C. Grosman

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Surfing the Conformational Wave of Acetylcholine Receptor Channel Gating

A. Auerbach, G. Cymes, C. Grosman, 2001, Microscopy and Microanalysis.

INTO ALTERNATING ACCESS MECHANISM OF SECONDARY ACTIVE TRANSPORTERS FROM MOLECULAR DYNAMICS SIMULATIONS

L. Jing, C. Grosman, 2014 .

Desensitization of neurotransmitter‐gated ion channels during high‐frequency stimulation: a comparative study of Cys‐loop, AMPA and purinergic receptors

D. Papke, C. Grosman, G. Gonzalez-Gutierrez, 2011, The Journal of physiology.

Probing function in ligand-gated ion channels without measuring ion transport.

C. Grosman, Nicole E. Godellas, 2022, The Journal of general physiology.

Single-Channel Characterization of a Nonselective Cation Channel from Human Placental Microvillous Membranes. Large Conductance, Multiplicity of Conductance States, and Inhibition by Lanthanides

C. Grosman, I. Reisin, 2000, The Journal of Membrane Biology.

Structure and function at the lipid–protein interface of a pentameric ligand-gated ion channel

Pramod Kumar, G. Cymes, C. Grosman, 2021, Proceedings of the National Academy of Sciences.

Cryo-EM structures of a lipid-sensitive pentameric ligand-gated ion channel embedded in a phosphatidylcholine-only bilayer

E. Tajkhorshid, Zhening Zhang, Zhiyu Zhao, 2020, Proceedings of the National Academy of Sciences.

A Crucial Role for Side-Chain Conformation in the Versatile Charge Selectivity of Cys-Loop Receptors.

T. Harpole, C. Grosman, Tyler J. Harpole, 2019, Biophysical journal.

Signal transduction through Cys-loop receptors is mediated by the nonspecific bumping of closely apposed domains

G. Cymes, C. Grosman, 2021, Proceedings of the National Academy of Sciences.

Chasing the open-state structure of pentameric ligand-gated ion channels

E. Tajkhorshid, G. Cymes, C. Grosman, 2017, The Journal of general physiology.

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals

S. Nair, T. Lukk, V. Agarwal, 2012, Proceedings of the National Academy of Sciences.

An experimental test of the nicotinic hypothesis of COVID-19

G. Cymes, C. Grosman, Nicole E Godellas, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Electrodiffusional ATP movement through the cystic fibrosis transmembrane conductance regulator.

H. Cantiello, D. Ausiello, S. Borkan, 1998, The American journal of physiology.

Properties of two multisubstate Cl− channels from human syncytiotrophoblast reconstituted on planar lipid bilayers

C. Grosman, I. Reisin, M. Mariano, 1997, The Journal of Membrane Biology.

The interplay between basicity, conformation, and enzymatic reduction in biliverdins.

B. Frydman, R. Frydman, S. Bari, 1992, Biochemical and biophysical research communications.

The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold

C. Grosman, G. Gonzalez-Gutierrez, 2015, The Journal of general physiology.

The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element

A. Auerbach, S. Sine, C. Grosman, 2000, The Journal of general physiology.

Kinetic, Mechanistic, and Structural Aspects of Unliganded Gating of Acetylcholine Receptor Channels

A. Auerbach, C. Grosman, 2000, The Journal of general physiology.

Probing ion-channel pores one proton at a time

G. Cymes, C. Grosman, Y. Ni, 2005, Nature.

Detection and characterization of an ovine placental lactogen stable intermediate in the urea‐induced unfolding process

J. M. Delfino, G. Cymes, C. Grosman, 1996, Protein science : a publication of the Protein Society.

Interconverting Gating Modes of a Nonselective Cation Channel from the Tapeworm Echinococcus granulosus Reconstituted on Planar Lipid Bilayers

C. Grosman, I. Reisin, 1997, The Journal of Membrane Biology.

Estimating Binding Affinities of the Nicotinic Receptor for Low-efficacy Ligands Using Mixtures of Agonists and Two-dimensional Concentration–Response Relationships

Y. Purohit, C. Grosman, 2006, The Journal of general physiology.

Identifying the elusive link between amino acid sequence and charge selectivity in pentameric ligand-gated ion channels

G. Cymes, C. Grosman, 2016, Proceedings of the National Academy of Sciences.

The Role of Intracellular Linkers in Gating and Desensitization of Human Pentameric Ligand-Gated Ion Channels

D. Papke, C. Grosman, 2014, The Journal of Neuroscience.

Gating of the proton-gated ion channel from Gloeobacter violaceus at pH 4 as revealed by X-ray crystallography

Satish K Nair, S. Nair, L. G. Cuello, 2013, Proceedings of the National Academy of Sciences.

Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states.

C. Grosman, G. Gonzalez-Gutierrez, 2010, Journal of molecular biology.

Decremental Response to High-Frequency Trains of Acetylcholine Pulses but Unaltered Fractional Ca2+ Currents in a Panel of “Slow-Channel Syndrome” Nicotinic Receptor Mutants

G. Cymes, C. Grosman, S. Elenes, 2009, The Journal of general physiology.

Desensitization Contributes to the Synaptic Response of Gain-of-Function Mutants of the Muscle Nicotinic Receptor

G. Cymes, C. Grosman, Y. Ni, 2006, The Journal of general physiology.

The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors

G. Cymes, C. Grosman, 2012, Nature chemical biology.

Rapid multi-directed cholinergic transmission in the central nervous system

G. Awatramani, D. Berson, Keisuke Yonehara, 2021, Nature Communications.

Side-chain conformation at the selectivity filter shapes the permeation free-energy landscape of an ion channel

Tyler J Harpole, Claudio Grosman, C. Grosman, 2014, Proceedings of the National Academy of Sciences.

Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer

G. Cymes, C. Grosman, 2008, Nature Structural &Molecular Biology.

Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors

G. Cymes, C. Grosman, 2011, Nature.

Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis.

A. Auerbach, G. Cymes, C. Grosman, 2002, Biochemistry.

The dissociation of acetylcholine from open nicotinic receptor channels

A. Auerbach, C. Grosman, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Mapping the conformational wave of acetylcholine receptor channel gating

Ming Zhou, Anthony Auerbach, A. Auerbach, 2000, Nature.

Asymmetric and Independent Contribution of the Second Transmembrane Segment 12′ Residues to Diliganded Gating of Acetylcholine Receptor Channels

A. Auerbach, C. Grosman, 2000, The Journal of general physiology.

Block of Muscle Nicotinic Receptors by Choline Suggests that the Activation and Desensitization Gates Act as Distinct Molecular Entities

Y. Purohit, C. Grosman, 2006, The Journal of general physiology.

Engineered Ionizable Side Chains.

G. Cymes, C. Grosman, 2015, Advances in experimental medicine and biology.

Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels.

C. Grosman, 2003, Biochemistry.

Estimating the pKa values of basic and acidic side chains in ion channels using electrophysiological recordings: A robust approach to an elusive problem

G. Cymes, C. Grosman, 2011, Proteins.

Probing function in ligand-gated ion channels without measuring ion transport

C. Grosman, Nicole E Godellas, 2022, bioRxiv.