Ri-lei Yu

发表

Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors

David John Adams, Q. Kaas, Nargis Tabassum, 2017, ACS omega.

Molecular Determinants Conferring the Stoichiometric-Dependent Activity of α-Conotoxins at the Human α9α10 Nicotinic Acetylcholine Receptor Subtype.

David John Adams, Nargis Tabassum, Han-Shen Tae, 2018, Journal of Medicinal Chemistry.

Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors

David John Adams, Q. Kaas, Nargis Tabassum, 2017, ACS omega.

Exploring the binding energy profiles of full agonists, partial agonists, and antagonists of the α7 nicotinic acetylcholine receptor

Nargis Tabassum, Tao Jiang, Ri-lei Yu, 2017, Journal of Molecular Modeling.

Delineation of the unbinding pathway of α-conotoxin ImI from the α7 nicotinic acetylcholine receptor.

Quentin Kaas, David J Craik, D. Craik, 2012, The journal of physical chemistry. B.

2‐Pyridinyl‐4(3H)‐Quinazolinone: A Scaffold for Anti‐influenza A Virus Compounds

Wei Wang, Tao Jiang, Ri-lei Yu, 2015, Chemical biology & drug design.

Application of reverse docking for target prediction of marine compounds with anti-tumor activity.

Ximing Xu, Jinbo Yang, Tao Jiang, 2017, Journal of molecular graphics & modelling.

Antidiabetic activity in vitro and in vivo of BDB, a selective inhibitor of protein tyrosine phosphatase 1B, from Rhodomela confervoides

Meiling Zheng, Xiangqian Li, B. Jiang, 2020, British Journal of Pharmacology.

Structure-activity relationship of propylene glycol alginate sodium sulfate derivatives for blockade of selectins binding to tumor cells.

Ximing Xu, Peiju Qiu, Huashi Guan, 2019, Carbohydrate polymers.

Cyclic analogues of α‐conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

D. Craik, David John Adams, Q. Kaas, 2018, British journal of pharmacology.

Isothiouronium modification empowers pyrimidine-substituted curcumin analogs potent cytotoxicity and Golgi localization.

Meng Zhang, Tao Jiang, Ri-lei Yu, 2016, European journal of medicinal chemistry.

Synthesis and DNA-binding properties of novel DNA cyclo-intercalators containing purine-glucuronic acid hybrids.

S. Ren, Renshuai Zhang, Tao Jiang, 2016, Carbohydrate research.

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor

Yuan Ma, David John Adams, Han-Shen Tae, 2022, Marine drugs.

α‐Conotoxins active at α3‐containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition

David John Adams, Han-Shen Tae, Ri-lei Yu, 2018, British journal of pharmacology.

Virtual screening and molecular dynamics simulation for identification of natural antiviral agents targeting SARS-CoV-2 NSP10

Lei He, Huilin Zhao, Ri-lei Yu, 2022, Biochemical and Biophysical Research Communications.

Molecular dynamics simulations of dihydro‐β‐erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

D. Craik, David John Adams, Q. Kaas, 2019, British journal of pharmacology.

The Startle Disease Mutation E103K Impairs Activation of Human Homomeric α1 Glycine Receptors by Disrupting an Intersubunit Salt Bridge across the Agonist Binding Site*

D. Jane, P. Biggin, L. Sivilotti, 2017, The Journal of Biological Chemistry.

In silico design of anti-tumor mini-protein targeting MDM2

Peiju Qiu, Jinbo Yang, Tao Jiang, 2022, Chinese Chemical Letters.

Cytotoxic and glycosaminoglycan priming activities of novel 4-anilinequinazoline β-D-xylosides.

Jinpeng Wang, Meng Zhang, Lijuan Zhang, 2018, Carbohydrate research.

Design, synthesis and activity of Mnk1 and Mnk2 selective inhibitors containing thieno[2,3-d]pyrimidine scaffold.

Shuye Tian, C. Proud, Jiajun Zhao, 2019, European journal of medicinal chemistry.

