U. Mende

发表

Dilated Cardiomyopathy and Heart Failure Caused by a Mutation in Phospholamban

Ulrike Mende, Christine E Seidman, Ferhaan Ahmad, 2003, Science.

In vitro models of the cardiac microenvironment to study myocyte and non‐myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

U. Mende, C. M. Kofron, 2017, The Journal of physiology.

Differential Contribution of GTPase Activation and Effector Antagonism to the Inhibitory Effect of RGS Proteins on Gq-mediated Signaling in Vivo*

Wei Zhang, U. Mende, T. Anger, 2004, Journal of Biological Chemistry.

Investigative Approaches to Mechanisms and Functional Consequences

U. Mende, P. Zhang, J. Su, 2012 .

Directed fusion of cardiac spheroids into larger heterocellular microtissues enables investigation of cardiac action potential propagation via cardiac fibroblasts

Tae Yun Kim, Z. Qu, Bum-Rak Choi, 2018, PloS one.

An Improved Isolation Procedure for Adult Mouse Cardiomyocytes

J. Ingwall, U. Mende, I. Pinz, 2011, Cell Biochemistry and Biophysics.

G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart.

E. Neer, P. Huang, M. Fishman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Isoprenaline-induced increase in the 40/41 kDa pertussis toxin substrates and functional consequences on contractile response in rat heart

M. Steinfath, J. Schulte am Esch, W. Schmitz, 2004, Naunyn-Schmiedeberg's Archives of Pharmacology.

Isoprenaline-induced increase in mRNA levels of inhibitory G-protein α-subunits in rat heart

W. Schmitz, T. Eschenhagen, A. Warnholtz, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Effect of captopril on myocardial β-adrenoceptor density and Giα-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy

M. Steinfath, J. Schulte am Esch, W. Schmitz, 2004, European Journal of Clinical Pharmacology.

PKC δ and βII regulate angiotensin II-mediated fibrosis through p38: a mechanism of RV fibrosis in pulmonary hypertension.

H. Chichger, G. Choudhary, U. Mende, 2015, American journal of physiology. Lung cellular and molecular physiology.

Cardiac Overexpression of Constitutively Active Galpha q Causes Angiotensin II Type1 Receptor Activation, Leading to Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

Y. Takeishi, A. Sanbe, Satoshi Suzuki, 2014, PloS one.

Beyond Pharmaceuticals: Fit-for-Purpose New Approach Methodologies for Environmental Cardiotoxicity Testing

P. McMullen, Mark C. Daley, Bum-Rak Choi, 2022, ALTEX.

Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

A. Maldonado, Leonard Chaves, Darragh Cullen, 2012, PloS one.

Reduced α1‐ and β2‐adrenoceptor‐mediated positive inotropic effects in human end‐stage heart failure

M. Steinfath, W. Schmitz, A. Haverich, 1992 .

Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure.

W. Schmitz, A. Haverich, T. Eschenhagen, 1992, Circulation research.

Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart.

J. Schulte am Esch, W. Schmitz, M. Diederich, 1992, Molecular pharmacology.

Cardioprotective effects of early intervention with sacubitril/valsartan on pressure overloaded rat hearts

G. Choudhary, Xiaofei Li, U. Mende, 2021, Scientific Reports.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

D. Kass, E. Lakatta, Xianhua Wang, 2011, Journal of molecular and cellular cardiology.

Regulation of cardiomyocyte signaling by RGS proteins: differential selectivity towards G proteins and susceptibility to regulation.

Wei Zhang, U. Mende, J. Hao, 2006, Journal of molecular and cellular cardiology.

Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations

W. Schmitz, A. Haverich, H. Leyen, 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase inhibition and positive inotropy in failing human myocardium.

F. Müller, W. Schmitz, T. Eschenhagen, 1992, Basic Research in Cardiology.

Stable guanosine 5'-triphosphate-analogues inhibit specific (+)-[3H]isradipine binding in rat hearts by a Ca(2+)-lowering, G protein-independent mechanism.

