Alun Williams

发表

Glimepiride reduces CD14 expression and cytokine secretion from macrophages

V. Ingham, Alun Williams, C. Bate, 2014, Journal of Neuroinflammation.

PEGylated polycyanoacrylate nanoparticles as vector for drug delivery in prion diseases

P. Couvreur, D. Dormont, I. Brigger, 2001, Journal of Neuroscience Methods.

Sialic Acid within the Glycosylphosphatidylinositol Anchor Targets the Cellular Prion Protein to Synapses*

Alun Williams, C. Bate, William Nolan, 2016, The Journal of Biological Chemistry.

Neurodegeneration Induced by Clustering of Sialylated Glycosylphosphatidylinositols of Prion Proteins*

Alun Williams, C. Bate, 2012, The Journal of Biological Chemistry.

Glycosylphosphatidylinositol Anchor Analogues Sequester Cholesterol and Reduce Prion Formation*

Alun Williams, C. Bate, M. Tayebi, 2010, The Journal of Biological Chemistry.

Manipulation of PrPres production in scrapie-infected neuroblastoma cells

J. Langeveld, Alun Williams, C. Bate, 2004, Journal of Neuroscience Methods.

An adapted ImmunoMagnetic cell separation method for use in quantification of Escherichia coli O157:H7 from bovine faeces.

D. Mellor, M. Roberts, DavidN. Taylor, 2003, Journal of microbiological methods.

The role of platelet activating factor in prion and amyloid-b neurotoxicity

M. Salmona, Alun Williams, C. Bate, 2004 .

Cholesterol esterification reduces the neurotoxicity of prions

Alun Williams, C. Bate, M. Tayebi, 2008, Neuropharmacology.

Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation

Alun Williams, C. Bate, M. Tayebi, 2008, BMC Biology.

Does the tail wag the dog? How the structure of a glycosylphosphatidylinositol anchor affects prion formation

Alun Williams, C. Bate, William Nolan, 2016, Prion.

Sialic Acid on the Glycosylphosphatidylinositol Anchor Regulates PrP-mediated Cell Signaling and Prion Formation*

Alun Williams, C. Bate, William Nolan, 2015, The Journal of Biological Chemistry.

Polyunsaturated Fatty Acids Protect Against Prion-Mediated Synapse Damage In Vitro

M. Salmona, L. Diomede, Alun Williams, 2010, Neurotoxicity Research.

Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage

Alun Williams, C. Bate, L. Rumbold, 2007, Journal of Neuroinflammation.

Virus infection induces neuronal apoptosis: A comparison with trophic factor withdrawal

J. Fazakerley, T. Allsopp, Alun Williams, 1998, Cell Death and Differentiation.

Glimepiride Reduces the Expression of PrPC, Prevents PrPSc Formation and Protects against Prion Mediated Neurotoxicity

M. Salmona, L. Diomede, Alun Williams, 2009, PloS one.

Docosahexaenoic and eicosapentaenoic acids increase prion formation in neuronal cells

M. Salmona, L. Diomede, Alun Williams, 2008, BMC Biology.

Role of glycosylphosphatidylinositols in the activation of phospholipase A2 and the neurotoxicity of prions.

Alun Williams, C. Bate, 2004, The Journal of general virology.

A role for B lymphocytes in anti-infective prion therapies?

S. Hawke, Alun Williams, C. Bate, 2007, Expert review of anti-infective therapy.

Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro

Alun Williams, C. Bate, M. Tayebi, 2008, Molecular Neurodegeneration.

Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A2 by Aβ1–42

Alun Williams, C. Bate, 2007, Neuropharmacology.

The role of platelet activating factor in prion and amyloid-beta neurotoxicity.

M. Salmona, Alun Williams, C. Bate, 2004, Neuroreport.

Interferon-γ increases neuronal death in response to amyloid-β1-42

Alun Williams, C. Bate, S. Kempster, 2006, Journal of Neuroinflammation.

A glycosylphosphatidylinositol analogue reduced prion-derived peptide mediated activation of cytoplasmic phospholipase A2, synapse degeneration and neuronal death

Alun Williams, C. Bate, M. Tayebi, 2010, Neuropharmacology.

Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2 activation

Alun Williams, C. Bate, M. Tayebi, 2008, BMC Biology.

Neurones treated with cyclo-oxygenase-1 inhibitors are resistant to amyloid-&bgr;1-42

R. Veerhuis, P. Eikelenboom, Alun Williams, 2003, Neuroreport.

The glycosylphosphatidylinositol anchor is a major determinant of prion binding and replication.

