N. Bischofberger

发表

The tertiary structure of a DNA aptamer which binds to and inhibits thrombin determines activity.

N Bischofberger, S. Swaminathan, P. Bolton, 1993, Biochemistry.

Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

Norbert Bischofberger, Matt Williams, C. Sweet, 1998, Antimicrobial Agents and Chemotherapy.

Disarming flu viruses.

R. Webster, W. G. Laver, N. Bischofberger, 1999, Scientific American.

Adenosine A1 Receptor Agonists as Clinically Viable Agents for Treatment of Ischemic Brain Disorders

K. Jacobson, N. Bischofberger, D. Lubitz, 1997, Annals of the New York Academy of Sciences.

Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques

D. Watkins, J. Altman, D. Venzon, 2000, Nature Medicine.

Evaluation of Oral Tenofovir Disoproxil Fumarate and Topical Tenofovir GS-7340 to Protect Infant Macaques Against Repeated Oral Challenges With Virulent Simian Immunodeficiency Virus

William A. Lee, Norbert Bischofberger, B. Kearney, 2006, Journal of acquired immune deficiency syndromes.

Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.

N. Pedersen, J. Lifson, K. V. Van Rompay, 1998, AIDS research and human retroviruses.

Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection

N. Pedersen, K. V. Van Rompay, P. Lietman, 1998, AIDS.

Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection.

K. V. Van Rompay, M. Marthas, N. Bischofberger, 2001, The Journal of infectious diseases.

Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus.

R. Singh, K. V. Van Rompay, M. Marthas, 2002, The Journal of infectious diseases.

Tenofovir primes rhesus macaque cells in vitro for enhanced interleukin-12 secretion.

K. V. Van Rompay, M. Marthas, N. Bischofberger, 2004, Antiviral research.

Fetal and Maternal Outcome After Administration of Tenofovir to Gravid Rhesus Monkeys (Macaca mulatta)

A. Tarantal, A. Castillo, J. Ekert, 2002, Journal of acquired immune deficiency syndromes.

Cellular Transport of Nucleotide Analogs

T. Cihlar, N. Bischofberger, D. Mccoll, 2002 .

Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies.

J. Shaw, A. Tarantal, M. Marthas, 1999, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Chapter 14. Non-HIV Antiviral Agents

S. Krawczyk, N. Bischofberger, 1997 .

Synthesis and influenza neuraminidase inhibitory activity of aromatic analogues of sialic acid

S. Swaminathan, Matthew A. Williams, N. Bischofberger, 1995 .

Acyclic Phosphonomethylether Nucleoside Inhibitors of Respiratory Viruses

W. Lew, N. Bischofberger, D. Barnard, 1997 .

Minireview: nucleotide prodrugs.

N. Bischofberger, R. J. Jones, Robert Jones, 1995, Antiviral research.

Rabbit muscle aldolase as a catalyst in organic synthesis

H. Waldmann, Mj. Kim, W. Lees, 1989 .

GS 4071 is a potent and selective inhibitor of the growth and neuraminidase activity of influenza A and B viruses in vitro

R. Sidwell, J. Huffman, Matthew A. Williams, 1997 .

The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years

B. Gazzard, J. Montaner, B. Clotet, 2007, AIDS.

Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor.

K. Jacobson, T. K. Harden, B. Joshi, 2004, Biochemical pharmacology.

Chapter 16. Recent developments in antiretroviral therapies

T. Cihlar, N. Bischofberger, T. Cihlář, 2000 .

1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivo

Z. H. Li, K. Kent, D. Mendel, 1994, Antimicrobial Agents and Chemotherapy.

Thermal denaturation profiles and gel mobility shift analysis of oligodeoxynucleotide triplexes.

