Ralph Holl

发表

Bioactive pyrrole-based compounds with target selectivity

V. Spanò, A. Montalbano, P. Barraja, 2020, European Journal of Medicinal Chemistry.

Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring

H. Humpf, P. Bednarski, B. Wünsch, 2009, ChemMedChem.

Relationships between the structure of 6-allyl-6,8-diazabicyclo[3.2.2]nonane derivatives and their sigma receptor affinity and cytotoxic activity.

P. Bednarski, B. Wünsch, R. Grünert, 2009, Bioorganic & medicinal chemistry.

Relationships between the structure of 6-substituted 6,8-diazabicyclo[3.2.2]nonan-2-ones and their sigma receptor affinity and cytotoxic activity.

P. Bednarski, B. Wünsch, R. Grünert, 2009, Bioorganic & medicinal chemistry.

A New, Efficient and Direct Preparation of TlTp and Related Complexes with TlBH4

B. Wünsch, M. Kitamura, Ralph Holl, 2008 .

Synthesis and biological evaluation of enantiomerically pure glyceric acid derivatives as LpxC inhibitors.

W. Sippl, Jelena Melesina, Jens Köhler, 2016, Bioorganic & medicinal chemistry.

Insights into the Zinc-Dependent Deacetylase LpxC: Biochemical Properties and Inhibitor Design.

D. Kalinin, Ralph Holl, 2016, Current topics in medicinal chemistry.

Chiral pool synthesis and biological evaluation of C-furanosidic and acyclic LpxC inhibitors.

Ralph Holl, V. Gabrielli, Oriana Agoglitta, 2016, European journal of medicinal chemistry.

Synthesis and biological evaluation of flexible and conformationally constrained LpxC inhibitors.

M. Teese, J. Jose, Alberto Oddo, 2013, Organic & biomolecular chemistry.

Pyrrolidine in Drug Discovery: A Versatile Scaffold for Novel Biologically Active Compounds

V. Spanò, A. Montalbano, P. Barraja, 2021, Topics in Current Chemistry.

Homologous piperazine-alcanols: chiral pool synthesis and pharmacological evaluation

B. Wünsch, D. Schepmann, Ralph Holl, 2012 .

Novel Potent Proline-Based Metalloproteinase Inhibitors: Design, (Radio)Synthesis, and First in Vivo Evaluation as Radiotracers for Positron Emission Tomography.

S. Rose-John, M. Schäfers, D. Kalinin, 2016, Journal of medicinal chemistry.

Development of novel LpxC inhibitors: chiral-pool synthesis of C-triazolyl glycosides

C. Daniliuc, J. Jose, Ralph Holl, 2013 .

Synthesis and biological evaluation of triazolyl-substituted benzyloxyacetohydroxamic acids as LpxC inhibitors.

W. Sippl, Jelena Melesina, Ralph Holl, 2020, Bioorganic & medicinal chemistry.

Proline-based hydroxamates targeting the zinc-dependent deacetylase LpxC: Synthesis, antibacterial properties, and docking studies.

W. Sippl, M. Schäfers, Jelena Melesina, 2019, Bioorganic & medicinal chemistry.

Stereocontrolled synthesis of four diastereomeric C-aryl manno- and talofuranosides.

Ralph Holl, S. Jana, R. Fröhlich, 2012, Carbohydrate research.

Chiral Pool Synthesis, Biological Evaluation and Molecular Docking Studies of C‐Furanosidic LpxC Inhibitors

W. Sippl, Jelena Melesina, Ralph Holl, 2019, ChemMedChem.

Design and stereoselective synthesis of a C-aryl furanoside as a conformationally constrained CHIR-090 analogue.

Alberto Oddo, Ralph Holl, 2012, Carbohydrate research.

Synthesis, biological evaluation, and molecular docking studies of deoxygenated C-glycosides as LpxC inhibitors.

W. Sippl, Jelena Melesina, Ralph Holl, 2021, Bioorganic chemistry.

Synthesis, biological evaluation, and molecular docking studies of aldotetronic acid-based LpxC inhibitors.

W. Sippl, P. Heisig, Jelena Melesina, 2022, Bioorganic chemistry.

Structure and Function of an Irreversible Agonist-β2 Adrenoceptor complex

Cheng Zhang, Ron O. Dror, Brian K. Kobilka, 2010, Nature.

Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

W. Sippl, C. Romier, M. Jung, 2019, ChemMedChem.

LpxC inhibitors: a patent review (2010-2016)

D. Kalinin, Ralph Holl, 2017, Expert opinion on therapeutic patents.

Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants.

Takayoshi Suzuki, W. Sippl, C. Romier, 2018, Journal of medicinal chemistry.

Synthesis and biological evaluation of C -ethynyl furanosides as LpxC inhibitors

C. Daniliuc, Ralph Holl, S. Jana, 2015 .

Synthesis of 2,5-Diazabicyclo[2.2.2]octanes by Dieckmann Analogous Cyclization

B. Wünsch, E. Würthwein, M. Kitamura, 2008 .

Phenylethylene glycol-derived LpxC inhibitors with diverse Zn2+-binding groups

J. Kirchmair, F. Galla, Ralph Holl, 2019, Tetrahedron.

Antibacterial activity of xylose-derived LpxC inhibitors - Synthesis, biological evaluation and molecular docking studies.

J. Kirchmair, P. Heisig, M. Brönstrup, 2020, Bioorganic chemistry.

C-Triazolyl β-d-furanosides as LpxC inhibitors: stereoselective synthesis and biological evaluation

C. Daniliuc, Ralph Holl, S. Jana, 2014 .

Synthesis, biological evaluation and molecular docking studies of benzyloxyacetohydroxamic acids as LpxC inhibitors.

W. Sippl, K. Wichapong, Jelena Melesina, 2014, Bioorganic & medicinal chemistry.