Alun Williams, C. Bate, M. Tayebi, 2010, The Biochemical journal.

Inducible cytokine gene expression in the brain in the ME7/CV mouse model of scrapie is highly restricted, is at a strikingly low level relative to the degree of gliosis and occurs only late in disease.

Alan R. Brown, R. Walker, J. Fazakerley, 2003, The Journal of general virology.

Inhibition of phospholipase A2 increased the removal of the prion derived peptide PrP82-146 from cultured neurons

V. Ingham, Alun Williams, C. Bate, 2011, Neuropharmacology.

Monoacylated Cellular Prion Protein Modifies Cell Membranes, Inhibits Cell Signaling, and Reduces Prion Formation*

Alun Williams, C. Bate, 2011, The Journal of Biological Chemistry.

Simvastatin treatment prolongs the survival of scrapie-infected mice

Alun Williams, C. Bate, S. Kempster, 2007, Neuroreport.

Temporal and spatial relationship between the death of PrP-damaged neurones and microglial activation

J. Langeveld, R. Boshuizen, Alun Williams, 2002, Neuroreport.

The cellular prion protein with a monoacylated glycosylphosphatidylinositol anchor modifies cell membranes, inhibits cell signaling and reduces prion formation

Alun Williams, C. Bate, 2011, Prion.

Prion protein accumulation and neuroprotection in hypoxic brain damage.

J. Bell, A. McNeill, J. Ironside, 2004, The American journal of pathology.

Gene expression profiling of the preclinical scrapie-infected hippocampus.

Kevin A. Robertson, Alan R. Brown, J. Fazakerley, 2005, Biochemical and biophysical research communications.

Immunocytochemical appearance of cytokines, prostaglandin E2 and lipocortin-1 in the CNS during the incubation period of murine scrapie correlates with progressive PrP accumulations

H. Fraser, P. Eikelenboom, D. Ritchie, 1997, Brain Research.

Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures

Alun Williams, C. Bate, 2018, Neurobiology of Disease.

Phospholipase A2 Inhibitors or Platelet-activating Factor Antagonists Prevent Prion Replication*

Alun Williams, C. Bate, S. Reid, 2004, Journal of Biological Chemistry.

The Molecular Assembly of Amyloid Aβ Controls Its Neurotoxicity and Binding to Cellular Proteins

Claudia Manzoni, Cristina Airoldi, Monica Lupi, 2011, PloS one.

Platelet-activating factor antagonists protect amyloid-β damaged neurons from microglia-mediated death

Alun Williams, C. Bate, S. Kempster, 2006, Neuropharmacology.

Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity*

M. Salmona, L. Diomede, Alun Williams, 2004, Journal of Biological Chemistry.

Killing of prion-damaged neurones by microglia

Alun Williams, C. Bate, S. Reid, 2001, Neuroreport.

Prostaglandin D2 mediates neuronal damage by amyloid-β or prions which activates microglial cells

Alun Williams, C. Bate, S. Kempster, 2006, Neuropharmacology.

Tumor Necrosis Factor Alpha-Deficient, but Not Interleukin-6-Deficient, Mice Resist Peripheral Infection with Scrapie

M. Pasparakis, N. Mabbott, G. Kollias, 2000, Journal of Virology.

Cyclo-oxygenase inhibitors protect against prion-induced neurotoxicity in vitro

Alun Williams, C. Bate, S. Reid, 2002, Neuroreport.

Astrocyte lesions in cerebral cortex and cerebellum of dogs with congenital ortosystemic shunting

N. Jeffery, M. Tivers, R. Mellanby, 2020, Journal of veterinary science.

α-Synuclein-Induced Synapse Damage in Cultured Neurons Is Mediated by Cholesterol-Sensitive Activation of Cytoplasmic Phospholipase A2

Alun Williams, C. Bate, 2015, Biomolecules.

α-synuclein induced synapse damage is enhanced by amyloid-β1-42

S. Gentleman, Alun Williams, C. Bate, 2010, Molecular Neurodegeneration.

Clustering of sialylated glycosylphosphatidylinositol anchors mediates PrP-induced activation of cytoplasmic phospholipase A2 and synapse damage

Alun Williams, C. Bate, 2012, Prion.

Do prion-induced changes in membrane cholesterol trigger neurodegeneration?

