D. Aubele

发表

The "aqueous" Prins reaction.

P. Floreancig, D. Aubele, C. A. Lee, 2003, Organic letters.

Discovery of 4-alkylamino-7-aryl-3-cyanoquinoline LRRK2 kinase inhibitors.

R. Motter, M. Adler, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Triazolopyridazine LRRK2 kinase inhibitors.

M. Adler, H. Sham, M. Franzini, 2013, Bioorganic & medicinal chemistry letters.

Novel cinnoline-based inhibitors of LRRK2 kinase activity.

R. Neitz, M. Adler, H. Sham, 2013, Bioorganic & medicinal chemistry letters.

Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.

M. Bergeron, G. Tonn, A. Olaharski, 2013, Toxicology and applied pharmacology.

Oxidative Synthesis of Cyclic Acyl Aminals through Carbon−Carbon σ-Bond Activation

P. Floreancig, D. Aubele, 2002 .

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

H. Sham, T. Yednock, M. Bova, 2009, Bioorganic & medicinal chemistry letters.

Aerobic organocatalytic photoinitiated arene oxidations: application to electron transfer initiated cyclization reactions.

P. Floreancig, D. Aubele, V. S. Kumar, 2001, Organic letters.

Mechanistic and Stereochemical Studies of Photoinduced Electron Transfer Initiated Cyclization Reactions: The Role of Nitrogen. The Aqueous Prins Reaction and Efforts Towards the Total Synthesis of (+)-Dactylolide

D. Aubele, 2004 .

Total synthesis of (+)-dactylolide through an efficient sequential Peterson olefination and Prins cyclization reaction.

P. Floreancig, Shuangyi Wan, D. Aubele, 2005, Angewandte Chemie.

A facile synthesis of multigram quantity of ethyl 3-ethylmorpholine-3-carboxylate

H. Sham, L. Latimer, D. Quincy, 2011 .

Oxidatively generated electrophiles as initiators of epoxide cascade cyclization processes

P. Floreancig, Shuangyi Wan, D. Aubele, 2005 .

Electron transfer initiated heterogenerative cascade cyclizations: polyether synthesis under nonacidic conditions.

P. Floreancig, D. Aubele, V. S. Kumar, 2002, Organic letters.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Kent Fitzgerald, Paul Beroza, Lee Latimer, 2013, ChemMedChem.

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.

P. Beroza, R. Motter, R. Neitz, 2013, Bioorganic & medicinal chemistry letters.

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

R. Motter, D. Kholodenko, R. Barbour, 2010, Alzheimer's Research & Therapy.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitor

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

H. Sham, L. Latimer, M. Bova, 2013, Bioorganic & medicinal chemistry letters.

Catalytic Aerobic Generation of Acyliminium Ions through Electron‐Transfer‐Mediated Carbon‐Carbon Bond Activation

P. Floreancig, J. Rech, D. Aubele, 2004 .

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2011, Bioorganic & Medicinal Chemistry Letters.

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

M. Bova, J. Sauer, G. Basi, 2011, Bioorganic & medicinal chemistry letters.

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Novel cinnoline-based inhibitors of LRRK2 kinase activity.

M. Adler, H. Sham, M. Franzini, 2013, Bioorganic & medicinal chemistry letters.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

P. Beroza, R. Motter, R. Neitz, 2013, ChemMedChem.

Design, Synthesis and Structure—Activity Relationship of Novel [3.3.1] Bicyclic Sulfonamide‐Pyrazoles as Potent γ‐Secretase Inhibitors.

D. Aubele, 2012 .