M. Plummer

发表

Target selection for FDA-approved medicines.

M. Kinch, D. Hoyer, Eric Patridge, 2015, Drug discovery today.

Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1).

C. Humblet, E. Lunney, H. Albrecht, 2002, Bioorganic & medicinal chemistry.

Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.

C. Humblet, E. Lunney, J. Rubin, 2001, Bioorganic & medicinal chemistry letters.

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Daniel F Ortwine, J. A. Spicer, W. Denny, 2007, Journal of medicinal chemistry.

Discovery of potent selective bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model. Part II: optimization studies and demonstration of in vivo efficacy.

J. Pandit, C. Whitehead, Cindy Spessard, 2013, Bioorganic & medicinal chemistry letters.

An analysis of FDA-approved drugs for infectious disease: antibacterial agents.

M. Kinch, D. Hoyer, Eric Patridge, 2014, Drug discovery today.

Topographically designed peptidomimetic inhibitors of human renin: Incorporation of novel, tethered P1 → P3 side chain functionalization

C. Humblet, E. Lunney, J. M. Hamby, 1994 .

Sequential allylic C-H amination/vinylic C-H arylation: a strategy for unnatural amino acid synthesis from α-olefins.

A. Stepan, M. White, D. Covell, 2012, Organic letters.

Novel monobactams utilizing a siderophore uptake mechanism for the treatment of gram-negative infections.

V. Shanmugasundaram, M. Huband, T. Harris, 2012, Bioorganic & medicinal chemistry letters.

Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging.

Steven H. Liang, Bradley E. Enerson, S. Haggarty, 2016, Angewandte Chemie.

A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.

R. Bonomo, D. van Duin, K. Hujer, 2021, European journal of medicinal chemistry.

High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development.

Choukri Ben Mamoun, Peter C. Gareiss, B. Staker, 2022, Structure.

A γ-Lactam Siderophore Antibiotic Effective Against Multidrug-Resistant Gram-Negative Bacilli.

R. Bonomo, D. van Duin, K. Hujer, 2020, Journal of medicinal chemistry.

Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma

R. Lifton, U. Scholl, Junhui Zhang, 2017, The Journal of clinical investigation.

Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.

C. Humblet, E. Lunney, A. Doherty, 1995, Journal of medicinal chemistry.

Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.

A. Stepan, jin-quan yu, Yanghui Zhang, 2011, Journal of the American Chemical Society.

Peptidomimetic inhibitors of renin incorporating topographically modified isosteres spanning the P1(→ P3)-P1' sites

J. M. Hamby, M. Plummer, G. Hingorani, 1993 .

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

A. Doherty, A M Doherty, W C Patt, 1995, Journal of medicinal chemistry.

Diversification of a β-Lactam Pharmacophore via Allylic C-H Amination: Accelerating Effect of Lewis Acid Co-Catalyst.

M. White, M. Plummer, M. Lall, 2010, Tetrahedron.

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

A. Doherty, J. Keiser, H. Hallak, 1997, Journal of medicinal chemistry.

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

V. Shanmugasundaram, M. Huband, T. Harris, 2013, Journal of medicinal chemistry.

The fluorine atom as a cation-stabilizing auxiliary in biomimetic polyene cyclizations. IV: Total synthesis of dl-β-amyrin

W. S. Johnson, M. Plummer, W. R. Bartlett, 1993 .

One-pot (1-ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate ring-opening and Wittig reaction.

Laura A McAllister, Robert M. Oliver, Seungwon Chung, 2011, Organic letters.

Peptidomimetic Ligands for Src Homology-2 Domains

T. Sawyer, C. Stankovic, M. Plummer, 1999 .

The efficient synthesis of (3R,4R,5R)-3-amino-4,5-dimethyl-octanoic acid, a chiral β-amino acid with potent affinity for the α2δ protein

Paul D. Johnson, A. Thorpe, J. Schwarz, 2009 .

Small molecule fluoride toxicity agonists.

R. Breaker, T. Ames, K. Blount, 2015, Chemistry & biology.

Design, synthesis, and cocrystal structure of a nonpeptide Src SH2 domain ligand.