O. Brørs, M. Stokke, U. Mende, 1996, Pharmacology & toxicology.

The role of alpha 1-adrenergic and muscarinic receptors in cardiac function.

F. Müller, W. Schmitz, T. Eschenhagen, 1991, European heart journal.

Signal transduction pathway of the muscarinic receptors mediating gallbladder contraction

H. Greten, U. Mende, A. Raedler, 1994, Naunyn-Schmiedeberg’s Archives of Pharmacology.

Protein kinase D activation induces mitochondrial fragmentation and dysfunction in cardiomyocytes

A. K. Landi, R. Clements, Y. Yoon, 2018, The Journal of physiology.

Nicorandil Prevents Gαq-Induced Progressive Heart Failure and Ventricular Arrhythmias in Transgenic Mice

Y. Takeishi, Kiyoshi Matsumoto, Satoshi Suzuki, 2012, PloS one.

Increased Messenger RNA Level ofthe Inhibitory G Protein a Subunit Gia,2 inHumanEnd-Stage HeartFailure

W. Schmitz, U. Mende, V. Döring, 2000 .

Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.

J. Harney, P. Larsen, A. Bianco, 2004, Molecular endocrinology.

Adrenergic Receptor Signaling Regulates rAAV Transduction through Calcineurin in Heart Muscle Cells

Masaaki, J. Rasko, R. Aikawa, 2010 .

Signal transduction in atria and ventricles of mice with transient cardiac expression of activated G protein alpha(q).

E. Neer, U. Mende, A. Kagen, 1999, Circulation research.

Regulation and possible functional implications of G-protein mRNA expression in nonfailing and failing ventricular myocardium.

J. Schulte am Esch, W. Schmitz, T. Eschenhagen, 1992, Basic research in cardiology.

RGS protein specificity towards Gq- and Gi/o-mediated ERK 1/2 and Akt activation, in vitro.

W. Daniel, N. Klintworth, C. Stumpf, 2007, Journal of biochemistry and molecular biology.

Selective Loss of Fine Tuning of Gq/11 Signaling by RGS2 Protein Exacerbates Cardiomyocyte Hypertrophy*

Wei Zhang, R. Liao, A. Gach, 2006, Journal of Biological Chemistry.

Isoproterenol infusion induces alterations in expression of hypertrophy-associated genes in rat heart.

E. Lakatta, M. Crow, M. Boluyt, 1995, The American journal of physiology.

Responsiveness Chronic Cardiac-Specific Thyrotoxicosis Increases Myocardial -Adrenergic

J. Harney, P. Reed, A. Bianco, 2004 .

A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues

Tae Yun Kim, F. Munarin, Arvin H. Soepriatna, 2021, Scientific Reports.

NO and PGI2 in coronary endothelial dysfunction in transgenic mice with dilated cardiomyopathy

A. Jasiński, L. Wojnar, G. Csányi, 2008, Basic Research in Cardiology.

Reduced a1- and fl2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure

M. Steinfath, W. Schmitz, H. Scholz, 2006 .

Beta-adrenoceptor stimulation-induced increase in cardiac Gi-protein expression and in carbachol sensitivity.

J. Schulte am Esch, W. Schmitz, T. Eschenhagen, 1991, European heart journal.

Narrow time window of metabolic changes associated with transition to overt heart failure in Tgaq*44 mice.

J. Bierła, E. Czarnowska, A. Ratajska, 2016, Pharmacological reports : PR.

Increased sensitivity to α-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats

M. Böhm, W. Schmitz, H. Scholz, 1986, Naunyn-Schmiedeberg's Archives of Pharmacology.

Phosphodiesterase inhibition by enoximone in preparations from nonfailing and failing human hearts.

H. E. von der Leyen, T. Eschenhagen, J. Neumann, 1992, Arzneimittel-Forschung.

Increased responsiveness to stimulation of alpha- but not beta-adrenoceptors in the hereditary cardiomyopathy of the Syrian hamster. Intact adenosine- and cholinoceptor-mediated isoprenaline antagonistic effect.