R. G. Shea, N. Bischofberger, P. Ng, 1990, Nucleic acids research.

Efficacy and Safety of Three Antiretroviral Regimens for Initial Treatment of HIV-1: A Randomized Clinical Trial in Diverse Multinational Settings

M. Wulfsohn, S. Hammer, R. Schooley, 2012, PLoS medicine.

Comparison of the efficacy of AZT and PMEA treatment against acute SIVmne infection in macaques

R. Grant, K. E. Follis, C. Tsai, 1994, Journal of medical primatology.

Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation.

K. Jacobson, Aishe Chen, M. Cattaneo, 2002, Journal of medicinal chemistry.

Orally bioavailable acyclic nucleoside phosphonate prodrugs: Adefovir dipivoxil and bis(POC)PMPA

J. Dougherty, K. Cundy, N. Bischofberger, 1999 .

Effects of (R)-9-(2-phosphonylmethoxypropyl)adenine monotherapy on chronic SIV infection in macaques.

K. E. Follis, C. Tsai, P. Dailey, 1997, AIDS research and human retroviruses.

Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine

E. De Clercq, L. Naesens, J. Balzarini, 1996, Antimicrobial agents and chemotherapy.

Kinetic Interaction of the Diphosphates of 9-(2-phosphonylmethoxyethyl)adenine and Other anti-HIV Active Purine Congeners with HIV Reverse Transcriptase and Human DNA Polymerases α, β and γ

J. Cherrington, M. S. Chen, N. Bischofberger, 1995 .

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

N. Pedersen, R. Martin, P. Allen, 2004, Antimicrobial Agents and Chemotherapy.

PMEA and PMPA: Acyclic Nucleoside Phosphonates with Potent anti-HIV Activity.

T. Cihlar, N. Bischofberger, 1998 .

Preexposure prophylaxis with 9-(2-phosphonylmethoxyethyl)adenine against simian immunodeficiency virus infection in macaques.

R. Grant, K. E. Follis, C. Tsai, 1994, The Journal of infectious diseases.

Antiretroviral Efficacy and Pharmacokinetics of Oral Bis(isopropyloxycarbonyloxymethyl)9-(2-Phosphonylmethoxypropyl)adenine in Mice

E. De Clercq, L. Naesens, P. Annaert, 1998, Antimicrobial Agents and Chemotherapy.

Antiviral efficacy of PMPA in macaques chronically infected with SIV

R. Grant, K. E. Follis, P. Dailey, 1996 .

Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity.

W G Laver, M A Williams, R C Stevens, 1997, Journal of the American Chemical Society.

Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection

L M Wahl, M A Nowak, A L Lloyd, 1997, Journal of virology.

SYNTHESIS OF ANALOGS OF 1,3-DIHYDROXYACETONE PHOSPHATE AND GLYCERALDEHYDE-3-PHOSPHATE FOR USE IN STUDIES OF FRUCTOSE-1,6-DIPHOSPHATE ALDOLASE

G. Whitesides, M. Bednarski, H. Waldmann, 1988 .

Effects of 16-heterosubstitution on the regiochemistry of the D-homo rearrangement

K. A. Walker, N. Bischofberger, 1985 .

Selective 5′-O-Acetylation of 2′-Deoxynucleosides and Nucleosides by a Modified Mitsunobu Procedure

N. Bischofberger, G. He, 1997 .

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates

M. Connelly, B. Robbins, R. V. Srinivas, 1993, Antimicrobial Agents and Chemotherapy.

Anti-Human Immunodeficiency Virus Activity and Cellular Metabolism of a Potential Prodrug of the Acyclic Nucleoside Phosphonate 9-R-(2-Phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA

B. Robbins, R. V. Srinivas, A. Fridland, 1998, Antimicrobial Agents and Chemotherapy.

Synthesis, in Vitro Biological Evaluation and Oral Bioavailability of 9-[2-(Phosphonomethoxy)Propyl]Adenine (PMPA) Prodrugs

J. Dougherty, J. Shaw, R. Oliyai, 1997 .

N2- and C8-substituted oligodeoxynucleotides with enhanced thrombin inhibitory activity in vitro and in vivo.

