S. Yamada

A. Sugawara, S. Ito, T. Yoshikawa, 2018, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Chondroitin Sulfate N‐acetylgalactosaminyltransferase‐1 (CSGalNAcT‐1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity

A. Janecke, S. Ikegawa, T. Müller, 2017, Human mutation.

Molecular interactions between chondroitin-dermatan sulfate and growth factors/receptors/matrix proteins.

Shuji Mizumoto, S. Yamada, K. Sugahara, 2015, Current opinion in structural biology.

Structure Determination of the Octa- and Decasaccharide Sequences Isolated from the Carbohydrate-Protein Linkage Region of Porcine Intestinal Heparin (*)

K. Yoshida, J. Vliegenthart, T. de Beer, 1995, The Journal of Biological Chemistry.

Involvement of Human Natural Killer-1 (HNK-1) Sulfotransferase in the Biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in α-Thrombomodulin from Human Urine*

Shuji Mizumoto, S. Yamada, K. Sugahara, 2011, The Journal of Biological Chemistry.

Myopathy Associated With Dermatan Sulfate-Deficient Decorin and Myostatin in Musculocontractural Ehlers-Danlos Syndrome: A Mouse Model Investigation

Guillermo Posadas-Herrera, Y. Inoue, Takayoshi Inoue, 2021, Frontiers in Cell and Developmental Biology.

Loss‐of‐function mutations of CHST14 in a new type of Ehlers‐Danlos syndrome

Y. Fukushima, N. Matsumoto, M. Shiina, 2010, Human mutation.

Isolation of reducing oligosaccharide chains from the chondroitin/dermatan sulfate-protein linkage region and preparation of analytical probes by fluorescent labeling with 2-aminobenzamide.

M. Watanabe, S. Yamada, K. Sugahara, 2001, Journal of biochemistry.

Defect in dermatan sulfate in urine of patients with Ehlers-Danlos syndrome caused by a CHST14/D4ST1 deficiency.

N. Miyake, N. Okamoto, T. Kosho, 2017, Clinical biochemistry.

A response to: Loss of dermatan‐4‐sulfotransferase 1 (D4ST1/CHST14) function represents the first dermatan sulfate biosynthesis defect, “dermatan sulfate‐deficient Adducted Thumb–Clubfoot Syndrome”. Which name is appropriate, “Adducted Thumb–Clubfoot Syndrome” or “Ehlers–Danlos syndrome”?

Y. Fukushima, N. Matsumoto, N. Miyake, 2011, Human mutation.

A Non-sulfated Chondroitin Stabilizes Membrane Tubulation in Cnidarian Organelles*

Takashi Gojobori, Shuhei Yamada, T. Gojobori, 2010, The Journal of Biological Chemistry.

Identification of a Novel Chondroitin Hydrolase in Caenorhabditis elegans*

S. Mitani, Shuji Mizumoto, S. Yamada, 2008, Journal of Biological Chemistry.

The uniform galactose 4-sulfate structure in the carbohydrate-protein linkage region of human urinary trypsin inhibitor.

M. Oyama, K. Kato, Y. Yuki, 1995, European journal of biochemistry.

Novel tetrasaccharides isolated from squid cartilage chondroitin sulfate E contain unusual sulfated disaccharide units GlcA(3-O-sulfate)beta1-3GalNAc(6-O-sulfate) or GlcA(3-O-sulfate)beta1-3GalNAc.

A. Dell, H. Morris, S. Haslam, 1997, The Journal of biological chemistry.

Development of a mouse monoclonal antibody against the chondroitin sulfate-protein linkage region derived from shark cartilage

P. Kongtawelert, Duriya Fongmoon, J. Jacquinet, 2010, Glycoconjugate Journal.

Structure of Oligosaccharides Isolated from Heparan Sulfate/Heparin and Substrate Specificities of the Degrading Enzymes of Bacterial Origin

S. Yamada, K. Sugahara, 1998 .

Catabolism of chondroitin sulfate

S. Yamada, 2015, Cellular & molecular biology letters.

Structural Recognition by Recombinant Human Heparanase That Plays Critical Roles in Tumor Metastasis

M. Nakajima, S. Yamada, K. Sugahara, 2002, The Journal of Biological Chemistry.

Structural Requirements of Heparan Sulfate for the Binding to the Tumor-derived Adhesion Factor/Angiomodulin That Induces Cord-like Structures to ECV-304 Human Carcinoma Cells*

K. Miyazaki, S. Yamada, K. Sugahara, 2000, The Journal of Biological Chemistry.

Preparation of oligosaccharides from sulfated glycosaminoglycans using bacterial enzymes.