Unusual Tetrahydropyridoindole-Containing Tetrapeptides with Human Nicotinic Acetylcholine Receptors Targeting Activity Discovered from Antarctica-Derived Psychrophilic Pseudogymnoascus sp. HDN17-933

T. Zhu, Dehai Li, Guojian Zhang, 2022, Marine drugs.

Discovery and Structural and Functional Characterization of a Novel A-Superfamily Conotoxin Targeting α9α10 Nicotinic Acetylcholine Receptor.

Chenyun Guo, Shuo Yu, Qiuyun Dai, 2022, ACS chemical biology.

Fructose-1,6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARα-regulated gene transcription and tumour growth

T. Liang, Meisi Yan, Haitao Li, 2022, Nature Cell Biology.

Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4.

Ri-lei Yu, Zongjiang Yu, Tao Jiang, 2016, Molecular pharmaceutics.

Design, synthesis, and biological evaluation of novel 7-substituted 10,11-methylenedioxy-camptothecin derivatives against drug-resistant small-cell lung cancer in vitro and in vivo.

Xin Qi, Guorui Zhang, Tao Jiang, 2022, European journal of medicinal chemistry.

Synthesis and evaluation of novel non-covalent binding quinazoline glycoside derivatives targeting the L858R and T790M variants of EGFR

M. Geng, Renshuai Zhang, Tao Jiang, 2016 .

Key Structural Determinants in the Agonist Binding Loops of Human (cid:2) 2 and (cid:2) 4 Nicotinic Acetylcholine Receptor Subunits Contribute to (cid:3) 3 (cid:2) 4 Subtype Selectivity of (cid:3) -Conotoxins

David John Adams, Han-Shen Tae, Ri-lei Yu, 2020 .

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening

Tao Jiang, Ri-lei Yu, Tingting Qiu, 2022, Marine drugs.

Blockade of Human α7 Nicotinic Acetylcholine Receptor by α-Conotoxin ImI Dendrimer: Insight from Computational Simulations

Xiaoxiao Xu, Tao Jiang, Ri-lei Yu, 2019, Marine drugs.

A 4/8 Subtype α-Conotoxin Vt1.27 Inhibits N-Type Calcium Channels With Potent Anti-Allodynic Effect

David John Adams, Shuo Yu, Qiuyun Dai, 2022, Frontiers in Pharmacology.

Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways

Tao Jiang, Ri-lei Yu, Xin Wang, 2019, International journal of molecular sciences.

A novel inhibitor of PGK1 suppresses the aerobic glycolysis and proliferation of hepatocellular carcinoma.

Xin Qi, Jing Li, Mingfeng Li, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Mechanism of Action and Structure-Activity Relationship of α-Conotoxin Mr1.1 at the Human α9α10 Nicotinic Acetylcholine Receptor.

David John Adams, Han-Shen Tae, Tao Jiang, 2022, Journal of medicinal chemistry.

Efficient Synthesis of Five Types of Heterocyclic Compounds via Intramolecular Elimination Using Ultrasound-Static Heating Technique.

Tao Jiang, Ri-lei Yu, S. Wan, 2018, Chemistry, an Asian journal.

Design and synthesis of neolamellarin a derivatives targeting heat shock protein 90.

Jing Li, Jiajia Dai, Tao Jiang, 2017, European journal of medicinal chemistry.

Design, synthesis, and antitumor activity of novel benzoheterocycle derivatives as inhibitors of vascular endothelial growth factor receptor-2 tyrosine kinase

Ri-lei Yu, Kai Liu, Ying-tao Lv, 2020 .

Boronic Acid Modifications Enhance the Anti-Influenza A Virus Activities of Novel Quindoline Derivatives.

Cui Hao, Wei Wang, Meng Zhang, 2017, Journal of medicinal chemistry.

Chemoreactive-inspired discovery of influenza A virus dual inhibitor to block hemagglutinin-mediated adsorption and membrane fusion.

Shuang Yang, T. Zhu, Dehai Li, 2020, Journal of medicinal chemistry.

