Koichi Kobayashi

N. Ikeda, I. Yoshino, J. Nakajima, 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma

H. Horinouchi, M. Sakamoto, Y. Izumi, 2008, Modern Pathology.

Long-Term Survival After Incomplete Resection of Immunohistochemically Diagnosed T0N1 Lung Cancer: Report of a Case

Y. Izumi, M. Mukai, Koichi Kobayashi, 2005, Surgery Today.

Intratumoral gene expression of 5-fluorouracil pharmacokinetics-related enzymes in stage I and II non-small cell lung cancer patients treated with uracil-tegafur after surgery: a prospective multi-institutional study in Japan.

R. Kato, H. Horio, T. Abiko, 2015, Lung cancer.

Influence of O(2)-carrying plasma hemoprotein "albumin-heme" on complement system and platelet activation in vitro and physiological responses to exchange transfusion.

H. Horinouchi, Yubin Huang, E. Tsuchida, 2007, Journal of biomedical materials research. Part A.

Acute 40 percent exchange‐transfusion with hemoglobin‐vesicles (HbV) suspended in recombinant human serum albumin solution: degradation of HbV and erythropoiesis in a rat spleen for 2 weeks

H. Horinouchi, S. Takeoka, E. Tsuchida, 2006, Transfusion.

Physiological Capacity of the Reticuloendothelial System for the Degradation of Hemoglobin Vesicles (Artificial Oxygen Carriers) after Massive Intravenous Doses by Daily Repeated Infusions for 14 Days

H. Horinouchi, M. Suematsu, S. Takeoka, 2004, Journal of Pharmacology and Experimental Therapeutics.

Change of Nitric Oxide Concentration in Exhaled Gas After Lung Resection

H. Horinouchi, Y. Izumi, M. Kohno, 1998 .

Removal of cellular-type hemoglobin-based oxygen carrier (hemoglobin-vesicles) from blood using centrifugation and ultrafiltration.

H. Horinouchi, E. Tsuchida, K. Sou, 2012, Artificial organs.

HEMOGLOBIN VESICLES AND RED BLOOD CELLS AS CARRIERS OF CARBON MONOXIDE PRIOR TO OXYGEN FOR RESUSCITATION AFTER HEMORRHAGIC SHOCK IN A RAT MODEL

H. Horinouchi, E. Tsuchida, Koichi Kobayashi, 2009, Shock.

Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.

Y. Okada, I. Maruyama, A. Ishizaka, 2004, American journal of respiratory and critical care medicine.

Systemic administration of hemoglobin vesicle elevates tumor tissue oxygen tension and modifies tumor response to irradiation.

Y. Teramura, H. Horinouchi, S. Takeoka, 2009, The Journal of surgical research.

Enhanced radiation response of a solid tumor with the artificial oxygen carrier ‘albumin‐heme’

H. Horinouchi, Yubin Huang, E. Tsuchida, 2008, Cancer science.

High-performance diamond soft-X-ray detectors with internal amplification function

O. Maida, Toshimichi Ito, H. Matsubara, 2007 .

Effect of the Cellular-Type Artificial Oxygen Carrier Hemoglobin Vesicle as a Resuscitative Fluid for Prehospital Treatment: Experiments in a Rat Uncontrolled Hemorrhagic Shock Model

H. Horinouchi, Koichi Kobayashi, H. Sakai, 2012, Shock.

Role of Rho-kinase in reexpansion pulmonary edema in rabbits.

A. Ishizaka, S. Tasaka, M. Kohno, 2005, American journal of physiology. Lung cellular and molecular physiology.

Hemoglobin-Vesicles (HbV) as Artificial Oxygen Carriers

S. Takeoka, E. Tsuchida, K. Sou, 2005 .

One-Year Observation of Wistar Rats after Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers)

H. Horinouchi, E. Tsuchida, Koichi Kobayashi, 2007, Artificial cells, blood substitutes, and immobilization biotechnology.

