N. Micale

发表

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands.

J. Greenwood, S. Traynelis, K. Hansen, 2008, Journal of medicinal chemistry.

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Bearing a Pyrazole Scaffold and a Cinnamoyl Linker

A. Scala, A. Rescifina, C. Zagni, 2019, International journal of molecular sciences.

Anticancer study of heterobimetallic platinum(II)-ruthenium(II) and platinum(II)-rhodium(III) complexes with bridging dithiooxamide ligand

H. A. Rudbari, T. Schirmeister, M. Navarra, 2019, Journal of Organometallic Chemistry.

Synthesis, Characterization and Anticancer Studies of Rh(I), Rh(III), Pd(II) and Pt(II) Complexes Bearing A Dithiooxamide Ligand

H. A. Rudbari, G. Bruno, N. Micale, 2020 .

Antimicrobial peptide capsids of de novo design

B. Hoogenboom, M. Ryadnov, Santanu Ray, 2017, Nature Communications.

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

T. Schirmeister, M. D. Di Francesco, E. Nizi, 2008, Journal of medicinal chemistry.

Synthesis, solution behaviour and potential anticancer activity of new trinuclear organometallic palladium(II) complex of {S}-1-phenylethyl dithiooxamide: Comparison with the trinuclear heterobimetallic platinum(II) analogue

H. A. Rudbari, V. Mirkhani, T. Schirmeister, 2019, Polyhedron.

Development of Novel Peptidomimetics Containing a Vinyl Sulfone Moiety as Proteasome Inhibitors

T. Schirmeister, M. Zappalà, R. Ettari, 2011, ChemMedChem.

Hydrogels for the Delivery of Plant-Derived (Poly)Phenols

M. Cristani, A. Speciale, F. Cimino, 2020, Molecules.

Peptide‐Based Proteasome Inhibitors in Anticancer Drug Design

M. Zappalà, R. Ettari, S. Grasso, 2014, Medicinal research reviews.

Synthesis and antitumor activity of 1,3-benzodioxole derivatives.

M. Zappalà, S. Grasso, N. Micale, 2002, Farmaco.

Physicochemical properties of inclusion complexes of highly soluble β-cyclodextrins with highly hydrophobic testosterone propionate.

A. Scala, A. Grattoni, D. Paolino, 2017, International journal of pharmaceutics.

Antiproliferative Properties of a Few Auranofin-Related Gold(I) and Silver(I) Complexes in Leukemia Cells and their Interferences with the Ubiquitin Proteasome System

T. Efferth, T. Schirmeister, L. Massai, 2020, Molecules.

Peptide-based boronates: How to achieve tissue specificity in anticancer therapy

N. Micale, 2013 .

State of the Art on Green Route Synthesis of Gold/Silver Bimetallic Nanoparticles

A. Scala, M. Cordaro, A. Piperno, 2022, Molecules.

Copper(II) complexes with tridentate halogen-substituted Schiff base ligands: synthesis, crystal structures and investigating the effect of halogenation, leaving groups and ligand flexibility on antiproliferative activities.

A. R. Fernandes, P. Baptista, J. Wouters, 2021, Dalton transactions.

Antimicrobial and antiprotozoal activities of silver coordination polymers derived from the asymmetric halogenated Schiff base ligands

H. A. Rudbari, L. Maes, A. Scala, 2020, Applied Organometallic Chemistry.

Ensemble‐based ADME–Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE

L. Maes, A. Scala, A. Rescifina, 2018, Chemical biology & drug design.

Targeting of the Leishmania mexicana cysteine protease CPB2.8ΔCTE by decorated fused benzo[b]thiophene scaffold

A. Scala, A. Rescifina, T. Schirmeister, 2016 .

Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines

T. Efferth, A. Rescifina, T. Schirmeister, 2022, International journal of molecular sciences.

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents

L. Maes, T. Schirmeister, L. Massai, 2017, BioMetals.

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

A. Schimmer, M. Zappalà, S. Grasso, 2012, Medicinal Chemistry Research.

Antileukemia Activity and Mechanism of Platinum(II)-Based Metal Complexes

T. Efferth, M. P. Germanò, M. D. Di Pietro, 2022, Molecules.

Peptidomimetics containing a vinyl ketone warhead as falcipain-2 inhibitors.

T. Schirmeister, S. Giofrè, M. Zappalà, 2011, European journal of medicinal chemistry.

Novel peptidomimetic cysteine protease inhibitors as potential antimalarial agents.