A Novel Natural Influenza A H1N1 Virus Neuraminidase Inhibitory Peptide Derived from Cod Skin Hydrolysates and Its Antiviral Mechanism

M. Zeng, Haohao Wu, Yuanhui Zhao, 2018, Marine drugs.

Chetracins E and F, cytotoxic epipolythiodioxopiperazines from the marine-derived fungus Acrostalagmus luteoalbus HDN13-530

T. Zhu, Dehai Li, Q. Gu, 2018 .

MomL inhibits bacterial antibiotic resistance through the starvation stringent response pathway

Yan Wang, Zhiqing Liu, Hongan Long, 2022, mLife.

The hydrogen-bond network around Glu160 contributes to the structural stability of chitosanase CsnA from Renibacterium sp. QD1.

Xinzhi Lu, Wengong Yu, Ri-lei Yu, 2017, International journal of biological macromolecules.

Self-assembling nanoparticles of dually hydrophobic prodrugs constructed from camptothecin analogue for cancer therapy.

Mingming Yu, Huashi Guan, Tao Jiang, 2020, European journal of medicinal chemistry.

Guanidine modifications enhance the anti‐herpes simplex virus activity of (E,E)‐4,6‐bis(styryl)‐pyrimidine derivatives in vitro and in vivo

Wei Wang, Jin-ping Wang, Tao Jiang, 2019, British journal of pharmacology.

Efficient Total Synthesis of Lissodendrin B, 2-Aminoimidazole Marine Alkaloids Isolated from Lissodendoryx (Acanthodoryx) fibrosa

Tao Jiang, Ri-lei Yu, S. Wan, 2019, Marine drugs.

Dimerization of α-conotoxins as a strategy to enhance the inhibition of the human α7 and α9α10 nicotinic acetylcholine receptors.

David John Adams, Xiaoxiao Xu, Han-Shen Tae, 2020, Journal of medicinal chemistry.

Molecular dynamic simulation on the conformation of mouse muscle type nAChR

Ri-lei Yu, Yanni Li, Sheng Sun, 2010 .

Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects in vivo

Cui Hao, Feng Liu, Tao Jiang, 2019, RSC advances.

Nucleus-exported CLOCK acetylates PRPS to promote de novo nucleotide synthesis and liver tumour growth

L. Ye, Meisi Yan, Tong Liu, 2023, Nature Cell Biology.

SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.

Y. Tong, Zhimin Lu, Jing Fang, 2021, Molecular cell.

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

David J. Craik, Quentin Kaas, Rilei Yu, 2011, Nucleic Acids Res..

In Silico Design of MDM2‐Targeting Peptides from a Naturally Occurring Constrained Peptide

D. Craik, P. Harvey, Q. Kaas, 2019, ChemMedChem.

Design and syntheses of a bimolecular STING agonist based on the covalent STING antagonist.

Tao Jiang, Jinbo Yang, Ri-lei Yu, 2023, European journal of medicinal chemistry.

α-Conotoxin Vc1.1 Structure-Activity Relationship at the Human α9α10 Nicotinic Acetylcholine Receptor Investigated by Minimal Side Chain Replacement.

David John Adams, Han-Shen Tae, Tao Jiang, 2019, ACS chemical neuroscience.

Pathophysiology of obesity and its associated diseases

C. Proud, Ri-lei Yu, Tao Jiang, 2023, Acta pharmaceutica Sinica. B.

Progress in developing MNK inhibitors.

Tao Jiang, C. Proud, Xuemin Wang, 2021, European journal of medicinal chemistry.

Medicinal chemistry, pharmacology, and therapeutic potential of α-conotoxins antagonizing the α9α10 nicotinic acetylcholine receptor.

Yan-yan Chu, Han-Shen Tae, Tao Jiang, 2020, Pharmacology & therapeutics.

Centipede Venom Peptides Acting on Ion Channels

Peiju Qiu, Yan-yan Chu, Ri-lei Yu, 2020, Toxins.

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1

D. Craik, David John Adams, Q. Kaas, 2015, Scientific Reports.

Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor.

D. Craik, David John Adams, Q. Kaas, 2013, Journal of medicinal chemistry.

Agonist and antagonist binding in human glycine receptors.

P. Biggin, L. Sivilotti, R. Lape, 2014, Biochemistry.

Rational Design of α-Conotoxin RegIIA Analogues Specifically Inhibiting the Human α3β2 Nicotinic Acetylcholine Receptor through Computational Scanning.