Oxygen infusions (hemoglobin‐vesicles and albumin‐hemes) based on nano‐molecular sciences

Y. Teramura, S. Takeoka, Yubin Huang, 2005 .

Pretreatment of Serum Containing Hemoglobin Vesicles (Oxygen Carriers) to Prevent Their Interference in Laboratory Tests

H. Horinouchi, S. Takeoka, E. Tsuchida, 2003, Clinical chemistry and laboratory medicine.

NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers.

J. Frangos, S. Takeoka, E. Tsuchida, 2008, Biochimica et biophysica acta.

Involvement of E-cadherin cleavage in reperfusion injury.

A. Ishizaka, S. Fujishima, S. Tasaka, 2009, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Circumstances of surgical stapler use during pulmonary resection

H. Horinouchi, Y. Izumi, Masazumi Watanabe, 2004 .

Primary osteogenic sarcoma of the mediastinum

K. Kikuchi, M. Kasahara, T. Ishihara, 1974, Thorax.

FLUID RESUSCITATION WITH ARTIFICIAL OXYGEN CARRIERS IN HEMORRHAGED RATS: PROFILES OF HEMOGLOBIN-VESICLE DEGRADATION AND HEMATOPOIESIS FOR 14 DAYS

S. Takeoka, E. Tsuchida, Koichi Kobayashi, 2009, Shock.

A new technique of bronchial microsampling and proteomic analysis of epithelial lining fluid in a rat model of acute lung injury.

Hidetoshi Nakamura, M. Kohno, I. Kamiyama, 2014, Molecular immunology.

PEGylated albumin-heme as an oxygen-carrying plasma expander: Exchange transfusion into acute anemia rat model.

H. Horinouchi, Yubin Huang, E. Tsuchida, 2006, Biomaterials.

Use of Hemoglobin Vesicles During Cardiopulmonary Bypass Priming Prevents Neurocognitive Decline in Rats

R. Yozu, Koichi Kobayashi, R. Aeba, 2006, Circulation.

The sealing effect of fibrin glue against alveolar air leakage evaluated up to 48 h; comparison between different methods of application.

H. Horinouchi, Y. Izumi, M. Mukai, 2005, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Frequency of transmission of human parvovirus B19 infection by fibrin sealant used during thoracic surgery.

H. Horinouchi, Masazumi Watanabe, M. Sawafuji, 2002, The Annals of thoracic surgery.

Hemostatic efficacy of a recombinant thrombin-coated polyglycolic acid sheet coupled with liquid fibrinogen, evaluated in a canine model of pulmonary arterial hemorrhage.

Y. Izumi, Masatoshi Gika, Koichi Kobayashi, 2007, The Journal of trauma.

Restenosis of superior vena cava after treatment using a self-expanding metallic stent in a patient with idiopathic fibrosing mediastinitis.

I. Hasegawa, S. Nakatsuka, Koichi Kobayashi, 2003, Interactive cardiovascular and thoracic surgery.

Artificial oxygen carriers, hemoglobin vesicles and albumin-hemes, based on bioconjugate chemistry.

E. Tsuchida, K. Sou, A. Nakagawa, 2009, Bioconjugate chemistry.

Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.

H. Horinouchi, E. Tsuchida, M. Otagiri, 2010, Toxicology and applied pharmacology.

Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier

H. Horinouchi, E. Tsuchida, M. Otagiri, 2009, Drug Metabolism and Disposition.

Carbon monoxide-bound hemoglobin-vesicles for the treatment of bleomycin-induced pulmonary fibrosis.

H. Horinouchi, M. Otagiri, T. Maruyama, 2014, Biomaterials.

Primary and secondary immune responses to keyhole limpet hemocyanin in rats after infusion of hemoglobin vesicle, an artificial oxygen carrier.

