G. Bouma

发表

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice.

J. Hartwig, L. Notarangelo, J. Walter, 2012, Blood.

Recent advances in the understanding of genetic defects of neutrophil number and function

S. Burns, A. Thrasher, G. Bouma, 2010, British journal of haematology.

Phosphorylation of WASp is a key regulator of activity and stability in vivo

S. Snapper, Gareth E. Jones, A. Worth, 2009, Proceedings of the National Academy of Sciences of the United States of America.

Long-term expression from non-integrating lentiviral vectors in muscle

Nj Ward, Luis Apolonia, Gerben Bouma, 2007 .

Immunode fi ciency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL 1

G. Charras, S. Nejentsev, V. Plagnol, 2022 .

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Y. Lau, S. Mostowy, S. Burns, 2017, Nature Communications.

An increased MRP8/14 expression and adhesion, but a decreased migration towards proinflammatory chemokines of type 1 diabetes monocytes

H. Drexhage, S. Sozzani, W. Luini, 2005, Clinical and experimental immunology.

Migratory and antigen presentation functions of IFN-producing killer dendritic cells.

John Anderson, S. Howe, M. Yan, 2009, Cancer research.

Cells with dendritic cell morphology and immunophenotype, binuclear morphology, and immunosuppressive function in dendritic cell cultures.

A. Duncan, John Anderson, Prabhjoat S. Chana, 2011, Cellular immunology.

WASp-deficient dendritic cells Impaired T-cell priming in vivo resulting from dysfunction of

S. Burns, A. Thrasher, G. Bouma, 2011 .

Impaired T-cell priming in vivo resulting from dysfunction of WASp-deficient dendritic cells.

S. Burns, A. Thrasher, G. Bouma, 2007, Blood.

impaired peripheral homeostasis Wiskott-Aldrich syndrome protein deficiency in B cells results in

D. Rawlings, A. Thrasher, F. Batista, 2012 .

Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis

D. Rawlings, A. Thrasher, F. Batista, 2008, Blood.

CCL20 neutralization by a monoclonal antibody in healthy subjects selectively inhibits recruitment of CCR6+ cells in an experimental suction blister

M. Herdman, S. Zamuner, D. Robertson, 2017, British journal of clinical pharmacology.

Diabetes‐prone NOD mice show an expanded subpopulation of mature circulating monocytes, which preferentially develop into macrophage‐like cells in vitro

H. Drexhage, T. Nikolić, P. Leenen, 2005, Journal of leukocyte biology.

Epigenetically quantified immune cells in salivary glands of Sjögren’s syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology

R. Goldschmeding, J. V. van Roon, A. Kruize, 2019, Rheumatology.

Improvement of migratory defects in a murine model of Wiskott-Aldrich syndrome gene therapy.

A. Thrasher, C. Kinnon, Y. Calle, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Structure and Functional Characterization of a Humanized Anti-CCL20 Antibody following Exposure to Serum Reveals the Formation of Immune Complex That Leads to Toxicity

M. Herdman, J. R. White, J. Taylor, 2021, The Journal of Immunology.

Immune complex disease in a chronic monkey study with a humanised, therapeutic antibody against CCL20 is associated with complement-containing drug aggregates

M. Herdman, J. R. White, T. Ramani, 2020, PloS one.

compartment in mice (WASp) causes severe abnormalities of the peripheral B-cell intrinsic deficiency of the Wiskott-Aldrich syndrome protein - B cell

J. Hartwig, F. Frugoni, M. Massaad, 2012 .

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011, Blood.

necessary for normal immune synapse formation and T-cell priming Cytoskeletal remodeling mediated by WASp in dendritic cells is

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin.

H. Drexhage, M. Versnel, A. Wierenga-wolf, 2004, Diabetes.

ImmUniverse Consortium: Multi-omics integrative approach in personalized medicine for immune-mediated inflammatory diseases

J. Raes, A. Kaser, P. Rosenstiel, 2022, Frontiers in Immunology.

Exacerbated experimental arthritis in Wiskott–Aldrich syndrome protein deficiency: Modulatory role of regulatory B cells

L. Notarangelo, S. Burns, A. Thrasher, 2014, European journal of immunology.

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts

G. Charras, Peter M. G. Munro, Hannah E. J. Armer, 2015, Journal of leukocyte biology.

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.

