K. Cundy

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Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs

G. Liversidge, Kenneth C. Cundy, K. Cundy, 1995 .

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Norbert Bischofberger, Matt Williams, C. Sweet, 1998, Antimicrobial Agents and Chemotherapy.

Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.

B. Ames, Y. Yamamoto, R. Kohen, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Unexpected pehnomenon in the high-performance liquid chromatographic anlaysis of racemic 14C-labelled nicotine: Separation of enantiomers in a totally achiral system

P. Crooks, K. Cundy, 1983 .

High-performance liquid chromatographic method for the determination of N-methylated metabolites of nicotine.

P. Crooks, K. Cundy, 1984, Journal of chromatography.

Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage.

B. Ames, R. Kohen, K. Cundy, 1988, Basic life sciences.

Properties Compared to R-Baclofen.

M. Gallop, J. Sukbuntherng, K. Koller, 2009 .

XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

R. Barrett, M. Gallop, T. Chernov-Rogan, 2004, Journal of Pharmacology and Experimental Therapeutics.

Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.

N. Pedersen, J. Lifson, K. V. Van Rompay, 1998, AIDS research and human retroviruses.

Penetration of GS4071, a novel influenza neuraminidase inhibitor, into rat bronchoalveolar lining fluid following oral administration of the prodrug GS4104

K. Cundy, E. Eisenberg, A. Bidgood, 1997, Antimicrobial agents and chemotherapy.

Penetration of GS 4071 , a Novel Influenza Neuraminidase Inhibitor , into Rat Bronchoalveolar Lining Fluid following Oral Administration of the Prodrug GS 4104

K. Cundy, E. Eisenberg, A. Bidgood, 1997 .

Efficacy of gabapentin enacarbil vs placebo in patients with postherpetic neuralgia and a pharmacokinetic comparison with oral gabapentin.

M. Backonja, K. Cundy, D. Canafax, 2011, Pain medicine.

Evaluation of gabapentin enacarbil on cardiac repolarization: a randomized, double-blind, placebo- and active-controlled, crossover thorough QT/QTc study in healthy adults.

K. Zomorodi, Dan Chen, R. Lal, 2012, Clinical therapeutics.

The surface modified drug nanoparticles

G. Liversidge, K. Cundy, J. F. Bishop, 1992 .

A Novel Oligodeoxynucleotide Inhibitor of Thrombin. II. Pharmacokinetics in the Cynomolgus Monkey

William A. Lee, J. Shaw, L. C. Bock, 1995, Pharmaceutical Research.

Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies.

J. Shaw, A. Tarantal, M. Marthas, 1999, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection.

B. Ames, J. Park, K. Cundy, 1989, Carcinogenesis.

[54] In vivo oxidative DNA damage : measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection

B. Ames, C. J. Gimeno, Jeen-Woo Park, 1990 .

Metabolism of the influenza neuraminidase inhibitor prodrug oseltamivir in the rat.

W. Lew, K. Y. Wang, K. Cundy, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects.

M. Wachsman, H. Jaffe, P. Lietman, 1996, Antiviral research.

The design of potent and stable benzisothiazolone inhibitors of human leukocyte elastase

R. Gordon, A. Rowlands, D. Hlasta, 1995 .

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Z. H. Li, K. Kent, D. Mendel, 1994, Antimicrobial Agents and Chemotherapy.

Clinical pharmacokinetics of gabapentin after administration of gabapentin enacarbil extended-release tablets in patients with varying degrees of renal function using data from an open-label, single-dose pharmacokinetic study.

J. Sukbuntherng, Dan Chen, R. Lal, 2012, Clinical therapeutics.

Aryl Ester Prodrugs of Cyclic HPMPC. I: Physicochemical Characterization and In Vitro Biological Stability

William A. Lee, J. Shaw, R. Oliyai, 1999, Pharmaceutical Research.