H. Horinouchi, M. Fujihara, H. Azuma, 2014, Artificial organs.

Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs

H. Horinouchi, Koichi Kobayashi, H. Sakai, 2013 .

A Fourteen-Day Observation and Pharmacokinetic Evaluation after a Massive Intravenous Infusion of Hemoglobin-Vesicles (Artificial Oxygen Carriers) in Cynomolgus Monkeys

H. Horinouchi, M. Otagiri, T. Maruyama, 2012 .

Intravenous infusion of Hb-vesicles (artificial oxygen carriers) after repetitive blood exchange with a series of plasma expanders (water-soluble biopolymers) in a rat model†

H. Horinouchi, S. Takeoka, E. Tsuchida, 2011 .

Phagocytosis of Liposome Particles by Rat Splenic Immature Monocytes Makes Them Transiently and Highly Immunosuppressive In Ex Vivo Culture Conditions

H. Horinouchi, M. Fujihara, H. Azuma, 2011, Journal of Pharmacology and Experimental Therapeutics.

Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model

H. Horinouchi, M. Otagiri, T. Maruyama, 2011, Journal of Pharmacology and Experimental Therapeutics.

Repeated Injection of High Doses of Hemoglobin-Encapsulated Liposomes (Hemoglobin Vesicles) Induces Accelerated Blood Clearance in a Hemorrhagic Shock Rat Model

H. Horinouchi, M. Otagiri, T. Maruyama, 2011, Drug Metabolism and Disposition.

Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyte activity.

H. Horinouchi, E. Tsuchida, M. Otagiri, 2011, Journal of pharmaceutical sciences.

Microsoft Word-42482512-file00.docx

Panayiotis D. Megaloikonomos, H. Horinouchi, M. Otagiri, 2010 .

Hemoglobin Vesicles, Polyethylene Glycol (PEG)ylated Liposomes Developed as a Red Blood Cell Substitute, Do Not Induce the Accelerated Blood Clearance Phenomenon in Mice

H. Horinouchi, E. Tsuchida, M. Otagiri, 2009, Drug Metabolism and Disposition.

Pharmacokinetics of single and repeated injection of hemoglobin-vesicles in hemorrhagic shock rat model.

H. Horinouchi, E. Tsuchida, M. Otagiri, 2009, Journal of controlled release : official journal of the Controlled Release Society.

Microsoft Word-82519030-file00

Panayiotis D. Megaloikonomos, H. Horinouchi, E. Tsuchida, 2009 .

Hemoglobin vesicles as a molecular assembly. Characteristics of preparation process and performances as artificial oxygen carriers

S. Takeoka, E. Tsuchida, K. Sou, 2006 .

Hemoglobin-Vesicles as a Transfusion Alternative

H. Horinouchi, E. Tsuchida, Koichi Kobayashi, 2006, Artificial cells, blood substitutes, and immobilization biotechnology.

Hemorrhagic Shock Resuscitation With an Artificial Oxygen Carrier, Hemoglobin Vesicle, Maintains Intestinal Perfusion and Suppresses the Increase in Plasma Tumor Necrosis Factor-&agr;

H. Horinouchi, S. Takeoka, Sungick Park, 2004, ASAIO journal.

Metabolism of hemoglobin-vesicles (artificial oxygen carriers) and their influence on organ functions in a rat model.

Hiromi Sakai, Eishun Tsuchida, Koichi Kobayashi, 2004, Biomaterials.

Hemoglobin-vesicles suspended in recombinant human serum albumin for resuscitation from hemorrhagic shock in anesthetized rats*

H. Horinouchi, S. Takeoka, E. Tsuchida, 2004, Critical care medicine.

Human serum albumin incorporating synthetic heme: red blood cell substitute without hypertension by nitric oxide scavenging.

M. Suematsu, E. Tsuchida, A. Nakagawa, 2003, Journal of biomedical materials research. Part A.

Hemoglobin Vesicles as a Cellular‐Type Hemoglobin‐Based Oxygen Carrier

H. Horinouchi, E. Tsuchida, Koichi Kobayashi, 2011 .

Cross-linked poly (gamma-glutamic acid) attenuates peritoneal adhesion in a rat model.