G. Charras, S. Nejentsev, V. Plagnol, 2015, Blood.

Adhesion and Migration of Monocytes and Dendritic Cells in Type 1 Diabetes

G. Bouma, 2005 .

The Wiskott-Aldrich Syndrome: The Actin Cytoskeleton and Immune Cell Function

A. Worth, A. Thrasher, G. Bouma, 2010, Disease markers.

Wiskott–Aldrich Syndrome: Immunodeficiency resulting from defective cell migration and impaired immunostimulatory activation

Adrian J. Thrasher, Gerben Bouma, Siobhan O. Burns, 2009, Immunobiology.

Wiskott-Aldrich syndrome as a model of cytoskeleton defects

S. Burns, A. Thrasher, G. Bouma, 2006 .

A partial down-regulation of WASP is sufficient to inhibit podosome formation in dendritic cells.

W. Vainchenker, A. Olivier, O. Danos, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Stable gene transfer to muscle using non-integrating lentiviral vectors.

Luis Apolonia, Gerben Bouma, N. Philpott, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Deletion of Wiskott–Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells

S. Snapper, Marisa A. P. Baptista, A. Worth, 2016, Nature Communications.

Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency

T. Mak, S. Scheu, D. Häussinger, 2013, The Journal of allergy and clinical immunology.

Impaired neutrophil migration and phagocytosis in IRAK‐4 deficiency

Smita Y. Patel, S. Burns, A. Thrasher, 2009, British journal of haematology.

Disease-associated missense mutations in the EVH1 domain disrupt intrinsic WASp function causing dysregulated actin dynamics and impaired dendritic cell migration.

G. Charras, A. Worth, S. Burns, 2013, Blood.

NOD mice have a severly impaired ability to recruit leukocytes into sites of inflammation

H. Drexhage, S. Sozzani, M. Versnel, 2005, European journal of immunology.

Brain-derived human immunodeficiency virus-1 Tat exerts differential effects on LTR transactivation and neuroimmune activation

J. McArthur, C. Power, C. Pardo, 2007, Journal of NeuroVirology.

Randomized Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2831781 in Healthy Japanese and White Participants

A. S. Gross, L. Liefaard, G. Bouma, 2022, Clinical pharmacology in drug development.

Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse

Michael Loran Dustin, T. Springer, D. Stokes, 2018, Wellcome open research.

Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse

Michael Loran Dustin, T. Springer, D. Stokes, 2018, Wellcome open research.

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

S. Degn, G. Victora, G. Bajic, 2019, Cell reports.

Evidence for an enhanced adhesion of DC to fibronectin and a role of CCL19 and CCL21 in the accumulation of DC around the pre‐diabetic islets in NOD mice

H. Drexhage, S. Sozzani, M. Versnel, 2005, European journal of immunology.

Functional Gap Junctions Accumulate at the Immunological Synapse and Contribute to T Cell Activation

K. Webb, A. Thrasher, A. Kalergis, 2011, The Journal of Immunology.

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

K. Karwacz, A. Thrasher, M. Collins, 2009, Journal of Virology.

A randomised, double‐blind, placebo‐controlled study of the LAG‐3‐depleting monoclonal antibody GSK2831781 in patients with active ulcerative colitis

S. Hanauer, G. D'Haens, L. Peyrin-Biroulet, 2023, Alimentary pharmacology & therapeutics.

Activation Immunological Synapse and Contribute to T Cell Functional Gap Junctions Accumulate at the

K. Webb, A. Thrasher, A. Kalergis, 2011 .

Phosphorylation of WASp is a key regulator of activity and stability in vivo

S. Snapper, A. Worth, S. Burns, 2009, Proceedings of the National Academy of Sciences.

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts

G. Charras, Peter M. G. Munro, Hannah E. J. Armer, 2015, Journal of leukocyte biology.

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming.

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011, Blood.

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Cytoskeletal remodeling mediated by WASp in dendritic cells is necessary for normal immune synapse formation and T-cell priming

Kathryn L. Parsley, S. Burns, A. Thrasher, 2011 .

Nonintegrating Lentivector Vaccines Stimulate Prolonged T-Cell and Antibody Responses and Are Effective in Tumor Therapy

K. Karwacz, A. Thrasher, M. Collins, 2009, Journal of Virology.

Immunodeficiency and severe susceptibility to bacterial infection associated with a loss-of-function homozygous mutation of MKL1.

G. Charras, S. Nejentsev, V. Plagnol, 2015, Blood.

Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells

Y. Lau, S. Mostowy, S. Burns, 2017, Nature Communications.