P. Bisignano

发表

Stochastic steps in secondary active sugar transport

D. Loo, E. Wright, J. Rosenberg, 2016, Proceedings of the National Academy of Sciences.

Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

A. Cavalli, V. Andrisano, G. Bottegoni, 2016, Journal of medicinal chemistry.

Cilia-Associated Oxystero ls Activate Smoothened Graphical Abstract Highlights

D. Elnatan, A. Renslo, P. Beachy, 2018 .

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1.

Edward T Chouchani, L. Kazak, M. Grabe, 2022, Nature.

Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice

Yong Zi Tan, J. Weissman, R. Fetter, 2022, Nature Biotechnology.

Mitochondrial uncouplers induce proton leak by activating AAC and UCP1

Edward T Chouchani, L. Kazak, M. Grabe, 2022, Nature.

Mechanistic Insights into the Allosteric Modulation of Opioid Receptors by Sodium Ions

G. Pasternak, M. Filizola, S. Schneider, 2014, Biochemistry.

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1

A. Laganowsky, C. Altenbach, W. Hubbell, 2017, Proceedings of the National Academy of Sciences.

A Triazolotriazine‐Based Dual GSK‐3β/CK‐1δ Ligand as a Potential Neuroprotective Agent Presenting Two Different Mechanisms of Enzymatic Inhibition

A. Cavalli, Maicol Bissaro, S. Moro, 2019, ChemMedChem.

Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

Andrea Armirotti, Paola Bisignano, Maria Laura Bolognesi, 2015, Angewandte Chemie.

Inhibitor binding mode and allosteric regulation of Na+-glucose symporters

M. Jacobson, C. Kalyanaraman, C. Ghezzi, 2018, Nature Communications.

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site

W. Y. Wahlgren, J. Bengtsson-Palme, A. Farewell, 2018, Nature Communications.

Cilia-Associated Oxysterols Activate Smoothened.

D. Elnatan, A. Renslo, P. Beachy, 2018, Molecular cell.

Selective Targeting of Ras Mutant Cancers via a New Small Molecule

Yong Zi Tan, J. Weissman, R. Fetter, 2020, bioRxiv.

SOX11 Inhibitors Are Cytotoxic in Mantle Cell Lymphoma

A. Laganà, R. Jain, A. Wiestner, 2021, Clinical Cancer Research.

Conformational transitions of the sodium-dependent sugar transporter, vSGLT

Paola Bisignano, Michael Grabe, Aviv Paz, 2018, Proceedings of the National Academy of Sciences.

Kinetic Characterization of Fragment Binding in AmpC β-Lactamase by High-Throughput Molecular Simulations

Andrea Cavalli, Paola Bisignano, Matthew J. Harvey, 2014, J. Chem. Inf. Model..

A systems-biology approach to molecular machines: Exploration of alternative transporter mechanisms

M. Grabe, A. George, P. Bisignano, 2019, bioRxiv.

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

E. Cao, J. Reiter, D. Raleigh, 2022, bioRxiv.

A kinetic mechanism for enhanced selectivity of membrane transport

J. Rosenberg, D. Zuckerman, M. Grabe, 2020, PLoS Comput. Biol..

Development and Application of a Virtual Screening Protocol for the Identification of Multitarget Fragments

Paola Bisignano, Angelo D. Favia, Giovanni Bottegoni, 2016, ChemMedChem.

Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake

M. Mezei, L. Devi, M. Filizola, 2016, Science Signaling.

Molecular dynamics analysis of the wild type and dF508 mutant structures of the human CFTR-nucleotide binding domain 1.

Paola Bisignano, Oscar Moran, O. Moran, 2010, Biochimie.

SERAPhiC: A Benchmark for in Silico Fragment-Based Drug Design

Irene Nobeli, Andrea Cavalli, Paola Bisignano, 2011, J. Chem. Inf. Model..

Inhibitor binding mode and allosteric regulation of Na+-glucose symporters

E. Wright, M. Jacobson, C. Kalyanaraman, 2018, Nature Communications.

MerlinS13 phosphorylation controls meningioma Wnt signaling and magnetic resonance imaging features

J. Villanueva-Meyer, D. Raleigh, D. Swaney, 2023, Research square.

In Silico Deconstruction of ATP-Competitive Inhibitors of Glycogen Synthase Kinase-3β

Manuele Bicego, Vittorio Murino, Andrea Cavalli, 2012, J. Chem. Inf. Model..

An Innovative Protocol for Comparing Protein Binding Sites via Atomic Grid Maps

Manuele Bicego, Vittorio Murino, Andrea Cavalli, 2011, KDIR.

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site

W. Y. Wahlgren, J. Bengtsson-Palme, A. Farewell, 2018, Nature Communications.

Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

Marta Filizola, Paola Bisignano, Yi Shang, 2015, J. Chem. Inf. Model..

Kinetic Characterization of Fragment Binding in AmpC β-Lactamase by High-Throughput Molecular Simulations

Angelo D. Favia, A. Cavalli, M. Harvey, 2014, J. Chem. Inf. Model..