S. Yamada, K. Sugahara, 2003, Methods in molecular biology.

Characterization of heparinase from an oral bacterium Prevotella heparinolytica.

M. Watanabe, S. Yamada, K. Sugahara, 1998, Journal of biochemistry.

Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection.

Eunmi Kim, H. Sawa, Takashi Kimura, 2011, Biochemical and biophysical research communications.

Conversion of N-sulfated glucosamine to N-sulfated mannosamine in an unsaturated heparin disaccharide by non-enzymatic, base-catalyzed C-2 epimerization during enzymatic oligosaccharide preparation.

M. Watanabe, S. Yamada, K. Sugahara, 1998, Carbohydrate research.

A Major Common Trisulfated Hexasaccharide Core Sequence, Hexuronic Acid(2-Sulfate)-Glucosamine(N-Sulfate)-Iduronic Acid-N-Acetylglucosamine-Glucuronic Acid-Glucosamine(N-Sulfate), Isolated from the Low Sulfated Irregular Region of Porcine Intestinal Heparin*

K. Yoshida, S. Yamada, Y. Yamane, 1998, The Journal of Biological Chemistry.

Structures of Five Sulfated Hexasaccharides Prepared from Porcine Intestinal Heparin Using Bacterial Heparinase

J. Hopwood, S. Yamada, K. Sugahara, 1996, The Journal of Biological Chemistry.

Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.

K. Yoshida, T. Murakami, S. Yamada, 1995, The Journal of biological chemistry.

Structural studies on the oligosaccharides isolated from bovine kidney heparan sulphate and characterization of bacterial heparitinases used as substrates.

K. Khoo, A. Dell, H. Morris, 1994, Glycobiology.

Structural studies on the tri- and tetrasaccharides isolated from porcine intestinal heparin and characterization of heparinase/heparitinases using them as substrates.

K. Khoo, A. Dell, H. Morris, 1994, Glycobiology.

Structural studies on the bacterial lyase-resistant tetrasaccharides derived from the antithrombin III-binding site of porcine intestinal heparin.

K. Khoo, A. Dell, H. Morris, 1993, The Journal of biological chemistry.

One- and two-dimensional 1H-NMR characterization of two series of sulfated disaccharides prepared from chondroitin sulfate and heparan sulfate/heparin by bacterial eliminase digestion.

K. Yoshida, S. Yamada, K. Sugahara, 1992, Journal of biochemistry.

Pseudodiastrophic dysplasia expands the known phenotypic spectrum of defects in proteoglycan biosynthesis

H. Scott, A. Schreiber, C. Barnett, 2020, Journal of Medical Genetics.

Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis

Shuji Mizumoto, S. Yamada, 2021, Frontiers in Genetics.

Novel Sulfated Oligosaccharides Containing 3-O-Sulfated Glucuronic Acid from King Crab Cartilage Chondroitin Sulfate K

H. Kitagawa, A. Dell, H. Morris, 1996, The Journal of Biological Chemistry.

Involvement of chondroitin sulfate E in the liver tumor focal formation of murine osteosarcoma cells.

Basappa, Shuhei Yamada, K. Sugahara, 2009, Glycobiology.

Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells*

Fuchuan Li, T. V. van Kuppevelt, G. T. ten Dam, 2008, Journal of Biological Chemistry.

Chondroitin Sulfate Chains on Syndecan-1 and Syndecan-4 from Normal Murine Mammary Gland Epithelial Cells Are Structurally and Functionally Distinct and Cooperate with Heparan Sulfate Chains to Bind Growth Factors

Shuhei Yamada, O. Goldberger, Kazuyuki Sugahara, 2004, Journal of Biological Chemistry.

Potential therapeutic application of chondroitin sulfate/dermatan sulfate.

Shuhei Yamada, Kazuyuki Sugahara, S. Yamada, 2008, Current drug discovery technologies.

