Xiaojin Zhang

发表

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.

Q. You, Zhengyu Jiang, Dongdong Li, 2018, Bioorganic chemistry.

The prolyl hydroxylase inhibitor roxadustat: paradigm in drug discovery and prospects for clinical application beyond anemia.

Xiaojin Zhang, Su Kaijun, Zhihong Li, 2020, Drug discovery today.

Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy

Q. You, N. Wang, Xiaojin Zhang, 2016 .

Discovery of prolyl hydroxylase 2 inhibitors with new chemical scaffolds as in vivo active erythropoietin inducers through a combined virtual screening strategy

Hui-peng Song, Xiaojin Zhang, Zhihong Li, 2020, Chemical biology & drug design.

Small-Molecule Modulators of the Hypoxia-Inducible Factor Pathway: Development and Therapeutic Applications.

Q. You, Xiaojin Zhang, Zhihong Li, 2019, Journal of medicinal chemistry.

Affinity-Based Fluorescence Polarization Assay for High-Throughput Screening of Prolyl Hydroxylase 2 Inhibitors.

Q. You, Haopeng Sun, Xiaojin Zhang, 2015, ACS medicinal chemistry letters.

Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014 .

Medicinal chemistry of metal chelating fragments in metalloenzyme active sites: A perspective.

Q. You, Xiaojin Zhang, Zhensheng Jiang, 2019, European journal of medicinal chemistry.

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

Fang Liu, Q. You, Dongdong Li, 2015 .

Studies on gambogic acid (IV): Exploring structure-activity relationship with IκB kinase-beta (IKKβ).

Q. You, Q. Guo, L. Qiang, 2012, European journal of medicinal chemistry.

Synthesis and evaluation of novel aza-caged Garcinia xanthones.

Q. You, Q. Guo, Zhengyu Jiang, 2012, Organic & biomolecular chemistry.

Identification of Hydroxyxanthones as Na/K-ATPase Ligands

Jiang Tian, J. Shapiro, Zijian Xie, 2010, Molecular Pharmacology.

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

M. Zhang, R. Hu, Q. You, 2013, Journal of medicinal chemistry.

Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, PloS one.

Structure-activity relationship of Garcinia xanthones analogues: Potent Hsp90 inhibitors with cytotoxicity and antiangiogenesis activity.

Q. You, Xiaoli Xu, Xiaojin Zhang, 2016, Bioorganic & medicinal chemistry.

Prodrug strategy for cancer cell-specific targeting: A recent overview.

Q. You, Xiaojin Zhang, Xiang Li, 2017, European journal of medicinal chemistry.

Tetrahydropyridin-4-ylpicolinoylglycines as novel and orally active prolyl hydroxylase 2 (PHD2) inhibitors for the treatment of renal anemia.

Mingxuan Mao, Xiaojin Zhang, Zhihong Li, 2022, European journal of medicinal chemistry.

Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy.

C. Schofield, M. McDonough, Xiaojin Zhang, 2021, Journal of medicinal chemistry.

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation.

C. Schofield, A. Tumber, M. McDonough, 2020, Chemical communications.

Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.

Q. You, Changyong Yang, Xiaojin Zhang, 2020, Journal of medicinal chemistry.

Application of in-vitro screening methods on hypoxia inducible factor prolyl hydroxylase inhibitors.

Q. You, Xiaojin Zhang, Yue Wu, 2017, Bioorganic & medicinal chemistry.

Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape‐Based Similarity Screening

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Garcinia xanthones as orally active antitumor agents.

S. Zeng, Q. You, Q. Guo, 2013, Journal of medicinal chemistry.

A comprehensive review on β-lapachone: Mechanisms, structural modifications, and therapeutic potentials.

Xiang Li, X. Li, Jiabao Hu, 2020, European journal of medicinal chemistry.

Allosteric inhibition of HIF-2α as a novel therapy for clear cell renal cell carcinoma.

Xiaojin Zhang, Quanwei Yu, Yancheng Yu, 2019, Drug discovery today.

