N. Takeguchi

发表

Proton-Potassium (H(+)/K(+)) ATPases: Properties and Roles in Health and Diseases.

H. Sakai, Takuto Fujii, N. Takeguchi, 2016, Metal ions in life sciences.

Molecular and cellular regulation of the gastric proton pump.

N. Takeguchi, S. Asano, M. Morii, 2004, Biological & pharmaceutical bulletin.

Alanine-scanning Mutagenesis of the Sixth Transmembrane Segment of Gastric H+,K+-ATPase α-Subunit*

T. Kimura, N. Takeguchi, S. Asano, 2001, The Journal of Biological Chemistry.

Ca(2+)-activated outward-rectifier K+ channels and histamine release by rat gastric enterochromaffin-like cells.

Y. Tabuchi, H. Sakai, N. Takeguchi, 1995, European journal of pharmacology.

Specific localization of an inwardly rectifying K+ channel, Kir4.1, at the apical membrane of rat gastric parietal cells; its possible involvement in K+ recycling for the H+‐K+‐pump

Y. Horio, Y. Kurachi, F. Hata, 2002, The Journal of physiology.

Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.

H. Sakai, Takuto Fujii, N. Takeguchi, 2011, Biological & pharmaceutical bulletin.

Functional Association between K+-Cl- Cotransporter-4 and H+,K+-ATPase in the Apical Canalicular Membrane of Gastric Parietal Cells*

Y. Tabuchi, A. Ikari, K. Tsukada, 2009, Journal of Biological Chemistry.

Inhibition of P-type ATPases by [(dihydroindenyl)oxy]acetic acid (DIOA), a K+ -Cl- cotransporter inhibitor.

H. Sakai, Takuto Fujii, N. Takeguchi, 2007, European journal of pharmacology.

Up‐regulation of Na+,K+‐ATPase α3‐isoform and down‐regulation of the α1‐isoform in human colorectal cancer

Tomoyuki Suzuki, K. Tsukada, H. Sakai, 2004 .

Development and characterization of conditionally immortalized gastric epithelial cell lines from transgenic rats harboring temperature-sensitive simian virus 40 large T-antigen gene.

Y. Tabuchi, M. Obinata, R. Takahashi, 2002, Cell structure and function.

Molecular and pharmacological properties of inwardly rectifying K+ channels of human lung cancer cells.

Takahiro Shimizu, A. Ikari, H. Sakai, 2002, European journal of pharmacology.

Effects of caffeine on gluconeogenesis and urea synthesis induced by alpha-adrenergic stimulation in suspensions of rat hepatocytes.

N. Takeguchi, T. Kashiwagura, T. Kagaya, 1987, The Japanese journal of physiology.

INHIBITION OF THE MULTIDRUG EFFLUX PUMP IN ISOLATED HEPATOCYTE COUPLETS BY IMMUNOSUPPRESSANTS FK506 AND CYCLOSPORINE

K. Kawahara, W. Matsui, N. Takeguchi, 1993, Transplantation.

Physiological assay of liposome-mediated transport of a drug across Xenopus intestine: cell-liposome interaction.

N. Takeguchi, T. Kashiwagura, K. Sakurai, 1987, Biochimica et biophysica acta.

Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells

Takahiro Shimizu, H. Sakai, Takuto Fujii, 2011, The Journal of Physiological Sciences.

Protein kinase C-mediated up-regulation of Na+/Ca2+-exchanger in rat hepatocytes determined by a new Na+/Ca2+-exchanger inhibitor, KB-R7943.

A. Ikari, H. Sakai, N. Takeguchi, 1998, European journal of pharmacology.

Overexpression of heat shock protein 70 restores the structural stability and functional defects of temperature-sensitive mutant of large T antigen at nonpermissive temperature

Y. Tabuchi, I. Takasaki, T. Kondo, 2006, Cell stress & chaperones.

E3040 sulphate, a novel thromboxane synthase inhibitor, blocks the Cl− secretion induced by platelet‐activating factor in isolated rat colon

Tomoyuki Suzuki, Miki Murota, H. Sakai, 2002, British journal of pharmacology.

Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon.

T. Suzuki, H. Sakai, N. Takeguchi, 2000, European journal of pharmacology.

Small‐conductance Cl‐ channels in rabbit parietal cells activated by prostaglandin E2 and inhibited by GTP gamma S.

H. Sakai, N. Takeguchi, 1993, The Journal of physiology.

C-terminal topology of gastric H+,K(+)-ATPase.

M. Ohta, M. Hirasawa, H. Sakai, 1994, The Biochemical journal.

Inhibition of gastric H+,K+-ATPase by 4-(2-butyl-6,7-dichloro-2-cyclopentylindan-1-on-5-yl)oxybutyric acid (DCPIB), an inhibitor of volume-regulated anion channel.

Takahiro Shimizu, H. Takeshima, H. Sakai, 2015, European journal of pharmacology.

K+-Cl- Cotransporter-3a Up-regulates Na+,K+-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells*

Y. Tabuchi, K. Tsukada, H. Sakai, 2008, Journal of Biological Chemistry.

Quality control of gastric proton pump in the endoplasmic reticulum by ubiquitin/proteasome system.

Tohru Kimura, N. Takeguchi, S. Asano, 2003, Annals of the New York Academy of Sciences.

A light scattering study on membrane permeability, regulation of (H+ + K+)-ATPase reaction in gastric vesicles

N. Takeguchi, M. Morii, Rie Arakawa, 1985 .

Quasi-elastic light-scattering studies of conformational states of the H,K-ATPase. Intervesicular aggregation of gastric vesicles by disulfide cross-linking.

N. Takeguchi, M. Morii, N. Ishimura, 1984, Biochemistry.

A Vesicle-Coated Particle Method for the Determination of Electrophoretic Mobility of Gastric Vesicles

N. Takeguchi, M. Morii, T. Kashiwagura, 1981 .

Monoclonal antibody HK4013 recognizes an epitope specific for gastric subtype of H+,K(+)-ATPase.

N. Takeguchi, S. Asano, M. Ohshika, 1994, Journal of biochemistry.

Rabeprazoleof its Use in Acid-Related Disorders

B. Thjódleifsson, N. Takeguchi, C. Florent, 2001 .

Binding site of omeprazole in hog gastric H+,K(+)-ATPase.

N. Takeguchi, M. Morii, H. Takata, 1990, Biochemical and biophysical research communications.

Up-regulation of Na(+),K(+)-ATPase alpha 3-isoform and down-regulation of the alpha1-isoform in human colorectal cancer.

Tomoyuki Suzuki, K. Tsukada, H. Sakai, 2004, FEBS letters.

Inhibitions of acid secretion by E3810 and omeprazole, and their reversal by glutathione.

I. Yamatsu, H. Fujisaki, H. Sakai, 1991, Biochemical pharmacology.

Scopadulciol, an inhibitor of gastric H+, K(+)-ATPase from Scoparia dulcis, and its structure-activity relationships.

N. Takeguchi, S. Asano, T. Hayashi, 1991, Journal of natural products.

Scopadulcic acid B, a new tetracyclic diterpenoid from Scoparia dulcis L. Its structure, H+, K(+)-adenosine triphosphatase inhibitory activity and pharmacokinetic behaviour in rats.

Y. Tezuka, M. Kakemi, T. Kikuchi, 1990, Chemical & pharmaceutical bulletin.

Silyl ethers of cycloheptene, novel proton pump inhibitors obtained during the total synthesis of the scopadulcic acids

L. Overman, S. O'connor, N. Takeguchi, 1995 .

Reversible inhibitions of gastric H+,K(+)-ATPase by scopadulcic acid B and diacetyl scopadol. New biochemical tools of H+,K(+)-ATPase.

