O. Zefirova

发表

Novel analogs of 5-hydroxymethyl-2-methoxyphenyl adamantane-1-acetate: synthesis, biotesting, and molecular modeling

S. Kuznetsov, N. Zefirov, A. Mamaeva, 2021, Russian Chemical Bulletin.

Targeted application of bridged fragments in the design of physiologically active compounds

N. Zefirov, O. Zefirova, N. Zefirov, 2013, Russian Chemical Bulletin.

Screening of a series of 3,5-disubstituted 1,2,4-thiadiazoles for selectivity of cytotoxic action to cancer cells

S. Bachurin, T. P. Trofimova, D. A. Skvortsov, 2021, Russian Chemical Bulletin.

Molecular design and synthesis of new heterobivalent compounds based on chlorambucil and colchicine

S. Kuznetsov, N. Zefirov, E. Milaeva, 2020 .

Adamantyl-substituted ligands of colchicine binding site in tubulin: different effects on microtubule network in cancer cells

S. Kuznetsov, N. Zefirov, Y. Evteeva, 2018, Structural Chemistry.

Unusual Tubulin‐Clustering Ability of Specifically C7‐Modified Colchicine Analogues

H. Lemcke, N. S. Zefirov, Gareth Griffiths, 2013, Chembiochem : a European journal of chemical biology.

Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity

V. Zarubaev, A. Baranova, V. Alferova, 2022, Molecules.

Cyclic Isothiourea in Drug Design

O. Zefirova, E. Nurieva, A. A. Alexeev, 2021, Chemistry of Heterocyclic Compounds.

Syntheses of Compounds Active toward Glutamate Receptors: I. New Preparative Synthesis of Aminoindandicarboxylic Acid (AIDA)

N. Zefirov, S. Bachurin, R. Pellicciari, 2002 .

Bicyclic bridged isothioureas: synthesis and evaluation of activity in a model of lipopolysaccharide-induced septic shock

K. Lyssenko, Y. Grishin, O. Zefirova, 2019, Mendeleev Communications.

Physiologically active compounds interacting with serotonin (5-hydroxytryptamine) receptors

N. Zefirov, O. Zefirova, 2001 .

Syntheses of Compounds Active toward Glutamate Receptors: II. Synthesis of Spiro Hydantoins of the Indan Series

N. Zefirov, S. Bachurin, R. Pellicciari, 2002 .

Synthesis and antimitotic activity of novel 5-aminoisoxazoles bearing alkoxyaryl moieties

N. S. Zefirov, S. Kuznetsov, Y. Grishin, 2017 .

Taxol: Synthesis, Bioactive Conformations, and Structure-Activity Relationships in Its Analogs

N. Zefirov, N. Zyk, O. Zefirova, 2005 .

Synthesis and SAR requirements of adamantane-colchicine conjugates with both microtubule depolymerizing and tubulin clustering activities.

D. Weiss, H. Lemcke, N. S. Zefirov, 2011, Bioorganic & medicinal chemistry.

Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core.

D. Weiss, H. Lemcke, N. S. Zefirov, 2008, Bioorganic & medicinal chemistry letters.

Design, synthesis and bioactivity of simplified taxol analogues on the basis of bicyclo[3.3.1]nonane derivatives

D. Weiss, H. Lemcke, A. Ivanov, 2008 .

Synthetic Approaches to Physiologically Active Polycyclic Compounds: VI. Synthesis of 1-[(2R,3S)-N-Benzoyl-phenylisoseryloxy]-4,4-dimethyladamantane

N. Zyk, O. Zefirova, N. Zyk, 2005 .

Diels-alder reaction as a synthetic approach to bicyclo[3.3.1]nonane colchicine analogs

N. Zefirov, I. Baskin, O. Zefirova, 2010 .

THE CRYSTAL AND MOLECULAR-STRUCTURE OF 3,7-DIMETHYL-1,5-DIPHENYLBISPIDONE-9 - COPPER(II) CHLORIDE 1-1 COMPLEX

N. Zefirov, O. Zefirova, K. A. Potekhin, 1986 .

Synthetic approach to preparation of indole derivatives fused with a bicyclo[3.3.1]nonane framework

N. Zefirov, N. Zyk, O. Zefirova, 2007 .

Vibrational spectra and stable conformations of N-methylacetamide and (1S,5S,6R)-6-acetylamino-(5′-methoxyindolo[2,3-b])bicyclo[3.2.1]oct-2-ene

O. Zefirova, G. Kuramshina, Y. Pentin, 2014, Russian Journal of Physical Chemistry.

Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation

N. S. Zefirov, S. Kuznetsov, N. Zefirov, 2017, Molecular Diversity.

Crystallographic study and molecular modeling on the oxidation product of N-[(8R)-2-methoxy-5,6,7,8,9,10-hexahydro-6,9-methanocyclohepta[b]indol-8-yl]acetamide

A. Ivanov, A. A. Ivanova, O. Zefirova, 2012, Russian Journal of Organic Chemistry.

Tick-borne flavivirus reproduction inhibitors based on isoxazole core linked with adamantane.

