S. Komuro

发表

Metabolomic investigation of cholestasis in a rat model using ultra-performance liquid chromatography/tandem mass spectrometry.

Koji Umemura, T. Katsumata, M. Aoki, 2011, Rapid communications in mass spectrometry : RCM.

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Y. Mizuki, S. Komuro, H. Nishimuta, 2011, Drug metabolism and pharmacokinetics.

Consideration of reliable concentrations for prediction of change in enzyme activity by mechanism-based inactivation using physiologically-based pharmacokinetic model simulations.

Y. Mizuki, S. Komuro, Kimihiko Sato, 2010, Drug metabolism and pharmacokinetics.

In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury

T. Yokoi, Toru Usui, T. Katsumata, 2011, Drug Metabolism and Disposition.

Systematic approach to optimize a pretreatment method for ultrasensitive liquid chromatography with tandem mass spectrometry analysis of multiple target compounds in biological samples.

H. Yamazaki, M. Kataoka, S. Yamashita, 2016, Journal of separation science.

Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes

S. Komuro, T. Hashizume, M. Mise, 2008, Drug Metabolism and Disposition.

A new methodology for simultaneous quantification of total-Aβ, Aβx-38, Aβx-40, and Aβx-42 by column-switching LC/MS/MS

Ken-ichi Watanabe, Shiro Watanabe, T. Nakagawa, 2012, Analytical and Bioanalytical Chemistry.

Microsoft Word-11623028-file00

Toru Usui, S. Komuro, M. Yabuki, 2009 .

Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.

S. Komuro, M. Yabuki, H. Kanamaru, 2005, Biopharmaceutics & drug disposition.

Quantitative determination of F6-1,25(OH)2 vitamin D3 in human serum by gas chromatography/mass spectrometry with high-resolution selected ion monitoring.

A. Yoshitake, I. Nakatsuka, S. Komuro, 1994, Biological mass spectrometry.

DISPOSITION AND METABOLISM OF F6-1α,25(OH)2 VITAMIN D3 AND 1α,25(OH)2 VITAMIN D3 IN THE PARATHYROID GLANDS OF RATS DOSED WITH TRITIUM-LABELED COMPOUNDS

S. Komuro, Masayuki Sato, H. Kanamaru, 2003 .

Distribution and metabolism of F6-1,25(OH)2 Vitamin D3 and 1,25(OH)2 Vitamin D3 in the bones of rats dosed with tritium-labeled compounds

A. Yoshitake, I. Nakatsuka, S. Komuro, 1998, Steroids.

Disposition and Metabolism of ST-630 (1): Absorption, Distribution and Excretion after Single Oral Administration of 3H-ST-630 in Rats

A. Yoshitake, I. Nakatsuka, S. Komuro, 1996 .

Disposition and Metabolism of ST-630 (2): Metabolism after Single Administration of 3H-ST-630 in Rats

A. Yoshitake, I. Nakatsuka, S. Komuro, 1996 .

In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes

S. Komuro, J. Shimakura, H. Kanamaru, 2010, European journal of drug metabolism and pharmacokinetics.

In vitro metabolism of perospirone in rat, monkey and human liver microsomes

I. Nakatsuka, S. Komuro, H. Kanamaru, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

Masashi Yabuki, Setsuko Komuro, Masashi Mise, 2009, Drug Metabolism and Disposition.

Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys

Y. Mizuki, S. Komuro, Kimihiko Sato, 2010, Drug Metabolism and Disposition.

Pharmacokinetics of miriplatin in experimental dog models of hepatic or renal impairment

S. Komuro, M. Yabuki, Hiroyuki Asano, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

The new acyl‐CoA cholesterol acyltransferase inhibitor SMP‐797 does not interact with statins via OATP1B1 in human cryopreserved hepatocytes and oocytes expressing systems

S. Komuro, M. Yabuki, Atsushi Kitamura, 2007, Biopharmaceutics & drug disposition.

Disposition and Metabolism of ST-630 (3): Dose-response, Effect of Food Intake, Bioavailability after Single Oral Administration, and Serum Concentration, Distribution, Metabolism, Excretion after Single Intravenous A dministration of 3-ST-630 in Rats

A. Yoshitake, I. Nakatsuka, S. Komuro, 1996 .

Liver uptake of biguanides in rats.

Y. Sogame, S. Komuro, M. Yabuki, 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Characterization of the enzymes involved in the in vitro metabolism of amrubicin hydrochloride

S. Komuro, M. Yabuki, H. Kanamaru, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Transport of biguanides by human organic cation transporter OCT2.

M. Takano, Y. Sogame, S. Komuro, 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Metabolism of L-DOPS in Animals

A. Yoshitake, I. Nakatsuka, S. Komuro, 1987 .

In vivo and in vitro pharmacokinetics and metabolism studies of 26,26,26,27,27,27-F6-1,25(OH)2 vitamin D3 (Falecalcitriol) in rat: induction of vitamin D3-24-hydroxylase (CYP24) responsible for 23S-hydroxylation in target tissues and the drop in serum levels.

A. Yoshitake, I. Nakatsuka, S. Komuro, 1999, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetics Characterization of Liposomal Amphotericin B: Investigation of Clearance Process and Drug Interaction Potential

S. Komuro, M. Yabuki, Satoki Imai, 2009, Arzneimittelforschung.

Disposition and metabolism of F6-1alpha,25(OH)2 vitamin D3 and 1alpha,25(OH)2 vitamin D3 in the parathyroid glands of rats dosed with tritium-labeled compounds.

S. Komuro, Masayuki Sato, H. Kanamaru, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data.

S. Komuro, Kimihiko Sato, M. Yabuki, 2011, Drug metabolism and pharmacokinetics.

A comparison of uptake of metformin and phenformin mediated by hOCT1 in human hepatocytes

Y. Sogame, S. Komuro, M. Yabuki, 2009, Biopharmaceutics & drug disposition.

Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

Toru Usui, S. Komuro, M. Yabuki, 2009, Drug Metabolism and Disposition.

Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data.

S. Komuro, Kimihiko Sato, M. Yabuki, 2011, Drug metabolism and pharmacokinetics.

Prediction of the Intestinal First-Pass Metabolism of CYP3A Substrates in Humans Using Cynomolgus Monkeys

Y. Mizuki, S. Komuro, Kimihiko Sato, 2010, Drug Metabolism and Disposition.

In Vitro Investigation of the Glutathione Transferase M1 and T1 Null Genotypes as Risk Factors for Troglitazone-Induced Liver Injury

T. Yokoi, Toru Usui, T. Katsumata, 2011, Drug Metabolism and Disposition.

Liver uptake of biguanides in rats.

Y. Sogame, S. Komuro, M. Yabuki, 2011, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Long-term disposition of a novel lipophilic platinum complex SM-11355 in dog after intrahepatic arterial administration: highly sensitive detection of platinum and radioactivity

S. Komuro, J. Shimakura, K. Fujimoto, 2002, Xenobiotica; the fate of foreign compounds in biological systems.

Species differences in intestinal metabolic activities of cytochrome P450 isoforms between cynomolgus monkeys and humans.

Y. Mizuki, S. Komuro, Kimihiko Sato, 2011, Drug metabolism and pharmacokinetics.

CYP1A2-deficient and wild-type dog liver microsomes

S. Komuro, T. Hashizume, M. Mise, 2008 .