Current Development of ROS-Modulating Agents as Novel Antitumor Therapy.

Q. You, Jinlei Bian, Haopeng Sun, 2017, Current cancer drug targets.

An NAD(P)H:Quinone Oxidoreductase 1 Responsive and Self-Immolative Prodrug of 5-Fluorouracil for Safe and Effective Cancer Therapy.

Q. You, Xiaojin Zhang, Zhihong Li, 2018, Organic letters.

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Q. You, Meng-Chen Lu, Haopeng Sun, 2016, Scientific Reports.

‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents

Q. You, Xiaojin Zhang, Yue Wu, 2017, Molecules.

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Q. You, Jinlei Bian, Xiaoli Xu, 2016, Scientific Reports.

Design, synthesis, and evaluation of benzofuran derivatives as novel anti-pancreatic carcinoma agents via interfering the hypoxia environment by targeting HIF-1α pathway.

Q. You, Xiaoli Xu, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Q. You, J. Zhuang, Dongdong Li, 2015, European journal of medicinal chemistry.

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Jing Xu, Q. You, Qian Yang, 2013, Bioorganic & medicinal chemistry.

Synthesis, SAR and biological evaluation of natural and non-natural hydroxylated and prenylated xanthones as antitumor agents.

Q. You, Q. Guo, Xiaoli Xu, 2012, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of a Potent and Orally Bioavailable Hypoxia-Inducible Factor 2α (HIF-2α) Agonist and Its Synergistic Therapy with Prolyl Hydroxylase Inhibitors for the Treatment of Renal Anemia.

Fulai Yang, Xiaojin Zhang, Zhihong Li, 2021, Journal of medicinal chemistry.

Palladium(II)-catalyzed hydroxy-involved enolate-type efficient C–C functionalization of hydroxynaphthoquinones at room temperature

Q. You, Xiaojin Zhang, Jianrui Zhou, 2016 .

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Organic letters.

NbCl5 mediated biomimetic cascade reaction: efficient and scalable one-pot synthesis of dunnione and nor-β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Affinity-based small fluorescent probe for NAD(P)H:quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

1,4-Alkylcarbonylation of 1,3-Enynes to Access Tetra-Substituted Allenyl Ketones via an NHC-Catalyzed Radical Relay

Ding Du, Simiao Zhang, Xiaojin Zhang, 2021, ACS Catalysis.

Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation.

Jinlei Bian, Tingting Yang, Jing Gu, 2016, Bioorganic & medicinal chemistry.

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2014, European journal of medicinal chemistry.

Synthesis and Anti‐tumor Evaluation of B‐ring Modified Caged Xanthone Analogues of Gambogic Acid

Q. You, Q. Guo, Nianguang Li, 2012 .

Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light.

Qidong You, Q. You, Zhihong Li, 2019, Journal of medicinal chemistry.

Microwave-assisted transition-metal-free intramolecular Ullmann-type O-arylation in water for the synthesis of xanthones and azaxanthones

Li Yang, Q. You, Haopeng Sun, 2014 .

Lewis acid mediated highly regioselective intramolecular cyclization for the synthesis of β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2014 .

Synthesis and antibacterial evaluation of a novel series of 10-hydroxyl ketolide derivatives.

Ying Sun, Q. You, Haopeng Sun, 2013, Bioorganic & medicinal chemistry letters.

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Studies on Chemical‐Structure Modification and StructureActivity Relationship of Gambogic Acid Derivatives at Carbon(34)

Q. You, Q. Guo, Haopeng Sun, 2012, Chemistry & biodiversity.

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

Dong-Dong Li, Xiao-Li Xu, Wei-Lin Chen, 2016, Bioorganic & medicinal chemistry.

New techniques and strategies in drug discovery

Guan Wang, Zhen Zhang, Jing Guo, 2020 .

Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.

Q. You, Xiaojin Zhang, Zhihong Li, 2018, Journal of medicinal chemistry.

Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification

Fang Liu, Xiaoli Xu, Xiaowen Wu, 2013, J. Chem. Inf. Model..

