N. Klinman

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In vitro tolerance induction of bone marrow cells: a marker for B cell maturation.

E. Metcalf, N. Klinman, Eleanor S. Metcalf, 1977, Journal of immunology.

Valence and Affinity of Equine Nonprecipitating Antibody to a Haptenic Group

F. Karush, N. Klinman, J. Rockey, 1964, Science.

The cellular origins of memory B cells.

N. Klinman, 1997, Seminars in immunology.

Defining the B-Cell Repertoire with Hybridomas Derived from Monoclonal Fragment Cultures

R. Kennett, L. Sherman, Kathleen Denis, 1980 .

The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice

W. Gerhard, N. Klinman, M. Cancro, 1978, The Journal of experimental medicine.

The stimulation of splenic foci in vitro.

N. Klinman, G. Aschinazi, 1971, Journal of immunology.

Changes in Naive CD 4 T Cells

S. Swain, P. Linton, L. Haynes, 2002 .

Defining the immune mechanism with monoclonal antibodies

L. Sherman, N. Klinman, K. Denis, 1981, In Vitro.

domas with ant ibody-producing cells derived from dinitrophenyl (DNp)l-responsive neonatal B cells. The use of these monoclonal antibodies and antiidiotypic reagents has confirmed several previously established basic tenants of neonatal responses (21). In addition, the availability of large quantiti

N. Klinman, K. Denis, 2003 .

Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells

D. Wylie, L. Sherman, N. Klinman, 1982, The Journal of experimental medicine.

Predominance of nonproductive rearrangements of VH81X gene segments evidences a dependence of B cell clonal maturation on the structure of nascent H chains.

N. Klinman, D. Decker, N. Boyle, 1991, Journal of immunology.

T-cell and B-cell responses to viral antigens at the clonal level.

A. Vitiello, L. Sherman, N. Klinman, 1983, Annual review of immunology.

Altered VH gene segment utilization in the response to phosphorylcholine by aged mice.

K. Marcu, P. Linton, D. Zharhary, 1989, Journal of immunology.

Heavy chain V gene-specific elimination of B cells during the pre-B cell to B cell transition.

N. Klinman, D. Decker, T. Hayden, 1995, Journal of immunology.

RNA to DNA Polymerase Formation in Mice Expressing Antisense Maturation but Intact Germinal Center Hypermutation and Impaired Affinity Decreased Frequency of Somatic

M. Flajnik, L. Verkoczy, N. Klinman, 2001 .

EQUINE ANTIHAPTEN ANTIBODY

F. Karush, N. Klinman, J. Rockey, 1964, The Journal of experimental medicine.

B-cell development.

D. Wylie, J. Teale, N. Klinman, 1981, Immunology today.

In vitro tolerance induction of neonatal murine B cells

N. Sigal, E. Metcalf, N. Klinman, 1976, The Journal of experimental medicine.

Defining the heterogeneity of anti-tumor antibody responses.

N. Klinman, G. P. Segal, 1976, Journal of immunology.

General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice.

N. Klinman, R. B. Taylor, 1969, Clinical and experimental immunology.

Susceptibility to in vitro tolerance induction of adult B cells from mice with an X-linked B-cell defect

E. Metcalf, N. Klinman, I. Scher, 1980, The Journal of experimental medicine.

Relative roles of somatic and darwinian evolution in shaping the antibody response

N. Klinman, M. Diaz, Norman R. Klinman, 2000, Immunologic research.

Equine antihapten antibody II. The γG(7Sγ) components and their specific interaction

F. Karush, N. Klinman, J. Rockey, 1965 .

Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations

H. Mcdevitt, N. Klinman, J. L. Press, 1976, The Journal of experimental medicine.

The allogeneic bisection of carrier-specific enhancement of monoclonal B-cell responses

S. Pierce, N. Klinman, 1975, The Journal of experimental medicine.

Individual antigen-specific T lymphocytes: helper function in enabling the expression of multiple antibody isotypes

S. Pierce, N. Klinman, M. Cancro, 1978, The Journal of experimental medicine.

Multiple B cell stimulation by individual antigen‐specific T lymphocytes

S. Pierce, N. Klinman, 1981, European journal of immunology.

Murine Models of Tolerance Induction in Developing and Mature B Cells

E. Metcalf, N. Klinman, A. Schrater, 1979, Immunological reviews.

The frequency of phosphorylcholine-specific B cells in conventional and germfree BALB/C mice.

