T. Hajian

发表

Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).

G. Poda, C. Arrowsmith, M. Schapira, 2016, Journal of medicinal chemistry.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, eLife.

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2.

J. Min, M. Schapira, M. Vedadi, 2012, Journal of the American Chemical Society.

Fluorescence-Based Methods for Screening Writers and Readers of Histone Methyl Marks

C. Arrowsmith, M. Vedadi, A. Allali-Hassani, 2012, Journal of biomolecular screening.

A Basic Post-SET Extension of NSDs Is Essential for Nucleosome Binding In Vitro

C. Arrowsmith, M. Schapira, S. Gräslund, 2014, Journal of biomolecular screening.

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

L. Qin, L. Mazutis, J. Min, 2019, bioRxiv.

Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain

P. Atadja, E. Li, C. Arrowsmith, 2018, SLAS discovery : advancing life sciences R & D.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors

Matthieu Schapira, James E. Bradner, John R. Engen, 2012, Nature Communications.

Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence

R. Blumenthal, Xiaodong Cheng, A. Mai, 2022, Journal of medicinal chemistry.

Trimethylation of Histone H3 Lysine 36 by Human Methyltransferase PRDM9 Protein

C. Arrowsmith, M. Schapira, M. Vedadi, 2014, The Journal of Biological Chemistry.

A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

Chao Xu, C. Arrowsmith, M. Vedadi, 2016, Journal of biomolecular screening.

Targeting human SET1/MLL family of proteins

C. Arrowsmith, M. Vedadi, M. Eram, 2017, Protein science : a publication of the Protein Society.

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions

R. Blumenthal, Xiaodong Cheng, M. Vedadi, 2021, Nucleic acids research.

Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.

G. Poda, C. Arrowsmith, M. Schapira, 2013, ACS medicinal chemistry letters.

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

G. Poda, C. Arrowsmith, M. Schapira, 2012, The Biochemical journal.

Crystal structure of SARS‐CoV‐2 nsp10–nsp16 in complex with small molecule inhibitors, SS148 and WZ16

M. Vedadi, E. Bouřa, M. Luo, 2022, Protein science : a publication of the Protein Society.

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

Xiaodong Cheng, M. Vedadi, Xing Zhang, 2019, Cell Discovery.

SS148 and WZ16 inhibit the activities of nsp10-nsp16 complexes from all seven human pathogenic coronaviruses

M. Vedadi, Sumera Perveen, E. Bouřa, 2023, Biochimica et Biophysica Acta (BBA) - General Subjects.

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

P. Fish, M. Schapira, M. Vedadi, 2021, SLAS Discovery.

A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex

M. Vedadi, Sumera Perveen, Fengling Li, 2021, bioRxiv.

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

M. Vedadi, Sumera Perveen, P. Loppnau, 2020, bioRxiv.

Probing the SAM Binding Site of SARS-CoV-2 nsp14 in vitro Using SAM Competitive Inhibitors Guides Developing Selective bi-substrate Inhibitors

P. Fish, M. Schapira, M. Vedadi, 2021, bioRxiv.

Kinetic Characterization of SARS-CoV-2 nsp13 ATPase Activity and Discovery of Small-Molecule Inhibitors

M. Vedadi, Sumera Perveen, Fengling Li, 2022, ACS infectious diseases.

An allosteric inhibitor of protein arginine methyltransferase 3.

Jian Jin, Matthieu Schapira, Alena Siarheyeva, 2012, Structure.

Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase

R. Blumenthal, Xiaodong Cheng, A. Mai, 2023, ACS chemical biology.

Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2.

Laura E. Herring, J. Licht, C. Arrowsmith, 2023, Journal of the American Chemical Society.

Self-assembled porphyrin nanodiscs with structure-dependent activation for phototherapy and photodiagnostic applications.

Gang Zheng, Ali Vedadi, Jonathan F Lovell, 2013, ACS nano.

Design of a fluorescent ligand targeting the S-adenosylmethionine binding site of the histone methyltransferase MLL1.

C. Arrowsmith, S. Houliston, M. Vedadi, 2016, Organic & biomolecular chemistry.

Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro.

Xiaodong Cheng, M. Vedadi, Xing Zhang, 2019, Cell discovery.

Detection of bovine viral diarrhea virus in bovine semen using nested-PCR

S. Ghorashi, D. Morshedi, M. Daliri, 2007 .

A scintillation proximity assay for histone demethylases.

M. Vedadi, N. Burgess-Brown, M. Eram, 2014, Analytical biochemistry.