M. Böhm, W. Schmitz, H. Scholz, 1986, European journal of pharmacology.

Maintenance of cellular levels of G-proteins: different efficiencies of alpha s and alpha o synthesis in GH3 cells.

E. Neer, Y. Li, U. Mende, 1996, The Biochemical journal.

Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences.

P Zhang, J Su, U Mende, 2012, American journal of physiology. Heart and circulatory physiology.

Pertussis toxin unmasks stimulatory myocardial A2-adenosine receptors on ventricular cardiomyocytes.

W. Schmitz, H. Scholz, J. Neumann, 1993, Journal of molecular and cellular cardiology.

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model.

J. Schmitt, D. Kass, J. Seidman, 2002, The Journal of clinical investigation.

Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy

Saptarsi M. Haldar, S. Heymans, Y. Pinto, 2007, Proceedings of the National Academy of Sciences.

Radioimmunochemical quantification of Gi alpha in right and left ventricles from patients with ischaemic and dilated cardiomyopathy and predominant left ventricular failure.

M. Steinfath, M. Böhm, P. Schnabel, 1994, Journal of molecular and cellular cardiology.

Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues

Tae Yun Kim, P. Bronk, Arvin H. Soepriatna, 2023, PloS one.

Diacylglycerol Kinase ζRescues Gαq-Induced Heart Failure in Transgenic Mice

I. Kubota, Y. Takeishi, T. Arimoto, 2008 .

Effect of deletion of the major brain G‐protein α subunit (αo) on coordination of G‐protein subunits and on adenylyl cyclase activity

E. Neer, M. Fishman, Ying-Lan Li, 1998 .

c-Src-dependent phosphorylation of Mfn2 regulates endoplasmic reticulum-mitochondria tethering

T. Tachibana, K. Ford, U. Mende, 2022, bioRxiv.

Diacylglycerol kinase ζ inhibits G α q-induced atrial remodeling in transgenic mice

Mitsuhiko Yamada, Isao Kubota, Ulrike Mende, 2009 .

Diacylglycerol kinase zeta inhibits G(alpha)q-induced atrial remodeling in transgenic mice.

Mitsuhiko Yamada, Isao Kubota, Ulrike Mende, 2009, Heart rhythm.

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways.

E. Neer, F. Schoen, J. Aramburu, 1998, Proceedings of the National Academy of Sciences of the United States of America.

α7 Nicotinic acetylcholine receptor mediates right ventricular fibrosis and diastolic dysfunction in pulmonary hypertension

E. Hawrot, A. Morrison, R. Clements, 2021, JCI insight.

Gαo is necessary for muscarinic regulation of Ca2+ channels in mouse heart

E. Neer, M. Fishman, H. Mashimo, 1997 .

The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

J. Schmitt, D. Kass, J. Seidman, 2002 .

Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart.

U. Mende, C. M. Kofron, Peng Zhang, 2015, Life sciences.

Cardiac myosin missense mutations cause dilated cardiomyopathy in mouse models and depress molecular motor function

Ferhaan Ahmad, J. Schmitt, J. Seidman, 2006, Proceedings of the National Academy of Sciences.

Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts

P. Karczewski, E. Krause, W. Schmitz, 2004, Molecular and Cellular Biochemistry.

Regulators of G-Protein Signaling in the Heart and Their Potential as Therapeutic Targets

U. Mende, Peng Zhang, 2011, Circulation research.

Regulator of G protein signaling 2 is a functionally important negative regulator of angiotensin II-induced cardiac fibroblast responses.

A. Maldonado, U. Mende, M. King, 2011, American journal of physiology. Heart and circulatory physiology.

Altered regulation of potassium and calcium channels by GABA(B) and adenosine receptors in hippocampal neurons from mice lacking Galpha(o).

E. Neer, B. Bean, U. Mende, 2000, Journal of neurophysiology.

Functional scaffold-free 3-D cardiac microtissues: a novel model for the investigation of heart cells.