J. Dougherty, S. Krawczyk, S. Swaminathan, 1998, Journal of medicinal chemistry.

Synthesis, hybridization properties and antiviral activity of lipid- oligodeoxynucleotide conjugates

James C. Marsters, Regan G. Shea, Norbert Bischofberger, 1990, Nucleic Acids Res..

Photochemical Reactions. 149th Communication. Photochemistry of 7,8‐dihydro‐4‐hydroxy‐β‐ionone and derivatives

N. Bischofberger, A. Pascual, B. Frei, 1988 .

Prevention of SIV Infection in Macaques by (R)-9-(2-Phosphonylmethoxypropyl)adenine

R. Grant, K. E. Follis, T. Beck, 1995, Science.

Containment of Simian Immunodeficiency Virus Infection: Cellular Immune Responses and Protection from Rechallenge following Transient Postinoculation Antiretroviral Treatment

B. M. Flynn, M. Nowak, D. Wodarz, 2000, Journal of Virology.

Photochemical Reactions. 128th Communication. Isolation of a Thermally Labile 2,8‐Dioxabicyclo[3.2.1]oct‐3‐ene Intermediate on Photolysis of 3,4: 5,6‐Diepoxy‐5,6‐dihydro‐β‐ionone

N. Bischofberger, B. Frei, O. Jeger, 1983 .

Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans.

N Bischofberger, M. Martin, Y. Endo, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Biological Effects of Short-Term or Prolonged Administration of 9-[2-(Phosphonomethoxy)Propyl]Adenine (Tenofovir) to Newborn and Infant Rhesus Macaques

N. Pedersen, R. Martin, P. Allen, 2004, Antimicrobial Agents and Chemotherapy.

Prophylactic and Therapeutic Benefits of Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine (PMPA) Administration to Newborn Macaques following Oral Inoculation with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

N. Pedersen, J. Cherrington, K. V. Van Rompay, 2000, Journal of Virology.

The Clinical Benefits of Tenofovir for Simian Immunodeficiency Virus–Infected Macaques Are Larger Than Predicted by its Effects on Standard Viral and Immunologic Parameters

R. Singh, K. V. Van Rompay, D. Canfield, 2004, Journal of acquired immune deficiency syndromes.

CD8+-Cell-Mediated Suppression of Virulent Simian Immunodeficiency Virus during Tenofovir Treatment

R. Singh, K. V. Van Rompay, M. Marthas, 2004, Journal of Virology.

Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus.

E. De Clercq, L. Naesens, J. Balzarini, 1998, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

Chronic Administration of Tenofovir to Rhesus Macaques from Infancy through Adulthood and Pregnancy: Summary of Pharmacokinetics and Biological and Virological Effects

K. Abel, T. Cihlar, H. Reiser, 2008, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of Tenofovir in Breast Milk of Lactating Rhesus Macaques

B. Kearney, K. V. Van Rompay, N. Bischofberger, 2005, Antimicrobial Agents and Chemotherapy.

Erratum: Biological effects of short-term or prolonged administration of 9-[2-(phosphonomethoxy)propyl]adenine (tenofovir) to newborn and infant rhesus macaques (Antimicrobial Agents and Chemotherapy (2004) 48, 5 (1469-1487))

N. Pedersen, R. Martin, P. Allen, 2004 .

Chapter 30. Sequence-defined Oligonucleotides as Potential Therapeutics

M. Matteucci, N. Bischofberger, 1991 .

Probing structural factors stabilizing antisense oligonucleotide duplexes: NMR studies of a DNA.DNA duplex containing a formacetal linkage.

N Bischofberger, F. Brown, K. Lin, 1992, Biochemistry.

In vitro and in vivo activities of oligodeoxynucleotide-based thrombin inhibitors containing neutral formacetal linkages.