Evgenia V. Dueva, D. Osolodkin, L. Kozlovskaya, 2019, Bioorganic chemistry.

Synthesis and biological testing of (5Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones as antimitotic agents

A. Majouga, S. Kuznetsov, E. Beloglazkina, 2016, Medicinal Chemistry Research.

Heterocycles as classical and nonclassical ring B isosters in combretastatin A-4

N. Zefirov, O. Zefirova, 2017, Chemistry of Heterocyclic Compounds.

Ligands of the colchicine site of tubulin: A common pharmacophore and new structural classes

N. Zefirov, N. Zyk, O. Zefirova, 2007 .

Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues.

N. S. Zefirov, A. A. Ivanova, A. Ivanov, 2011, Bioorganic chemistry.

Novel substituted 5‐methyl‐4‐acylaminoisoxazoles as antimitotic agents: Evaluation of selectivity to LNCaP cancer cells

A. Shtil, E. Shevtsova, E. Radchenko, 2022, Archiv der Pharmazie.

Phosphates of bridgehead alcohols as putative inositol monophosphatase inhibitors: molecular design and synthetic approach

M. Belenikin, O. Zefirova, E. V. Nurieva, 2011 .

Role of structural components of the 2-methoxyestradiol—chlorambucil conjugate in microtubule stabilization

E. Shevtsova, N. Zefirov, A. Mamaeva, 2022, Russian Chemical Bulletin.

Design, synthesis and biotest of a bicyclo[3.3.1]nonane analogue of 2-amino-5,6-dihydro-4H-1,3-thiazine

V. Chupakhin, M. Onufriev, N. Gulyaeva, 2010 .

Tubulin targeted antimitotic agents based on adamantane lead compound: synthesis, SAR and molecular modeling

N. Zefirov, A. Mamaeva, A. Krasnoperova, 2020 .

Tubuloclustin analogues with ether moiety: synthesis and evaluation of tubulin clustering and antimitotic activity in cancer cells

S. Kuznetsov, G. Butov, N. Zefirov, 2020 .

Synthesis, Antiproliferative Activity, and Effect on Carcinoma A549 Cell Microtubules of New Tubuloclustin Analogs

S. Kuznetsov, N. Zefirov, Y. Evteeva, 2019, Pharmaceutical Chemistry Journal.

Podophyllotoxin esters with alicyclic residues: an insight into the origin of microtubule-curling effect in cancer cells

S. Kuznetsov, N. Zefirov, E. Milaeva, 2022, Mendeleev Communications.

New podophyllotoxin and epipodophyllotoxin derivatives with substituted isoxazole fragments

D. Vasilenko, E. Averina, N. Zefirov, 2023, Russian Chemical Bulletin.

C(7)-Derivatives of colchicine with guanosine and biphenyl moieties: molecular modeling, synthesis, and tubulin clustering effect in cancer cells

S. Kuznetsov, N. Zefirov, O. Zefirova, 2020, Russian Chemical Bulletin.

“Triple” mutual prodrug based on 2-methoxyestradiol: synthesis and biotesting in vitro

S. Kuznetsov, E. Shevtsova, N. Zefirov, 2020, Russian Chemical Bulletin.

Novel bridged and caged C4-podophyllotoxin derivatives as microtubule disruptors: synthesis, cytotoxic evaluation and structure–activity relationship

S. Kuznetsov, N. Zefirov, O. Zefirova, 2018, Mendeleev Communications.

Synthesis of adamantane and bicyclo[3.3.1]nonane derivatives with the oxetane moiety

N. Zefirov, N. Zyk, O. Zefirova, 2007 .

Synthetic approaches to physiologically active polycyclic compounds: VII. Synthesis of 2-(7-Hydroxybicyclo-[3.3.1]non-3-ylmethyl)propane-1,3-diol

A. Ivanov, N. Zyk, O. Zefirova, 2008 .

Synthetic approaches to physiologically active polycyclic compounds: V. Ritter reaction of 4-hydroxyadamantan-2-one

S. Aldoshin, N. Zefirov, G. Shilov, 2004 .

Synthetic Approaches to Physiologically Active Polycyclic Compounds: IV. X-Ray Diffraction Study of Isomeric Amino Acid Derivatives of Adamantane

P. Nesterenko, S. Aldoshin, N. Zefirov, 2004 .

Synthetic Approaches to Physiologically Active Polycyclic Compounds: III. Ritter Reaction with Ketones of the Adamantane and Oxahomoadamantane Series

N. Zefirov, N. Zyk, O. Zefirova, 2004 .

Synthetic Approach to the Synthesis of Physiologically Active Compounds: II. Synthesis of Disubstituted Adamantanes Containing an N-Benzoylphenylisoserine Fragment

