journal of medicinal chemistry.

Design and synthesis of novel sialyl Lewis x mimics

N. Kaila, Hsiang‐Ai Yu, Xia Yibin, 1995 .

Design and synthesis of sialyl Lewisx mimics as E‐ and P‐selectin inhibitors

N. Kaila, Bert E. Thomas IV, 2002, Medicinal research reviews.

Design and synthesis of sialyl Lewis x mimics as E-selectin inhibitors.

J. Alvarez, R. Camphausen, N. Kaila, 2001, Bioorganic & medicinal chemistry letters.

Structural basis for isoform-specific inhibition of human CTPS1

Steven K. Albanese, J. McElwee, K. Borrelli, 2021, Proceedings of the National Academy of Sciences.

Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.

Bert E Thomas, J. Alvarez, W. Somers, 2005, Journal of medicinal chemistry.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

Inhibitors of immuno-oncology target HPK1 – a patent review (2016 to 2020)

I. Linney, N. Kaila, 2021, Expert opinion on therapeutic patents.

Characterization of the Novel P-Selectin Inhibitor PSI-697 [2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] Quinoline-4-carboxylic acid] in Vitro and in Rodent Models of Vascular Inflammation and Thrombosis

G. Shaw, R. Schaub, J. Keith, 2008, Journal of Pharmacology and Experimental Therapeutics.

Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.

D. Joseph-McCarthy, J. Telliez, J. Cuozzo, 2007, Journal of medicinal chemistry.

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.

A. Moretto, G. Shaw, R. Schaub, 2007, Journal of medicinal chemistry.

Identification and structural determination of a potent P-selectin inhibitor.

Y. Xiang, R. Camphausen, G. Y. Xu, 2001, Bioorganic & Medicinal Chemistry.

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)

Atli Thorarensen, Joseph McDonald, A. Moretto, 2016, ChemMedChem.

Biophysical and Mechanistic Insights into Novel Allosteric Inhibitor of Spleen Tyrosine Kinase

A. Aulabaugh, Zhao‐Kui Wan, Shenping Liu, 2012, The Journal of Biological Chemistry.

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279.

J. McElwee, Phani Ghanakota, Wenyan Miao, 2023, Journal of medicinal chemistry.

Imidazotriazines: Spleen Tyrosine Kinase (Syk) Inhibitors Identified by Free‐Energy Perturbation (FEP)

A. Moretto, L. Fitz, A. Thorarensen, 2016, ChemMedChem.