N. Sigal, N. Klinman, P. Gearhart, 1975, Journal of immunology.

Recovery of antibody activity upon reoxidation of completely reduced polyalanyl heavy chain and its Fd fragment derived from anti-2,4-dinitrophenyl antibody.

M. Sela, D. Givol, J. Jaton, 1968, Biochemistry.

Equine anti-hapten antibody. 3. The comparative properties of gamma G- and gammaA-antibodies.

F. Karush, N. Klinman, J. Rockey, 1966, Journal of immunology.

The Specificity Repertoire of Prereceptor and Mature B Cells a

D. Wylie, M. Stone, D. Zharhary, 1983, Annals of the New York Academy of Sciences.

Characterization of B cell subpopulations by velocity sedimentation, surface la antigens and immune function

S. Strober, N. Klinman, J. L. Press, 1977, European journal of immunology.

Equine anti-hapten antibody-V the non-precipitability of bivalent antibody

F. Karush, N. Klinman, 1967 .

B cell repertoire diversity in athymic mice

N. Klinman, M. Cancro, 1980, The Journal of experimental medicine.

The murine B cell repertoire responsive to an influenza-infected syngeneic cell line.

D. Wylie, N. Klinman, 1981, Journal of immunology.

Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes.

C. Pinkert, U. Storb, J. Manz, 1989, Veterinary immunology and immunopathology.

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

R. Ogata, N. Klinman, S. Connors, 1986, Proceedings of the National Academy of Sciences of the United States of America.

AN ASSAY METHOD FOR DISULFIDE GROUPS BY FLUORESCENCE QUENCHING.

F. Karush, N. Klinman, R. Marks, 1964, Analytical biochemistry.

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.

D. Katz, H. Yamamoto, L. Sherman, 1980, Journal of immunology.

The B-cell clonotype repertoire.

N. Sigal, N. Klinman, 1978, Advances in immunology.

The characterization fo the B-cell repertoire specific for the 2,4- dinitrophenyl and 2,4,6-trinitrophenyl determinants in neonatal BALB/c mice

N. Klinman, J. L. Press, 1975, The Journal of experimental medicine.

Enumeration and analysis of antibody-forming cell precursors in the neonatal mouse.

N. Klinman, J. L. Press, 1973, Journal of immunology.

Hybrid plasmacytoma production: fusions with adult spleen cells, monoclonal spleen fragments, neonatal spleen cells and human spleen cells.

R. Kennett, N. Klinman, K. Denis, 1978, Current topics in microbiology and immunology.

THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

N. Klinman, 1972, The Journal of experimental medicine.

Cellular Response to Partial Hepatectomy

A. Erslev, N. Klinman, 1963, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Interaction of gangliosides with B cells in splenic fragment cultures.

W. J. Esselman, N. Klinman, W. Chaney, 1984, Cellular immunology.

Surface IgG-bearing cells retain the capacity to secrete IgM.

J. Teale, S. Strober, N. Klinman, 1986, Journal of immunology.

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations

P. Linton, N. Klinman, D. Decker, 1989, Cell.

Regulation of B cell tolerance by murine gangliosides.

W. J. Esselman, N. Klinman, W. Chaney, 1982, Cellular immunology.

Antigen responsiveness of the mature and generative B cell populations of aged mice

D. Zharhary, N. Klinman, 1983, The Journal of experimental medicine.

Analysis of the primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) responsive B cells in BALB/C and B10.D2 mice.

P. Stashenko, N. Klinman, 1980, Journal of immunology.

A selective increase in the generation of phosphorylcholine-specific B cells associated with aging.

D. Zharhary, N. Klinman, 1986, Journal of immunology.

THE MECHANISM OF ANTIGENIC STIMULATION OF PRIMARY AND SECONDARY CLONAL PRECURSOR CELLS

N. Klinman, 1972, The Journal of experimental medicine.

B cell maintenance in aged mice reflects both increased B cell longevity and decreased B cell generation.

N. Klinman, T. Hayden, G. H. Kline, 1999, Journal of immunology.

Decreased B Cell Generation Both Increased B Cell Longevity and B Cell Maintenance in Aged Mice Reflects

N. Klinman, T. Hayden, G. H. Kline, 1999 .

The B‐cell biology of aging

N. Klinman, G. H. Kline, 1997, Immunological reviews.

Interrelating B cell subpopulations and environmental regulation with the expression of three tiers of repertoire diversity.

