Vincent Mascitti

发表

From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.

Michael D. Hamilton, S. Wright, A. Kalgutkar, 2013, Bioorganic & medicinal chemistry letters.

Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.

A. Kalgutkar, M. Munchhof, B. Lefker, 2011, Journal of medicinal chemistry.

C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization.

T. Maurer, M. Leininger, C. Steppan, 2010, Bioorganic & medicinal chemistry letters.

Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase (ACC) Inhibitors Through Liver Targeting.

David A. Price, A. Kalgutkar, S. Liras, 2020, Journal of medicinal chemistry.

From Natural Product to New Diabetes Therapy: Phlorizin and the Discovery of SGLT2 Inhibitor Clinical Candidates

R. Robinson, Vincent Mascitti, 2014 .

Metabolism and Excretion of the Anti-Diabetic Agent Ertugliflozin ( PF-04971729 ) in Healthy Male Subjects

G. Nucci, A. Kalgutkar, A. Vaz, 2012 .

Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.

A. Kalgutkar, T. Maurer, T. Zhu, 2011, Journal of medicinal chemistry.

C2-Selective Branched Alkylation of Benzimidazoles by Rhodium(I)-Catalyzed C-H Activation.

J. Ellman, Vincent Mascitti, Kevin D. Hesp, 2017, The Journal of organic chemistry.

Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C-H ortho-Alkylation of Azines without Preactivation.

J. Ellman, Vincent Mascitti, Kevin D. Hesp, 2017, Angewandte Chemie.

Pyridine sulfinates as general nucleophilic coupling partners in palladium-catalyzed cross-coupling reactions with aryl halides† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc00675f Click here for additional data file.

M. Willis, D. Blakemore, Vincent Mascitti, 2017, Chemical science.

Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants

S. Hanessian, R. Oehrlein, Vincent Mascitti, 2001 .

Preclinical Species and Human Disposition of PF-04971729, a Selective Inhibitor of the Sodium-Dependent Glucose Cotransporter 2 and Clinical Candidate for the Treatment of Type 2 Diabetes Mellitus

Bo Feng, Zhuang Miao, A. Kalgutkar, 2011, Drug Metabolism and Disposition.

One-Step Stereocontrolled Synthesis of α-Anomeric Carboxylic Acid Esters from Unprotected Glycosyl Donors: A Water-Soluble Aspirin Pro-Drug Analogue

S. Hanessian, H. Ishida, Vincent Mascitti, 2002 .

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers.

J. Hartwig, D. Blakemore, J. Kohrt, 2016, Angewandte Chemie.

Total synthesis of the cytotoxic cyclodepsipeptide (-)-doliculide: the "ester" effect in acyclic 1,3-induction of deoxypropionates.

S. Hanessian, Vincent Mascitti, Simon Giroux, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Catalyst Selection Facilitates the Use of Heterocyclic Sulfinates as General Nucleophilic Coupling Partners in Palladium-Catalyzed Coupling Reactions.

M. Willis, D. Blakemore, Vincent Mascitti, 2017, Organic letters.

One-Step Synthesis of Sulfonamides from N-Tosylhydrazones.

Vincent Mascitti, John M. Curto, A. Tsai, 2016, Organic letters.

Synthesis of sulfones from organozinc reagents, DABSO, and alkyl halides.

A. Shavnya, Christian Perreault, Vincent Mascitti, 2014, Organic letters.

Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.

Bryan M. Li, David A. Price, A. Kalgutkar, 2013, Journal of medicinal chemistry.

Palladium-Catalyzed Synthesis of (Hetero)Aryl Alkyl Sulfones from (Hetero)Aryl Boronic Acids, Unactivated Alkyl Halides, and Potassium Metabisulfite.

Aaron C. Smith, A. Shavnya, Vincent Mascitti, 2015, Angewandte Chemie.

Progress towards the decalin portion of (+)-compactin

N. Tsou, C. Dufresne, Vincent Mascitti, 2002 .

On the importance of synthetic organic chemistry in drug discovery: reflections on the discovery of antidiabetic agent ertugliflozin

A. Kalgutkar, T. Maurer, R. Robinson, 2013 .

Enantioselective synthesis of pentacycloanammoxic acid.