A. Chishti, Ajay Kumar, A. Kozikowski, 2006, Journal of medicinal chemistry.

Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.

A. Yakovlev, A. Kozikowski, N. Micale, 2004, Journal of medicinal chemistry.

Synthesis and anticonvulsant activity of novel and potent 6,7-methylenedioxyphthalazin-1(2H)-ones.

M. Baraldi, G. De Sarro, A. De Sarro, 2000, Journal of medicinal chemistry.

Heteroleptic enantiopure Pd(ii)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity

J. Wouters, David E. Herbert, N. Tumanov, 2021 .

Synthesis and in vitro antitumour activity evaluation of 1-aryl-1H,3H-thiazolo[4,3-b]quinazolines.

A. Monforte, P. Monforte, M. Zappalà, 2000, European journal of medicinal chemistry.

Synthesis of C3/C1-Substituted Tetrahydroisoquinolines

A. Scala, T. Schirmeister, A. Piperno, 2015, Molecules.

1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.

F. Menniti, G. De Sarro, C. De Micheli, 2003, Bioorganic & medicinal chemistry letters.

Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.

A. Cagnotto, T. Mennini, M. Zappalà, 2008, Bioorganic & medicinal chemistry.

Some new antimicrobial/antioxidant nanostructure zinc complexes: Synthesis, crystal structure, Hirshfeld surface analyses and thermal behavior

J. White, M. Cristani, Z. Akbari, 2022, Results in Chemistry.

Inhibition of rhodesain as a novel therapeutic modality for human African trypanosomiasis.

A. Pinto, L. Tamborini, P. Conti, 2013, Journal of medicinal chemistry.

1‐Aryl‐6,7‐methylenedioxy‐3H‐quinazolin‐4‐ones as Anticonvulsant Agents.

F. Menniti, G. Sarro, M. Zappalà, 2004 .

Ruthenium(ii) and palladium(ii) homo- and heterobimetallic complexes: synthesis, crystal structures, theoretical calculations and biological studies.

T. Efferth, T. Schirmeister, Ean-jeong Seo, 2019, Dalton transactions.

Synthesis of benzothiazole derivatives and their biological evaluation as anticancer agents

A. Schimmer, M. Zappalà, S. Grasso, 2011, Medicinal Chemistry Research.

Synthesis of Novel 3‐(Alkylcarbamoyl)‐2‐aryl‐1,2‐dihydro‐6,7‐(methylenedioxy)‐3H‐quinazolin‐4‐ones as Anticonvulsant Agents

M. Zappalà, S. Grasso, G. Zuccalà, 2006, Chemistry & biodiversity.

Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-d-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007, Molecular Pharmacology.

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, C. Gelhaus, 2010, Bioorganic & medicinal chemistry.

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent.

Vittorio Pace, W. Holzer, N. Micale, 2019, Organic letters.

Synthesis and cytotoxic activity of 1,3-benzodioxole derivatives. Note II.

M. Zappalà, S. Grasso, N. Micale, 2003, Farmaco.

Falcipain‐2 inhibitors

M. Zappalà, R. Ettari, S. Grasso, 2010, Medicinal research reviews.

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

Enantioselective recognition of 2,3-benzodiazepin-4-one derivatives with anticonvulsant activity on several polysaccharide chiral stationary phases.

S. Alcaro, P. Ficarra, R. Ficarra, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Subunit-Specific Agonist Activity at NR 2 A-, NR 2 B-, NR 2 C-, and NR 2 D-Containing N-Methyl-D-aspartate Glutamate Receptors

Matthew T. Geballe, J. Snyder, S. Traynelis, 2007 .

Chloro-substituted Hoveyda-Grubbs ruthenium carbene : Investigation of electronic effects

R. Ettari, N. Micale, 2007 .

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, A. Evers, 2009, Bioorganic & medicinal chemistry.

Synthesis and Cytotoxic Activity of 1,3-Benzodioxole Derivatives. Part 2.

M. Zappalà, S. Grasso, N. Micale, 2003 .

A SIMPLE AND EFFICIENT SYNTHESIS OF GYKI 52466 AND GYKI 52895

C. De Micheli, M. Zappalà, S. Grasso, 2002 .

SARS-CoV-2 Mpro: A Potential Target for Peptidomimetics and Small-Molecule Inhibitors

A. Scala, A. Piperno, N. Micale, 2021, Biomolecules.

Cyrene: A Green Solvent for the Synthesis of Bioactive Molecules and Functional Biomaterials

D. Passarella, N. Micale, A. Citarella, 2022, International journal of molecular sciences.

Mechanism of Inhibition of the GluA2 AMPA Receptor Channel Opening: the Role of 4-Methyl versus 4-Carbonyl Group on the Diazepine Ring of 2,3-Benzodiazepine Derivatives.