J. Morgan, G. Koren, M E King, 2012, American journal of physiology. Heart and circulatory physiology.

Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.

W. Koch, C. Lim, R. Liao, 2008, American journal of physiology. Heart and circulatory physiology.

Does an impaired adenosine mediated feedback control play a role in the development of hereditary dystrophic cardiomyopathy?

M. Böhm, W. Schmitz, H. Scholz, 1986, Cardiovascular research.

The G protein gamma subunit. Requirements for dimerization with beta subunits.

E. Neer, C. J. Schmidt, D. Spring, 1995, The Journal of biological chemistry.

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein βγ-subunits

E. Neer, P. Hammer, C. Berul, 2002 .

Effects of Isomazole on Force of Contraction and Phosphodiesterase Isoenzymes I‐IV in Nonfailing and Failing Human Hearts

W. Schmitz, A. Haverich, H. E. von der Leyen, 1991, Journal of cardiovascular pharmacology.

Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia.

M. Steinfath, M. Böhm, W. Schmitz, 1996, Circulation.

Dilated cardiomyopathy in two transgenic mouse lines expressing activated G protein alpha(q): lack of correlation between phospholipase C activation and the phenotype.

E. Neer, F. Schoen, C. Semsarian, 2001, Journal of molecular and cellular cardiology.

Reduced alpha 1- and beta 2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure.

M. Steinfath, W. Schmitz, H. E. von der Leyen, 1992, British journal of pharmacology.

The G Protein γ Subunit

E. Neer, C. J. Schmidt, D. Spring, 1995, The Journal of Biological Chemistry.

Gq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a three-dimensional microtissue environment.

Tae Yun Kim, Z. Qu, Bum-Rak Choi, 2017, American journal of physiology. Heart and circulatory physiology.

Preserved cardiomyocyte function and altered desmin pattern in transgenic mouse model of dilated cardiomyopathy.

B. Lewartowski, G. Csányi, E. Czarnowska, 2012, Journal of molecular and cellular cardiology.

Diacylglycerol kinase ζ inhibits ventricular tachyarrhythmias in a mouse model of heart failure.

I. Kubota, Y. Takeishi, Miwa Horiuchi-Hirose, 2011, Circulation journal : official journal of the Japanese Circulation Society.

Cardiac alpha-receptors and cardiac hypertrophy in genetic predisposition to hypertension.

M. Böhm, W. Schmitz, H. Scholz, 1986, American heart journal.

Increased sensitivity to alpha-adrenoceptor stimulation but intact purinergic and muscarinergic effects in prehypertensive cardiac hypertrophy of spontaneously hypertensive rats.

M. Böhm, W. Schmitz, H. Scholz, 1986, Naunyn-Schmiedeberg's archives of pharmacology.

Functional role, mechanisms of regulation, and therapeutic potential of regulator of G protein signaling 2 in the heart.

U. Mende, Peng Zhang, 2014, Trends in cardiovascular medicine.

Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences.

U. Mende, Peng Zhang, Jialin Su, 2012, American journal of physiology. Heart and circulatory physiology.

Gq/11-Mediated Signaling and Hypertrophy in Mice with Cardiac-Specific Transgenic Expression of Regulator of G-Protein Signaling 2

A. Maldonado, Leonard Chaves, Darragh Cullen, 2012, PloS one.

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein betagamma-subunits.

E. Neer, P. Hammer, C. Berul, 2002, American journal of physiology. Heart and circulatory physiology.

Mitochondrial Ca2+ uniporter (MCU) variants form plasma-membrane channels

U. Mende, B. Jhun, Jyotsna Mishra, 2023, bioRxiv.

Effect of captopril on myocardial beta-adrenoceptor density and Gi alpha-proteins in patients with mild to moderate heart failure due to dilated cardiomyopathy.

M. Steinfath, J. Schulte am Esch, W. Schmitz, 1995, European journal of clinical pharmacology.