A. Plat

发表

The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment.

G. D. de Bock, T. van Hall, H. Nijman, 2017, European journal of cancer.

Mutagenesis of nisin’s leader peptide proline strongly modulates export of precursor nisin

R. Rink, G. Moll, A. Kuipers, 2017, Antonie van Leeuwenhoek.

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

H. Hollema, G. Wisman, T. Daemen, 2017, Oncoimmunology.

TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancer

T. Bosse, R. Arnold, P. van der Vlies, 2018, bioRxiv.

Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

J. Adam, N. Leffers, H. Nijman, 2020, Oncoimmunology.

Transcriptional Activity and Stability of CD39+CD103+CD8+ T Cells in Human High-Grade Endometrial Cancer

D. Spierings, R. Fehrmann, D. Spierings, 2020, International journal of molecular sciences.

CD103 defines intraepithelial CD8+ PD1+ tumour-infiltrating lymphocytes of prognostic significance in endometrial adenocarcinoma.

H. Hollema, H. Arts, H. Klip, 2016, European journal of cancer.

Tumor infiltrating CD8/CD103/TIM-3-expressing lymphocytes in epithelial ovarian cancer co-express CXCL13 and associate with improved survival

G. Huls, H. Nijman, E. Bremer, 2022, Frontiers in Immunology.

Requirements of the Engineered Leader Peptide of Nisin for Inducing Modification, Export, and Cleavage

R. Rink, G. Moll, L. Kluskens, 2010, Applied and Environmental Microbiology.

Activity and Export of Engineered Nisin-(1-22) Analogs

R. Rink, G. Moll, A. Kuipers, 2011 .

Prognostic image-based quantification of CD8CD103 T cell subsets in high-grade serous ovarian cancer patients

H. Hollema, H. Arts, J. Bart, 2021, Oncoimmunology.

Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration

H. van Eenennaam, P. Elsinga, Sander M. J. van Duijnhoven, 2022, Journal for ImmunoTherapy of Cancer.

A Transcriptionally Distinct CXCL13+CD103+CD8+ T-cell Population Is Associated with B-cell Recruitment and Neoantigen Load in Human Cancer

T. Bosse, R. Arnold, H. Nijman, 2019, Cancer Immunology Research.

Expression of CD39 Identifies Activated Intratumoral CD8+ T Cells in Mismatch Repair Deficient Endometrial Cancer

D. Spierings, P. Elsinga, N. van Rooij, 2022, Cancers.

Combined STING levels and CD103+ T cell infiltration have significant prognostic implications for patients with cervical cancer

J. Bart, G. Wisman, H. Nijman, 2021, Oncoimmunology.

The Major Myelin-Resident Protein PLP Is Transported to Myelin Membranes via a Transcytotic Mechanism: Involvement of Sulfatide

D. Hoekstra, A. Nomden, W. Baron, 2009, Molecular and Cellular Biology.

Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

K. Mertz, T. Bosse, E. M. van der Steen-Banasik, 2020, Cancer Immunology Research.

Prediction model for regional or distant recurrence in endometrial cancer based on classical pathological and immunological parameters

H. Mackay, H. Kitchener, H. Hollema, 2015, British Journal of Cancer.

University of Groningen CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy Komdeur,

H. Hollema, H. Klip, G. Wisman, 2017 .

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy

H. Hollema, H. Klip, G. Wisman, 2016, Oncotarget.

Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

H. Hollema, T. Bosse, G. D. de Bock, 2016, Oncotarget.

Discovery, Production and Modification of Five Novel Lantibiotics Using the Promiscuous Nisin Modification Machinery.

Auke J van Heel, Oscar P Kuipers, O. Kuipers, 2016, ACS synthetic biology.

Mechanistic aspects of lanthipeptide leaders.

R. Rink, G. Moll, A. Kuipers, 2013, Current protein & peptide science.

Association of homozygous variants of STING1 with outcome in human cervical cancer

H. Hollema, N. van Rooij, H. Nijman, 2020, Cancer science.

L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition

H. Hollema, X. Matías-Guiu, T. Bosse, 2018, Virchows Archiv.

L1CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial–mesenchymal transition

X. Matías-Guiu, T. Bosse, C. Krakstad, 2018, Virchows Archiv.

University of Groningen L 1 CAM expression in uterine carcinosarcoma is limited to the epithelial component and may be involved in epithelial-mesenchymal transition

X. Matías-Guiu, T. Bosse, C. Krakstad, 2018 .

Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Constantinos G. Neochoritis, L. Skalniak, B. Musielak, 2023, Journal of medicinal chemistry.

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer

H. Hollema, G. Wisman, T. Daemen, 2017, Oncoimmunology.

Treatment Regimen, Surgical Outcome, and T-cell Differentiation Influence Prognostic Benefit of Tumor-Infiltrating Lymphocytes in High-Grade Serous Ovarian Cancer

H. Hollema, S. de Jong, H. Klip, 2015, Clinical Cancer Research.

Immune predictors of response to immune checkpoint inhibitors in mismatch repair-deficient endometrial cancer

C. Genestie, S. Gouy, A. Oaknin, 2024, Journal for immunotherapy of cancer.

Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study

D. Spierings, A. ter Elst, A. Plat, 2024, Nature communications.

Novel immune checkpoint biomarkers for medical imaging

H. Eenennaam, P. Elsinga, A. Plat, 2022 .

University of Groningen Transcriptional Activity and Stability of CD39+CD103+CD8+T Cells in Human High-Grade Endometrial Cancer

D. Spierings, R. Fehrmann, H. Nijman, 2020 .