N. Takeguchi, S. Asano, T. Hayashi, 1990, The Journal of biological chemistry.

Inhibition of small‐conductance Cl− channels by the interleukin‐1β‐stimulated production of superoxide in rabbit gastric parietal cells

A. Ikari, Tomoyuki Suzuki, A. Tanaka, 2003, The Journal of physiology.

Mutational Study on the Roles of Disulfide Bonds in the β-Subunit of Gastric H+,K+-ATPase*

Y. Tabuchi, Tohru Kimura, N. Takeguchi, 2002, The Journal of Biological Chemistry.

Thromboxane A2, released by the anti‐ tumour drug irinotecan, is a novel stimulator of Cl− secretion in isolated rat colon

A. Ikari, H. Sakai, N. Takeguchi, 1997, The Journal of physiology.

The presence of H+,K(+)-ATPase in the crypt of rabbit distal colon demonstrated with monoclonal antibodies against gastric H+,K(+)-ATPase.

Y. Tabuchi, N. Takeguchi, S. Asano, 1990, Gastroenterology.

The energy transduction mechanism is different among P-type ion-transporting ATPases. Acetyl phosphate causes uncoupling between hydrolysis and ion transport in H+,K(+)-ATPase.

N. Takeguchi, S. Asano, S. Kamiya, 1992, The Journal of biological chemistry.

Involvement of the H3O+-Lys-164 -Gln-161-Glu-345 Charge Transfer Pathway in Proton Transport of Gastric H+,K+-ATPase*

H. Sakai, Takuto Fujii, N. Takeguchi, 2008, Journal of Biological Chemistry.

Involvement of aquaporin-5 in differentiation of human gastric cancer cells

Y. Tabuchi, Tomoko Watanabe, T. Oya, 2009, The Journal of Physiological Sciences.

Identification of genes responsive to sodium butyrate in colonic epithelial cells.

Y. Tabuchi, T. Kondo, N. Takeguchi, 2002, Biochemical and biophysical research communications.

Functional expression of putative H+-K+-ATPase from guinea pig distal colon.

N. Takeguchi, S. Asano, Toshiyuki Watanabe, 1998, American journal of physiology. Cell physiology.

Is the ClC‐2 chloride channel involved in the Cl− secretory mechanism of gastric parietal cells?

T. Furukawa, K. Tsukada, H. Sakai, 2004, FEBS letters.

The potency of substituted benzimidazoles such as E3810, omeprazole, Ro 18-5364 to inhibit gastric H+, K(+)-ATPase is correlatedwith the rate of acid-activation of the inhibitor.

N. Takeguchi, M. Morii, H. Takata, 1990, Biochemical pharmacology.

Establishment and characterization of a colonic epithelial cell line MCE301 from transgenic mice harboring temperature-sensitive simian virus 40 large T-antigen gene.

M. Kawahara, Y. Tabuchi, M. Furusawa, 2000, Cell structure and function.

The Roles of Carbohydrate Chains of the β-Subunit on the Functional Expression of Gastric H+,K+-ATPase*

A. Grishin, M. Caplan, N. Takeguchi, 2000, The Journal of Biological Chemistry.

Significance of lysine/glycine cluster structure in gastric H+,K+-ATPase.

Y. Tabuchi, H. Yashiro, N. Takeguchi, 2000, The Japanese journal of physiology.

Formation of a leakage-type ion pathway in lipid bilayer membranes by divalent cationic cyanine dyes in cooperation with inorganic phosphate. Role of the cyanine dye in uncoupling of oxidative phosphorylation.

T. Saitoh, H. Terada, K. Yoshikawa, 1985, The Journal of biological chemistry.

A pungent ingredient of mustard, allylisothiocyanate, inhibits (H+ + K+)-ATPase.