Alun Williams, C. Bate, 2008 .

Glimepiride protects neurons against amyloid-β-induced synapse damage

Alun Williams, C. Bate, William Nolan, 2016, Neuropharmacology.

Inhibition of cytosolic Phospholipase A2 prevents prion peptide-induced neuronal damage and co-localisation with Beta III Tubulin

D. Werling, Alun Williams, Victoria Last, 2012, BMC Neuroscience.

The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.

A. Doig, C. Eyers, D. Scopes, 2012, Biochemistry.

Amyloid-β(1-40) inhibits amyloid-β(1-42) induced activation of cytoplasmic phospholipase A2 and synapse degeneration.

Alun Williams, C. Bate, 2010, Journal of Alzheimer's disease : JAD.

Amyloid-β-induced Synapse Damage Is Mediated via Cross-linkage of Cellular Prion Proteins

Alun Williams, C. Bate, 2011, The Journal of Biological Chemistry.

Phospholipase A2 inhibitors protect against prion and Aβ mediated synapse degeneration

Alun Williams, C. Bate, M. Tayebi, 2010, Molecular Neurodegeneration.

Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases

Alun Williams, C. Bate, Victoria J. Ingham, 2014, Alzheimer's Research & Therapy.

Docosahexaenoic and eicosapentaenoic acids increase neuronal death in response to HuPrP82–146 and Aβ1–42

M. Salmona, L. Diomede, L. Colombo, 2008, Neuropharmacology.

Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42

M. Salmona, Alun Williams, C. Bate, 2004, Journal of Neuroinflammation.

Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide

R. Boshuizen, Alun Williams, C. Bate, 2007, BMC Neuroscience.

Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage

Clive Bate, Alun Williams, Alun Williams, 2011, Neuropharmacology.

Microglia kill amyloid-&bgr;1-42 damaged neurons by a CD14-dependent process

R. Veerhuis, P. Eikelenboom, Alun Williams, 2004, NeuroReport.

Detoxified lipopolysaccharide reduces microglial cell killing of prion-infected neurons

Alun Williams, C. Bate, 2004, Neuroreport.

cAMP-Inhibits Cytoplasmic Phospholipase A2 and Protects Neurons against Amyloid-β-Induced Synapse Damage

Alun Williams, C. Bate, 2015, Biology.

Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro

Alun Williams, C. Bate, M. Tayebi, 2008, Molecular Neurodegeneration.

Neuroinflammation in Alzheimer's disease and prion disease

R. Veerhuis, P. Eikelenboom, W. V. van Gool, 2002, Glia.

Platelet-activating factor antagonists enhance intracellular degradation of amyloid-β42 in neurons via regulation of cholesterol ester hydrolases

Alun Williams, C. Bate, Victoria J. Ingham, 2014, Alzheimer's Research & Therapy.

Cytokines, prostaglandins and lipocortin-1 are present in the brains of scrapie-infected mice

H. Fraser, Alun Williams, F. Berkenbosch, 1994, Journal of Neuroimmunology.

COX-2 expression in canine anal sac adenocarcinomas and in non-neoplastic canine anal sacs.

C. Knudsen, Alun Williams, M. Brearley, 2013, Veterinary journal.

Interferon-γ increases neuronal death in response to amyloid-β1-42

Alun Williams, C. Bate, S. Kempster, 2006, Journal of Neuroinflammation.

PrP Deposition, Microglial Activation, and Neuronal Apoptosis in Murine Scrapie

P. Lucassen, A. Williams, P. J. Lucassen, 1997, Experimental Neurology.

Ginkgolides protect against amyloid-β1–42-mediated synapse damage in vitro

Alun Williams, C. Bate, M. Tayebi, 2008, Molecular Neurodegeneration.

Glimepiride protects neurons against amyloid-β-induced synapse damage

Alun Williams, C. Bate, William Nolan, 2016, Neuropharmacology.

The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.

A. Doig, C. Eyers, D. Scopes, 2012, Biochemistry.

An in vitro screening assay based on synthetic prion protein peptides for identification of fibril-interfering compounds.

J. Langeveld, R. Boshuizen, M. Salmona, 2004, Analytical biochemistry.

Cholesterol esterification reduces the neurotoxicity of prions

Alun Williams, C. Bate, M. Tayebi, 2008, Neuropharmacology.

Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage

Alun Williams, C. Bate, L. Rumbold, 2007, Journal of Neuroinflammation.