Xiaoke Guo

发表

Design, synthesis, and initial evaluation of affinity-based small molecular probe for detection of WDR5.

Q. You, Zhengyu Jiang, Dongdong Li, 2018, Bioorganic chemistry.

Indenoisoquinoline derivatives as topoisomerase I inhibitors that suppress angiogenesis by affecting the HIF signaling pathway.

F. Liu, Yong Yang, Q. You, 2013, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Identification of novel JMJD2A inhibitor scaffold using shape and electrostatic similarity search combined with docking method and MM-GBSA approach

Fang Liu, Q. You, Dongdong Li, 2015 .

Recent developments of small molecules targeting RNA m6A modulators.

Q. You, J. Gu, Jun Xu, 2020, European journal of medicinal chemistry.

Identification, Design and Bio-Evaluation of Novel Hsp90 Inhibitors by Ligand-Based Virtual Screening

Q. You, Meng-Chen Lu, Shengmiao Zhang, 2013, PloS one.

3-aroylmethylene-2,3,6,7-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4(11bH)-ones as potent Nrf2/ARE inducers in human cancer cells and AOM-DSS treated mice.

M. Zhang, R. Hu, Q. You, 2013, Journal of medicinal chemistry.

Insight into the Intermolecular Recognition Mechanism between Keap1 and IKKβ Combining Homology Modelling, Protein-Protein Docking, Molecular Dynamics Simulations and Virtual Alanine Mutation

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, PloS one.

Hybrids of the Benzofuran Core from Natural Products and the 2,4‐Dihydroxy‐5‐isopropylbenzene Fragment as Potent Hsp90 Inhibitors: Design, Synthesis and Bioevaluation

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Discovery and Bioevaluation of Novel Pyrazolopyrimidine Analogs as Competitive Hsp90 Inhibitors Through Shape‐Based Similarity Screening

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Molecular informatics.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2015, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of arylmethylpiperidines as Kv1.5 potassium channel inhibitors

Q. You, Qian Yang, Xiaoke Guo, 2022, Journal of enzyme inhibition and medicinal chemistry.

Antiarrhythmic efficacy of CPUY102122, a multiple ion channel blocker, on rabbits with ischemia/reperfusion injury

Q. You, Qian Yang, Xiaoke Guo, 2014, Pharmacological reports : PR.

CPUY201112, a novel synthetic small-molecule compound and inhibitor of heat shock protein Hsp90, induces p53-mediated apoptosis in MCF-7 cells

Q. You, Meng-Chen Lu, Haopeng Sun, 2016, Scientific Reports.

Novel 5-carboxy-8-HQ based histone demethylase JMJD2A inhibitors: introduction of an additional carboxyl group at the C-2 position of quinoline.

Q. You, J. Zhuang, Dongdong Li, 2015, European journal of medicinal chemistry.

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Jing Xu, Q. You, Qian Yang, 2013, Bioorganic & medicinal chemistry.

Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I).

R. Hu, Q. You, Q. Guo, 2013, European journal of medicinal chemistry.

Synthesis and Evaluation of Gambogic Acid Derivatives as Antitumor Agents. Part III

Q. You, Q. Guo, Cheng Jiang, 2013, Chemistry & biodiversity.

Discovery, design and synthesis of 6H-anthra[1,9-cd]isoxazol-6-one scaffold as G9a inhibitor through a combination of shape-based virtual screening and structure-based molecular modification.

Dong-Dong Li, Xiao-Li Xu, Wei-Lin Chen, 2016, Bioorganic & medicinal chemistry.

Identification and optimization of novel Hsp90 inhibitors with tetrahydropyrido[4,3-d]pyrimidines core through shape-based screening.

Hao-Ze Huang, Fang Liu, Xiao-Li Xu, 2014, European journal of medicinal chemistry.

Methods for the Discovery and Identification of Small Molecules Targeting Oxidative Stress-Related Protein–Protein Interactions: An Update

Lei Wang, Q. You, Heng-Yuan Zhang, 2022, Antioxidants.