Oversulfated Chondroitin/Dermatan Sulfates Containing GlcAβ1/IdoAα1–3GalNAc(4,6-O-disulfate) Interact with L- and P-selectin and Chemokines*

Shuhei Yamada, M. Miyasaka, Kazuyuki Sugahara, 2002, The Journal of Biological Chemistry.

Novel sulfated octa- and decasaccharides from squid cartilage chondroitin sulfate E: sequencing and application for determination of the epitope structure of the monoclonal antibody MO-225.

P. Kongtawelert, S. Yamada, T. Mikami, 2007, Biochemistry.

Identification of novel LFNG mutations in spondylocostal dysostosis

Long Guo, M. Matsumoto, Kota Watanabe, 2018, Journal of Human Genetics.

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

M. Taira, Takayoshi Yamamoto, S. Takada, 2017, Nature Communications.

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain.

H. Kitagawa, T. Matsuda, D. Nadano, 2020, Biochimica et biophysica acta. General subjects.

Mass preparation of oligosaccharides by the hydrolysis of chondroitin sulfate polysaccharides with a subcritical water microreaction system.

S. Yamada, K. Sugahara, H. Ura, 2013, Carbohydrate research.

Demonstration of glycosaminoglycans in Caenorhabditis elegans

H. Kitagawa, D. H. van den Eijnden, I. van Die, 1999, FEBS letters.

Recent Advances in the Pathophysiology of Musculocontractural Ehlers-Danlos Syndrome

N. Miyake, Takafumi Watanabe, T. Kosho, 2019, Genes.

CSGALNACT1‐congenital disorder of glycosylation: A mild skeletal dysplasia with advanced bone age

N. Katsanis, M. McDonald, G. Povysil, 2019, Human mutation.

Substrate specificity studies of Flavobacterium chondroitinase C and heparitinases towards the glycosaminoglycan--protein linkage region. Use of a sensitive analytical method developed by chromophore-labeling of linkage glycoserines using dimethylaminoazobenzenesulfonyl chloride.

K. Yoshida, S. Yamada, K. Morikawa, 1999, European journal of biochemistry.

Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus.

Eunmi Kim, Takashi Kimura, Yasuo Suzuki, 2011, Biochemical and biophysical research communications.

Chondroitin sulfate of appican, the proteoglycan form of amyloid precursor protein, produced by C6 glioma cells interacts with heparin‐binding neuroregulatory factors

Shuhei Yamada, J. Shioi, N. Robakis, 2004, FEBS letters.

Preparation of a series of sulfated tetrasaccharides from shark cartilage chondroitin sulfate D using testicular hyaluronidase and structure determination by 500 MHz1H NMR spectroscopy

S. Yamada, K. Sugahara, Yukako Tanaka, 1996, Glycoconjugate Journal.

Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome

Shuji Mizumoto, S. Yamada, 2023, Genes.

The sulphated carbohydrate-protein linkage region isolated from chondroitin 4-sulphate chains of inter-alpha-trypsin inhibitor in human plasma.

K. Khoo, A. Dell, H. Morris, 1995, Glycobiology.

Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus

Y. Matsuura, Chikako Kataoka, S. Taguwa, 2012, Glycoconjugate Journal.

Important role of heparan sulfate in postnatal islet growth and insulin secretion.

A. Sugawara, N. Noguchi, S. Takasawa, 2009, Biochemical and biophysical research communications.

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development.

U. Landegren, C. Betsholtz, H. Gerhardt, 2007, Genes & development.

b3galt6 Knock-Out Zebrafish Recapitulate β3GalT6-Deficiency Disorders in Human and Reveal a Trisaccharide Proteoglycan Linkage Region

G. Larson, P. Coucke, A. Willaert, 2020, bioRxiv.

Instructions for use Title Expression of N-Acetylgalactosamine 4-Sulfate 6O-Sulfotransferase Involved in Chondroitin Sulfate Synthesis

Shuji Mizumoto, S. Yamada, K. Sugahara, 2019 .

Expression of N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Involved in Chondroitin Sulfate Synthesis Is Responsible for Pulmonary Metastasis

Shuji Mizumoto, S. Yamada, K. Sugahara, 2013, BioMed research international.

Compositional analysis of the glycosaminoglycan family in velvet antlers of Sika deer (Cervus nippon) at different growing stages

Soo‐Ki Kim, B. Jeon, Chi-Ho Lee, 2019, Glycoconjugate Journal.