T. Watanabe, Y. Nishimura, N. Takeguchi, 1983, Biochemical and biophysical research communications.

Anion and cation channels in the basolateral membrane of rabbit parietal cells

H. Sakai, N. Takeguchi, M. Morii, 1989, Pflügers Archiv.

Intracellular potassium ion in relation to acid secretory rate by frog gastric mucosa.

I. Horikoshi, N. Takeguchi, A. Sano, 1979, The American journal of physiology.

Uptake of K+ by frog gastric mucosa from submucosal side and acid secretory rate.

I. Horikoshi, N. Takeguchi, M. Hattori, 1977, The American journal of physiology.

Water and salt permeability of gastric vesicles

G. Sachs, N. Takeguchi, E. Rabon, 1980, The Journal of Membrane Biology.

Leukotrienes-mediated effects of water extracts from Sargassum horneri, a marine brown alga, on Cl- absorption in isolated rat colon.

Tomoyuki Suzuki, Jung-Bum Lee, Toshimitsu Hayashi, 2004, The Japanese journal of physiology.

Nitric oxide‐induced Cl− secretion in isolated rat colon is mediated by the release of thromboxane A2

Tomoyuki Suzuki, Miki Murota, H. Sakai, 2002, The Journal of physiology.

Specific proton pump inhibitors E3810 and lansoprazole affect the recovery process of gastric secretion in rats differently.

N. Takeguchi, M. Morii, Y. Tomiyama, 1994, Biochemical pharmacology.

Effects of the Proton Pump Inhibitor, E3810, on Gastric Secretion and Gastric and Duodenal Ulcers or Erosions in Rats

I. Yamatsu, H. Fujisaki, N. Takeguchi, 1991 .

Eicosanoid-mediated Cl− secretion induced by the antitumor drug, irinotecan (CPT-11), in the rat colon

M. Diener, H. Sakai, N. Takeguchi, 1995, Naunyn-Schmiedeberg's Archives of Pharmacology.

The Phospholipid Flippase Activity of Gastric Vesicles*

N. Takeguchi, M. Morii, Hidehiro Suzuki, 1997, Journal of Biological Chemistry.

Arachidonic acid and prostaglandin E2 activate small‐conductance Cl‐ channels in the basolateral membrane of rabbit parietal cells.

H. Sakai, N. Takeguchi, M. Morii, 1992, The Journal of physiology.

A GTP-binding protein inhibits a gastric housekeeping chloride channel via intracellular production of superoxide.

H. Sakai, N. Takeguchi, 1994, The Journal of biological chemistry.

Expression of ATP1AL1, a non-gastric proton pump, in human colorectum.

Tomoyuki Suzuki, K. Tsukada, H. Sakai, 2002, The Japanese journal of physiology.

Cyclic GMP-dependent cytoprotection against ethanol-induced damage in rabbit isolated gastric parietal cells.

A. Ikari, H. Sakai, N. Takeguchi, 1998, European journal of pharmacology.

A Gastric Housekeeping Cl− Channel Activated via Prostaglandin EP3 Receptor-mediated Ca2+/Nitric Oxide/cGMP Pathway (*)

A. Ikari, H. Sakai, N. Takeguchi, 1995, The Journal of Biological Chemistry.

[Application of personal drug (P-drug) seminar to clinical pharmacy education in the graduate school of pharmaceutical sciences].

N. Takeguchi, I. Adachi, J. Kawakami, 2002, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

The Cavity Structure for Docking the K+-competitive Inhibitors in the Gastric Proton Pump*

H. Ogawa, Yusuke Kobayashi, H. Yashiro, 2004, Journal of Biological Chemistry.

The Phospholipid Flippase in Isolated Hog Gastric Vesicles : Evidence for Translocation of Endogenous Glycerophospholipids

N. Takeguchi, M. Morii, T. Murata, 2000 .

Oligomeric Regulation of Gastric H,K-ATPase (*)

N. Takeguchi, M. Morii, K. Mizoguchi, 1996, The Journal of Biological Chemistry.

The Cl- channel in hog gastric vesicles is part of the function of H,K-ATPase.

