P. Bonin

发表

From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.

Michael D. Hamilton, S. Wright, A. Kalgutkar, 2013, Bioorganic & medicinal chemistry letters.

Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.

A. Kalgutkar, M. Munchhof, B. Lefker, 2011, Journal of medicinal chemistry.

Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.

G. S. Walker, A. Stepan, A. Kalgutkar, 2011, Chemical research in toxicology.

Growth factor-induced modulation of endothelin-1 binding to human smooth-muscle cells.

P. Bonin, L. Erickson, R. Leadley, 1993, Journal of cardiovascular pharmacology.

Rapid modulation of a 64 K dalton fibroblast protein: a PDGF mediated early cellular event.

L. Adams, P. Bonin, J. P. Singh, 1989, Biochemical and biophysical research communications.

Mode of fibroblast growth enhancement by human interleukin-1

L. Adams, P. Bonin, J. P. Singh, 1988, The Journal of cell biology.

A peptide inhibitor of cholesteryl ester transfer protein identified by screening a bacteriophage display library.

C. Bannow, H. Fischer, P. Bonin, 2009, The journal of peptide research : official journal of the American Peptide Society.

Interleukin-1 promotes proliferation of vascular smooth muscle cells in coordination with PDGF or a monocyte derived growth factor.

P. Bonin, G. Fici, J. P. Singh, 1989, Experimental cell research.

Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS‐Based Detection Methods

L. Marroquin, T. Schroeter, Lisa D. Marroquin, 2017, Current protocols in toxicology.

Direct photocapture of bromodomains using tropolone chemical probes

R. Denny, M. Pletcher, E. Hett, 2015 .

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

A. Kalgutkar, T. Maurer, J. Warmus, 2015, Journal of medicinal chemistry.

PF-1355, a Mechanism-Based Myeloperoxidase Inhibitor, Prevents Immune Complex Vasculitis and Anti–Glomerular Basement Membrane Glomerulonephritis

A. Kalgutkar, T. Maurer, L. Buckbinder, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Modulation of interleukin-1 receptor expression and interleukin-1 response in fibroblasts by platelet-derived growth factor.

P. Bonin, J. P. Singh, J. Singh, 1988, The Journal of biological chemistry.

Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

A. D. Rodrigues, M. Aleo, K. He, 2017, Chemical research in toxicology.

Two signal transduction pathways mediate interleukin-1 receptor expression in Balb/c3T3 fibroblasts.

W. Chiou, P. Bonin, J. Mcgee, 1990, The Journal of biological chemistry.

Platelet-derived growth factor induces interleukin-1 receptor gene expression in Balb/c 3T3 fibroblasts.

W. Chiou, P. Harris, D. Carter, 1989, The Journal of biological chemistry.

Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities.

Kevin Lee, R. Denny, M. Pletcher, 2015, Chemistry & biology.

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Graham M. West, J. Culp, E. Carpenter, 2019, eLife.

Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)

Graham M. West, J. Culp, E. Carpenter, 2019, bioRxiv.

Resistance mapping and mode of action of a novel class of antibacterial anthranilic acids: evidence for disruption of cell wall biosynthesis.

K. Marotti, D. Romero, J. Mott, 2008, The Journal of antimicrobial chemotherapy.

Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.

Bryan M. Li, David A. Price, A. Kalgutkar, 2013, Journal of medicinal chemistry.

Resolution of the diadenosine 5',5"'-P1,P4-tetraphosphate binding subunit from a multiprotein form of HeLa cell DNA polymerase alpha.

P. Zamecnik, P. Bonin, E. Baril, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Exonuclease activity associated with a multiprotein form of HeLa cell DNA polymerase alpha. Purification and properties of the exonuclease.

W. Skarnes, P. Bonin, E. Baril, 1986, The Journal of biological chemistry.

Human drug‐induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump

M. Aleo, Yi Luo, Y. Will, 2014, Hepatology.

Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation

B. Monks, E. Latz, D. Hepworth, 2016, The Journal of Immunology.

Pulmonary Inflammation ( CRID 3 ) in Murine Models of Dermal and Inflammasome Inhibitor CP-456 , 773 Efficacy and Pharmacology of the NLRP 3

B. Monks, E. Latz, D. Hepworth, 2016 .

Expression, purification, and characterization of peptidyl-tRNA hydrolase from Staphylococcus aureus.

G. Choi, J. Mott, R. Sarver, 2002, Protein expression and purification.

In vitro and in vivo inhibition of rat vascular smooth muscle cell migration and proliferation by a 2-aminochromone U-86983.

D. Williams, D. Wishka, P. Bonin, 1994, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of fibroblast and smooth muscle cell proliferation and migration in vitro by a novel aminochromone U-67154.

P. Bonin, L. Erickson, R. Gammill, 1993, Journal of vascular research.

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.

W. Soeller, Edward L. Conn, Paul S. Humphries, 2009, Bioorganic & medicinal chemistry letters.

Structure-Based Design of Highly Selective Inhibitors of the CREB Binding Protein Bromodomain.

R. Denny, P. Brennan, M. Pletcher, 2017, Journal of medicinal chemistry.

Development of a fluorescence polarization assay for peptidyl-tRNA hydrolase.

P. Bonin, L. Erickson, 2002, Analytical biochemistry.

Inhibition of proliferation of fibroblasts by lazaroids (21-aminosteroids).

P. Bonin, J. Singh, 1991, Life sciences.

Obligatory action of polypeptide growth factors for the IL-1-mediated prostaglandin E2 production in fibroblasts. Potential role of growth factors in modulation of tissue response to IL-1.

W. Chiou, P. Bonin, J. Singh, 1990, Journal of immunology.

Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.

A. Kalgutkar, K. Farley, M. Munchhof, 2011, Bioorganic & Medicinal Chemistry Letters.

Design and chemoproteomic functional characterization of a chemical probe targeted to bromodomains of BET family proteins

S. Wright, K. Geoghegan, P. Sahasrabudhe, 2014 .