Y. Hase

发表

Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models.

Hiromasa Hashimoto, T. Yamasaki, T. Adachi, 2019, Bioorganic & medicinal chemistry letters.

Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952.

Hiromasa Hashimoto, T. Yamasaki, Kazutaka Ikegashira, 2019, Bioorganic & medicinal chemistry letters.

How to determine the force constants of MM2 force field in a consistent way

M. Hirota, Y. Hase, K. Sakakibara, 1989 .

Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia.

K. Fukui, M. Yokota, Soichiro Ito, 2017, ACS medicinal chemistry letters.

Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.

Takayoshi Suzuki, Hiromasa Hashimoto, Makoto Shiozaki, 2019, Journal of medicinal chemistry.

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors.

H. Ueno, K. Aisaka, Hidetsura Cho, 2005, Bioorganic & Medicinal Chemistry Letters.

Structure-activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa.

H. Ueno, K. Aisaka, Hidetsura Cho, 2004, Bioorganic & medicinal chemistry letters.

Synthesis, SAR studies, and pharmacological evaluation of 3-anilino-4-(3-indolyl) maleimides with conformationally restricted structure as orally bioavailable PKCbeta-selective inhibitors.

Masahiro Tanaka, T. Sasase, Nobuhisa Ueda, 2006, Bioorganic & medicinal chemistry.

Catalytic Asymmetric Aminolysis of 3,5,8-Trioxabicyclo[5.1.0]octane Providing an Optically Pure 2-Amino-1,3,4-butanetriol Equivalent.

Y. Hase, T. Inaba, S. Sagawa, 1999, The Journal of organic chemistry.

Conformational Analysis of Febrifugines and Halofuginones in Organic Solvents

Masahiro Kato, S. Uesato, Y. Hase, 1998 .

Synthesis and structure-activity relationships of 5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine derivatives: novel arginine vasopressin antagonists.

K. Hayakawa, K. Aisaka, Hidenori Watanabe, 2004, Journal of medicinal chemistry.

Femtosecond Spectroscopic Study on Photochromic Diarylethenes with Terthiophene

N. Tamai, Y. Hase, M. Irie, 2000 .

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Hiroshi Yamamoto, S. Noji, Hiromasa Hashimoto, 2020, Journal of medicinal chemistry.

Discovery of (1S,2R,3R)-2,3-dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: novel and highly selective aggrecanase inhibitors.

Masahiro Tanaka, E. Laird, Makoto Shiozaki, 2011, Journal of medicinal chemistry.

Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.

Satoru Ikeda, Toru Noguchi, Shin‐ichi Hirashima, 2006, Journal of medicinal chemistry.

SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.

R. Babine, Shin‐ichi Hirashima, Hiromasa Hashimoto, 2016, ACS medicinal chemistry letters.