Click Chemistry-Based Discovery of [3-Hydroxy-5-(1 H-1,2,3-triazol-4-yl)picolinoyl]glycines as Orally Active Hypoxia-Inducing Factor Prolyl Hydroxylase Inhibitors with Favorable Safety Profiles for the Treatment of Anemia.

Jing Gu, Qidong You, Q. You, 2018, Journal of medicinal chemistry.

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2016, Mini reviews in medicinal chemistry.

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential.

Q. You, Zhengyu Jiang, Yali Li, 2017, Bioorganic & medicinal chemistry.

Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex.

H. Riezman, Q. You, J. Hannich, 2020, Cell chemical biology.

VISTA inhibitors in cancer immunotherapy: a short perspective on recent progresses.

Xiaojin Zhang, Xin Cao, Chenyang Wu, 2021, RSC medicinal chemistry.

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, European journal of medicinal chemistry.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation.

Xiaojin Zhang, Quanwei Yu, Yancheng Yu, 2020, European journal of medicinal chemistry.

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014, Journal of medicinal chemistry.

Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

Investigation of the intermolecular recognition mechanism between the E3 ubiquitin ligase Keap1 and substrate based on multiple substrates analysis

Yang Pan, Zhengyu Jiang, Li-Li Xu, 2014, Journal of Computer-Aided Molecular Design.

Microwave-assisted copper- and palladium-catalyzed sonogashira-type coupling of aryl bromides and iodides with trimethylsilylacetylene

Q. You, H. Xiang, Haopeng Sun, 2016 .

Novel NQO1 substrates bearing two nitrogen redox centers: Design, synthesis, molecular dynamics simulations, and antitumor evaluation.

Jiabao Hu, Fulai Yang, Xiaojin Zhang, 2023, Bioorganic chemistry.

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Reactive Oxygen Species (ROS)-Responsive Prodrugs, Probes, and Theranostic Prodrugs: Applications in the ROS-Related Diseases.

Jiabao Hu, Xiaojin Zhang, Xiang Li, 2020, Journal of medicinal chemistry.

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Q. You, Qian Yang, Haopeng Sun, 2014, European journal of medicinal chemistry.

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Q. You, Zhengyu Jiang, 2015 .

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

Q. You, Zhengyu Jiang, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Lei Wang, Q. You, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Fang Liu, Xiaoli Xu, Lei Wang, 2013, J. Chem. Inf. Model..

Synthesis and Anti‐tumor Evaluation of Novel C‐37 Modified Derivatives of Gambogic Acid

Q. You, Q. Guo, Haopeng Sun, 2012 .

A Carbon-Carbon Bond Cleavage-Based Prodrug Activation Strategy Applied to β-Lapachone for Cancer-Specific Targeting.

Jiabao Hu, Fulai Yang, Xiaojin Zhang, 2022, Angewandte Chemie.

2-Substituted 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery

C. Schofield, M. McDonough, Fulai Yang, 2022, Angewandte Chemie.

Recent advances in the structure-based and ligand-based design of IKKβ inhibitors as anti-inflammation and anti-cancer agents.

Q. You, Zhengyu Jiang, Haopeng Sun, 2014, Current Medicinal Chemistry.

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Q. You, Lei Wang, Haopeng Sun, 2016 .

Novel N-hydroxyfurylacrylamide-based histone deacetylase (HDAC) inhibitors with branched CAP group (Part 2).

Q. You, Haopeng Sun, H. Su, 2013, Bioorganic & medicinal chemistry.

Discovery and Modification of in Vivo Active Nrf2 Activators with 1,2,4-Oxadiazole Core: Hits Identification and Structure-Activity Relationship Study.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of Medicinal Chemistry.

Palladium(II)-catalyzed hydroxy-involved enolate-type efficient C–C functionalization of hydroxynaphthoquinones at room temperature

Q. You, Xiaojin Zhang, Jianrui Zhou, 2016 .