Discovery and Design of Tricyclic Scaffolds as Protein Kinase CK2 (CK2) Inhibitors through a Combination of Shape-Based Virtual Screening and Structure-Based Molecular Modification

Fang Liu, Xiaoli Xu, Xiaowen Wu, 2013, J. Chem. Inf. Model..

Targeting protein-protein interaction between MLL1 and reciprocal proteins for leukemia therapy.

Q. You, Dongdong Li, Wei-lin Chen, 2018, Bioorganic & medicinal chemistry.

Recent Advances in the Discovery of HIF-1α-p300/CBP Inhibitors as Anti-Cancer Agents.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2016, Mini reviews in medicinal chemistry.

Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)-WDR5 interaction.

Q. You, Yi-Yue Xie, Dongdong Li, 2016, Bioorganic & medicinal chemistry.

Synthesis and evaluation of N-(benzofuran-5-yl)aromaticsulfonamide derivatives as novel HIF-1 inhibitors that possess anti-angiogenic potential.

Q. You, Zhengyu Jiang, Yali Li, 2017, Bioorganic & medicinal chemistry.

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method.

Q. You, Zhengyu Jiang, Haopeng Sun, 2013, European journal of medicinal chemistry.

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective.

Q. You, Xiaoke Guo, Xin Chen, 2021, Journal of medicinal chemistry.

Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia.

Q. You, Zhengyu Jiang, Dongdong Li, 2021, Journal of medicinal chemistry.

Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis.

Q. You, Meng-Chen Lu, Zhengyu Jiang, 2014, Journal of medicinal chemistry.

Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction.

Q. You, Zhengyu Jiang, Dongdong Li, 2019, European journal of medicinal chemistry.

The development of small molecules targeting methyltransferase-like 3.

Xiaoke Guo, Qidong You, Qinglan Feng, 2023, Drug discovery today.

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Discovery of 1-aryloxyethyl piperazine derivatives as Kv1.5 potassium channel inhibitors (part I).

Q. You, Qian Yang, Haopeng Sun, 2014, European journal of medicinal chemistry.

Discovery and identification of Cdc37-derived peptides targeting the Hsp90–Cdc37 protein–protein interaction

Lei Wang, Q. You, Zhengyu Jiang, 2015 .

High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity.

Q. You, Zhengyu Jiang, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Structure-based design and synthesis of small molecular inhibitors disturbing the interaction of MLL1-WDR5.

Lei Wang, Q. You, Yi-Yue Xie, 2016, European journal of medicinal chemistry.

Effective Screening Strategy Using Ensembled Pharmacophore Models Combined with Cascade Docking: Application to p53-MDM2 Interaction Inhibitors

Fang Liu, Xiaoli Xu, Lei Wang, 2013, J. Chem. Inf. Model..

Synthesis and evaluation of a novel class Hsp90 inhibitors containing 1-phenylpiperazine scaffold.

Q. You, Haopeng Sun, Xiaoli Xu, 2014, Bioorganic & medicinal chemistry letters.

Betulinic acid acetate, an antiproliferative natural product, suppresses client proteins of heat shock protein pathways through a CDC37-binding mechanism

Q. You, Lei Wang, Haopeng Sun, 2016 .

Novel Hydrogen Sulfide Hybrid Derivatives of Keap1-Nrf2 Protein–Protein Interaction Inhibitor Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis

Zhengyu Jiang, Xiaoke Guo, Xian Zhang, 2023, Antioxidants.

G9a - An Appealing Antineoplastic Target.

Q. You, Dongdong Li, Wei-lin Chen, 2017, Current cancer drug targets.

Discovery of Pyrazolo[1,5-a]pyrimidine Derivative as a Novel and Selective ALKBH5 Inhibitor for the Treatment of AML.

Zhengyu Jiang, Xiaoke Guo, Qidong You, 2023, Journal of medicinal chemistry.