R. Edupuganti

发表

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis

Pengyu Y. Ren, K. Dalby, Qiantaoa Wang, 2015, Front. Mol. Biosci..

Computational insights into the binding of IN17 inhibitors to MELK

Brandon D. Walker, Pengyu Y. Ren, Matthew Harger, 2019, Journal of Molecular Modeling.

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.

Pengyu Y. Ren, K. Dalby, C. Bartholomeusz, 2017, Bioorganic & medicinal chemistry.

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.

T. Kaoud, K. Dalby, C. Bartholomeusz, 2017, ACS medicinal chemistry letters.

Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines.

Michael J. Zdilla, R. Raines, M. Shoulders, 2011, The Journal of organic chemistry.

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

Pengyu Y. Ren, K. Dalby, E. Anslyn, 2014, Bioorganic & medicinal chemistry.

Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis.

F. A. Davis, R. Edupuganti, 2012, Organic & biomolecular chemistry.

Mechanistic studies on covalent assemblies of metal-mediated hemi-aminal ethers

K. Dalby, H. Jo, E. Anslyn, 2014, Chemical science.

Asymmetric total synthesis of (S)-(+)-cocaine and the first synthesis of cocaine C-1 analogs from N-sulfinyl β-amino ester ketals.

F. A. Davis, R. Edupuganti, Naresh Theddu, 2010, Organic letters.

Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(ii) complexes.

A. Ellington, V. Lynch, E. Anslyn, 2016, Dalton transactions.

Conformational preferences of substrates for human prolyl 4-hydroxylase.

R. Raines, R. Edupuganti, Kelly L. Gorres, 2008, Biochemistry.

Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.

R. Krug, E. Anslyn, J. Robertus, 2014, European journal of medicinal chemistry.

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib

T. Kaoud, K. Dalby, N. Ebelt, 2017, Oncotarget.

High-Throughput Screens for eEF-2 Kinase

K. Dalby, B. Ozpolat, W. Johnson, 2014, Journal of biomolecular screening.

Reversible Covalent Inhibition of eEF‐2K by Carbonitriles

Pengyu Y. Ren, T. Kaoud, Chunli Yan, 2014, Chembiochem : a European journal of chemical biology.

Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo

Pengyu Y. Ren, K. Tsai, Matthew Harger, 2019, Nature Communications.

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

Y. Qi, N. Gray, Tinghu Zhang, 2017, Oncogene.

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

Pengyu Y. Ren, K. Tsai, T. Kaoud, 2015, ACS medicinal chemistry letters.

Definition of a Novel Feed-Forward Mechanism for Glycolysis-HIF1α Signaling in Hypoxic Tumors Highlights Aldolase A as a Therapeutic Target.

R. Liddington, G. Powis, K. Dalby, 2016, Cancer research.

Computational and Experimental Studies of Inhibitor Design for Aldolase A.

Pengyu Ren, Zhifeng Jing, Kevin N Dalby, 2019, The journal of physical chemistry. B.

Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics.

R. Raines, M. Shoulders, P. Carroll, 2012, The Journal of organic chemistry.

Asymmetric synthesis of substituted homotropinones from N-sulfinyl beta-amino ketone ketals. (-)-Euphococcinine and (-)-adaline.

F. A. Davis, R. Edupuganti, 2010, Organic letters.

Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer

Diane D. Liu, G. Hortobagyi, Jian Wang, 2023, Cancer research communications.