Antiviral Efficacy and Pharmacokinetics of Oral Adefovir Dipivoxil in Chronically Woodchuck Hepatitis Virus-Infected Woodchucks

C. Gibbs, J. Cullen, K. Cundy, 2001, Antimicrobial Agents and Chemotherapy.

Evidence of stereospecificity in the in vivo methylation of [14C](+/-)-nicotine in the guinea pig.

P. Crooks, C. Godin, K. Cundy, 1984, Drug metabolism and disposition: the biological fate of chemicals.

Orally bioavailable acyclic nucleoside phosphonate prodrugs: Adefovir dipivoxil and bis(POC)PMPA

J. Dougherty, K. Cundy, N. Bischofberger, 1999 .

Pharmacokinetics, bioavailability, metabolism, and tissue distribution of cidofovir (HPMPC) and cyclic HPMPC in rats.

J. Shaw, L. Griffin, K. Cundy, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.

William A. Lee, P. Tellier, K. Cundy, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Clinical Pharmacokinetics of 1-[((S)-2-Hydroxy-2-Oxo-1,4,2-Dioxaphosphorinan-5-yl)methyl]cytosine in Human Immunodeficiency Virus-Infected Patients

P. Lietman, B. Petty, K. Cundy, 1999, Antimicrobial Agents and Chemotherapy.

Anti-human immunodeficiency virus (HIV) activity, safety, and pharmacokinetics of adefovir dipivoxil (9-[2-(bis-pivaloyloxymethyl)-phosphonylmethoxyethyl]adenine) in HIV-infected patients.

C. Hendrix, J. Toole, H. Jaffe, 1997, The Journal of infectious diseases.

Distribution and metabolism of intravitreal cidofovir and cyclic HPMPC in rabbits.

J. Shaw, K. Cundy, M. Hitchcock, 1996, Current eye research.

Metabolism and Pharmacokinetics of Novel Oral Prodrugs of 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA) in Dogs

William A. Lee, J. Shaw, R. Oliyai, 1997, Pharmaceutical Research.

Pharmacokinetics and Bioavailability of the Anti-Human Immunodeficiency Virus Nucleotide Analog 9-[(R)2-(Phosphonomethoxy)Propyl]Adenine (PMPA) in Dogs

William A. Lee, J. Shaw, L. Griffin, 1998, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.

J. Shaw, V. Krishnamurthy, K. Cundy, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Isolation and identification of a metabolite of cidofovir from rat kidney.

K. Krishnamurty, K. Cundy, E. Eisenberg, 1998, Journal of pharmaceutical and biomedical analysis.

Bioavailability and metabolism of cidofovir following topical administration to rabbits.

K. Cundy, W. A. Lee, G. Lynch, 1997, Antiviral research.

Safety, Pharmacokinetics, and Antiretroviral Activity of Intravenous 9-[2-(R)-(Phosphonomethoxy)propyl]adenine, a Novel Anti-Human Immunodeficiency Virus (HIV) Therapy, in HIV-Infected Adults

Steven G. Deeks, James F. Rooney, J. Kahn, 1998, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high‐flux hemodialysis

F. Aweeka, M. Humphreys, J. Gambertoglio, 1999, Clinical pharmacology and therapeutics.

Oral Bioavailability of the Antiretroviral Agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) from Three Formulations of the Prodrug Bis(pivaloyloxymethyl)-PMEA in Fasted Male Cynomolgus Monkeys

William A. Lee, J. Shaw, K. Soike, 1994, Pharmaceutical Research.

Pharmacokinetic measurement of drugs in lung epithelial lining fluid by microdialysis: aminoglycoside antibiotics in rat bronchi.

W. Eickhoff, K. Cundy, E. Eisenberg, 1993, Journal of pharmacological and toxicological methods.

Determination of Allopurinol and Oxypurinol in Rat Plasma, Intestinal Wash, and Bile by High-Performance Liquid Chromatography with Electrochemical Detection (HPLC/EC) Following Automated Solid Phase Extraction

G. Liversidge, K. Cundy, E. Eisenberg, 1991, Pharmaceutical Research.

Amperometric high-performance liquid chromatographic detection of NADH at a base-activated glassy carbon electrode

K. Cundy, E. Eisenberg, 1991 .

High-performance liquid chromatographic determination of GS4071, a potent inhibitor of influenza neuraminidase, in plasma by precolumn fluorescence derivatization with naphthalenedialdehyde.