Koichi Kobayashi, Takeshi Adachi, Masafumi Kawamura, 2007, Surgery.

Hyperoxia-induced emphysematous changes in subacute phase of endotoxin-induced lung injury in rats.

T. Shiomi, Y. Okada, Akira Ohashi, 2004, American journal of physiology. Lung cellular and molecular physiology.

Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph-node metastasis and sensitivity to anti-cancer drugs

Yusuke Nakamura, Tatsuhiko Tsunoda, Hitoshi Zembutsu, 2003, Oncogene.

DNA Hypermethylation at the D 17 S 5 Locus in Non-Small Cell Lung Cancers : Its Association with Smoking History 1

S. Hirohashi, Y. Kanai, Koichi Kobayashi, 2006 .

The short-term efficacy of fibrin glue combined with absorptive sheet material in visceral pleural defect repair.

Y. Izumi, Masatoshi Gika, Koichi Kobayashi, 2006, Interactive cardiovascular and thoracic surgery.

Frequency of transmission of human parvovirus B19 and hepatitis virus type B and C infection by fibrin sealant used during thoracic surgery

H. Horinouchi, I. Kamiyama, Masazumi Watanabe, 2002 .

Staple-Line Reinforcement With a New Type of Polyglycolic Acid Felt

H. Horinouchi, Masazumi Watanabe, M. Sawafuji, 2001, Surgical laparoscopy, endoscopy & percutaneous techniques.

Phase II trial of gemcitabine and docetaxel in patients with completely resected stage IIA–IIIA non-small-cell lung cancer

Y. Izumi, T. Koike, Koichi Kobayashi, 2007, Cancer Chemotherapy and Pharmacology.

Fluid Resuscitation of Hemorrhagic Shock with Hemoglobin Vesicles in Beagle Dogs: Pilot Study

H. Horinouchi, Koichi Kobayashi, H. Sakai, 2012, Artificial cells, blood substitutes, and immobilization biotechnology.

Traumatic pulmonary pseudocyst with hemopneumothorax in a football player.

N. Igarashi, Masazumi Watanabe, Koichi Kobayashi, 2005, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

Experimental tracheal replacement using the esophagus and an expandable metallic stent

R. Kato, Y. Izumi, M. Sawafuji, 1995, Surgery Today.

Review of hemoglobin-vesicles as artificial oxygen carriers.

H. Horinouchi, E. Tsuchida, K. Sou, 2009, Artificial organs.

Hyperthermia-enhanced tumor accumulation and antitumor efficacy of a doxorubicin-conjugate with a novel macromolecular carrier system in mice with non-small cell lung cancer.

Y. Izumi, H. Kuga, T. Abiko, 2007, Oncology reports.

Evaluation of the Capabilities of a Hemoglobin Vesicle as an Artificial Oxygen Carrier in a Rat Exchange Transfusion Model

S. Takeoka, H. Nishide, Y. Izumi, 1997, ASAIO journal.

Clinical evaluation of chemosensitivity testing for patients with unresectable non-small cell lung cancer (NSCLC) using collagen gel droplet embedded culture drug sensitivity test (CD-DST)

Y. Izumi, T. Abiko, Y. Inoue, 2007, Cancer Chemotherapy and Pharmacology.

Video-assisted thoracoscopic lobectomy for a inflammatory pseudotumor of the lung ; a case report

H. Horinouchi, M. Mukai, T. Abiko, 1999 .

Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

M. Kawakubo, H. Horinouchi, Y. Izumi, 2008, Cancer Chemotherapy and Pharmacology.

Syndrome of inappropriate secretion of antidiuretic hormone after chemotherapy with vinorelbine

M. Kawakubo, H. Horinouchi, Y. Izumi, 2007, Cancer Chemotherapy and Pharmacology.

[Stenting of central airways].

