G. Skiles

发表

Reductive Isoxazole Ring Opening of the Anticoagulant Razaxaban Is the Major Metabolic Clearance Pathway in Rats and Dogs

P. Lam, K. He, R. Knabb, 2008, Drug Metabolism and Disposition.

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

Jeremy K Nicholson, Andrew W Nicholls, Bruce A. Johnson, 2004, Chemical research in toxicology.

Metabolite Generation via Microbial Biotransformations with Actinomycetes: Rapid Screening for Active Strains and Biosynthesis of Important Human Metabolites of Two Development-Stage Compounds, 5-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methy

W. Humphreys, G. Skiles, J. Josephs, 2008, Drug Metabolism and Disposition.

Detection and Characterization of Metabolites in Biological Matrices Using Mass Defect Filtering of Liquid Chromatography/High Resolution Mass Spectrometry Data

Donglu Zhang, Mingshe Zhu, W Griffith Humphreys, 2006, Drug Metabolism and Disposition.

Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate

J. G. Slatter, R. Subramanian, M. Emery, 2013, Xenobiotica; the fate of foreign compounds in biological systems.

Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta).

S. Prahalada, A. Hendrickx, K. Ellsworth, 1997, Teratology.

Clinical Pharmacokinetics and Pharmacodynamics of Etelcalcetide, a Novel Calcimimetic for Treatment of Secondary Hyperparathyroidism in Patients With Chronic Kidney Disease on Hemodialysis

Benjamin Wu, R. Subramanian, A. Chow, 2018, Journal of clinical pharmacology.

Biosynthesis of Drug Metabolites Using Microbes in Hollow Fiber Cartridge Reactors: Case Study of Diclofenac Metabolism by Actinoplanes Species

R. Subramanian, S. Surapaneni, G. Skiles, 2008, Drug Metabolism and Disposition.

Mechanistic studies on the cytochrome P450-catalyzed dehydrogenation of 3-methylindole.

G. Yost, G. Skiles, 1996, Chemical research in toxicology.

Pharmacokinetics, Biotransformation, and Excretion of [14C]Etelcalcetide (AMG 416) Following a Single Microtracer Intravenous Dose in Patients with Chronic Kidney Disease on Hemodialysis

J. G. Slatter, Benjamin Wu, R. Subramanian, 2016, Clinical Pharmacokinetics.

An ion exchange liquid chromatography/mass spectrometry method for the determination of reduced and oxidized glutathione and glutathione conjugates in hepatocytes.

W. H. Schaefer, G. Skiles, D. Alberts, 2001, Journal of pharmaceutical and biomedical analysis.

Chapter 9 Quantification and structural elucidation of low quantities of radiolabeled metabolites using microplate scintillation counting (msc) techniques in conjunction with lc-ms

Mingshe Zhu, Donglu Zhang, G. Skiles, 2005 .

Modeling, Prediction, and in Vitro in Vivo Correlation of CYP3A4 Induction

K. Morrissey, Magang Shou, Yang Xu, 2008, Drug Metabolism and Disposition.

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

Magang Shou, Gary L. Skiles, Yvonne Pan, 2009, Drug Metabolism and Disposition.

Detection and characterization of DNA adducts of 3-methylindole.

C. Yuan, G. Yost, G. Skiles, 2001, Chemical research in toxicology.

Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse.

B. Wlodarczyk, G. Bennett, R. Finnell, 1996, The Journal of pharmacology and experimental therapeutics.

Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity.

G. Bennett, R. Finnell, S. Nelson, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Evidence supporting the formation of 2,3-epoxy-3-methylindoline: a reactive intermediate of the pneumotoxin 3-methylindole.

G. Yost, G. Skiles, D. L. Lanza, 1998, Chemical Research in Toxicology.

Novel cytochrome p450 bioactivation of a terminal phenyl acetylene group: formation of a one-carbon loss benzaldehyde and other oxidative products in the presence of N-acetyl cysteine or glutathione.

R. Subramanian, G. Skiles, D. Reid, 2011, Chemical research in toxicology.

Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages, and subcellular fractions from rabbit lungs.

G. Yost, G. Skiles, B. Manning, 1993, Toxicology and applied pharmacology.

Identification of goat and mouse urinary metabolites of the pneumotoxin, 3-methylindole.

D. J. Smith, G. Yost, J. Carlson, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)

R. Subramanian, Raju Subramanian, Roger Pham, 2016, Drug Metabolism and Disposition.

Determination of Etelcalcetide Biotransformation and Hemodialysis Kinetics to Guide the Timing of Its Dosing

Benjamin Wu, R. Subramanian, K. Z. Edson, 2016, Kidney international reports.

Toxicity of 3-methyleneoxindole, a proposed reactive intermediate in the metabolism of 3-methylindole.

G. Yost, M. Appleton, G. Skiles, 1991, Advances in experimental medicine and biology.

Simulation of Clinical Drug-Drug Interactions from Hepatocyte CYP3A4 Induction Data and Its Potential Utility in Trial Designs

G. Skiles, Yang Xu, M. Shou, 2011, Drug Metabolism and Disposition.

Cytochrome P450-mediated epoxidation of 2-aminothiazole-based AKT inhibitors: identification of novel GSH adducts and reduction of metabolic activation through structural changes guided by in silico and in vitro screening.

Q. Zeng, G. E. Wohlhieter, Guomin Yao, 2010, Chemical research in toxicology.

P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors.

D. Branstetter, H. Lebrec, R. Subramanian, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

G. Skiles, M. Shou, Yuping Chen, 2009, Drug Metabolism and Disposition.

Identification of a cysteinyl adduct of oxidized 3-methylindole from goat lung and human liver microsomal proteins.

G. Skiles, W. Ruangyuttikarn, Garold S. Yost, 1992, Chemical research in toxicology.