K. Cundy, E. Eisenberg, 1998, Journal of chromatography. B, Biomedical sciences and applications.

Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and Adefovir

K. Cundy, 1999, Clinical pharmacokinetics.

Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients

A. Collier, J. Toole, H. Jaffe, 1995, Antimicrobial agents and chemotherapy.

Oral formulations of adefovir dipivoxil: in vitro dissolution and in vivo bioavailability in dogs.

J. Shaw, G. Visor, C. Nakamura, 1997, Journal of pharmaceutical sciences.

Oral, subcutaneous, and intramuscular bioavailabilities of the antiviral nucleotide analog 9-(2-phosphonylmethoxyethyl) adenine in cynomolgus monkeys

J. Shaw, K. Cundy, W. A. Lee, 1994, Antimicrobial Agents and Chemotherapy.

(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogue.

J. C. Martin, J. Hannigan, J. Lalezari, 1995, The Journal of infectious diseases.

Effect of probenecid on the distribution, metabolism, and excretion of cidofovir in rabbits.

Z. H. Li, K. Cundy, W. A. Lee, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Pharmacokinetics of cidofovir in monkeys. Evidence for a prolonged elimination phase representing phosphorylated drug.

Z. H. Li, K. Cundy, M. Hitchcock, 1996, Drug Metabolism And Disposition.

Selective Intracellular Activation of a Novel Prodrug of the Human Immunodeficiency Virus Reverse Transcriptase Inhibitor Tenofovir Leads to Preferential Distribution and Accumulation in Lymphatic Tissue

William A. Lee, T. Cihlar, S. Swaminathan, 2005, Antimicrobial Agents and Chemotherapy.

Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients

M. Polis, M. Wachsman, J. Lalezari, 1995, Antimicrobial agents and chemotherapy.

Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1

S. Blanchard, J. Rodman, J. Shenep, 2000, Antimicrobial Agents and Chemotherapy.

High-performance liquid chromatographic determination of cytosine-containing compounds by precolumn fluorescence derivatization with phenacyl bromide: application to antiviral nucleosides and nucleotides.

K. Cundy, E. Eisenberg, 1996, Journal of chromatography. B, Biomedical applications.

Pharmacokinetics and tolerability of single escalating doses of gabapentin enacarbil: a randomized-sequence, double-blind, placebo-controlled crossover study in healthy volunteers.

J. Sukbuntherng, Dan Chen, R. Lal, 2009, Clinical therapeutics.

Arbaclofen Placarbil, a Novel R-Baclofen Prodrug: Improved Absorption, Distribution, Metabolism, and Elimination Properties Compared with R-Baclofen

M. Gallop, J. Sukbuntherng, K. Koller, 2009, Journal of Pharmacology and Experimental Therapeutics.

A Randomized, Double-Blind, Placebo-Controlled, Dose-Response Study to Assess the Pharmacokinetics, Efficacy, and Safety of Gabapentin Enacarbil in Subjects With Restless Legs Syndrome

K. Zomorodi, A. Ellenbogen, Dan Chen, 2012, Clinical neuropharmacology.

Remarkable substrate-inhibitor properties of nicotine enantiomers towards a guinea pig lung aromatic azaheterocycle N-methyltransferase.

P. Crooks, C. Godin, K. Cundy, 1985, Biochemical and Biophysical Research Communications - BBRC.

Stereospecific in vitro N-methylation of nicotine in guinea pig tissues by an S-adenosylmethionine-dependent N-methyltransferase.

