I. Hwang

发表

Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity.

D. Boger, B. Cravatt, D. Leung, 2005, Bioorganic & medicinal chemistry letters.

Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase

Benjamin F. Cravatt, Dale L. Boger, D. Boger, 2007 .

Acute Inhibition of Selected Membrane-Proximal Mouse T Cell Receptor Signaling by Mitochondrial Antagonists

I. Hwang, Kwangmi Kim, Lin Wang, 2009, PloS one.

Development of an oral immunoadjuvant from cheonggukjang that is efficacious for both mucosal and systemic immunity

I. Chung, Seong-Il Lim, D. Shon, 2014, Food Science and Biotechnology.

Synthesis and evaluation of a thio analogue of duocarmycin SA.

D. Boger, P. Baraldi, R. Romagnoli, 2009, Bioorganic & medicinal chemistry letters.

T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

M. Jackson, P. A. Peterson, J. Sprent, 2000, The Journal of experimental medicine.

Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.

D. Boger, I. Hwang, David B. Kastrinsky, 2010, Bioorganic & medicinal chemistry letters.

Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

D. Boger, M. Hedrick, F. Stauffer, 2003, Bioorganic & medicinal chemistry.

Enhancement of an In Vivo Anti-Inflammatory Activity of Oleanolic Acid through Glycosylation Occurring Naturally in Stauntonia hexaphylla

Le Ba Vinh, L. Ye, Y. H. Kim, 2020, Molecules.

Absorption and Internalization of Ligands Role of the Actin Cytoskeleton in T Cell

I. Hwang, Inkyu Hwang, 2001 .

Total synthesis of ningalin D.

D. Boger, I. Hwang, Akiyuki Hamasaki, 2005, Journal of the American Chemical Society.

Optimization of α -Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

D. Boger, F. A. Romero, C. Ezzili, 2009 .

Receptor-mediated T cell absorption of antigen presenting cell-derived molecules.

I. Hwang, Dalim Ki, Inkyu Hwang, 2011, Frontiers in bioscience.

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

D. Boger, I. Hwang, B. Crowley, 2003, Bioorganic & medicinal chemistry letters.

Anti-allergic effects of Rosae multiflorae fructus via inhibition of T cell proliferation and the mast cell function

Y. H. Kim, H. Shin, D. Shon, 2017, Applied Biological Chemistry.

Anti-allergic effects of the ethanol extract of Syzygium formosum (Wall.) Masam leaves and its immunoregulatory mechanisms.

Y. H. Kim, J. Kang, I. Hwang, 2018, Journal of ethnopharmacology.

Potentiation of T Cell Stimulatory Activity by Chemical Fixation of a Weak Peptide-MHC Complex

I. Hwang, Kwangmi Kim, M. Lomunova, 2017, Molecules and cells.

Anti-allergic effect of inotodiol, a lanostane triterpenoid from Chaga mushroom, via selective inhibition of mast cell function.

Y. H. Kim, I. Hwang, Thi Minh Nguyet Nguyen, 2020, International immunopharmacology.

Crucial role of miR-31 in induction of CD8+ T-cell exhaustion and reinforcement of type 1 interferon signaling

I. Hwang, Lin Ying Li, 2018, Cellular & Molecular Immunology.

Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits.

D. Boger, C. Gauss, Karen S Macmillan, 2009, Tetrahedron.

Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

J. Sprent, D. Tough, Siquan Sun, 1998, Immunity.

Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin.

D. Boger, Trinh-Don Nguyen, Karen S Macmillan, 2009, Journal of the American Chemical Society.

Structure−Activity Relationships of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

D. Boger, B. Cravatt, F. A. Romero, 2007 .

Total synthesis of piericidin A1 and B1 and key analogues.

D. Boger, T. Yagi, F. A. Romero, 2006, Journal of the American Chemical Society.

Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues.

Hayato Ishikawa, Dale L. Boger, D. Boger, 2009, Journal of the American Chemical Society.

Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors.

D. Boger, F. A. Romero, I. Hwang, 2006, Journal of the American Chemical Society.

Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition.

D. Boger, C. Gauss, S. Ichikawa, 2003, Journal of the American Chemical Society.

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives.

D. Boger, I. Hwang, Houchao Tao, 2004, Bioorganic & medicinal chemistry letters.

A unique class of duocarmycin and CC-1065 analogues subject to reductive activation.

D. Boger, W. Jin, S. Weir, 2007, Journal of the American Chemical Society.

Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer.

D. Boger, F. Shiga, Mark S Tichenor, 2006, Journal of the American Chemical Society.

Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase.

D. Boger, C. Ezzili, Dustin G Hochstatter, 2008, Journal of medicinal chemistry.

Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) alkylation subunit.

D. Boger, I. Hwang, David B. Kastrinsky, 2003, The Journal of organic chemistry.

Multidrug resistance reversal activity of permethyl ningalin B amide derivatives.

D. Boger, I. Hwang, Houchao Tao, 2004, Bioorganic & medicinal chemistry letters.

Multidrug resistance reversal activity of key ningalin analogues.

D. Boger, M. Hedrick, I. Hwang, 2003, Bioorganic & medicinal chemistry letters.

Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase.

D. Boger, I. Wilson, Lan Xu, 2006, Journal of medicinal chemistry.

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

D. Boger, W. L. Jorgensen, O. Acevedo, 2005, Journal of medicinal chemistry.

Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives.

D. Boger, T. V. Hughes, I. Hwang, 2004, Bioorganic & medicinal chemistry.

Establishing the parabolic relationship between reactivity and activity for derivatives and analogues of the duocarmycin and CC-1065 alkylation subunits.