N. Klinman, D. Decker, D. J. Decker, 1992, International reviews of immunology.

Alterations in B Cells and Antibodies of Aged Mice

G. Powers, P. Linton, D. Zharhary, 1990 .

The clonotype repertoire of B cell subpopulations.

P. Linton, N. Klinman, P. Linton, 1988, Advances in immunology.

Functional Maturation of B Cell Repertoire Expression

N. Klinman, B. G. Froscher, 1987 .

The frequency and fine specificity of B cells responsive to (4-hydroxy-3-nitrophenyl)acetyl in aged mice.

D. Zharhary, N. Klinman, 1986, Cellular immunology.

Pre-B Cell Receptor-Mediated Selection of Pre-B Cells Synthesizing Functional μ Heavy Chains

H. Jäck, N. Klinman, U. Keyna, 1998, The Journal of Immunology.

Pre-B cell receptor-mediated selection of pre-B cells synthesizing functional mu heavy chains.

L. Hartwell, H. Jäck, G. Beck-Engeser, 1998, Journal of immunology.

Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell.

N H Sigal, N. Sigal, N. Klinman, 1975, Proceedings of the National Academy of Sciences of the United States of America.

The parameters of B-cell inactivation in transgenic mice vs classical model studies.

D. Scott, J. Alés-Martínez, N. Klinman, 1992, Research in immunology.

The expression of the Ig H chain repertoire in developing bone marrow B lineage cells.

J. Koziol, N. Klinman, D. Decker, 1991, Journal of immunology.

Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire

N. Klinman, M. R. Stone, 1983, The Journal of experimental medicine.

Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level

N H Sigal, N. Sigal, N. Klinman, 1975, The Journal of experimental medicine.

The monoclonal anti-phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire

N. Sigal, N. Klinman, P. Gearhart, 1977, The Journal of experimental medicine.

Phosphotyrosine‐dependent association between CD22 and protein tyrosine phosphatase 1C

M. Campbell, N. Klinman, 1995, European journal of immunology.

The "clonal selection hypothesis" and current concepts of B cell tolerance.

N. Klinman, 1996, Immunity.

Repertoire diversification of primary vs memory B cell subsets.

N. Klinman, 1998, Current topics in microbiology and immunology.

Selection in the expression of functionally distinct B-cell subsets.

N. Klinman, 1994, Current opinion in immunology.

B cell repertoire diversification precedes immunoglobulin receptor expression

D. Wylie, R. Riley, N. Klinman, 1983, Journal of Experimental Medicine.

In vitro tolerance induction of neonatal murine B cells.

E. Metcalf, N. Klinman, 1976, The Journal of experimental medicine.

Segregation at a locus determining an immunoglobulin genetic marker for the light chain variable region affects inheritance of expression of an idiotype.

P. Gottlieb, A. Nisonoff, N. Klinman, 1977, Proceedings of the National Academy of Sciences of the United States of America.

Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n

S. Pierce, N. Klinman, P. Maurer, 1980, The Journal of experimental medicine.

Assessing B cell diversification by antigen receptor and precursor cell analysis.

N. Sigal, S. Pierce, N. Klinman, 1976, Annales d'immunologie.

The B Cell Specificity Repertoire: Its Relationship to Definable Subpopulations

N. Klinman, J. L. Press, 1975, Transplantation reviews.

Genetic and temporal control of neonatal antibody expression

N. Klinman, K. Denis, 1983, The Journal of experimental medicine.

The acquisition of b-cell competence and diversity.

N. Klinman, 1976, The American journal of pathology.

Repertoire expression in surface immunoglobulin-negative bone marrow B cell precursors.

G. Neil, N. Klinman, 1987, International reviews of immunology.

Genetic and Environmental Control of B-Cell Idiotype Expression

D. Zharhary, R. Riley, N. Klinman, 1984 .

Allogeneic carrier-specific enhancement of hapten-specific secondary B- cell responses

S. Pierce, N. Klinman, 1976, The Journal of experimental medicine.

Specific immunoglobulin cDNA clones produced from hybridoma cell lines and murine spleen fragment cultures by 3SR amplification.

