C. Mao

发表

Lipase-mediated stereoselective hydrolysis of stampidine and other phosphoramidate derivatives of stavudine.

F. Uckun, S. Pendergrass, T. Venkatachalam, 2004, Bioorganic & medicinal chemistry.

Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia.

H. Sather, G. Reaman, F. Uckun, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

F. Uckun, Hong Ma, P. Goodman, 2012, Proceedings of the National Academy of Sciences.

Structural Requirements for Potent Anti-Human Immunodeficiency Virus (HIV) and Sperm-Immobilizing Activities of Cyclohexenyl Thiourea and Urea Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase1

F. Uckun, T. Venkatachalam, S. Qazi, 2002, Biology of reproduction.

X-ray crystallographic analysis of pokeweed antiviral protein-II after reductive methylation of lysine residues.

I. Kurinov, F. Uckun, J. Irvin, 2000, Biochemical and biophysical research communications.

Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).

F. Uckun, Hong Ma, A. Vassilev, 2007, Bioorganic & medicinal chemistry.

Anti-HIV activity of aromatic and heterocyclic thiazolyl thiourea compounds.

F. Uckun, E. Sudbeck, T. Venkatachalam, 2001, Bioorganic & medicinal chemistry letters.

Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.

F. Uckun, E. Sudbeck, T. Venkatachalam, 1999, Bioorganic & medicinal chemistry letters.

Structure-based design of N-[2-(1-piperidinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea and N-[2-(1-piperazinylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.

F. Uckun, E. Sudbeck, T. Venkatachalam, 1998, Bioorganic & medicinal chemistry letters.

5-Alkyl-2-[(methylthiomethyl)thio]-6-(benzyl)-pyrimidin-4-(1H)-ones as potent non-nucleoside reverse transcriptase inhibitors of S-DABO series.

F. Uckun, E. Sudbeck, T. Venkatachalam, 1998, Bioorganic & medicinal chemistry letters.

Polo‐like‐kinase 1 (PLK1) as a molecular target to overcome SYK‐mediated resistance of B‐lineage acute lymphoblastic leukaemia cells to oxidative stress

F. Uckun, L. Tuel-ahlgren, S. Qazi, 2010, British journal of haematology.

Structure-Based Design and Engineering of a Nontoxic Recombinant Pokeweed Antiviral Protein with Potent Anti-Human Immunodeficiency Virus Activity

F. Uckun, S. Pendergrass, B. Waurzyniak, 2003, Antimicrobial Agents and Chemotherapy.

Piperidinylethyl, Phenoxyethyl and Fluoroethyl Bromopyridyl Thiourea Compounds with Potent Anti-HIV Activity

F. Uckun, E. Sudbeck, C. Mao, 2000, Antiviral chemistry & chemotherapy.

CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.

F. Uckun, E. Sudbeck, C. Mao, 2002, Drug metabolism and disposition: the biological fate of chemicals.

N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency virus-1.

F. Uckun, S. Pendergrass, T. Venkatachalam, 1999, Bioorganic & medicinal chemistry letters.

Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.

X. P. Liu, F. Uckun, S. Ghosh, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Spongistatins as tubulin targeting agents.

F. Uckun, A. Vassilev, C. Navara, 2001, Current pharmaceutical design.

Structure-based design of a novel synthetic spiroketal pyran as a pharmacophore for the marine natural product spongistatin 1.

F. Uckun, A. Vassilev, C. Mao, 2000, Bioorganic & medicinal chemistry letters.

Effect of stereochemistry on the anti-HIV activity of chiral thiourea compounds.

F. Uckun, T. Venkatachalam, C. Mao, 2004, Bioorganic & medicinal chemistry.

Effect of stereo and regiochemistry towards wild and multidrug resistant HIV-1 virus: viral potency of chiral PETT derivatives.

F. Uckun, T. Venkatachalam, C. Mao, 2004, Biochemical pharmacology.

Stereochemistry as a Major Determinant of the Anti-HIV Activity of Chiral Naphthyl Thiourea Compounds

F. Uckun, C. Mao, T. Venkatachalam, 2001, Antiviral chemistry & chemotherapy.

Stereochemistry of halopyridyl and thiazolyl thiourea compounds is a major determinant of their potency as nonnucleoside inhibitors of HIV-1 reverse transcriptase.

F. Uckun, E. Sudbeck, T. Venkatachalam, 2000, Bioorganic & medicinal chemistry letters.

Structure-based drug design of non-nucleoside inhibitors for wild-type and drug-resistant HIV reverse transcriptase.