Clinical and pathophysiological delineation of musculocontractural Ehlers—Danlos syndrome caused by dermatan sulfate epimerase deficiency (mcEDS‐DSE): A detailed and comprehensive glycobiological and pathological investigation in a novel patient

M. Taki, Takafumi Watanabe, T. Kosho, 2022, Human mutation.

Structural alteration of glycosaminoglycan side chains and spatial disorganization of collagen networks in the skin of patients with mcEDS-CHST14.

N. Miyake, J. Minaguchi, J. Nakayama, 2019, Biochimica et biophysica acta. General subjects.

Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis

Soichiro Saito, K. Nakano, T. Okamura, 2023, PloS one.

A novel pentasaccharide sequence GlcA(3-sulfate)(beta1-3)GalNAc(4-sulfate)(beta1-4)(Fuc alpha1-3)GlcA(beta1-3)GalNAc(4-sulfate) in the oligosaccharides isolated from king crab cartilage chondroitin sulfate K and its differential susceptibility to chondroitinases and hyaluronidase.

H. Kitagawa, A. Dell, H. Morris, 1997, Biochemistry.

Roles of two types of heparan sulfate clusters in Wnt distribution and signaling in Xenopus

M. Taira, Takayoshi Yamamoto, S. Takada, 2017, Nature Communications.

Collagen Network Formation in In Vitro Models of Musculocontractural Ehlers–Danlos Syndrome

Takafumi Watanabe, T. Kosho, S. Miyata, 2023, Genes.

Delineation of musculocontractural Ehlers–Danlos Syndrome caused by dermatan sulfate epimerase deficiency

N. Matsumoto, N. Miyake, C. Lautrup, 2020, Molecular genetics & genomic medicine.

A new mouse model of Ehlers-Danlos syndrome generated using CRISPR/Cas9-mediated genomic editing

Guillermo Posadas-Herrera, Y. Inoue, Takayoshi Inoue, 2021, Disease models & mechanisms.

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

H. Nakanishi, S. Sakamoto, J. Ikeda, 2023, Scientific reports.

Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

H. Moritake, Hong-shan Liu, Yusuke Saito, 2021, Cancer science.

Screening of known disease genes in congenital scoliosis

N. Matsumoto, M. Nakajima, M. Matsumoto, 2018, Molecular genetics & genomic medicine.

Novel function of transglutaminase 2 in extracellular histone-induced acute lung injury.

S. Maruyama, H. Tatsukawa, K. Hitomi, 2023, Biochemical and biophysical research communications.

Involvement of Human Natural Killer-1 (HNK-1) Sulfotransferase in the Biosynthesis of the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in α-Thrombomodulin from Human Urine*

Shuji Mizumoto, S. Yamada, K. Sugahara, 2011, The Journal of Biological Chemistry.

Instructions for use

Shuji Mizumoto, S. Yamada, K. Sugahara, 2022 .

Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage.

Toshikazu Nakamura, Duriya Fongmoon, Shuji Mizumoto, 2011, Biochimica et Biophysica Acta.

Instructions for use

Shuji Mizumoto, S. Yamada, Takanari Kobayashi, 2000 .

Structural determination of sulfated tetrasaccharides and hexasaccharides containing a rare disaccharide sequence, -3GalNAc(4,6-disulfate)beta1-4IdoAalpha1-, isolated from porcine intestinal dermatan sulfate.

K. Sakamoto, S. Yamada, Y. Yamane, 1998, European journal of biochemistry.

Instructions for use

Shuji Mizumoto, S. Yamada, Takanari Kobayashi, 2023 .

Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus.

Eunmi Kim, Takashi Kimura, Yasuo Suzuki, 2011, Biochemical and biophysical research communications.

Identification of a novel LFNG variant in a Chinese fetus with spondylocostal dysostosis and a systematic review.

Long Guo, Shuji Mizumoto, S. Yamada, 2024, Journal of human genetics.

Identification of novel LFNG mutations in spondylocostal dysostosis

Long Guo, M. Matsumoto, Kota Watanabe, 2018, Journal of Human Genetics.

Integrative analysis of Lunatic Fringe variants associated with spondylocostal dysostosis type-III.

Shuji Mizumoto, S. Yamada, Parker Wengryn, 2024, The FASEB Journal.