G. Addona

发表

Dynamics and orientation of N+(CD3)3-bromoacetylcholine bound to its binding site on the nicotinic acetylcholine receptor

K. Miller, A. Watts, P. Williamson, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model

I. Kariv, Sarah Javaid, R. Cristescu, 2019, Journal of cellular and molecular medicine.

Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states.

Daniel P. Downes, D. Kelley, D. McLaren, 2019, American journal of physiology. Endocrinology and metabolism.

Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.

Nadine H. Elowe, Brian T. Campbell, J. Berger, 2017, Bioorganic & medicinal chemistry letters.

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010, Journal of Lipid Research.

Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Shirly Pinto, D. McLaren, Sheng-ping Wang, 2015, Journal of medicinal chemistry.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, J. Lisnock, P. Orth, 2019, Cell chemical biology.

Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.

Nadine H. Elowe, Brian T. Campbell, J. Berger, 2017, Bioorganic & medicinal chemistry letters.

STimulator of INterferon Genes Agonism Accelerates Antitumor Activity in Poorly Immunogenic Tumors

J. Cumming, Sarah Javaid, A. Tse, 2021, Molecular Cancer Therapeutics.

Low chemical specificity of the nicotinic acetylcholine receptor sterol activation site.

K. Miller, H. Sandermann, G. Addona, 2003, Biochimica et biophysica acta.

Identification of DGAT2 Inhibitors Using Mass Spectrometry

Shirly Pinto, D. McLaren, M. Garcia-Calvo, 2016, Journal of biomolecular screening.

Where does cholesterol act during activation of the nicotinic acetylcholine receptor?

S. Husain, K. Miller, H. Sandermann, 1998, Biochimica et biophysica acta.

Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic.

R. Olsen, M. B. Pratt, S. Husain, 1999, Journal of medicinal chemistry.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Andrew M Haidle, Matthew L. Maddess, J. Cumming, 2022, Journal of medicinal chemistry.

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

A multiplexed microfluidic system for evaluation of dynamics of immune-tumor interactions.

J T Borenstein, J. Chevillet, I. Kariv, 2018, Lab on a chip.

Biochemical characterization of cholesteryl ester transfer protein inhibitors

Nadine H. Elowe, B. Hubbard, M. Garcia-Calvo, 2010, Journal of Lipid Research.

Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery

I. Kariv, Ruojing Yang, Jongwon Lim, 2021, SLAS discovery : advancing life sciences R & D.

A thermodynamic analysis of the partitioning of cholesterol and related compounds between trioleoylglycerol and egg phosphatidylcholine bilayers.

K. Miller, H. Sandermann, G. Addona, 1997, Biochimica et biophysica acta.

Approaches to proving there are general anesthetic sites on ligand gated ion channels.

K. Miller, G. Addona, M. Kloczewiak, 1998, Toxicology letters.

Geometric Isomers of a Photoactivable General Anesthetic Delineate a Binding Site on Adenylate Kinase*

S. Husain, K. Miller, T. Stehle, 2002, The Journal of Biological Chemistry.

Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors

I. Kariv, X. Chai, X. Fradera, 2020, SLAS discovery : advancing life sciences R & D.

The cholesterol dependence of activation and fast desensitization of the nicotinic acetylcholine receptor.

K. Miller, S. Rankin, G. Addona, 1997, Biophysical journal.

The Location and Nature of General Anesthetic Binding Sites on the Active Conformation of Firefly Luciferase; A Time Resolved Photolabeling Study

S. Husain, K. Miller, K. Nguyen, 2012, PloS one.

PCSK 9 is not involved in the degradation of LDL receptors and BACE 1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010 .

Estimating the electrostatic potential at the acetylcholine receptor agonist site using power saturation EPR.

D. Cafiso, G. Addona, S. Andrews, 1997, Biochimica et biophysica acta.

Identification of a General Anesthetic Binding Site in the Diacylglycerol-binding Domain of Protein Kinase Cδ*

S. Husain, K. Miller, T. Stehle, 2004, Journal of Biological Chemistry.

Antigen-based heteropolymers facilitate, via primate erythrocyte complement receptor type 1, rapid erythrocyte binding of an autoantibody and its clearance from the circulation in rhesus monkeys.

D. Cafiso, R. Taylor, G. Addona, 1995, Journal of immunology.

C-terminal Loop Mutations Determine Folding and SecretionProperties of PCSK9

D. Johns, T. Vogt, D. Wisniewski, 2016 .

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain

J. Renger, J. Mudgett, G. Pavlovic, 2010, Journal of Lipid Research.

Time-resolved photolabeling of membrane proteins: application to the nicotinic acetylcholine receptor.

K. Miller, G. Addona, M. Kloczewiak, 1999, Analytical biochemistry.

From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9.

Sujata Sharma, P. Orth, J. Shipman, 2021, Cell chemical biology.