M. Migawa

发表

Elucidation of the Biotransformation Pathways of a Galnac3-conjugated Antisense Oligonucleotide in Rats and Monkeys

S. Henry, R. Yu, T. P. Prakash, 2016, Molecular therapy. Nucleic acids.

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

A. Siwkowski, T. P. Prakash, H. Gaus, 2010, Journal of medicinal chemistry.

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

T. P. Prakash, H. Gaus, E. Swayze, 2010, The Journal of organic chemistry.

A Solid-Phase Synthesis of N,N‘-Disubstituted Ureas and Perhydroimidazo[1,5-a]pyrazines via the Curtius Rearrangement

E. Swayze, M. Migawa, 2000 .

Interaction of ASOs with PC4 is highly influenced by the cellular environment and ASO chemistry.

S. Crooke, T. Vickers, P. Seth, 2020, Journal of the American Chemical Society.

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides

S. Crooke, S. Murray, Audrey Low, 2020, Nucleic acids research.

The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis

S. Crooke, W. Lima, E. Swayze, 2007, Molecular Pharmacology.

Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate

S. Crooke, W. Lima, A. Siwkowski, 2007, Molecular Pharmacology.

Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames

S. Crooke, T. Vickers, Wen Shen, 2016, Nature Biotechnology.

A Combined Antitumor Strategy Mediated by a New Targeted Nanosystem to Hepatocellular Carcinoma

A. Sarmento-Ribeiro, D. Farinha, H. Faneca, 2021, International journal of nanomedicine.

Synthesis of 4-Substituted Imidazo[4,5-d][1,2,3]triazine (2-Azapurine)nucleosides

S. Krawczyk, M. Migawa, L. Townsend, 2000, Nucleosides, nucleotides & nucleic acids.

High-resolution visualization and quantification of nucleic acid–based therapeutics in cells and tissues using Nanoscale secondary ion mass spectrometry (NanoSIMS)

S. Young, K. Iyer, C. Bennett, 2020, Nucleic acids research.

Antisense oligonucleotides targeting translation inhibitory elements in 5′ UTRs can selectively increase protein levels

H. Bui, S. Crooke, M. Graham, 2017, Nucleic acids research.

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

A. Siwkowski, T. P. Prakash, H. Gaus, 2008, Nucleic acids symposium series.

A convenient synthesis of 5'-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid.

T. P. Prakash, Jinghua Yu, E. Swayze, 2016, Bioorganic & medicinal chemistry letters.

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

S. Booten, S. Murray, M. Graham, 2016, Journal of medicinal chemistry.

Solid-phase synthesis of 5'-triantennary N-acetylgalactosamine conjugated antisense oligonucleotides using phosphoramidite chemistry.

T. P. Prakash, Jinghua Yu, Audrey Low, 2015, Bioorganic & medicinal chemistry letters.

A Two Step Synthesis of the Nucleoside Q Precursor 2-Amino-5-cyanopyrrolo[2,3-d]pyrimidin 4-one (PreQo)

G. Hoops, M. Migawa, L. Townsend, 1996 .

Two Step Synthesis of the Nucleoside Q Precursor 2‐Amino‐5‐ cyanopyrrolo(2,3‐d)pyrimidin‐4‐one (PreQ0).

G. Hoops, M. Migawa, L. Townsend, 1996 .

Efficient Synthesis and Biological Evaluation of 5'-GalNAc Conjugated Antisense Oligonucleotides.

T. P. Prakash, Jinghua Yu, Audrey Low, 2015, Bioconjugate chemistry.

Alternative syntheses of (S)-cEt-BNA: a key constrained nucleoside component of bioactive antisense gapmer sequences.

S. Hanessian, M. Migawa, B. L. Merner, 2014, The Journal of organic chemistry.

Synthesis and Biological Activity of 5‐Fluorotubercidin

E. Swayze, P. Seth, R. Ranken, 2004, Nucleosides, nucleotides & nucleic acids.

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

S. Crooke, S. Burel, T. Vickers, 2021, Nucleic acids research.

Aryl urea analogs with broad-spectrum antibacterial activity.

E. Swayze, P. Seth, S. Osgood, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles.

J. Girardet, M. Migawa, L. Townsend, 1998, Journal of medicinal chemistry.

Design, Synthesis, and Antiviral Activity of α‐Nucleosides: D‐ and L‐Isomers of Lyxofuranosyl‐ and (5‐Deoxylyxofuranosyl)benzimidazoles.

John A. Walker, J. Girardet, M. Migawa, 1998 .

Probing the ribosomal RNA A-site with functionally diverse analogues of paromomycin—synthesis of ring I mimetics

R. Griffey, S. Hanessian, Xiaojing Wang, 2007 .

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

S. Crooke, T. P. Prakash, Jinghua Yu, 2021, Nucleic acids research.

The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides.

E. Swayze, K. Sannes-Lowery, M. Migawa, 2005, Bioorganic & medicinal chemistry letters.

An efficient synthesis of gougerotin and related analogues using solid- and solution-phase methodology.

R. Griffey, E. Swayze, L. Risen, 2005, Organic letters.

Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): useful for the preparation of crystalline 5′-O-DMPx-protected nucleosides

E. Swayze, M. Migawa, Y. Sanghvi, 2012 .

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.

E. Westhof, J. Kondo, S. Hanessian, 2010, Bioorganic & Medicinal Chemistry Letters.

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

Christopher E. Hart, S. Mukhopadhyay, S. Crooke, 2019, Nature Biotechnology.

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins

S. Crooke, S. Murray, Audrey Low, 2019, Nucleic acids research.

Structural Requirements at the Catalytic Site of the Heteroduplex Substrate for Human RNase H1 Catalysis*

S. Crooke, W. Lima, T. P. Prakash, 2004, Journal of Biological Chemistry.

Structure-Based Design, Synthesis, and A-Site rRNA Cocrystal Complexes of Functionally Novel Aminoglycoside Antibiotics: C2'' Ether Analogues of Paromomycin

E. Westhof, J. Kondo, S. Hanessian, 2007 .

Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.

R. Griffey, E. Westhof, S. Hanessian, 2004, Angewandte Chemie.

Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.

E. Westhof, J. Kondo, S. Hanessian, 2007, Journal of medicinal chemistry.

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages

Eric E. Swayze, Christopher E. Hart, W. Lima, 2014, Nucleic acids research.

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2′-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

P. Seth, Josh G. Nichols, Lingdi Zhang, 2022, Nucleic acid therapeutics.

Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides.

Audrey Low, E. Swayze, P. Seth, 2021, Nucleic acid therapeutics.

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

B. Monia, A. Siwkowski, G. Hung, 2006, Nucleic acids research.

AN EFFICIENT SYNTHESIS OF 2-NITROPYRROLE-3,4-DICARBOXAMIDE

M. Migawa, L. Townsend, 1999 .

Synthesis and biophysical properties of constrained D-altritol nucleic acids (cANA).

T. P. Prakash, E. Swayze, P. Seth, 2013, Organic letters.