Congzhou Wang, R. Ettari, L. Niu, 2011, ACS chemical neuroscience.

Peptidyl Fluoromethyl Ketones and Their Applications in Medicinal Chemistry

N. Micale, A. Citarella, 2020, Molecules.

Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses

G. Gribaudo, M. Sciortino, A. Rescifina, 2021, International journal of molecular sciences.

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain‐2 Inhibitors

Maria Zappalà, Giovanni Grazioso, Tanja Schirmeister, 2012, ChemMedChem.

Glutamate binding-site ligands of NMDA receptors.

M. Zappalà, R. Ettari, S. Grasso, 2011, Current medicinal chemistry.

Recent advances and perspectives on tropical diseases: Malaria

N. Micale, 2012 .

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities.

T. Schirmeister, L. Massai, L. Messori, 2014, Journal of inorganic biochemistry.

Development of Novel Selective Peptidomimetics Containing a Boronic Acid Moiety, Targeting the 20S Proteasome as Anticancer Agents

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, ChemMedChem.

Natural Product-Based Hybrids as Potential Candidates for the Treatment of Cancer: Focus on Curcumin and Resveratrol

M. Cristani, A. Speciale, A. Saija, 2021, Molecules.

Synthesis and structure-activity relationships of 2,3-benzodiazepines as AMPA receptor antagonists.

C. De Micheli, M. Zappalà, S. Grasso, 2001, Mini reviews in medicinal chemistry.

Enantioseparation, absolute configuration determination, and anticonvulsant activity of (+/-)-1-(4-aminophenyl)-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-one.

G. De Sarro, P. Ficarra, M. Zappalà, 2007, Chirality.

Synthesis, chiral resolution, and enantiopharmacology of a potent 2,3-benzodiazepine derivative as noncompetitive AMPA receptor antagonist.

F. Menniti, G. De Sarro, G. Roda, 2006, Journal of medicinal chemistry.

New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists.

F. Menniti, G. De Sarro, C. De Micheli, 2006, Bioorganic & medicinal chemistry letters.

Synthesis of 2-semicarbazonomethyl-4,5-methylenedioxyphenylacetic acids as anticonvulsant agents.

F. Menniti, G. De Sarro, M. Zappalà, 2005, Farmaco.

Characterization of the mechanism of anticonvulsant activity for a selected set of putative AMPA receptor antagonists.

F. Menniti, C. Costagli, A. Galli, 2003, Bioorganic & medicinal chemistry letters.

ChemInform Abstract: Synthesis and Structure-Activity Relationships of 2,3-Benzodiazepines as AMPA Receptor Antagonists.

M. Zappalà, S. Grasso, N. Micale, 2002 .

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro.

T. Schirmeister, L. Messori, M. Cinellu, 2011, Journal of inorganic biochemistry.

"Click" on PLGA-PEG and hyaluronic acid: Gaining access to anti-leishmanial pentamidine bioconjugates.

A. Scala, F. Vitale, Federica Bruno, 2018, Journal of biomedical materials research. Part B, Applied biomaterials.

Mechanism of inhibition of GluA2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives: functional consequences of replacing a 7,8-methylenedioxy with a 7,8-ethylenedioxy moiety.

S. Grasso, L. Niu, N. Micale, 2012, Biochemistry.

Synthesis, Chiral Resolution and Pharmacological Evaluation of a 2,3‐Benzodiazepine‐Derived Noncompetitive AMPA Receptor Antagonist

T. Mennini, P. Ficarra, M. Zappalà, 2009, ChemMedChem.

New 7,8‐Ethylenedioxy‐2,3‐benzodiazepines as Noncompetitive AMPA Receptor Antagonists.

F. Menniti, G. Sarro, M. Zappalà, 2006 .

Synthesis and anticonvulsant activity of novel and potent 2,3-benzodiazepine AMPA/kainate receptor antagonists.

M. Baraldi, G. Puia, G. De Sarro, 1999, Journal of medicinal chemistry.

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists.

G. De Sarro, A. De Sarro, R. Gitto, 1998, Bioorganic & medicinal chemistry letters.

Design of 1-substituted 2-arylmethyl-4,5-methylenedioxybenzene derivatives as antiseizure agents.

