J. Wetterau

发表

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains.

K. Weisgraber, L. Aggerbeck, S. C. Rall, 1988, The Journal of biological chemistry.

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

K. Weisgraber, L. Aggerbeck, F. Lindgren, 1988, The Journal of biological chemistry.

Purification and characterization of microsomal triglyceride and cholesteryl ester transfer protein from bovine liver microsomes.

D. B. Zilversmit, J. Wetterau, John R. Wettereau, 1985, Chemistry and physics of lipids.

Quantitative changes of fatty acids in soybean cotyledons during senescence and regreening

J. Jaworski, J. Wetterau, D. W. Newman, 1978 .

Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability.

H. Jamil, R. Gregg, D. Gordon, 1994, Proceedings of the National Academy of Sciences of the United States of America.

A triglyceride and cholesteryl ester transfer protein associated with liver microsomes.

D. B. Zilversmit, J. Wetterau, Donald B. ZilversmitS, 1984, The Journal of biological chemistry.

Localization of intracellular triacylglycerol and cholesteryl ester transfer activity in rat tissues.

D. B. Zilversmit, J. Wetterau, D. B. Zilversmit, 1986, Biochimica et biophysica acta.

Anderson's disease: exclusion of apolipoprotein and intracellular lipid transport genes.

L. Aggerbeck, P. Amati, V. Abadie, 1999, Arteriosclerosis, thrombosis, and vascular biology.

The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.

L. Aggerbeck, J. Wetterau, N. Berriot-Varoqueaux, 2000, Annual review of nutrition.

Quantitation of lipid transfer activity.

D. B. Zilversmit, J. Wetterau, 1984, Methods of biochemical analysis.

Enhanced expression of hepatic acyl‐coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation

S. Yamashita, T. Funahashi, Y. Matsuzawa, 1998, Hepatology.

Total deficiency of plasma cholesteryl ester transfer protein in subjects homozygous and heterozygous for the intron 14 splicing defect.

S. Yamashita, Y. Matsuzawa, D. Sprecher, 1990, Biochemical and biophysical research communications.

Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.

R. Lawrence, T. Harrity, L. Kunselman, 2003, Bioorganic & medicinal chemistry letters.

Microsomal Triglyceride Transfer Protein

H. Jamil, C. Chu, R. Gregg, 1995, The Journal of Biological Chemistry.

The molecular basis of abetalipoproteinemia.

R. Gregg, J. Wetterau, Richard E. Gregg, 1994, Current opinion in lipidology.

Design and synthesis of N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5- methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a novel peroxisome proliferator-activated receptor alpha/gamma dual agonist with efficacious glucose and lipid-lowering activities.

Weiqi Wang, A. Doweyko, W. Humphreys, 2005, Journal of medicinal chemistry.

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

B. Kienzle, D. Gordon, M. Lin, 1994, The Journal of biological chemistry.

Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinaemia

D. Rader, C. Turck, R. Gregg, 1993, Nature.

Human microsomal triglyceride transfer protein large subunit gene structure.

B. Kienzle, M. Lin, J. Wetterau, 1994, Biochemistry.

Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression.

Marie C. M. Lin, D. Gordon, M. Lin, 1995, Journal of lipid research.

Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia.

D. Rader, R. Gregg, A. Munck, 1992, Science.

Characterization of plasma lipoproteins in patients heterozygous for human plasma cholesteryl ester transfer protein (CETP) deficiency: plasma CETP regulates high-density lipoprotein concentration and composition.

S. Yamashita, Y. Matsuzawa, D. Sprecher, 1991, Metabolism: clinical and experimental.

Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport.

J. Wetterau, A. Atzel, Amy Atzel, 1993, Biochemistry.

An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells.

H. Jamil, C. Chu, R. Gregg, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Protein disulfide isomerase appears necessary to maintain the catalytically active structure of the microsomal triglyceride transfer protein.

L. Aggerbeck, L. McLean, J. Wetterau, 1991, Biochemistry.

Structural properties of the microsomal triglyceride-transfer protein complex.

L. Aggerbeck, L. McLean, J. Wetterau, 1991, Biochemistry.

Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells.

H. Jamil, C. Chu, R. Gregg, 1998, Journal of lipid research.

A delayed-addition enzyme immunoassay for the relative cholesteryl ester transfer protein mass in patients with deficient plasma cholesteryl ester transfer activity.

S. Yamashita, Y. Matsuzawa, D. Sprecher, 1990, Clinica chimica acta; international journal of clinical chemistry.

A Novel Abetalipoproteinemia Genotype

H. Jamil, B. Kienzle, D. Gordon, 1996, The Journal of Biological Chemistry.

Crystallization and preliminary X-ray diffraction studies on the amino-terminal (receptor-binding) domain of human apolipoprotein E3 from serum very low density lipoproteins.