E. Corey, E J Corey, Vincent Mascitti, 2006, Journal of the American Chemical Society.

Application of fundamental organometallic chemistry to the development of a gold-catalyzed synthesis of sulfinate derivatives.

R. Bergman, F. Toste, N. Mankad, 2014, Angewandte Chemie.

Palladium-catalyzed sulfination of aryl and heteroaryl halides: direct access to sulfones and sulfonamides.

Aaron C. Smith, A. Shavnya, Vincent Mascitti, 2013, Organic letters.

Application of conformation design in acyclic stereoselection: total synthesis of borrelidin as the crystalline benzene solvate.

S. Hanessian, Vincent Mascitti, Yang Yang, 2003, Journal of the American Chemical Society.

Total synthesis of (+/-)-pentacycloanammoxic acid.

E. Corey, E J Corey, Vincent Mascitti, 2004, Journal of the American Chemical Society.

Synthesis of spirofuranopyrimidine–piperidines

Vincent Mascitti, K. McClure, Etzer Darout, 2012 .

The Iterative Synthesis of Acyclic Deoxypropionate Units and Their Implication in Polyketide-Derived Natural Products

S. Hanessian, Vincent Mascitti, Simon Giroux, 2006 .

The Iterative Synthesis of Acyclic Deoxypropionate Units and Their Implication in Polyketide‐Derived Natural Products

S. Hanessian, Vincent Mascitti, Simon Giroux, 2006 .

Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.

M. Ammirati, David A. Price, S. Liras, 2017, Journal of the American Chemical Society.

Metabolism-guided drug design

A. Stepan, A. Kalgutkar, K. Beaumont, 2013 .

Glycomimetic ligands for the human asialoglycoprotein receptor.

David A. Price, M. Finn, J. Pfefferkorn, 2012, Journal of the American Chemical Society.

Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

A. Mathiowetz, P. Loria, David A. Price, 2015, Journal of medicinal chemistry.

Pharmacodynamic Model of Sodium–Glucose Transporter 2 (SGLT2) Inhibition: Implications for Quantitative Translational Pharmacology

T. Maurer, A. Ghosh, M. Leininger, 2011, The AAPS Journal.

Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects

Zhuang Miao, Ernesto Callegari, Gianluca Nucci, 2013, Drug Metabolism and Disposition.

Stereoselective synthesis of a dioxa-bicyclo[3.2.1]octane SGLT2 inhibitor.

Vincent Mascitti, Cathy Préville, 2010, Organic letters.

Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

M. Leininger, C. Steppan, R. Robinson, 2010 .

Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.

Kaihong Zhou, Spiros Liras, Meihua Tu, 2018, Journal of the American Chemical Society.

Total Synthesis of (.+‐.)‐Pentacycloanammoxic Acid.

E. Corey, Vincent Mascitti, 2005 .

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.

A. Kalgutkar, K. Farley, M. Munchhof, 2011, Bioorganic & Medicinal Chemistry Letters.

Modulateurs de gpr 119

Vincent Mascitti, K. McClure, Etzer Darout, 2012 .

Synthesis of a potent antagonist of E-selectin.

S. Hanessian, O. Rogel, Vincent Mascitti, 2002, The Journal of organic chemistry.

Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.

A. Kalgutkar, M. Munchhof, R. Robinson, 2011, Chemical research in toxicology.

Fluorodecarboxylation for the Synthesis of Trifluoromethyl Aryl Ethers.

J. Hartwig, D. Blakemore, J. Kohrt, 2016, Angewandte Chemie.

M. Willis, D. Blakemore, Vincent Mascitti, 2017, Chemical science.

Pharmacokinetics, Metabolism, and Excretion of the Antidiabetic Agent Ertugliflozin (PF-04971729) in Healthy Male Subjects

G. Nucci, A. Kalgutkar, A. Vaz, 2013, Drug Metabolism and Disposition.

Glycomimetic ligands for the human asialoglycoprotein receptor.

M. Finn, J. Pfefferkorn, Hong Wang, 2012, Journal of the American Chemical Society.