Chiara Bertagnin

发表

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

M. Loza, J. Brea, L. Goracci, 2020, European Journal of Medicinal Chemistry.

A novel small-molecule inhibitor of the human papillomavirus E6-p53 interaction that reactivates p53 function and blocks cancer cells growth.

F. Spyrakis, L. Goracci, G. Cruciani, 2019, Cancer letters.

Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.

Dongwei Kang, P. Zhan, Xinyong Liu, 2021, Journal of medicinal chemistry.

A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells

G. Palù, A. Loregian, B. Mercorelli, 2018, Scientific Reports.

Discovery of highly potent and selective influenza virus neuraminidase inhibitors targeting 150-cavity.

P. Zhan, Xinyong Liu, A. Loregian, 2020, European journal of medicinal chemistry.

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

P. Zhan, Xinyong Liu, A. Loregian, 2022, Molecules.

Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity.

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib

G. Alvisi, L. Banks, G. Palù, 2021, Cancers.

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells

A. Loregian, B. Mercorelli, Chiara Bertagnin, 2021, Cancers.

Optimization of N-Substituted Oseltamivir Derivatives as Potent Inhibitors of Group-1 and -2 Influenza A Neuraminidases, Including a Drug-Resistant Variant.

Peng Zhan, Xiao Ding, Ye Tian, 2018, Journal of medicinal chemistry.

Potent and broad‐spectrum cycloheptathiophene‐3‐carboxamide compounds that target the PA‐PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance

G. Palù, A. Loregian, B. Mercorelli, 2019, Antiviral research.

A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells

G. Palù, A. Loregian, B. Mercorelli, 2018, Scientific Reports.

A small molecule targeting the interaction between human papillomavirus E7 oncoprotein and cellular phosphatase PTPN14 exerts antitumoral activity in cervical cancer cells.

M. Sturlese, A. Loregian, B. Mercorelli, 2023, Cancer Letters.

1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.

A. Loregian, J. Neyts, Serena Massari, 2021, European journal of medicinal chemistry.

A novel N-heterocycles substituted oseltamivir derivatives as potent inhibitors of influenza virus neuraminidase: discovery, synthesis and biological evaluation

P. Zhan, Xinyong Liu, A. Loregian, 2023, Journal of enzyme inhibition and medicinal chemistry.

Exploring a New Generation of Pyrimidine and Pyridine Derivatives as Anti-Influenza Agents Targeting the Polymerase PA–PB1 Subunits Interaction

F. Musumeci, A. Loregian, Chiara Bertagnin, 2024, Pharmaceutics.