Xiaoli Xu

发表

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.

Q. You, Zhengyu Jiang, Dongdong Li, 2018, Bioorganic chemistry.

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway.

F. Liu, Yong Yang, Q. You, 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

Fang Liu, Q. You, Dongdong Li, 2015 .

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Q. You, Meng-Chen Lu, Shengmiao Zhang, 2013, PloS one.

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

M. Zhang, R. Hu, Q. You, 2013, Journal of medicinal chemistry.

HSP90 Inhibitors Blocking Multiple Oncogenic Signaling Pathways for the Treatment of Cancer

Q. You, Xiaoli Xu, Fen Jiang, 2019, Heat Shock Proteins.

Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors.

Q. You, Xiaoli Xu, Fen Jiang, 2017, European journal of medicinal chemistry.

Optimization and biological evaluation of celastrol derivatives as Hsp90-Cdc37 interaction disruptors with improved druglike properties.

Lei Wang, Q. You, Xiaoli Xu, 2016, Bioorganic & medicinal chemistry.

Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity.

Q. You, Xiaoli Xu, Xiaojin Zhang, 2016, Bioorganic & medicinal chemistry.

Hybrids of the Benzofuran Core from Natural Products and the 2,4‐Dihydroxy‐5‐isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Design, synthesis and bioevaluation of inhibitors targeting HSP90-CDC37 protein-protein interaction based on a hydrophobic core.

Lei Wang, Q. You, Lixiao Zhang, 2020, European journal of medicinal chemistry.

Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape‐Based Similarity Screening

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.

Q. You, Xiaoli Xu, Fen Jiang, 2018, Journal of medicinal chemistry.

Discovery and Optimization of Small Molecules Targeting the Protein-Protein Interaction of Heat Shock Protein 90 (Hsp90) and Cell Division Cycle 37 (Cdc37) As Orally Active Inhibitors for the treatment of colorectal cancer.

Li Li, Lei Wang, Q. You, 2020, Journal of medicinal chemistry.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Hematopoietic Progenitor Kinase 1 in Tumor Immunology: A Medicinal Chemistry Perspective.

Q. You, Xiaoli Xu, Qiangsheng Zhu, 2022, Journal of medicinal chemistry.

Heat shock protein 90 (Hsp90) Inhibitors: An Update on Achievements, Challenges, and Future Directions.

Li Li, Lei Wang, Q. You, 2020, Journal of medicinal chemistry.

Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.

Q. You, Cheng Jiang, Lei Yang, 2010, Bioorganic & medicinal chemistry.

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Lei Wang, Hao-Peng Sun, Chao Zhang, 2016, Oncotarget.

Discovery of 2-((2-methylbenzyl)thio)-6-oxo-4-(3,4,5-trimethoxyphenyl)-1,6-dihydropyrimidine-5-carbonitrile as a novel and effective bromodomain and extra-terminal (BET) inhibitor for the treatment of sepsis.

Zhengyu Jiang, X. Ye, Weikun Zhang, 2022, European journal of medicinal chemistry.

Medicinal chemistry perspective on cGAS-STING signaling pathway with small molecule inhibitors.

Wei Dai, Xiaoli Xu, Qiangsheng Zhu, 2022, European journal of medicinal chemistry.

Synthesis and evaluation of 4-(2-hydroxypropyl)piperazin-1-yl) derivatives as Hsp90 inhibitors.

Q. You, Haopeng Sun, Xiaoli Xu, 2016, Bioorganic & medicinal chemistry.

An updated patent review of anticancer Hsp90 inhibitors (2013-present)

Li Li, Q. You, Xiaoli Xu, 2020, Expert opinion on therapeutic patents.

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Q. You, Meng-Chen Lu, Haopeng Sun, 2016, Scientific Reports.

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Q. You, Jinlei Bian, Xiaoli Xu, 2016, Scientific Reports.

Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives.

Q. You, Haopeng Sun, Yuan Sun, 2013, Bioorganic & medicinal chemistry letters.

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.

Q. You, Xiaoli Xu, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Q. You, J. Zhuang, Dongdong Li, 2015, European journal of medicinal chemistry.

Synthesis, SAR and biological evaluation of natural and non-natural hydroxylated and prenylated xanthones as antitumor agents.

Q. You, Q. Guo, Xiaoli Xu, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening.

Yao Chen, Wei Li, Zong-liang Liu, 2015, Bioorganic & medicinal chemistry letters.

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2014, European journal of medicinal chemistry.

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

Dong-Dong Li, Xiao-Li Xu, Wei-Lin Chen, 2016, Bioorganic & medicinal chemistry.

Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective.

Q. You, Xiaoli Xu, Han Zhang, 2019, Journal of medicinal chemistry.

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Hao-Ze Huang, Fang Liu, Xiao-Li Xu, 2014, European journal of medicinal chemistry.

Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.

Li Li, W. Dai, Lei Wang, 2021, Cell chemical biology.

Modulation of protein fate decision by small molecules: targeting molecular chaperone machinery

Lei Wang, Q. You, Zhengyu Jiang, 2020, Acta pharmaceutica Sinica. B.

Imidazo[1,2-a]Pyridine Derivatives as Novel Dual-Target Inhibitors of ABCB1 and ABCG2 for Reversing Multidrug Resistance.

Hui Peng, Xiaoli Xu, Hui Li, 2023, Journal of medicinal chemistry.

Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification

Fang Liu, Xiaoli Xu, Xiaowen Wu, 2013, J. Chem. Inf. Model..

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2016, Mini reviews in medicinal chemistry.

Optimization and bioevaluation of Cdc37-derived peptides: An insight into Hsp90-Cdc37 protein-protein interaction modulators.

Li Li, Lei Wang, Q. You, 2017, Bioorganic & medicinal chemistry.

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential.

Q. You, Zhengyu Jiang, Yali Li, 2017, Bioorganic & medicinal chemistry.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Agonist of stimulator of interferon genes as antitumor agents: a patent review (2008-2020)

Q. You, Xiaoli Xu, Han Zhang, 2021, Expert opinion on therapeutic patents.

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

Jian Zhang, Li Li, Lei Wang, 2019, Science Advances.

Discovery of new scaffolds from approved drugs as acetylcholinesterase inhibitors

Wei Li, Zongliang Liu, Haopeng Sun, 2015 .

Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation

Q. You, Jinlei Bian, Xiaoli Xu, 2016 .

Structure-based virtual screening and optimization of modulators targeting Hsp90-Cdc37 interaction.

Li Li, Xiao-Li Xu, Li Li, 2017, European journal of medicinal chemistry.

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014, Journal of medicinal chemistry.

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90.

Lei Wang, Q. You, Dongdong Li, 2016, Journal of medicinal chemistry.

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Q. You, Zhengyu Jiang, 2015 .

Non-small molecule PROTACs (NSM-PROTACs): Protein degradation kaleidoscope

Zhengyu Jiang, Xiaoli Xu, Qi-dong You, 2022, Acta pharmaceutica Sinica. B.

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

Q. You, Zhengyu Jiang, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Lei Wang, Q. You, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Fang Liu, Xiaoli Xu, Lei Wang, 2013, J. Chem. Inf. Model..

Development of Orally Bioavailable Amidobenzimidazole Analogues Targeting Stimulator of Interferon Gene (STING) Receptor.

Q. You, Zhengyu Jiang, Xiaoli Xu, 2023, Journal of medicinal chemistry.

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Bioorganic & medicinal chemistry letters.

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Q. You, Lei Wang, Haopeng Sun, 2016 .

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of Medicinal Chemistry.