Brian P. Scott

发表

Preclinical Characterization of the FAAH Inhibitor JNJ-42165279.

Sandy J. Wilson, M. Karbarz, S. Chaplan, 2015, ACS medicinal chemistry letters.

The SAR of brain penetration for a series of heteroaryl urea FAAH inhibitors.

Sandy J. Wilson, M. Karbarz, S. Chaplan, 2016, Bioorganic & medicinal chemistry letters.

Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

T. Lovenberg, N. Carruthers, Hong Ao, 2016, Journal of medicinal chemistry.

Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human

A. Bittner, N. Lim, J. W. Higgins, 2022, Drug Metabolism and Disposition.

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.

Sandy J. Wilson, M. Karbarz, S. Chaplan, 2012, ACS medicinal chemistry letters.

Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Sandy J. Wilson, Jiejun Wu, M. Karbarz, 2009, Anesthesia and analgesia.

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.

Sandy J. Wilson, Jiejun Wu, K. Pattabiraman, 2008, Bioorganic & medicinal chemistry letters.

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).

Matthew T. Epperson, S. Chaplan, M. Seierstad, 2008, Bioorganic & medicinal chemistry letters.

Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.

Michael Albers, J. Edwards, J. Spurlino, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and Pharmacological Characterization of Two Novel, Brain Penetrating P2X7 Antagonists.

P. Bonaventure, N. Carruthers, Hong Ao, 2013, ACS medicinal chemistry letters.

1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.

Sandy J. Wilson, M. Karbarz, S. Chaplan, 2014, Bioorganic & medicinal chemistry letters.

Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.

Michael Albers, J. Edwards, M. Cummings, 2020, Bioorganic & medicinal chemistry letters.

Pharmacology and Antitussive Efficacy of 4-(3-Trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic Acid (5-Trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a Transient Receptor Potential Vanilloid 1 Antagonist in Guinea Pigs

A. Dubin, Hong Ao, A. Bhattacharya, 2007, Journal of Pharmacology and Experimental Therapeutics.

Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrimido-[4,5-d]azepines as novel TRPV1 antagonists.

Hong Ao, A. Bhattacharya, M. Hack, 2010, Bioorganic & medicinal chemistry letters.

Targeting the Ion Channel Kv1.3 with Scorpion Venom Peptides Engineered for Potency, Selectivity, and Half-life

W. Fung-Leung, K. Ngo, R. Swanson, 2014, The Journal of Biological Chemistry.

A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.

C. Dvorak, N. Carruthers, A. Bhattacharya, 2018, Journal of medicinal chemistry.

Identification and synthesis of 2,7-diamino-thiazolo[5,4-d]pyrimidine derivatives as TRPV1 antagonists.

M. Peterson, Hong Ao, A. Bhattacharya, 2009, Bioorganic & medicinal chemistry letters.

Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase.

M. Karbarz, S. Chaplan, J. Keith, 2014, Bioorganic & medicinal chemistry letters.

Heteroarylureas with Fused Bicyclic Diamine Cores as Inhibitors of Fatty Acid Amide Hydrolase.

M. Karbarz, S. Chaplan, J. Keith, 2020, Bioorganic & medicinal chemistry letters.

, Potency , Selectivity , and Half-life Scorpion Venom Peptides Engineered for Targeting the Ion Channel Kv 1 . 3 with Membrane Biology

Hong, Wickenden, K. Ngo, 2014 .

Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.

Hong Ao, A. Bhattacharya, A. Wickenden, 2011, European journal of pharmacology.

1,2-diamino-ethane-substituted-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepines as TRPV1 antagonists with improved properties.

Hong Ao, A. Bhattacharya, A. Wickenden, 2010, Bioorganic & medicinal chemistry letters.

Design, Synthesis and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.

T. Koudriakova, K. Coe, Xiaohui Jiang, 2020, Journal of medicinal chemistry.

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate.

M. Karbarz, S. Chaplan, J. Keith, 2012, ACS medicinal chemistry letters.

Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).

Matthew T. Epperson, S. Chaplan, M. Seierstad, 2008, Bioorganic & medicinal chemistry letters.