P. Crooks, C. Godin, K. Cundy, 1985, Biochemical pharmacology.

Randomised clinical trial: arbaclofen placarbil in gastro‐oesophageal reflux disease – insights into study design for transient lower sphincter relaxation inhibitors

N. Vakil, F. Huff, K. Cundy, 2013, Alimentary pharmacology & therapeutics.

Relationship between structure and bioavailability in a series of hydroxamate based metalloprotease inhibitors

R. Wahl, B. Morgan, D. Whipple, 1995 .

Biotransformation of primary nicotine metabolites. II. Metabolism of [3H]-S-(-)-cotinine in the guinea pig: determination of in vivo urinary metabolites by high-performance liquid-radiochromatography.

P. Crooks, K. Cundy, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Stereospecific in vivo N-methylation of nicotine in the guinea pig.

P. Crooks, M. Sato, K. Cundy, 1985, Drug metabolism and disposition: the biological fate of chemicals.

XP13512 [(±)-1-([(α-Isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: II. Improved Oral Bioavailability, Dose Proportionality, and Colonic Absorption Compared with Gabapentin in Rats and Monkeys

R. Barrett, M. Gallop, W. Luo, 2004, Journal of Pharmacology and Experimental Therapeutics.

aminomethyl )-1-cyclohexane Acetic Acid ] , A Novel Gabapentin Prodrug : II . Improved Oral Bioavailability , Dose Proportionality , and Colonic Absorption Compared with Gabapentin in Rats and Monkeys

R. Barrett, M. Gallop, W. Luo, 2004 .

Clinical Evaluation of Xp19986 as a Potential Treatment for GERD: 25

J. Sukbuntherng, F. Huff, R. Lal, 2008 .

Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine.

J. Sukbuntherng, R. Lal, W. Luo, 2010, British journal of clinical pharmacology.

A phase I, single-dose study of the disposition of 14C-radiolabeled gabapentin enacarbil in healthy male volunteers.

J. Sukbuntherng, R. Lal, K. Cundy, 2011, International journal of clinical pharmacology and therapeutics.

The effect of food with varying fat content on the clinical pharmacokinetics of gabapentin after oral administration of gabapentin enacarbil.

J. Sukbuntherng, F. Huff, R. Lal, 2010, International journal of clinical pharmacology and therapeutics.

XP13512 aminomethyl)-1-cyclohexane Acetic Acid], A Novel Gabapentin Prodrug: I. Design, Synthesis, Enzymatic Conversion to Gabapentin, and Transport by Intestinal Solute Transporters

R. Barrett, M. Gallop, T. Chernov-Rogan, 2004 .

Comparative Gastric Irritation of the Fumaric Acid Esters Dimethyl Fumarate (DMF) and XP23829 in Rat and Monkey (P01.159)

K. Cundy, D. Wustrow, T. Annamalai, 2013, Neurology.

NEUROPATHIC PAIN SECTION Original Research Articles Efficacy of Gabapentin Enacarbil vs Placebo in Patients with Postherpetic Neuralgia and a Pharmacokinetic Comparison with Oral Gabapentin

M. Backonja, K. Cundy, D. Canafax, 2011 .

Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs

J. Dougherty, J. Shaw, R. Oliyai, 1997 .

Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin

W. Luo, K. Cundy, D. Canafax, 2008, Journal of clinical pharmacology.

Double‐blind study of the actively transported levodopa prodrug XP21279 in Parkinson's disease

R. Hauser, D. Lissin, K. Zomorodi, 2014, Movement disorders : official journal of the Movement Disorder Society.

Population Pharmacokinetics and Pharmacodynamics of Gabapentin After Administration of Gabapentin Enacarbil

J. Sukbuntherng, R. Lal, W. Luo, 2013, Journal of clinical pharmacology.

In vivo oxidative DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection.

B. Ames, C. J. Gimeno, M. Shigenaga, 1990, Methods in enzymology.

Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis.

W. Freeman, E. Capparelli, F. Rahhal, 1998, Journal of Ocular Pharmacology and Therapeutics.