Douglas A Lauffenburger

发表

Pharmacometrics and Systems Pharmacology 2030

Stephen Duffull, Eric Sobie, France Mentré, 2019, Clinical pharmacology and therapeutics.

Querying quantitative logic models (Q2LM) to study intracellular signaling networks and cell-cytokine interactions

Douglas A Lauffenburger, Zachary Shriver, Melody K Morris, 2011, Biotechnology journal.

A biological approach to computational models of proteomic networks.

Kevin A Janes, Douglas A Lauffenburger, D. Lauffenburger, 2006, Current opinion in chemical biology.

Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

Murat Cirit, Gaurav Rohatgi, Xin Wang, 2018, Scientific Reports.

Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.

Mingsheng Zhang, Leonidas G Alexopoulos, Douglas A Lauffenburger, 2011, Cancer research.

PTMScout, a Web Resource for Analysis of High Throughput Post-translational Proteomics Studies*

Kristen M. Naegle, Melissa Gymrek, Forest M White, 2010, Molecular & Cellular Proteomics.

Computational translation of genomic responses from experimental model systems to humans

Douglas A Lauffenburger, Douglas K Brubaker, Elizabeth A Proctor, 2019, PLoS Comput. Biol..

Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering

James J Collins, Douglas A Lauffenburger, Shuai Li, 2019, Nature Biotechnology.

Insights into proteomic immune cell signaling and communication via data-driven modeling.

Douglas A Lauffenburger, Kelly F Benedict, D. Lauffenburger, 2013, Current topics in microbiology and immunology.

A mammalian functional-genetic approach to characterizing cancer therapeutics.

Douglas A Lauffenburger, Hai Jiang, Justin R Pritchard, 2010, Nature chemical biology.

Addressing genetic tumor heterogeneity through computationally predictive combination therapy.

Douglas A Lauffenburger, Boyang Zhao, Justin R Pritchard, 2013, Cancer discovery.

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development.

Jeffrey T Borenstein, Douglas A Lauffenburger, Linda G Griffith, 2014, Drug discovery today.

Predicting cancer drug mechanisms of action using molecular network signatures.

Douglas A Lauffenburger, Justin R Pritchard, Michael T Hemann, 2013, Molecular bioSystems.

Modeling and computational analysis of EGF receptor-mediated cell communication in Drosophila oogenesis.

Douglas A Lauffenburger, Stanislav Y Shvartsman, D. Lauffenburger, 2002, Development.

Cellular barcodes for efficiently profiling single-cell secretory responses by microengraving.

J Christopher Love, Douglas A Lauffenburger, Yvonne J Yamanaka, 2012, Analytical chemistry.

Directional persistence of EGF-induced cell migration is associated with stabilization of lamellipodial protrusions.

Douglas A Lauffenburger, Alan Rick Horwitz, D. Lauffenburger, 2005, Biophysical journal.

Multiple signaling pathways mediate compaction of collagen matrices by EGF-stimulated fibroblasts.

Alan Wells, Douglas A Lauffenburger, D. Lauffenburger, 2006, Experimental cell research.

Cutting to the chase: calpain proteases in cell motility.

Alan Wells, Douglas A Lauffenburger, Angela Glading, 2002, Trends in cell biology.

Co-regulation of cell adhesion by nanoscale RGD organization and mechanical stimulus.

Douglas A Lauffenburger, Linda G Griffith, Darrell J Irvine, 2002, Journal of cell science.

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities.

Douglas A Lauffenburger, Linda G Griffith, Andreas Herrlich, 2011, Integrative biology : quantitative biosciences from nano to macro.

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

Alan Wells, Douglas A Lauffenburger, H Steven Wiley, 2007, Journal of Cell Science.

Local remodeling of synthetic extracellular matrix microenvironments by co-cultured endometrial epithelial and stromal cells enables long-term dynamic physiological function.

Douglas A Lauffenburger, Linda G Griffith, Christi D Cook, 2017, Integrative biology : quantitative biosciences from nano to macro.

Effects of Bcl-2 Levels on Fas Signaling-Induced Caspase-3 Activation: Molecular Genetic Tests of Computational Model Predictions1

Douglas A Lauffenburger, Cynthia L Stokes, D. Lauffenburger, 2005, The Journal of Immunology.

Control of self-assembling oligopeptide matrix formation through systematic variation of amino acid sequence.

Roger D Kamm, Douglas A Lauffenburger, Michael R Caplan, 2002, Biomaterials.

Endothelial cell phenotypic behaviors cluster into dynamic state transition programs modulated by angiogenic and angiostatic cytokines.

Tharathorn Rimchala, Roger D Kamm, Douglas A Lauffenburger, 2013, Integrative biology : quantitative biosciences from nano to macro.

Microfluidic concentration-enhanced cellular kinase activity assay.

Jongyoon Han, Douglas A Lauffenburger, Jeong Hoon Lee, 2009, Journal of the American Chemical Society.

Quantitative modeling perspectives on the ErbB system of cell regulatory processes.

Douglas A Lauffenburger, D. Lauffenburger, M. Lazzara, 2008, Experimental cell research.

Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling.

Douglas A Lauffenburger, Wendy Prudhomme, Wendy A. Prudhomme, 2004, Proceedings of the National Academy of Sciences of the United States of America.

ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling

Jongyoon Han, Douglas A Lauffenburger, Linda G Griffith, 2013, Proceedings of the National Academy of Sciences.

Effects of systematic variation of amino acid sequence on the mechanical properties of a self-assembling, oligopeptide biomaterial

Roger D Kamm, Douglas A Lauffenburger, Michael R Caplan, 2002, Journal of biomaterials science. Polymer edition.

Computational model for cell migration in three-dimensional matrices.

Paul Matsudaira, Roger D Kamm, Douglas A Lauffenburger, 2005, Biophysical journal.

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Robert Langer, Michael J Cima, Douglas A Lauffenburger, 2016, Cancer discovery.

Enhancing protease activity assay in droplet-based microfluidics using a biomolecule concentrator.

Yong-Ak Song, Sung Jae Kim, Jongyoon Han, 2011, Journal of the American Chemical Society.

Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk

Murat Cirit, Jiajie Yu, Douglas A Lauffenburger, 2017, Biotechnology and bioengineering.

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions.

Forest M White, Douglas A Lauffenburger, Michael B Yaffe, 2012, Molecular bioSystems.

Cardiomyocyte hypertrophy and degradation of connexin43 through spatially restricted autocrine/paracrine heparin-binding EGF.

Richard T. Lee, Douglas A Lauffenburger, Hayden Huang, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Growth Factor-Induced Cell Motility in Tumor Invasion

Alan Wells, Douglas A Lauffenburger, Timothy Turner, 2002, Acta oncologica.

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

Douglas A Lauffenburger, Kevin M Haigis, D. Lauffenburger, 2009, Cancer research.

Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding.

Holger Conzelmann, Laura B. Kleiman, Thomas Maiwald, 2011, Molecular cell.

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Hakho Lee, Ralph Weissleder, Douglas A Lauffenburger, 2016, Cancer discovery.

Models of signalling networks – what cell biologists can gain from them and give to them

Kevin A Janes, Douglas A Lauffenburger, D. Lauffenburger, 2013, Journal of Cell Science.

Microarchitecture of three-dimensional scaffolds influences cell migration behavior via junction interactions.

Douglas A Lauffenburger, Muhammad H Zaman, D. Lauffenburger, 2008, Biophysical journal.

Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways.

Roger D Kamm, Douglas A Lauffenburger, Hao Xing, 2016, Cancer research.

Microfluidic shear devices for quantitative analysis of cell adhesion.

Douglas A Lauffenburger, Klavs F Jensen, Hang Lu, 2004, Analytical chemistry.

Intratumor heterogeneity alters most effective drugs in designed combinations

Douglas A Lauffenburger, Boyang Zhao, Michael T Hemann, 2014, Proceedings of the National Academy of Sciences.

A microphysiological system model of therapy for liver micrometastases

Alan Wells, Jeffrey T Borenstein, Douglas A Lauffenburger, 2014, Experimental biology and medicine.

Marrow‐Derived stem cell motility in 3D synthetic scaffold is governed by geometry along with adhesivity and stiffness

Douglas A Lauffenburger, Linda G Griffith, Shelly R Peyton, 2010, Biotechnology and bioengineering.

Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility.

Douglas A Lauffenburger, Linda G Griffith, Hilde Jørgensen, 2017, Fertility and sterility.

Clonal evolution of stem and differentiated cells can be predicted by integrating cell‐intrinsic and ‐extrinsic parameters

Peter W Zandstra, Douglas A Lauffenburger, Donavan T. Cheng, 2005, Biotechnology and applied biochemistry.

Kinetic model for lamellipodal actin-integrin 'clutch' dynamics

Douglas A Lauffenburger, D. Lauffenburger, Alice Macdonald, 2008, Cell adhesion & migration.

An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells.

Kristen M. Naegle, Forest M White, Douglas A Lauffenburger, 2008, Molecular bioSystems.

Effects of HER2 overexpression on cell signaling networks governing proliferation and migration

Sampsa Hautaniemi, Alejandro Wolf-Yadlin, Forest M White, 2006, Molecular systems biology.

Ligand accumulation in autocrine cell cultures.

Douglas A Lauffenburger, Stanislav Y Shvartsman, H Steven Wiley, 2005, Biophysical journal.

Identification of drug-specific pathways based on gene expression data: application to drug induced lung injury.

Julio Saez-Rodriguez, Theodore Sakellaropoulos, Leonidas G Alexopoulos, 2015, Integrative biology : quantitative biosciences from nano to macro.

Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis

Douglas A Lauffenburger, Suzanne Gaudet, Peter K Sorger, 2011, Molecular systems biology.

Quantitative methods for developing Fc mutants with extended half-lives.

Bruce Tidor, Daniel T Kamei, Douglas A Lauffenburger, 2005, Biotechnology and bioengineering.

Quantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer.

Douglas A Lauffenburger, D. Lauffenburger, Shannon K. Hughes-Alford, 2012, Current opinion in cell biology.

Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence.

Tiffany W Guo, Alan Wells, Douglas A Lauffenburger, 2008, Molecular biology of the cell.

Calpain proteases in cell adhesion and motility.

Alan Wells, Douglas A Lauffenburger, Anna Huttenlocher, 2005, International review of cytology.