M. Sawafuji, Koichi Kobayashi, 2003, Nihon Geka Gakkai zasshi.

Successful Angioplasty of the Left Pulmonary Artery Using the Vascular Clip System

Masazumi Watanabe, Koichi Kobayashi, M. Kawamura, 2000, Surgery Today.

EXPRESSION AND ACTIVITY OF MATRIX METALLO PROTEINASES 2 AND 9 AND THEIR INHIBITORS IN RAT LUNGS DURING THE PERINATAL PERIOD AND IN DIAPHRAGMATIC HERNIA

J. Greer, V. Baracos, W. Dixon, 2003, Experimental lung research.

A 25-YEAR FOLLOW-UP STUDY OF MEN 2 B TYPE

J. Utsunomiya, O. Ozaki, H. Takami, 1999 .

The Prognosis of Patients with Non-Small Cell Lung Cancer Found to Have Carcinomatous Pleuritis at Thoracotomy

R. Tsuchiya, Y. Ichinose, K. Yokoi, 2000, Surgery Today.

A case of sclerosing hemangioma of the lung presenting as a gigantic tumor occupying the left thoracic cavity

Y. Okada, M. Sakamoto, M. Mukai, 2003, Virchows Archiv.

Contributions of bronchoscopic microsampling in the supplemental diagnosis of small peripheral lung carcinoma.

Akira Ohashi, A. Ishizaka, E. Ikeda, 2003, The Annals of thoracic surgery.

Hemoglobin-vesicle, a cellular artificial oxygen carrier that fulfils the physiological roles of the red blood cell structure.

H. Horinouchi, E. Tsuchida, K. Sou, 2010, Advances in experimental medicine and biology.

Chapter 46 – Albumin-Heme: A Synthetic Heme-Based Oxygen Carrier

H. Horinouchi, Yubin Huang, E. Tsuchida, 2006 .

Exchange transfusion with synthetic oxygen-carrying plasma protein "albumin-heme" into an acute anemia rat model after seventy-percent hemodilution.

H. Horinouchi, Yubin Huang, E. Tsuchida, 2004, Journal of biomedical materials research. Part A.

Safety Evaluation of an Artificial O2 Carrier as a Red Blood Cell Substitute by Blood Biochemical Tests and Histopathology Observations

H. Horinouchi, Yubin Huang, E. Tsuchida, 2004, ASAIO journal.

Exchange transfusion with entirely synthetic red-cell substitute albumin-heme into rats: physiological responses and blood biochemical tests.

H. Horinouchi, Yubin Huang, E. Tsuchida, 2004, Journal of biomedical materials research. Part A.

Oxygenation of hypoxic region in solid tumor by administration of human serum albumin incorporating synthetic hemes.

H. Horinouchi, E. Tsuchida, Masazumi Watanabe, 2003, Journal of biomedical materials research. Part A.

Histopathological changes of rat brain after direct injection of Hb-vesicles (artificial oxygen carriers) and neurological impact in an intracerebral hemorrhage model.

H. Horinouchi, E. Tsuchida, E. Ikeda, 2009, Journal of biomedical materials research. Part A.

Preliminary experience with minimally invasive video-assisted surgery for thymic diseases, including myasthenia gravis, through a horizontal ministernotomy.

R. Yozu, Masazumi Watanabe, Koichi Kobayashi, 2005, The Journal of thoracic and cardiovascular surgery.

An Alternative Method for Screening EGFR Mutation Using RFLP in Non-small Cell Lung Cancer Patients

A. Ishizaka, K. Soejima, K. Naoki, 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Primary osteogenic sarcomaofthemediastinum

M. Kasahara, Koichi Kobayashi, H. Inoue, 1974 .

The acute effects of transthoracic cryoablation on normal lung evaluated in a porcine model.

