Ming-cheng Yu

发表

Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities.

Wei Li, Xicheng Yang, Jian Shen, 2018, European journal of medicinal chemistry.

RORγt agonist enhances anti-PD-1 therapy by promoting monocyte-derived dendritic cells through CXCL10 in cancers

K. Yu, Zhongen Wu, Ming-cheng Yu, 2022, Journal of experimental & clinical cancer research : CR.

Generation of Aryl Radicals from Aryl Halides: Rongalite-Promoted Transition-Metal-Free Arylation.

Yonghui Wang, Xianfeng Gu, R. Mao, 2019, The Journal of organic chemistry.

Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists.

Yonghui Wang, Hui-min Guo, Ming-cheng Yu, 2020, European journal of medicinal chemistry.

Ontogeny of RORγt+ cells in the intestine of newborns and its role in the development of experimental necrotizing enterocolitis

Yonghui Wang, R. Yi, Weijue Xu, 2022, Cell & bioscience.

Discovery of carbazole carboxamides as novel RORγt inverse agonists.

Wei-Chang Fu, Yonghui Wang, Ming-cheng Yu, 2018, European journal of medicinal chemistry.

Discovery, synthesis, biological evaluation and structure-based optimization of novel piperidine derivatives as acetylcholine-binding protein ligands

Wei Li, Hui Sun, Xicheng Yang, 2016, Acta Pharmacologica Sinica.

Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators: insights into different protein behaviors with “short” and “long” inverse agonists

Xiao-min Luo, C. Luo, Shijie Chen, 2020, Acta Pharmacologica Sinica.

Discovery of tetrahydroquinolines and benzomorpholines as novel potent RORγt agonists.

Yonghui Wang, Hui-min Guo, Ming-cheng Yu, 2020, European journal of medicinal chemistry.

Discovery of aryl-substituted indole and indoline derivatives as RORγt agonists.

Yonghui Wang, Hui-min Guo, Yan Zhu, 2019, European journal of medicinal chemistry.

Discovery of N-indanyl benzamides as potent RORγt inverse agonists.

Yonghui Wang, Xianfeng Gu, Ming-cheng Yu, 2019, European journal of medicinal chemistry.

Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists.

Yonghui Wang, Shijie Chen, Ming-cheng Yu, 2023, European journal of medicinal chemistry.

RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.

Di Zhu, Ming-cheng Yu, Qiong Xie, 2021, Pharmacological research.

Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy.

Yonghui Wang, Ming-cheng Yu, Yunpeng Zhao, 2023, Journal of medicinal chemistry.