N. Takeguchi, S. Asano, M. Inoie, 1987, The Journal of biological chemistry.

Effects of Cu2+-o-phenanthroline on gastric (H+ + K+)-ATPase. Evidence for opening of a closed anion conductance by S-S cross-linkings.

N. Takeguchi, M. Morii, T. Kashiwagura, 1983, The Journal of biological chemistry.

Viscosity and apparent molal volumes of aqueous triethylenediamine

N. Takeguchi, W. Wen, David P. Wilson, 1974 .

New Gastric Epithelial Cell Lines from Mice Transgenic for Temperature-Sensitive Simian Virus 40 Large T Antigen Show Distinct Types of Cell Differentiation

Y. Tabuchi, M. Obinata, K. Ishibashi, 2003, Digestion.

Studies of Membrane Phenomena. I. Membrane Potential

H. Fujita, Y. Kobatake, N. Takeguchi, 1965 .

BI-ionic potentials of bovine lens capsules and collodion membranes.

M. Nakagaki, N. Takeguchi, 1971, Biochimica et biophysica acta.

Membrane potentials across the bovine lens capsule in vitro.

M. Nakagaki, N. Takeguchi, 1970, Biochimica et biophysica acta.

Kinetic Analysis of the Transitory Overshooting of the H+ Concentration in the Cation-exchange Membrane System

I. Horikoshi, N. Takeguchi, Shigeo Tanaka, 1975 .

Studies of Membrane Phenomena. II. Theoretical Study of Membrane Potentials

Y. Kobatake, N. Takeguchi, Y. Toyoshima, 1966 .

Role of cholesterol in functional association between K(+)-Cl(-) cotransporter-3a and Na+,K(+)-ATPase.

Takahiro Shimizu, H. Sakai, Takuto Fujii, 2012, Biochemical and biophysical research communications.

Inhibition of thromboxane A(2)-induced Cl(-) secretion by antidiarrhea drug loperamide in isolated rat colon.

A. Ikari, T. Suzuki, H. Sakai, 2000, The Journal of pharmacology and experimental therapeutics.

Different biochemical modes of action of two irreversible H+,K(+)-ATPase inhibitors, omeprazole and E3810.

N. Takeguchi, M. Morii, 1993, The Journal of biological chemistry.

Functional Expression of Gastric H+,K+-ATPase and Site-directed Mutagenesis of the Putative Cation Binding Site and the Catalytic Center (*)

K. Konishi, M. Fujioka, N. Takeguchi, 1996, The Journal of Biological Chemistry.

Mutational analysis of the putative K(+)-binding site on the fourth transmembrane segment of the gastric H(+),K(+)-ATPase.

S. Matsuda, R. Furumoto, N. Takeguchi, 2000, Journal of biochemistry.

The proton pump inhibitor, E3810, binds to the N-terminal half of the α-subunit of gastric H+,K+-ATPase

N. Takeguchi, M. Morii, K. Hamatani, 1995 .

E3710, Long-Acting PPI as New Approach for the Treatment of Unmet Medical Needs for GERD

J. Nagakawa, Kotaro Kodama, H. Fujisaki, 2012 .

Cotransporter-3 a Upregulates Na , K-ATPase in Lipid Rafts of Gastric Luminal Parietal Cells *

Y. Tabuchi, K. Tsukada, H. Sakai, 2008 .

Acid activation of omeprazole in isolated gastric vesicles, oxyntic cells, and gastric glands.

N. Takeguchi, M. Morii, H. Takata, 1989, Gastroenterology.

Ca2+-dependent secretagogue stimulation in isolated rabbit gastric glands.

G. Sachs, N. Takeguchi, T. Berglindh, 1980, The American journal of physiology.

Upregulation of thromboxane synthase in human colorectal carcinoma and the cancer cell proliferation by thromboxane A2

Y. Tabuchi, Tomoyuki Suzuki, K. Tsukada, 2006, FEBS letters.

The proton pump inhibitor, E3810, binds to the N-terminal half of the alpha-subunit of gastric H+,K(+)-ATPase.

