T. Gharbaoui

发表

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists.

S. H. Kim, Michael E. Morgan, K. Whelan, 2014, Bioorganic & medicinal chemistry letters.

Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a.

D. Connolly, S. Tamura, Vu P Hong, 2007, Bioorganic & medicinal chemistry letters.

Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b.

D. Connolly, C. Sage, Jae-Kyu Jung, 2007, Journal of medicinal chemistry.

Agonist lead identification for the high affinity niacin receptor GPR109a.

Brian M. Smith, D. Connolly, S. Tamura, 2007, Bioorganic & medicinal chemistry letters.

3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): a partial agonist of the nicotinic acid receptor, G-protein coupled receptor 109a, with antilipolytic but no vasodilatory activity in mice.

D. Connolly, S. Tamura, C. Sage, 2008, Journal of medicinal chemistry.

Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.

John W. Adams, A. Blackburn, I. Gaidarov, 2017, Journal of medicinal chemistry.

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control.

C. Sage, B. Fioravanti, Albert S. Ren, 2011, Bioorganic & medicinal chemistry letters.

(7-Benzyloxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic Acids as S1P1 Functional Antagonists.

A. Blackburn, I. Gaidarov, S. H. Kim, 2014, ACS medicinal chemistry letters.

Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease.

D. Sengupta, Michael E. Morgan, K. Whelan, 2012, Bioorganic & medicinal chemistry letters.

Selective N1-alkylation of pyrimidine bases via radical (SRN1) mechanism

R. Benhida, T. Gharbaoui, R. Beugelmans, 1994 .

A Highly Selective and Efficient Access to N-9 Alkylated Purine Derivatives via Radical SRN1 Chemistry

R. Benhida, T. Gharbaoui, R. Beugelmans, 1994 .

An efficient synthesis of 9-[(1-hydroxymethyl)-cyclubut-1-ene-3-yl] adenine and 1-(adenin-9-yl)-3-methylidene-but-1-ene-4-ol via regiospecific addition of phenyl selenenyl bromide to the alkene precursor.

E. Bisagni, M. Legraverend, T. Gharbaoui, 1992 .

Asymmetric synthesis of (R)- and (S)-piperidin-2-yl-phosphonic acid by diastereoselective addition of trialkyl phosphite onto potential iminium salt

M. Chiadmi, J. Royer, T. Gharbaoui, 1997 .

Asymmetric Synthesis of α-Amino Phosphonic Acids by Diastereoselective Addition of Trimethyl Phosphite onto Chiral Oxazolidines.

J. Royer, T. Gharbaoui, H. Husson, 1996 .

Asymmetric Synthesis of α-Amino Phosphonic Acids by Diastereoselective Addition of Trimethyl Phosphite onto Chiral Oxazolidines1

J. Royer, T. Gharbaoui, H. Husson, 1996 .

Complementary asymmetric routes to (R)-2-(7-hydroxy-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate.

D. Sengupta, Robert M. Jones, D. Buzard, 2012, Organic letters.

Synthesis of new carbocyclic oxetanocin analogues

A. Aubertin, E. Bisagni, M. Legraverend, 1995 .

An Efficient Synthesis of 9-((1-Hydroxymethyl)cyclobut-1-ene-3-yl) adenine and 1-(Adenin-9-yl)-3-methylidenebut-1-ene-4-ol via Regiospecific Addition of Phenylselenenyl Bromide to the Alkene Precursor.

E. Bisagni, M. Legraverend, T. Gharbaoui, 1993 .

Asymmetric Synthesis of (R)- and (S)-Piperidin-2-yl-phosphonic Acid by Diastereoselective Addition of Trialkyl Phosphite onto Potential Iminium Salt.

M. Chiadmi, J. Royer, T. Gharbaoui, 1997 .

Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol

Cheng-yi Chen, T. Gharbaoui, Yuanpeng Chen, 2022, Organic Process Research & Development.

Anti-HIV Activities of Novel Nucleoside Analogues: Acyclic and Tricyclic Base Nucleosides

P. Roques, D. Dormont, Y. Merrouche, 1991 .

Bromoalkoxy Addition on N-Azolyl Olefins

R. Benhida, T. Gharbaoui, R. Beugelmans, 1995 .

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties.

M. Augustin, C. Allerston, Iriny Botrous, 2017, Journal of medicinal chemistry.

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor.

A. Blackburn, David Mills, I. Gaidarov, 2014, ACS medicinal chemistry letters.

SRN1 Synthesis of vic-dinitro compounds containing a nitrodioxane subunit

T. Gharbaoui, R. Beugelmans, A. Lechevallier, 1995 .

SRN1 Synthesis of vic-Dinitro Compounds Containing a Nitrodioxane Subunit.

T. Gharbaoui, R. Beugelmans, A. Lechevallier, 1995 .

An Efficient Scale-Up Process for the Preparation of the APD334 Precursor 4-Chloromethyl-1-cyclopentyl-2-(trifluoromethyl)benzene

Robert M. Jones, D. Sengupta, Robert M. Jones, 2015 .

Fused tricyclic indoles as S1P₁ agonists with robust efficacy in animal models of autoimmune disease.

D. Sengupta, Michael E. Morgan, K. Whelan, 2012, Bioorganic & medicinal chemistry letters.