T. Gingeras, P. Linton, P. Koutz, 1994, PCR methods and applications.

Antigen-independent changes in naive CD4 T cells with aging

S. Swain, P. Linton, L. Haynes, 1996, The Journal of experimental medicine.

Immunoglobulin class commitment exhibited by B lymphocytes separated according to surface isotype.

J. Teale, S. Strober, N. Klinman, 1981, Journal of immunology.

Antibody with homogeneous antigen binding produced by splenic foci in organ culture.

N. Klinman, 1967, Immunochemistry.

Diversity 1990

N. Klinman, D. Decker, D. J. Decker, 1990, Immunological reviews.

INDIVIDUAL ANTIGEN-SPECIFIC T LYMPHOCYTES methodology of the B-cell splenic focus analysis developed to s tudy ind iv idua l B-cell an t i body responses in vitro

M. Cancro, S. Pierce, N. Klinman, 2003 .

Evolution and the molecular basis of somatic hypermutation of antigen receptor genes.

M. Flajnik, N. Klinman, M. Diaz, 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

Late acquisition of a germ line antibody specificity

N. Sigal, P. Gearhart, N. Klinman, 1976, Nature.

In Vitro Analysis of the Generation and Propagation of Memory B Cells

N. Klinman, Norman R. Klinman, 1996, Immunological reviews.

Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response

N. Sigal, J. Owen, N. Klinman, 1982, Nature.

Isoelectric analysis of neonatal monofocal antibody.

N. Klinman, J. L. Press, 1973, Immunochemistry.

Nonsequential expression of multiple immunoglobulin classes by isola- ted phosphorylcholine specific clones. Abstr.

N. Sigal, N. Klinman, Patricia J. Gearhart, 1975 .

Aging associated changes in the generation and development of B cell memory.

G. Thorbecke, N. Klinman, 1995, International reviews of immunology.

Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro.

T. Gingeras, P. Linton, N. Klinman, 1995, Immunity.

Production of antibodies of monoclonal specificity without the use of hybridoma cell lines

T. Gingeras, P. Linton, P. Koutz, 1994 .

Analysis of the humoral immune response to influenza virus in vitro.

T. Braciale, W. Gerhard, N. Klinman, 1976, Journal of immunology.

Reply: developmental selection complements evolutionary determination

N. Klinman, D. Decker, 1991 .

Tolerance susceptibility of newly generating memory B cells.

A. Rudie, P. Linton, N. Klinman, 1991, Journal of immunology.

EQUINE ANTIHAPTEN ANTIBODY II. THE GAMMA-G(7S-GAMMA) COMPONENTS AND THEIR SPECIFIC INTERACTION.

F. Karush, N. Klinman, J. H. Rockey, 1965, Immunochemistry.

The generation of memory B cells.

N. Klinman, P. Linton, 1992, Seminars in immunology.

HAPTEN-SPECIFIC STIMULATION OF SECONDARY B CELLS INDEPENDENT OF T CELLS

N. Klinman, R. Doughty, 1973, The Journal of experimental medicine.

Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta.

W. Mcgregor, L. Verkoczy, N. Klinman, 2003, Molecular cancer research : MCR.

The generation of B-cell memory: a working hypothesis.

N. Klinman, P. Linton, 1990, Current topics in microbiology and immunology.

ROLE OF INORGANIC PHOSPHATE IN THIOSULFATE METABOLISM BY THIOBACILLUS THIOPARUS

M. Santer, N. Klinman, R. Kaback, 1960, Journal of bacteriology.

Equine Anti-Hapten Antibody: III. The Comparative Properties of γG- and γA-Antibodies

F. Karush, N. Klinman, G. Frauenberger, 1966 .

Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.

W. Gerhard, D. Wylie, N. Klinman, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Affinity labeling of equine anti-beta-lactoside antibodies.

L. Wofsy, F. Karush, N. Klinman, 1967, Biochemistry.

Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers

D. Lo, G. Thorbecke, P. Linton, 1992, European journal of immunology.

Analysis of an evolutionarily conserved antigenic site on mammalian cytochrome c using synthetic peptides.

P. R. Morrow, R. Jemmerson, Y. Paterson, 1985, Proceedings of the National Academy of Sciences of the United States of America.

The interplay of evolution and environment in B-cell diversification.

S K Pierce, N H Sigal, N. Sigal, 1977, Cold Spring Harbor symposia on quantitative biology.

