Michael Vicchiarelli

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Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Ashley N Brown, B. N. Tran, Tanaya R. Vaidya, 2018, Front. Pharmacol..

Inhibition of Protein Kinase C-Driven Nuclear Factor-κB Activation: Synthesis, Structure−Activity Relationship, and Pharmacological Profiling of Pathway Specific Benzimidazole Probe Molecules

John Calvin Reed, J. Cashman, G. Roth, 2010, Journal of medicinal chemistry.

Dilution Factor of Quantitative Bacterial Cultures Obtained by Bronchoalveolar Lavage in Patients with Ventilator-Associated Bacterial Pneumonia

Ronald N. Jones, R. Wunderink, J. Rello, 2017, Antimicrobial Agents and Chemotherapy.

Figure 4, Screening and Hit advancement flowchart

Tudor I. Oprea, Bruce S. Edwards, Larry A. Sklar, 2013 .

Table 3, CID 56639556 [ML307] MLS-0471611

Santhi Ganji, Ian Pass, Robert Ardecky, 2014 .

Polymyxin B Pharmacodynamics in the Hollow-Fiber Infection Model: What You See May Not Be What You Get

A. Louie, Weiguo Liu, Michael Vicchiarelli, 2021, Antimicrobial agents and chemotherapy.

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.

T. Chung, M. Hedrick, E. Sergienko, 2012, Bioorganic & medicinal chemistry letters.

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

John Calvin Reed, Brock T Brown, G. Roth, 2011, ACS medicinal chemistry letters.

Scheme 1, Synthesis of ML261, conditions

Jiwen Zou, Santhi Ganji, Ian Pass, 2013 .

Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed blaPDC in a Hollow-Fiber Infection Model

M. Adams, R. Bonomo, B. Kreiswirth, 2021, Antimicrobial Agents and Chemotherapy.

Developing New Drugs for Mycobacterium tuberculosis Therapy: What Information Do We Get from Preclinical Animal Models?

W. Yamada, M. Neely, G. Drusano, 2020, Antimicrobial Agents and Chemotherapy.

The Combination of Fosfomycin plus Meropenem Is Synergistic for Pseudomonas aeruginosa PAO1 in a Hollow-Fiber Infection Model

W. Yamada, M. Neely, G. Drusano, 2018, Antimicrobial Agents and Chemotherapy.

Screening for Selective Ligands for GPR55 - Antagonists

M. Caron, T. Chung, M. Hedrick, 2011 .

Figure 10, SAR strategy for Scaffold I

Jiwen Zou, Santhi Ganji, Ian Pass, 2014 .

Clinical Regimens of Favipiravir Inhibit Zika Virus Replication in the Hollow-Fiber Infection Model

Ashley N Brown, A. Kaushik, J. Bulitta, 2018, Antimicrobial Agents and Chemotherapy.

Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Stefan Vasile, Eigo Suyama, Michael Vicchiarelli, 2012, Journal of medicinal chemistry.

Determination of the Dynamically Linked Indices of Fosfomycin for Pseudomonas aeruginosa in the Hollow Fiber Infection Model

G. Drusano, A. Louie, Michael Vicchiarelli, 2018, Antimicrobial Agents and Chemotherapy.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Journal of medicinal chemistry.

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

M. Caron, T. Chung, M. Hedrick, 2013, ACS medicinal chemistry letters.

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

M. Caron, T. Chung, M. Hedrick, 2012, ACS chemical neuroscience.

Cardioprotective inhibitors of reperfusion injury

T. Chung, Derek A. Stonich, R. Kitsis, 2013 .

Functional Agonists of the Apelin (APJ) Receptor

T. Chung, M. Hedrick, E. Sergienko, 2013 .

Emergence of resistance to ceftazidime-avibactam in a derepressed bla PDC producing Pseudomonas aeruginosa isolate in a Hollow Fiber Infection Model.

M. Adams, R. Bonomo, G. Drusano, 2021, Antimicrobial Agents and Chemotherapy.

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

H. Freeze, Brock T Brown, M. Hedrick, 2011, Journal of medicinal chemistry.

Individual Components of Polymyxin B Modeled via Population Pharmacokinetics to Design Humanized Dosage Regimens for a Bloodstream and Lung Infection Model in Immune-Competent Mice

R. Bonomo, G. Drusano, B. Spellberg, 2023, Antimicrobial agents and chemotherapy.

Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis

R. Taichman, T. Chung, M. Hedrick, 2014 .

Selective UBC 13 Inhibitors

Tram A. Ngo, J. Reed, T. Chung, 2014 .