David John Adams, Han-Shen Tae, Tao Jiang, 2020, ACS chemical neuroscience.

Antagonistic Mechanism of α-Conotoxin BuIA toward the Human α3β2 Nicotinic Acetylcholine Receptor.

Huijie Liu, Ning-ning Wei, Yan-yan Chu, 2021, ACS chemical neuroscience.

Key Structural Determinants in the Agonist Binding Loops of Human β2 and β4 Nicotinic Acetylcholine Receptor Subunits Contribute to α3β4 Subtype Selectivity of α-Conotoxins*

David John Adams, Han-Shen Tae, Ri-lei Yu, 2016, The Journal of Biological Chemistry.

Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of NaV1.4

Yan-yan Chu, Xiaoxiao Xu, Tao Jiang, 2019, RSC advances.

Identification of inhibitors targeting HIF-2α/c-Myc by molecular docking and MM-GBSA technology

Ri-lei Yu, Yang Zhao, C. Kang, 2020, Journal of receptor and signal transduction research.

Dual-inhibitors of STAT5 and STAT3: studies from molecular docking and molecular dynamics simulations

Rilei Yu, Yanqing Yu, Ri-lei Yu, 2014, Journal of Molecular Modeling.

Influences of disulfide connectivity on structure and antimicrobial activity of tachyplesin I

Kwok‐yin Wong, Tao Jiang, Ri-lei Yu, 2018, Journal of peptide science : an official publication of the European Peptide Society.

Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors

Tao Jiang, Jieyu Liu, Chenyang Zhao, 2022, International journal of molecular sciences.

Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets.

R. Liu, Zhimin Lu, Qianming Chen, 2021, Molecular cell.

Differentiation of the Agonists and Antagonists of the α7 Nicotinic Acetylcholine Receptor

Tao Jiang, Ri-lei Yu, Guanzhao Wu, 2019, Journal of Ocean University of China.

Research on named entity recognition method of marine natural products based on attention mechanism

Zhiqiang Wei, Hao Liu, Ri-lei Yu, 2023, Frontiers in Chemistry.

Novel Natural Angiotensin Converting Enzyme (ACE)-Inhibitory Peptides Derived from Sea Cucumber-Modified Hydrolysates by Adding Exogenous Proline and a Study of Their Structure–Activity Relationship

Haohao Wu, Yuanhui Zhao, S. Dong, 2018, Marine drugs.

Blockade of Neuronal α7-nAChR by α-Conotoxin ImI Explained by Computational Scanning and Energy Calculations

David J. Craik, Quentin Kaas, Rilei Yu, 2011, PLoS Comput. Biol..

PGK1-coupled HSP90 stabilizes GSK3β expression to regulate the stemness of breast cancer stem cells

Zhimin Lu, Xin Qi, Jing Li, 2021, Cancer biology & medicine.

Design, synthesis and mechanism of action of novel μ-conotoxin KIIIA analogs for inhibition of the voltage-gated sodium channel Nav1.7.

D. Craik, P. Harvey, Linhong Huang, 2023, The Journal of biological chemistry.

Nanotechnology-mediated immunochemotherapy with Ingenol-3-Mebutate for Systematic Anti-tumor Effects

Miaoqing Zhao, Cheng Wang, Ri-lei Yu, 2019, Journal of controlled release : official journal of the Controlled Release Society.

Peptide Stapling through Site-Directed Conjugation of Triazine Moieties to the Tyrosine Residues of a Peptide.

Tao Jiang, Xuechen Li, Yue Zhang, 2023, Organic Letters.

Synthesis and biological activity study of the retro-isomer of RhTx against TRPV1

P. Harvey, Huijie Liu, Ning-ning Wei, 2020, RSC advances.

Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

P. Biggin, T. Lynagh, S. Pless, 2016, ACS chemical neuroscience.

Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1

David J. Craik, Quentin Kaas, Xinying Jia, 2016 .

Computational determination of the binding mode of α-conotoxin to nicotinic acetylcholine receptor

Nargis Tabassum, Tao Jiang, Ri-lei Yu, 2016, Journal of Ocean University of China.