F. Uckun, E. Sudbeck, T. Venkatachalam, 2000, Biochemical pharmacology.

N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.

F. Uckun, S. Pendergrass, T. Venkatachalam, 1999, Bioorganic & medicinal chemistry letters.

Stereocontrolled synthesis of a novel pharmacophore of the tubulin-depolymerizing marine natural product spongistatin

F. Uckun, He Huang, C. Mao, 2000 .

Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reverse transcriptase

F. Uckun, E. Sudbeck, T. Venkatachalam, 1998 .

Structure-Based Design of Non-Nucleoside Reverse Transcriptase Inhibitors of Drug-Resistant Human Immunodeficiency Virus

F. Uckun, E. Sudbeck, C. Mao, 1999, Antiviral chemistry & chemotherapy.

Structure-Based Design of Novel Dihydroalkoxybenzyloxopyrimidine Derivatives as Potent Nonnucleoside Inhibitors of the Human Immunodeficiency Virus Reverse Transcriptase

Rakesh Vig, Fatih M. Uckun, F. Uckun, 1998, Antimicrobial Agents and Chemotherapy.

Active center cleft residues of pokeweed antiviral protein mediate its high-affinity binding to the ribosomal protein L3.

F. Uckun, F. Rajamohan, C. Mao, 2001, Biochemistry.

Binding Interactions between the Active Center Cleft of Recombinant Pokeweed Antiviral Protein and the α-Sarcin/Ricin Stem Loop of Ribosomal RNA*

F. Uckun, F M Uckun, F. Rajamohan, 2001, The Journal of Biological Chemistry.

Leukemic T-cell Precursors from T-lineage All Patients Are Characterized by Profound Ku80 Deficiency as well as Functional IK Deficiency with Very Low Ikaros Target Gene Expression Levels

F. Uckun, S. Qazi, C. Mao, 2013 .

Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia

F. Uckun, A. Vassilev, P. Goodman, 2001, Oncogene.

Crystal Structure of Bruton's Tyrosine Kinase Domain Suggests a Novel Pathway for Activation and Provides Insights into the Molecular Basis of X-linked Agammaglobulinemia*

F. Uckun, Min Zhou, F M Uckun, 2001, The Journal of Biological Chemistry.

Tyrosine kinases as new molecular targets in treatment of inflammatory disorders and leukemia.

F. Uckun, C. Mao, 2004, Current pharmaceutical design.

Structure-based design of novel anticancer agents.

X. P. Liu, F. Uckun, A. Vassilev, 2001, Current cancer drug targets.

SPIKET and COBRA compounds as novel tubulin modulators with potent anticancer activity.

F. Uckun, A. Vassilev, E. Sudbeck, 2000, Current opinion in investigational drugs.

A rationally designed anticancer drug targeting a unique binding cavity of tubulin.

F. Uckun, A. Vassilev, C. Navara, 2000, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of phenethyl-5-bromopyridyl thiourea derivatives as potent non-nucleoside inhibitors of HIV reserve transcriptase.

F. Uckun, E. Sudbeck, T. Venkatachalam, 1998, Bioorganic & medicinal chemistry.

Defective Expression of Bruton's Tyrosine Kinase in Acute Lymphoblastic Leukemia

F. Uckun, A. Vassilev, P. Goodman, 2003, Leukemia & lymphoma.

A Rationally Designed Anticancer Drug Targeting a Unique Binding Cavity of Tubulin

F. Uckun, A. Vassilev, C. Navara, 2000 .

COBRA-1, a rationally-designed epoxy-THF containing compound with potent tubulin depolymerizing activity as a novel anticancer agent.

F. Uckun, A. Vassilev, C. Navara, 2000, Bioorganic & medicinal chemistry letters.

Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros

F. Uckun, Hong Ma, P. Goodman, 2012, Proceedings of the National Academy of Sciences of the United States of America.

X-Ray structure of glycerol kinase complexed with an ATP analog implies a novel mechanism for the ATP-dependent glycerol phosphorylation by glycerol kinase.

F. Uckun, C. Mao, Z. Ozer, 1999, Biochemical and biophysical research communications.

Structure-based design of potent inhibitors of EGF-receptor tyrosine kinase as anti-cancer agents.

X. P. Liu, F. Uckun, E. Sudbeck, 1999, Anti-cancer drug design.