S. Cottens

发表

Half-filter experiments for assignment, structure determination and hydration analysis of unlabelled ligands bound to 13C/15N labelled proteins

C. Dalvit, P. Ramage, U. Hommel, 1999, Journal of biomolecular NMR.

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors*

Michael D. Davis, M. Zollinger, C. A. Foster, 2002, The Journal of Biological Chemistry.

SDZ RAD, a new rapamycin derivative: synergism with cyclosporine.

T. Meerloo, H. Schuurman, R. Sedrani, 1997, Transplantation.

Cleavage of the cyclohexyl-subunit of rapamycin results in loss of immunosuppressive activity.

R. Sedrani, L. Jones, S. Cottens, 1999, Bioorganic & medicinal chemistry letters.

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

G. Rummel, M. Geiser, S. Cowan-Jacob, 2009, Journal of medicinal chemistry.

Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY7201

C. Ricordi, B. Hering, N. Kenyon, 2004, Transplantation.

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

Joerg Kallen, Volker Brinkmann, Christian Bruns, 2001, Nature Medicine.

The diels-alder approach to musk odor type arenes

S. Cottens, G. Shi, S. Shiba, 1992 .

The Halide-promoted fragmentation of 1-chloro-1-fluoro-2-(a-silylakyl))cyclopropanes: A new entry to fluorodienes†

M. Schlosser, S. Cottens, R. Dahan, 1984 .

Synthesis, and Helix or Hairpin-Turn Secondary Structures of ‘Mixed’ α/β-Peptides Consisting of Residues with Proteinogenic Side Chains and of 2-Amino-2-methylpropanoic Acid (Aib)

B. Jaun, D. Seebach, R. Mathad, 2006 .

Synthesis, and Helix or Hairpin-Turn Secondary Structures of “Mixed” α/β-Peptides Consisting of Residues with Proteinogenic Side Chains and of 2-Amino-2-methylpropanoic Acid (Aib).

B. Jaun, D. Seebach, R. Mathad, 2006 .

Chemical modification of rapamycin: the discovery of SDZ RAD.

J. Kallen, R. Sedrani, S. Cottens, 1998, Transplantation proceedings.

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

M. Schreier, H. Schuurman, H. Zerwes, 1997, Transplantation.

FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.

V. Brinkmann, R. Albert, Z. Nikolova, 2001, Transplantation proceedings.

Structure-activity relationship and pharmacokinetic studies of sotrastaurin (AEB071), a promising novel medicine for prevention of graft rejection and treatment of psoriasis.

B. Faller, R. Sedrani, C. Beerli, 2011, Journal of medicinal chemistry.

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

Gerhard Zenke, Volker Brinkmann, Jiri Kovarik, 2009, Journal of Pharmacology and Experimental Therapeutics.

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

R. Kriwacki, P. Ramage, J. Kallen, 1999, Journal of molecular biology.

Derivation of Rapamycin: Adventures in Natural Product Chemistry.

R. Sedrani, J. Kallen, S. Cottens, 2019, Chimia.

The ylid route to fluorodienes

K. Kondo, M. Schlosser, S. Cottens, 1984 .

Interactions between a symmetrical minor groove binding compound and DNA oligonucleotides: 1H and 19F NMR studies.

G. A. van der Marel, A. Wang, P. Dervan, 1989, Journal of biomolecular structure & dynamics.

Attempted and accomplished syntheses of a few monofluorinated chrysanthemic acid derivatives

M. Schlosser, S. Cottens, 1988 .

First asymmetric synthesis of chiral analogues of the novel immunosuppressant FTY720

R. Albert, S. Cottens, K. Hinterding, 2002 .

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

H. Towbin, G. Baier, V. Brinkmann, 2009, Journal of Pharmacology and Experimental Therapeutics.