S. Swaminathan, S. Coutre, R. G. Shea, 1998, Journal of medicinal chemistry.

Error rates in oligodeoxynucleotides synthesized by the H-phosphonate method.

P. Jhurani, M. Vasser, N. Bischofberger, 1990, Nucleic acids research.

IN VIVO ANTIRETROVIRAL EFFICACY OF ORAL BIS(POM)-PMEA, THE BIS(PIVALOYLOXYMETHYL)PRODRUG OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE (PMEA)

L. Naesens, J. Neyts, J. Balzarini, 1995 .

9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques

N. Pedersen, J. Cherrington, K. V. Van Rompay, 1996, Antimicrobial agents and chemotherapy.

Preparation of formacetal-linked purine-purine dinucleotide analogs

N. Bischofberger, G. He, 1997 .

Efficacy of 9-(2-phosphonylmethoxyethyl)adenine treatment against chronic simian immunodeficiency virus infection in macaques.

R. Grant, K. E. Follis, C. Tsai, 1995, The Journal of infectious diseases.

Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.

P. Rácz, J. B. Jiang, M. Lewis, 2000, AIDS research and human retroviruses.

Effectiveness of Postinoculation (R)-9-(2-Phosphonylmethoxypropyl)Adenine Treatment for Prevention of Persistent Simian Immunodeficiency Virus SIVmne Infection Depends Critically on Timing of Initiation and Duration of Treatment

J. Lifson, K. E. Follis, R. Benveniste, 1998, Journal of Virology.

Analogues de nucleosides de phosphonate de methylene et analogues d'oligonucleotides produits a partir des premiers analogues

B. Froehler, M. Matteucci, N. Bischofberger, 1992 .

A Convenient Preparation of Protected 3′-Deoxyguanosine from Guanosine.

N. Bischofberger, G. He, 1996 .

Synthesis of novel polycyclic nucleoside analogues, incorporation into oligodeoxynucleotides, and interaction with complementary sequences

M. Matteucci, N. Bischofberger, 1989 .

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

R. Sidwell, C. Sweet, J. Huffman, 1998, Antimicrobial Agents and Chemotherapy.

Long-Lasting Decrease in Viremia in Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251 after Therapeutic DNA Immunization

D. Weiner, P. Albert, G. Pavlakis, 2006, Journal of Virology.

Role of CD8+ Lymphocytes in Control of Simian Immunodeficiency Virus Infection and Resistance to Rechallenge after Transient Early Antiretroviral Treatment

B. M. Flynn, M. Nowak, D. Wodarz, 2001, Journal of Virology.

Competitive Formation of Ylide and Carbene Intermediates from 1π,π*‐Excited α,β‐Unsaturated γ,δ‐Epoxyketones

J. Wirz, N. Bischofberger, B. Frei, 1983 .

An anti‐HIV strategy combining chemotherapy and therapeutic vaccination

K. Überla, J. Heeney, K. Uberla, 1999, Journal of medical primatology.

Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.

J. Lifson, S. Buch, L. Foresman, 2001, Virology.

Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors.

Charles Y. Lin, S. Knapp, T. Westbrook, 2020, Cell chemical biology.

Suppression of Viremia and Evolution of Human Immunodeficiency Virus Type 1 Drug Resistance in a Macaque Model for Antiretroviral Therapy

J. Lifson, J. Mellors, J. Coffin, 2007, Journal of Virology.

Early Short-Term 9-[2-(R)-(Phosphonomethoxy)Propyl]Adenine Treatment Favorably Alters the Subsequent Disease Course in Simian Immunodeficiency Virus-Infected Newborn Rhesus Macaques

N. Pedersen, J. Cherrington, K. V. Van Rompay, 1999, Journal of Virology.

Structured Treatment Interruptions with Tenofovir Monotherapy for Simian Immunodeficiency Virus-Infected Newborn Macaques

