Jennifer M. Williams

发表

The crystal structure, mutagenesis, and activity studies reveal that patatin is a lipid acyl hydrolase with a Ser-Asp catalytic dyad.

W. Stallings, F. Moshiri, J. Purcell, 2003, Biochemistry.

Structure analysis reveals the flexibility of the ADAMTS‐5 active site

A. Tomasselli, A. Wittwer, M. Schnute, 2011, Protein science : a publication of the Protein Society.

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

A. Tomasselli, A. Wittwer, M. Schnute, 2009, The Journal of Biological Chemistry.

Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.

W. Stallings, D. J. Rogier, Y. M. Fobian, 2009, Bioorganic & medicinal chemistry letters.

Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.

Lifeng Geng, R. Kurumbail, W. Stallings, 2007, Journal of medicinal chemistry.

Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.

James R Kiefer, A. Tomasselli, J. Chrencik, 2010, Journal of molecular biology.

Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain.

A. Tomasselli, J. F. Schindler, J. Chrencik, 2010, Protein expression and purification.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

Li Xing, R. Kurumbail, J. F. Schindler, 2009, Biochemistry.

Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.

Ying Yu, Gary A Decrescenzo, James R Kiefer, 2010, Journal of medicinal chemistry.

Discovery of potent inhibitors of soluble epoxide hydrolase by combinatorial library design and structure-based virtual screening.

Li Xing, R. Kurumbail, S. Roberds, 2011, Journal of medicinal chemistry.

High Resolution Crystal Structure of the Catalytic Domain of ADAMTS-5 (Aggrecanase-2)*

A. Tomasselli, J. Kiefer, T. Benson, 2008, Journal of Biological Chemistry.

Structure of human ADAM-8 catalytic domain complexed with batimastat.

A. Tomasselli, A. F. Moon, J. Krahn, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804.

R. Kurumbail, J. F. Schindler, J. Monahan, 2009, Biochemistry.