Y. Izumi, E. Ikeda, Koichi Kobayashi, 2005, Annals of Thoracic Surgery.

Thyroid carcinoma infiltrating the trachea: Clinical, histologic, and morphometric analyses

O. Ozaki, Kunihiko Ito, C. Torikata, 1990, Journal of surgical oncology.

Effect of hemoglobin vesicle, a cellular-type artificial oxygen carrier, on middle cerebral artery occlusion- and arachidonic acid-induced stroke models in rats

H. Horinouchi, T. Ohmura, K. Ohta, 2007, Neuroscience Letters.

Structure, photophysical property, and cytotoxicity of human serum albumin complexed with tris(dicarboxymethylene)[60]fullerene.

H. Horinouchi, Takaaki Sato, E. Tsuchida, 2008, Bioconjugate chemistry.

Large chondrosarcoma of the rib invading the mediastinum and the spine.

Y. Toyama, S. Kaneko, Masazumi Watanabe, 2006, The Journal of thoracic and cardiovascular surgery.

Surgical treatment for both pulmonary and hepatic metastases from colorectal cancer.

T. Ishihara, Koichi Kobayashi, M. Kawamura, 1999, The Journal of thoracic and cardiovascular surgery.

Exacerbation of bleomycin-induced injury and fibrosis by pneumonectomy in the residual lung of mice.

I. Maruyama, K. Fukunaga, T. Miyasho, 2009, The Journal of surgical research.

Bcl-2 overexpression enhances in vitro sensitivity against docetaxel in non-small cell lung cancer.

Masato Nakamura, H. Yamazaki, T. Abiko, 2005, Oncology reports.

A Case of sleeve resection of left main bronchus for bronchial mucoepidermoid carcinoma.

H. Horinouchi, M. Mukai, I. Kamiyama, 2003 .

Immediate effects of systemic administration of normal and high O2-affinity haemoglobin vesicles as a transfusion alternative in a rat pneumonectomy model

H. Horinouchi, M. Kohno, Masazumi Watanabe, 2020, BMJ open respiratory research.

Serum concentration of 7S collagen and prognosis in patients with the adult respiratory distress syndrome.

A. Ishizaka, F. Sakamaki, F. Yamasawa, 1994, Thorax.

Bronchopulmonary Arterial Anastomosis at the Precapillary Level in Human Lung

I. Hasegawa, Koichi Kobayashi, E. Kohda, 1999, Acta radiologica.

Fluid Resuscitation with Hemoglobin Vesicles Prevents Escherichia coli Growth via Complement Activation in a Hemorrhagic Shock Rat Model

H. Horinouchi, M. Otagiri, T. Maruyama, 2011, Journal of Pharmacology and Experimental Therapeutics.

Hepatically-metabolized and -excreted artificial oxygen carrier, hemoglobin vesicles, can be safely used under conditions of hepatic impairment.

H. Horinouchi, E. Tsuchida, M. Otagiri, 2010, Toxicology and applied pharmacology.

Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier

H. Horinouchi, E. Tsuchida, M. Otagiri, 2009, Drug Metabolism and Disposition.

Importance of tumor necrosis factor-alpha cleavage process in post-transplantation lung injury in rats.

Y. Okada, I. Maruyama, A. Ishizaka, 2004, American journal of respiratory and critical care medicine.

HEMOGLOBIN VESICLES AND RED BLOOD CELLS AS CARRIERS OF CARBON MONOXIDE PRIOR TO OXYGEN FOR RESUSCITATION AFTER HEMORRHAGIC SHOCK IN A RAT MODEL

H. Horinouchi, E. Tsuchida, Koichi Kobayashi, 2009, Shock.

Accessory diaphragm associated with congenital posterolateral diaphragmatic hernia, aberrant systemic artery to the right lower lobe, and anomalous pulmonary vein. Review and report of a case.

K. Kikuchi, T. Ishihara, Koichi Kobayashi, 1972, The Journal of thoracic and cardiovascular surgery.