W. Heneine, D. Montefiori, R. Singh, 2006, Journal of Virology.

Inhibition of HIV-1 RNase H Activity by Nucleotide Dimers and Monomers

J. Cherrington, S. Krawczyk, N. Bischofberger, 1996 .

Antiretroviral Therapy during Primary Immunodeficiency Virus Infection Can Induce Persistent Suppression of Virus Load and Protection from Heterologous Challenge in Rhesus Macaques

K. Überla, J. Heeney, H. Niphuis, 2000, Journal of Virology.

Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection

W. Heneine, N. Pedersen, R. Singh, 2007, Retrovirology.

Anti-retrovirus activity and pharmacokinetics in mice of bis(POC)-PMPA, the bis(isopropyloxycarbonyloxymethyl) oral prodrug of PMPA

L. Naesens, N. Bischofberger, C. Kim, 1997 .

Post‐exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection

Joseph C. Sun, K. E. Follis, T. Beck, 2000, Journal of medical primatology.

9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) Therapy Prolongs Survival of Infant Macaques Inoculated with Simian Immunodeficiency Virus with Reduced Susceptibility to PMPA

N. Pedersen, J. Cherrington, K. V. Van Rompay, 1999, Antimicrobial Agents and Chemotherapy.

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

E. Masliah, J. Lifson, R. Schinazi, 2005, The Journal of clinical investigation.

Postinoculation PMPA Treatment, but Not Preinoculation Immunomodulatory Therapy, Protects against Development of Acute Disease Induced by the Unique Simian Immunodeficiency Virus SIVsmmPBj

H. McClure, S. Dewhurst, Daniel C. Anderson, 1999, Journal of Virology.

Photochemical reactions. 145th Communication. Carbonyl vs. epoxyketone photochemistry: Photolysis of 1,2;3,4‐diepoxy‐2,6,6‐trimethyl‐1‐cyclohexyl methyl ketone

N. Bischofberger, W. Petter, B. Frei, 1985 .

The Origin and Control of Pandemic Influenza

R. Webster, W. G. Laver, N. Bischofberger, 2000, Perspectives in biology and medicine.

Transient early post‐inoculation anti‐retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut‐associated lymphoid tissues in SIVmac239‐infected rhesus macaques, but not resistance to rechallenge

J. Blanchard, J. Lifson, M. Piatak, 2003, Journal of medical primatology.

Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils.

K. Jacobson, R. Lin, M. Beenhakker, 1996, European journal of pharmacology.

Antiviral treatment normalizes neurophysiological but not movement abnormalities in simian immunodeficiency virus-infected monkeys.

S. Henriksen, H. Fox, M. Weed, 2000, The Journal of clinical investigation.

Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist.

K. Jacobson, R. Lin, M. Beenhakker, 1999, European journal of pharmacology.

Enhanced cellular immune response and reduced CD8(+) lymphocyte apoptosis in acutely SIV-infected Rhesus macaques after short-term antiretroviral treatment.

P. Rácz, J. Heeney, U. Dittmer, 2001, Virology.

Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.

D. Wodarz, J. Lifson, S. Buch, 2000, Virology.

Chronic administration of adenosine A3 receptor agonist and cerebral ischemia: neuronal and glial effects.

K. Jacobson, R. Lin, D. V. von Lubitz, 1999, European journal of pharmacology.

Reduction of postischemic brain damage and memory deficits following treatment with the selective adenosine A1 receptor agonist.

K. Jacobson, R. Lin, M. Beenhakker, 1996, European journal of pharmacology.

W. Heneine, N. Pedersen, R. Singh, 2007, Retrovirology.

Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection

N. Pedersen, K. V. Van Rompay, P. Lietman, 1998, AIDS.

Purinoceptors in the central nervous system

T. Dunwiddie, R. North, S. Latini, 1996, Drug development research.

Structure-Activity Study of Oligodeoxynucleotides Which Inhibit Thrombin

S. Krawczyk, S. Swaminathan, L. Griffin, 1995 .