D. Agard, R. Mahley, K. Weisgraber, 1988, Journal of molecular biology.

A novel series of highly potent benzimidazole-based microsomal triglyceride transfer protein inhibitors.

H. Jamil, D. Gordon, T. Harrity, 2001, Journal of medicinal chemistry.

Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein.

J. Wetterau, A. Atzel, Amy Atzel, 1994, Biochemistry.

Microsomal triglyceride transfer protein: a protein complex required for the assembly of lipoprotein particles.

R. Gregg, D. Gordon, J. Wetterau, 1995, Trends in cell biology.

A 70-kDa apolipoprotein designated ApoJ is a marker for subclasses of human plasma high density lipoproteins.

D. G. Ferguson, W. Stuart, J. Wetterau, 1990, The Journal of biological chemistry.

Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models

Brian E. Mattioni, M. Kowala, Xiaohong Yu, 2022, Pharmacology research & perspectives.

Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.

R. Gregg, W. Fenderson, Wen-pin Yang, 2006, Diabetes.

Purification and characterization of apolipoprotein J.

S. Mao, S. Busch, W. Stuart, 1990, The Journal of biological chemistry.

Role in the Assembly of Intestinal Lipoproteins

J. Wetterau, 2001 .

Microsomal Triglyceride Transfer Protein: Role in the Assembly of Intestinal Lipoproteins

J. Wetterau, 2001 .

Microsomal triglyceride transfer protein.

H. Jamil, Marie C. M. Lin, M. Lin, 1997, Biochimica et biophysica acta.

Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats

Li Xin, Joseph R. Taylor, Songping Han, 2008, Diabetes.

Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.

W. Humphreys, O. Flint, E. Janovitz, 2008, Journal of medicinal chemistry.

Quantitative sphingosine measurement as a surrogate for total ceramide concentration-preclinical and potential translational applications.

C. M. Boustany-Kari, J. Wetterau, E. Kindt, 2009, Biomedical chromatography : BMC.

The Amino Terminus of Apolipoprotein B Is Necessary but Not Sufficient for Microsomal Triglyceride Transfer Protein Responsiveness (*)

P. Talmud, A. Attie, B. A. Lipton, 1996, The Journal of Biological Chemistry.

An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits.

H. Jamil, C. Chu, R. Gregg, 1998, Science.

Demonstration of a Physical Interaction between Microsomal Triglyceride Transfer Protein and Apolipoprotein B during the Assembly of ApoB-containing Lipoproteins (*)

Li-Shin Huang, X Wu, M Zhou, 1996, The Journal of Biological Chemistry.

Estimating the distribution of a novel clinical biomarker (FGF-23) in the US population using findings from a regional research registry

J. Johnston, D. Nelson, S. Curtis, 2019, PloS one.

Muraglitazar, a Novel Dual (α/γ) Peroxisome Proliferator–Activated Receptor Activator, Improves Diabetes and Other Metabolic Abnormalities and Preserves β-Cell Function in db/db Mice

Michael Cap, R. Gregg, W. Fenderson, 2006 .

MTP/apoB mediated lipoprotein assembly: an emerging pathway for lipid secretion and transport

J. Wetterau, 2004 .

Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex.

N., J. Wetterau, K. Combs, 1990, The Journal of biological chemistry.

Effects of probucol on plasma lipids, lipoproteins and parameters of high density lipoprotein metabolism.

E. Stein, E. M. Chi, R. Jackson, 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

A 30-Amino Acid Truncation of the Microsomal Triglyceride Transfer Protein Large Subunit Disrupts Its Interaction with Protein Disulfide-isomerase and Causes Abetalipoproteinemia (*)

D. Rader, R. Gregg, B. Kienzle, 1995, The Journal of Biological Chemistry.

5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP.

T. Harrity, L. Kunselman, J. Robl, 2004, Bioorganic & medicinal chemistry letters.

Factors affecting the size of complexes of dipalmitoylphosphatidylcholine with human apolipoprotein A-I.

A. Jonas, J. Wetterau, 1983, The Journal of biological chemistry.

Effect of dipalmitoylphosphatidylcholine vesicle curvature on the reaction with human apolipoprotein A-I.

J. Wetterau, Ana Jonast, 1982, The Journal of biological chemistry.

Anderson's disease: exclusion of apolipoprotein and intracellular lipid transport genes.

L. Aggerbeck, V. Abadie, J. Schmitz, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Effect of an NHE3 inhibitor in combination with an NPT2b inhibitor on gastrointestinal phosphate absorption in Rodent models

M. Kowala, J. Wetterau, Yanping Xu, 2024, PloS one.