D. France

发表

Structural basis for negative regulation of hypoxia-inducible factor-1α by CITED2

Gerhard Wagner, Andrew L Kung, G. Wagner, 2003, Nature Structural Biology.

Biological evaluation of 1-alkyl-3-phenylthioureas as orally active HDL-elevating agents.

J. Paterniti, G. Coppola, D. France, 2006, Bioorganic & medicinal chemistry letters.

1-Hydroxyalkyl-3-phenylthioureas as novel HDL-elevating agents.

J. Paterniti, G. Coppola, D. France, 2005, Bioorganic & medicinal chemistry letters.

Thiourea-based gemfibrozil analogues as HDL-elevating agents.

J. Paterniti, G. Coppola, D. France, 2002, Bioorganic & medicinal chemistry letters.

A Novel Platform for Accelerated Pharmacodynamic Profiling for Lead Optimization of Anticancer Drug Candidates

D. France, Jeff Szwaya, C. Bruseo, 2007, Journal of biomolecular screening.

Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase.

K. Bair, I. Piña, S. Remiszewski, 2003, The Journal of organic chemistry.

Oncology Drug Discovery Applications Using the FMAT™ 8100 HTS System

Jennifer Y. Lee, E. Swartzman, D. France, 2003, Journal of biomolecular screening.

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula.

W. Gerwick, M. Jung, Jörg Schemies, 2009, Journal of Organic Chemistry.

A new structural class of selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.

P. Furet, P. Imbach, M. Lang, 2001, Bioorganic & medicinal chemistry letters.

N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

P. Atadja, P. Lassota, K. Bair, 2003, Journal of medicinal chemistry.

Molecular Approaches to Discover Marine Natural Product Anticancer Leads – An Update from a Drug Discovery Group Collaboration

W. Gerwick, K. Bair, P. Crews, 2003 .

Using a kinase screen to investigate the constituents of the sponge Stelletta clavosa obtained from diverse habitats.

P. Crews, C. Wegerski, D. France, 2004, Bioorganic & medicinal chemistry.

Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors.

K. Nguyen, M. Ashwell, R. Nicewonger, 2012, Journal of medicinal chemistry.

Peyssonenynes a and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga peyssonneliacaulifera.

W. Gerwick, K. McPhail, D. France, 2004, Journal of natural products.

DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii.

W. Gerwick, D. France, S. Cornell-Kennon, 2006, Journal of natural products.

A Novel Mode of Protein Kinase Inhibition Exploiting Hydrophobic Motifs of Autoinhibited Kinases

M. Ashwell, Sudharshan Eathiraj, Erika Volckova, 2011, The Journal of Biological Chemistry.

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex.

Frank Petersen, Phillip Crews, R. Shivdasani, 2004, Cancer cell.

Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway.

D. Livingston, H. Naegeli, A. Kung, 2004, Cancer cell.

Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown

Massimo Broggini, M. Broggini, G. Abbadessa, 2011, Molecular Cancer Therapeutics.

ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity

S. Jeay, C. Li, D. Leggett, 2010, Molecular Cancer Therapeutics.

Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

M. Ashwell, Dennis S France, Sudharshan Eathiraj, 2011, The Journal of Biological Chemistry.

Structural and conformational requirements for high-affinity binding to the SH2 domain of Grb2(1).

P. Ettmayer, M. S. Martin, K. Bair, 1999, Journal of medicinal chemistry.

Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp.

W. Gerwick, K. Bair, H. Yoo, 2002, Journal of natural products.

Jumping into the 20th century before it is too late: is laboratory robotics still in its infancy?

David B. Weinstein, Dennis S. France, D. B. Weinstein, 1992, The Journal of automatic chemistry.

Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2.

A. Kung, M. Eck, Zhen-Yu J. Sun, 2003, Nature structural biology.

ARQ 197, a Novel and Selective Inhibitor of the Human c-Met Receptor Tyrosine Kinase with Antitumor Activity

S. Jeay, C. Li, D. Leggett, 2010, Molecular Cancer Therapeutics.

Discovery of a Novel Mode of Protein Kinase Inhibition Characterized by the Mechanism of Inhibition of Human Mesenchymal-epithelial Transition Factor (c-Met) Protein Autophosphorylation by ARQ 197

M. Ashwell, D. France, T. Chan, 2011, The Journal of Biological Chemistry.