SUSCEPTIBILITY T O I N V ITRO T OLERANCE I NDUCTION OF A DULT B CELLS F ROM MICE W ITH A N X -LINKED B -CELL D EFECT*

E. Metcalf, N. Klinman, I. Scher, 1980 .

Self-Nonself Discrimination by Precursors of Memory B Cells

N. Klinman, P. Linton, 1989 .

Tolerance as an active process

J. Teale, N. Klinman, 1980, Nature.

The affinity threshold for antigenic triggering differs for tolerance susceptible immature precursors vs mature primary B cells.

R. Riley, N. Klinman, 1986, Journal of immunology.

BIOGRAPHY OF THE B CELL

R. Woodland, N. Klinman, A. Pickard, 1974 .

MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY

N. Klinman, J. L. Press, 1973, The Journal of experimental medicine.

Differences in antibody repertoires for (4-hydroxy-3-nitrophenyl)acetyl (NP) in splenic vs immature bone marrow precursor cells.

R. Riley, N. Klinman, 1985, Journal of Immunology.

Immature B cells as the target for in vivo tolerance induction.

D. Katz, N. Klinman, A. Schrater, 1981, Journal of immunology.

Is tolerance the result of engaging surface Ig of B cells in cycle?

David Steven Scott, N. Klinman, 1987, Immunology today.

Comparison of immature B-cell populations in neonates and adults.

D. Zharhary, M. Schaefer, R. Riley, 1984, Annales d'immunologie.

B cell repertoire ontogeny: heritable but dissimilar development of parental and F1 repertoires.

N. Klinman, M. Cancro, 1981, Journal of Immunology.

A microtest radioimmunoassay for noncytotoxic tumor-specific antibody to cell-surface antigens.

L. Manson, N. Klinman, L. Goldstein, 1973, Journal of the National Cancer Institute.

When Two-Dimensional Structure Led the Way

N. Klinman, 2004, The Journal of Immunology.

Frequency of hapten‐specific B cells in neonatal and adult murine spleens

N. Klinman, J L Press, N R Klinman, 1974, European journal of immunology.

Idiotype‐specific neonatal suppression of phosphorylcholine‐responsive B cells

N. Sigal, M. Cancro, P. Gearhart, 1977, European journal of immunology.

Regain of homogeneous binding activity after recombination of chains of "mono- focal" antibody.

N. Klinman, 1971, Journal of immunology.

Molecular analysis of neonatal IgA expression: Implications for class switching, allelic polymorphism and somatic mutation

J. Teale, P. Tucker, N. Klinman, 1990, Immunologic research.

B-cell development.

D. Wylie, J. Teale, N. Klinman, 1981, Immunology today.

In vitro tolerance induction of neonatal murine B cells as a probe for the study of B-cell diversification

N. Sigal, E. Metcalf, N. Klinman, 1977, The Journal of experimental medicine.

THE SECONDARY IMMUNE RESPONSE TO A HAPTEN IN VITRO

N. Klinman, 1971, The Journal of experimental medicine.

OVERLAP STIMULATION OF PRIMARY AND SECONDARY B CELLS BY CROSS-REACTING DETERMINANTS

N. Klinman, J. L. Press, G. P. Segal, 1973, The Journal of experimental medicine.

Expression of specific clones during B cell development.

N. Klinman, J. L. Press, 1975, Federation proceedings.

The autoantigenic response to rabbit cytochrome c

Y. Paterson, N. Klinman, H. Cooper, 1989, European journal of immunology.

The analysis of the monoclonal immune response to influenza virus. I. Production of monoclonal anti‐viral antibodies in vitro

N. Klinman, T. Braciale, W. Gerhard, 1975, European journal of immunology.

EQUINE ANTIHAPTEN ANTIBODY

N. Klinman, J. H. Rockey, Fred Karush, 1964 .

Genetic and temporal control of neonatal antibody expression

N. Klinman, K. Denis, 1983, The Journal of experimental medicine.

Ia antigens on murine thymocytes: detection by cellular radioimmunoassay.

R. Mayol, N. Klinman, W. Elkins, 1977, Journal of immunology.

Antibody responses to synthetic peptides corresponding to antigenic determinants on mouse cytochrome. Abstr.

P. R. Morrow, R. Jemmerson, N. Klinman, 1982 .

Membrane and metabolic requirements for tolerance induction of neonatal B cells.

J. Teale, N. Klinman, 1984, Journal of immunology.