N. Zyk, O. Zefirova, V. N. Nuriev, 2003 .

Synthetic Approach to Preparation of Polycyclic Compounds Possessing Physiological Activity: I. Synthesis of 1,4-Disubstituted Adamantanes with Amino Acid Fragment

N. Zefirov, N. Zyk, O. Zefirova, 2002 .

Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4H)-ones and N-methyl-3,5-dihydro-4H-imidazol-4-ones as combretastatin A-4 analogs

A. Majouga, E. Beloglazkina, N. Zefirov, 2015, Russian Chemical Bulletin.

Bicyclic isothioureas for conjugation with tubulin targeted anticancer agents

K. Lyssenko, E. Milaeva, O. Zefirova, 2022, Mendeleev Communications.

Synthesis and biotesting of new carrier prodrugs of 2-methoxyestradiol

S. Kuznetsov, N. Maximova, N. Zefirov, 2020 .

Synthesis of steroid analogs of tubuloclustin, their cytotoxicity and effect on microtubules of A549 carcinoma cells

N. Zefirov, A. Mamaeva, O. Zefirova, 2018, Russian Chemical Bulletin.

Novel antimitotic agents related to tubuloclustin: synthesis and biological evaluation

S. Kuznetsov, N. Zefirov, O. Zefirova, 2017, Molecular Diversity.

Homologous series of novel adamantane–colchicine conjugates: synthesis and cytotoxic effect on human cancer cells

S. Kuznetsov, Y. Grishin, O. Maloshitskaya, 2018 .

Molecular and crystal structure of azabicyclo[3.3.1]nonane annelated with methylindole

O. Zefirova, A. Kurkin, E. V. Nurieva, 2012, Moscow University Chemistry Bulletin.

Molecular and crystal structures of hetero-analogues of bicyclo[3.3.1]nonane with nitrogen and sulfur atoms

T. P. Trofimova, O. Zefirova, Y. Slovokhotov, 2011 .

Molecular and crystal structure of indole derivatives fused with substituted bicyclo[3.3.1]nonane

N. Zyk, O. Zefirova, K. A. Potekhin, 2007 .

Molecular and crystal structure of ethylene acetal of endo-endo-3-trityloxymethylbicyclo[3.3.1]nonane-2-on-7-ol

N. Zyk, O. Zefirova, E. Nurieva, 2007 .

Synthesis and study of NOS-inhibiting activity of 2-N-acylamino-5,6-dihydro-4H-1,3-thiazine

M. Onufriev, N. Gulyaeva, O. Zefirova, 2008 .

Annulated bicyclic isothioureas: identification of active and selective butyrylcholinesterase inhibitors

G. Makhaeva, N. Zefirov, E. Milaeva, 2023, Mendeleev Communications.

N-(4-Methoxyphenyl)-substituted bicyclic isothioureas: effect on morphology of cancer cells

S. Kuznetsov, E. Milaeva, O. Zefirova, 2021, Mendeleev Communications.

Novel colchicine conjugate with unusual effect on the microtubules of cancer cells

S. Kuznetsov, N. Zefirov, O. Zefirova, 2020 .

Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues.

A. A. Ivanova, A. Ivanov, O. Zefirova, 2011, Bioorganic chemistry.

Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy

C. Morisseau, G. Butov, N. Zefirov, 2023, Journal of enzyme inhibition and medicinal chemistry.

Adamantane acid esters with alkoxyaryl alcohols: Synthesis, antiproliferative activity, and influence on microtubule network of tumor cells

N. Zefirov, O. Zefirova, S. Kuznetsov, 2017, Russian Chemical Bulletin.

Mono- and bis(steroids) containing a cyclooctane core: Synthesis, antiproliferative activity, and action on cell cytoskeleton microtubules.

K. Sedenkova, E. Averina, N. Zefirov, 2024, Archiv der Pharmazie.

Rimantadine derivatives with antiviral activity against flaviviruses and rimantadine-resistant strain of influenza A virus

E. V. Khvatov, O. Zefirova, E. Nurieva, 2024, Russian Chemical Bulletin.

New 1,1-dibenzyl-3-(1-benzyl-1H-pyrazol-4-yl)-2-methylisothioureas: synthesis and evaluation of antioxidant activity

V. Tafeenko, O. Zefirova, I. Serkov, 2024, Russian Chemical Bulletin.

Verubulin (Azixa) Analogues with Increased Saturation: Synthesis, SAR and Encapsulation in Biocompatible Nanocontainers Based on Ca2+ or Mg2+ Cross-Linked Alginate

A. Shtil, E. Shevtsova, K. Sedenkova, 2023, Pharmaceuticals.

New C(4)-esters of podophyllotoxin and epipodophyllotoxin with heterocyclic moieties

N. Zefirov, E. Milaeva, O. Zefirova, 2023, Russian Chemical Bulletin.