D. R. Holland, T K Sawyer, E. Lunney, 1997, Journal of medicinal chemistry.

Intramolecular cycloadditions to oxyallyl zwitterions generated from photorearrangements of 2,5-cyclohexadien-1-ones

M. Macielag, M. Plummer, A. Schultz, 1988 .

Intramolecular Cycloadditions of Alkenes to Oxyallyl Zwitterions Generated from Photorearrangements of 2,5-Cyclohexadien-1-ones.

M. Macielag, M. Plummer, A. Schultz, 1988 .

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.

V. Shanmugasundaram, K. Leach, M. Huband, 2012, Journal of medicinal chemistry.

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

V. Shanmugasundaram, J. Warmus, K. Leach, 2012, Journal of medicinal chemistry.

Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors.

Howard Miller, J. Pandit, C. Whitehead, 2013, Bioorganic & medicinal chemistry letters.

CHRONIC ORAL TOXICITY

J., P. Fellowes, A., 2008 .

The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation

A. Aly, D. Voelker, Lauren Lawres, 2017, Scientific Reports.

Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore

R. Bindra, J. Herrington, R. Sundaram, 2021, Oncotarget.

Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

R. Breaker, Daniel P. Walker, K. Blount, 2015, Antimicrobial Agents and Chemotherapy.

Design of peptidomimetic ligands for the pp60src SH2 domain.

C. Humblet, E. Lunney, A. Saltiel, 1997, Bioorganic & medicinal chemistry.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

Mark J. Mitton-Fry, V. Shanmugasundaram, Ye Che, 2012, Bioorganic & medicinal chemistry letters.

Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.

W. Roush, Jeremy T Starr, J. Choi, 2012, Journal of medicinal chemistry.

An annulation approach to the synthesis of pseudoguaianolide sesquiterpene lactones. Total syntheses of dl-confertin and dl-aromatin

M. Plummer, A. Schultz, L. Motyka, 1986 .

Intramolecular 2 + 2 photocycloadditions of 4-(3'-alkenyl)- and 4-(3'-pentynyl)-2,5-cyclohexadien-1-ones

A. Taveras, M. Plummer, R. Kullnig, 1988 .

Integrating intramolecular hydrogen bonding (IMHB) considerations in drug discovery using ΔlogP as a tool.

Giulia Caron, Marina Shalaeva, M. Shalaeva, 2013, Journal of medicinal chemistry.

Pyrrolocin A, a 3-Decalinoyltetramic Acid with Selective Biological Activity, Isolated from Amazonian Cultures of the Novel Endophyte Diaporthales sp. E6927E

K. Gustafson, S. Strobel, D. Spakowicz, 2015, Natural product communications.

An analysis of FDA-approved drugs for metabolic diseases.

M. Kinch, S. Umlauf, M. Plummer, 2015, Drug discovery today.

Biomimetic polyene cyclizations. Cationic cyclization of a substrate having an internal acetylenic bond. Synthesis of euphol and tirucallol

W. S. Johnson, M. Plummer, W. R. Bartlett, 1990 .

2,5-Cyclohexadien-1-one to bicyclo[3.1.0]hexenone photorearrangement. Development of the reaction for use in organic synthesis

Frank P. Lavieri, M. Macielag, M. Plummer, 1987 .

The antimalarial activity of the pantothenamide α-PanAm is via inhibition of pantothenate phosphorylation

A. Aly, D. Voelker, M. Plummer, 2017, Scientific Reports.

Novel Riboswitch-Binding Flavin Analog That Protects Mice against Clostridium difficile Infection without Inhibiting Cecal Flora

R. Breaker, Daniel P. Walker, C. Megyola, 2015, Antimicrobial Agents and Chemotherapy.

Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.

A. Stepan, jin-quan yu, Yanghui Zhang, 2011, Journal of the American Chemical Society.

Hydrophobic D-amino acids in the design of peptide ligands for the pp60src SH2 domain.

C. Humblet, E. Lunney, J. Marks, 1996, Drug design and discovery.