G. Puia, G. De Sarro, C. De Micheli, 2004, Bioorganic & medicinal chemistry.

Novel potent AMPA/kainate receptor antagonists: synthesis and anticonvulsant activity of a series of 2-[(4-alkylsemicarbazono)-(4-amino-phenyl)methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters.

G. De Sarro, L. Toma, A. De Sarro, 2002, Journal of medicinal chemistry.

Synthesis and anticonvulsant activity of novel and potent 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-benzodiazepin-4-ones.

M. Baraldi, G. Puia, G. De Sarro, 2001, Bioorganic & medicinal chemistry letters.

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists.

G. De Sarro, A. De Sarro, R. Gitto, 1999, Farmaco.

Mechanism of inhibition of the GluR2 AMPA receptor channel opening by 2,3-benzodiazepine derivatives.

S. Grasso, L. Niu, N. Micale, 2008, Biochemistry.

Supramolecular assembly of pentamidine and polymeric cyclodextrin bimetallic core–shell nanoarchitectures

L. Maes, A. Scala, A. Mazzaglia, 2022, Beilstein journal of nanotechnology.

A hyaluronic acid–pentamidine bioconjugate as a macrophage mediated drug targeting delivery system for the treatment of leishmaniasis

A. Scala, T. Schirmeister, A. Piperno, 2015 .

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester

Laura Legnani, Giovanni Grazioso, Carlo De Micheli, 2012, Journal of Computer-Aided Molecular Design.

Discovery of benzimidazole‐based Leishmania mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis

L. Maes, S. Ferro, A. Rescifina, 2018, Chemical biology & drug design.

5-phenyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-one.

G. Rosace, R. Gitto, G. Bruno, 2003, Acta crystallographica. Section C, Crystal structure communications.

Silibinin-conjugated graphene nanoplatform: Synthesis, characterization and biological evaluation

A. Scala, E. Fazio, S. Panseri, 2017 .

Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Identification of a new series of amides as non-covalent proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2014, European journal of medicinal chemistry.

Development of peptidomimetic boronates as proteasome inhibitors.

E. Novellino, A. Lavecchia, T. Schirmeister, 2013, European journal of medicinal chemistry.

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

M. Leippe, T. Schirmeister, M. D. Di Francesco, 2009, Journal of medicinal chemistry.

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

M. Leippe, T. Schirmeister, A. Evers, 2010, European journal of medicinal chemistry.

Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry

A. Scala, Z. Debyser, F. Christ, 2018, ACS medicinal chemistry letters.

Antimicrobial peptide capsids of de novo design

B. Hoogenboom, M. Ryadnov, Santanu Ray, 2017, Nature Communications.

Selective noncovalent proteasome inhibiting activity of trifluoromethyl‐containing gem‐quaternary aziridines

A. Rescifina, T. Schirmeister, Laura Ielo, 2023, Archiv der Pharmazie.

Nonpeptidic Vinyl and Allyl Phosphonates as Falcipain‐2 Inhibitors

T. Schirmeister, E. Nizi, M. Zappalà, 2008, ChemMedChem.

Recent Advances in SARS-CoV-2 Main Protease Inhibitors: From Nirmatrelvir to Future Perspectives

D. Passarella, A. Scala, A. Piperno, 2023, Biomolecules.

Synthesis of SARS-CoV-2 Mpro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses.

S. Pieraccini, G. Gribaudo, D. Passarella, 2023, Organic & biomolecular chemistry.

A comprehensive review on the development of chiral Cu, Ni, and Zn complexes as pharmaceutical agents over the past decades: Synthesis, molecular structure and biological activity.

N. Micale, Nakisa Moini, H. Rudbari, 2024, Medicinal research reviews.

Two palladium (II) complexes derived from halogen-substituted Schiff bases and 2-picolylamine induce parthanatos-type cell death in sensitive and multi-drug resistant CCRF-CEM leukemia cells.

T. Efferth, T. Schirmeister, J. Boulos, 2023, European journal of pharmacology.

Nano-Formulations of Natural Antioxidants for the Treatment of Liver Cancer

N. Micale, Andrea Citarella, Mariateresa Cristani, 2024, Biomolecules.

Bioactive Compounds from Medicinal Plants as Potential Adjuvants in the Treatment of Mild Acne Vulgaris

N. Micale, Mariateresa Cristani, 2024, Molecules.