Designing antimicrobial peptides using deep learning and molecular dynamic simulations

D. Craik, P. Harvey, M. Mobli, 2023, Briefings Bioinform..

Triazine-pyridine chemistry for protein labelling on tyrosine.

Xuechen Li, Zheng Zhong, Pilar Blasco, 2022, Chemical Communications.

Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway.

D. Craik, P. Harvey, Q. Kaas, 2020, Journal of medicinal chemistry.

Using Imidazo[2,1-b][1,3,4]thiadiazol Skeleton to Design and Synthesize Novel MNK Inhibitors.

Jianling Xie, Tao Jiang, Ri-lei Yu, 2022, ACS medicinal chemistry letters.

Exploring the Relationship between Nicotinic Acetylcholine Receptor Ligand Size, Efficiency, Efficacy, and C-Loop Opening

Han-Shen Tae, Tao Jiang, Ri-lei Yu, 2017, J. Chem. Inf. Model..

Partial activation of α7 nicotinic acetylcholine receptors: insights from molecular dynamics simulations

Ri-lei Yu, Yanni Li, Sheng-Ci Shao, 2013, Journal of Molecular Modeling.

Study on the interactions of pyrimidine derivatives with FAK by 3D-QSAR, molecular docking and molecular dynamics simulation

Yan-yan Chu, Ri-lei Yu, C. Kang, 2020 .

Molecular Dynamic Simulations Reveal the Activation Mechanisms of Oxidation-Induced TRPV1

Yan-yan Chu, Ri-lei Yu, Huanhuan Zhang, 2023, International journal of molecular sciences.

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor

Han-Shen Tae, Ri-lei Yu, L. Xue, 2021, Marine Life Science & Technology.

Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.

Xiangqian Li, B. Jiang, Dayong Shi, 2017, European journal of medicinal chemistry.

Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

Tao Jiang, Yuchao Gu, Wengong Yu, 2023, Cell death & disease.

ConoMode, a database for conopeptide binding modes

Yangyang Li, Chunxiao Gao, Hao Liu, 2020, Database J. Biol. Databases Curation.

Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations

Tao Jiang, Ri-lei Yu, Fangling Chen, 2018, Marine drugs.

Investigation of α-conotoxin unbinding using umbrella sampling.

Nargis Tabassum, Tao Jiang, Ri-lei Yu, 2016, Bioorganic & medicinal chemistry letters.

Mechanism of interactions between α-conotoxin RegIIA and carbohydrates at the human α3β4 nicotinic acetylcholine receptor

Tao Jiang, Han-Shen Tae, Ri-lei Yu, 2022 .

Design and screening of FAK, CDK 4/6 dual inhibitors by pharmacophore model, molecular docking, and molecular dynamics simulation

Ri-lei Yu, C. Kang, Lijun Feng, 2020, Journal of biomolecular structure & dynamics.

Dual Antagonism of α9α10 nAChR and GABAB Receptor-Coupled CaV2.2 Channels by an Analgesic αO-Conotoxin Analogue.

Arsalan Yousuf, Han-Shen Tae, Ri-lei Yu, 2024, Journal of medicinal chemistry.

Cytotoxic and glycosaminoglycan priming activities of novel 4-anilinequinazoline β-D-xylosides.

Jinpeng Wang, Meng Zhang, Lijuan Zhang, 2018, Carbohydrate research.

Discovery of D25, a Potent and Selective MNK Inhibitor for Sepsis-Associated Acute Spleen Injury.

Ri-lei Yu, Xin Jin, Ming-Zhi Su, 2024, Journal of medicinal chemistry.

CD13-specific Ligand Facilitates Xanthatin Nanomedicine Targeting Dendritic Cells for Therapy of Refractory Allergic Rhinitis.

Xuelian Xu, Miaoqing Zhao, Chao Sun, 2020, International journal of pharmaceutics.

Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor.

D. Craik, David John Adams, Q. Kaas, 2013, Journal of medicinal chemistry.

Rational Design of Potent α-Conotoxin PeIA Analogues with Non-Natural Amino Acids for the Inhibition of Human α9α10 Nicotinic Acetylcholine Receptors

Han-Shen Tae, Ri-lei Yu, Jiazhen Liang, 2024, Marine drugs.