D. Boger, T. V. Hughes, I. Hwang, 2004, Journal of the American Chemical Society.

Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity.

D. Boger, Karen S Macmillan, Mark S Tichenor, 2007, Journal of the American Chemical Society.

Asymmetric Total Synthesis of (+)- and ent-(-)-Yatakemycin (I) and Duocarmycin SA (II): Evaluation of Yatakemycin Key Partial Structures and Its Unnatural Enantiomer.

D. Boger, F. Shiga, Mark S Tichenor, 2007 .

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Sukwon Hong, Mark Searcey, Dale L Boger, 2009, Journal of the American Chemical Society.

Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins.

D. Boger, A. Zaid, P. Baraldi, 2007, Journal of the American Chemical Society.

Cytotoxic triterpene saponins from the mangrove Aegiceras corniculatum

Le Ba Vinh, Y. H. Kim, J. Kim, 2019, Natural product research.

Chemical Components from Aloe and their Inhibition of Indoleamine 2, 3-dioxygenase

Y. H. Kim, Wei Li, J. Kang, 2017, Pharmacognosy magazine.

Chemical constituents of Vietnamese mangrove Hibiscus tiliaceus with antioxidant and alpha-glucosidase inhibitory activity

Le Ba Vinh, Y. H. Kim, N. P. Thao, 2019, Natural product research.

A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

C. Van Minh, Nguyen Van Thanh, I. Hwang, 2018, Natural product research.

A Novel Flow Cytometric High Throughput Assay for a Systematic Study on Molecular Mechanisms Underlying T Cell Receptor-Mediated Integrin Activation

Kwangmi Kim, Lin Wang, Inkyu Hwang, 2009, PloS one.

Triterpenoids isolated from the rhizomes and roots of Gentiana scabra and their inhibition of indoleamine 2,3-dioxygenase

Wei Zhou, Wei Li, I. Hwang, 2015, Archives of Pharmacal Research.

Triterpenoids isolated from the rhizomes and roots of Gentiana scabra and their inhibition of indoleamine 2,3-dioxygenase

J. Ma, Wei Zhou, Wei Li, 2015, Archives of pharmacal research.

Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase.

D. Boger, Heather S Hoover, B. Cravatt, 2007, Journal of medicinal chemistry.

Structure-based Design, Synthesis, Evaluation, and Crystal Structures of Transition State Analogue Inhibitors of Inosine Monophosphate Cyclohydrolase*

D. Boger, I. Wilson, A. Olson, 2007, Journal of Biological Chemistry.

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF.

D. Boger, I. Wilson, S. Benkovic, 2005, Bioorganic & medicinal chemistry.

Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase.

D. Boger, I. Wilson, S. Connelly, 2008, Journal of medicinal chemistry.

The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol

J. Lee, J. Kang, I. Hwang, 2018, International immunopharmacology.

A Novel Bioanalytical Method for Determination of Inotodiol Isolated from Inonotus Obliquus and Its Application to Pharmacokinetic Study

H. M. Kim, J. Kang, I. Hwang, 2021, Plants.

Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects

I. Hwang, Nguyet Nguyen, Inkyu Hwang, 2015, Archives of Pharmacal Research.

Mechanisms of tumor-induced T cell immune suppression and therapeutics to counter those effects

I. Hwang, Nguyet Nguyen, Inkyu Hwang, 2015, Archives of pharmacal research.

Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.

D. Boger, M. Searcey, I. Hwang, 2009, Tetrahedron letters.

TCR-Mediated internalization of peptide-MHC complexes acquired by T cells.

M. Jackson, P. A. Peterson, J. Sprent, 1999, Science.

Direct stimulation of T cells by membrane vesicles from antigen-presenting cells.

J. Sprent, O. Boyman, Xuefei Shen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Direct stimulation of naïve T cells by membrane vesicles from antigen-presenting cells: Distinct roles for CD54 and B7 molecules

J. Sprent, Xuefei Shen, I. Hwang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Cell-cell communication via extracellular membrane vesicles and its role in the immune response

I. Hwang, Inkyu Hwang, 2013, Molecules and cells.

Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.

Dale L Boger, D. Boger, F. A. Romero, 2008, Journal of medicinal chemistry.

Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase.

D. Boger, B. Cravatt, F. A. Romero, 2007, Journal of medicinal chemistry.

Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase.

D. Boger, C. Hardouin, Wu Du, 2005, Bioorganic & medicinal chemistry letters.

Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization.

Dale L Boger, D. Boger, Romyr Dominique, 2005, Bioorganic & medicinal chemistry letters.

Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation.

J. Kang, I. Hwang, Rema Naskar, 2023, International immunopharmacology.

An Ex vivo Mast Cell Degranulation Assay using Crude Peritoneal Exudate Cells and Natural Antigen Stimulation.

L. Ye, I. Hwang, L. Son, 2021, Journal of visualized experiments : JoVE.

Beneficial effects of the mixed adjuvant of CpG plus monophosphoryl lipid a in immunization with a recombinant protein vaccine for hepatitis A

I. Chung, D. Shon, I. Hwang, 2013, Journal of the Korean Society for Applied Biological Chemistry.

LFA-1-dependent Ca2+ Entry following Suboptimal T Cell Receptor Triggering Proceeds without Mobilization of Intracellular Ca2+*

I. Hwang, Kwangmi Kim, Lin Wang, 2009, The Journal of Biological Chemistry.