N. Takeguchi, M. Morii, K. Hamatani, 1995, Biochemical pharmacology.

Endogenous arachidonic acid inhibits hypotonically-activated Cl- channels in isolated rat hepatocytes.

M. Diener, H. Sakai, N. Takeguchi, 1996, The Japanese Journal of Physiology.

Prostaglandin E(2)-activated housekeeping Cl(-) channels in the basolateral membrane of rat gastric parietal cells.

A. Ikari, A. Tanaka, H. Sakai, 1999, The Japanese Journal of Physiology.

Prostaglandin E2-Activated Housekeeping Cl- Channels in the Basolateral Membrane of Rat Gastric Parietal Cells

A. Ikari, Kanako Inoue, A. Tanaka, 1999 .

Cyclic AMP‐dependent Cl− secretion induced by thromboxane A2 in isolated human colon

Tomoyuki Suzuki, K. Tsukada, H. Sakai, 2005, The Journal of physiology.

Mobilization of intracellular Ca(2+) by thromboxane A(2) does not affect Ca(2+)-activated K(+) channels in rat colonic crypt cells.

A. Ikari, T. Suzuki, H. Sakai, 2000, The Japanese journal of physiology.

Thromboxane A2 receptor linked with the Ca2+ pathway in rat colonic crypt cells.

A. Ikari, H. Sakai, N. Takeguchi, 1999, Biochemical and Biophysical Research Communications - BBRC.

Cyclic AMP-dependent Cl - secretion induced by thromboxane A 2 in isolated rat colonic mucosa

Tomoyuki Suzuki, H. Sakai, N. Takeguchi, 2004 .

Thromboxane-induced Cl - secretion in isolated human colorectum

Tomoyuki Suzuki, K. Tsukada, H. Sakai, 2004 .

[Molecular mechanisms of H(+) and Cl(-) secretion in gastric parietal cells].

H. Sakai, Takuto Fujii, N. Takeguchi, 2011, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

[Inhibitory action of E3810 on H+,K(+)-ATPase and gastric acid secretion in vitro].

I. Yamatsu, H. Fujisaki, N. Takeguchi, 1993, Nihon yakurigaku zasshi. Folia pharmacologica Japonica.

Inhibition of ecto-ATPase activity by curcumin in hepatocellular carcinoma HepG2 cells

Takahiro Shimizu, H. Sakai, Takuto Fujii, 2011, The Journal of Physiological Sciences.

[Studies on inactivation of alkaline protease by tabletting].

I. Horikoshi, N. Takeguchi, M. Morii, 1973, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

H+ Transport and (H++K+)-ATPase Activity in Gastric Vesicles in Osmotically-Expanded and Shrunken States

N. Takeguchi, Rie Arakawa, T. Kashiwagura, 1982 .

Ouabain-insensitive, vanadate-sensitive K(+)-ATPase of rat distal colon is partly similar to gastric H+,K(+)-ATPase.

Y. Tabuchi, N. Takeguchi, S. Asano, 1992, The Japanese journal of physiology.

A cyclic GMP‐dependent housekeeping Cl− channel in rabbit gastric parietal cells activated by a vasodilator ecabapide

A. Ikari, H. Sakai, N. Takeguchi, 1996, British journal of pharmacology.

Ca2+ removal effects on bullfrog gastric mucosa in the presence of drugs.

Y. Nishimura, I. Horikoshi, N. Takeguchi, 1980, The Japanese journal of physiology.

Gluconeogenesis stimulated by extracellular ATP is triggered by the initial increase in the intracellular Ca2+ concentration of the periphery of hepatocytes.

N. Takeguchi, T. Kashiwagura, M. Koike, 1992, The Biochemical journal.