O. Provot

发表

p-Toluenesulfonic acid-mediated cyclization of o-(1-alkynyl)anisoles or thioanisoles: synthesis of 2-arylsubstituted benzofurans and benzothiophenes

J. Peyrat, J. Brion, M. Alami, 2009 .

Synthesis and antitumor activity of benzils related to combretastatin A-4.

J. Bignon, A. Giraud, C. Mousset, 2008, Bioorganic & medicinal chemistry letters.

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

J. Bignon, S. Thoret, J. Brion, 2010, European journal of medicinal chemistry.

B‐Ring‐Modified isoCombretastatin A‐4 Analogues Endowed with Interesting Anticancer Activities

J. Wdzieczak‐Bakala, J. Bignon, C. Mousset, 2011, ChemMedChem.

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.

Synthesis of ant venom alkaloids from chiral .beta.-enamino lactones: (3S,5R,8S)-3-heptyl-5-methylpyrrolizidine

J. Celerier, G. Lhommet, O. Provot, 1992 .

Developments of isoCombretastatin A-4 derivatives as highly cytotoxic agents.

M. Alami, Abdallah Hamze, O. Provot, 2020, European journal of medicinal chemistry.

Synthesis of 2,3-Substituted β-N-Glycosyl Indoles through C-H Activation/Annulation Process under Rh(III)-Catalysis.

Mingxiang Zhu, S. Messaoudi, M. Alami, 2019, Organic letters.

Cyclic bridged analogs of isoCA-4: Design, synthesis and biological evaluation.

J. Bignon, D. Borgel, F. Saller, 2020, European journal of medicinal chemistry.

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

A. Paci, J. Bignon, B. Gigant, 2018, Journal of medicinal chemistry.

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

J. Wdzieczak‐Bakala, J. Bignon, J. Rodrigo, 2012, European journal of medicinal chemistry.

Synthesis and antimalarial activity of 2-methoxyprop-2-yl peroxides derivatives.

L. Cointeaux, B. Meunier, M. Daniš, 2003, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationships of Synthetic Tricyclic Trioxanes Related to Artemisinin: The Unexpected Alkylative Property of a 3-(Methoxymethyl) Analog

D. Desmaële, J. D'angelo, B. Meunier, 1999 .

Wittig reaction: A new route to α-methoxyketones. Application to the synthesis of simplified analogs of artemisinin

O. Provot, L. Cicéron, J. Mayrargue, 1998 .

Enantioselective synthesis of functionalized 2-oxo-cyclohexane carbonitriles. Access to a trioxane analogue of artemisinin

A. Chiaroni, F. Grégoire, O. Provot, 1997 .

Xphos ligand and platinum catalysts: A versatile catalyst for the synthesis of functionalized β-(E)-vinylsilanes from terminal alkynes

J. Brion, M. Alami, Abdallah Hamze, 2008 .

Palladium mediated direct coupling of silylated arylalkynes with propargylic chlorides: an efficient access to functionalized conjugated allenynes

J. Brion, M. Alami, O. Provot, 2007 .

Synthesis of substituted quinolines by iron-catalyzed coupling reactions between chloroenynes and Grignard reagents

R. Hocquemiller, B. Figadère, X. Franck, 2004 .

Suzuki Coupling Reactions of (E)- and (Z)-Chloroenynes with Boronic Acids: Versatile Access to Functionalized 1,3-Enynes

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Synthesis of 2-substituted indoles through cyclization and demethylation of 2-alkynyldimethylanilines by ethanol

V. Gandon, M. Alami, O. Provot, 2019, Green Chemistry.

Therapeutic Modalities of Squalenoyl Nanocomposites in Colon Cancer: An Ongoing Search for Improved Efficacy

P. Couvreur, A. Maksimenko, J. Mougin, 2014, ACS nano.

Discovery and hit to lead optimization of novel combretastatin A-4 analogues: dependence of C-linker length and hybridization.

J. Peyrat, J. Brion, M. Alami, 2013, Anti-cancer agents in medicinal chemistry.

Discovery of azaisoerianin derivatives as potential antitumors agents.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2014, European journal of medicinal chemistry.

Synthesis and trichomonacidal activity of perketals and hydroperoxides.

L. Cointeaux, C. Bories, P. Loiseau, 2002, Farmaco.

Synthesis and in vitro Trichomonacidal activities of some new dialkylperoxides and 1,2,4-trioxanes.

L. Cointeaux, C. Bories, P. Loiseau, 2001, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors.

J. Bignon, G. Bollot, S. Apcher, 2022, European journal of medicinal chemistry.

One-pot hydrosilylation-protodesilylation of functionalized diarylalkynes : a highly selective access to Z-stilbenes. Application to the synthesis of combretastatin A-4

A. Giraud, J. Brion, M. Alami, 2008 .

α-iodination of ketones with MnO2/I2 reagent combination : A new environmentally friendly procedure

J. Peyrat, J. Brion, M. Alami, 2006 .

Recent Advances in Synthesis of Pyrrolo[3,2‐ b ]indole and Indolo[3,2‐ b ]indole Derivatives

J. Pozzo, Abdallah Hamze, O. Provot, 2022, Asian Journal of Organic Chemistry.

Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity.

É. Prina, O. Provot, J. Mayrargue, 2001, Chemical & pharmaceutical bulletin.

Mild Deprotection of Dithioacetals by TMSCl/NaI Association in CH 3 CN

M. Alami, Abdallah Hamze, O. Provot, 2020, European Journal of Organic Chemistry.

Synthesis of Isocoumarin via PTSA-Catalyzed Annulation of Diarylalkynes

S. Messaoudi, J. Brion, M. Alami, 2008 .

Synthesis of Isocoumarin via PTSA‐Catalyzed Annulation of Diarylalkynes.

S. Messaoudi, J. Brion, M. Alami, 2008 .

p-Toluenesulfonic acid-promoted selective functionalization of unsymmetrical arylalkynes: a regioselective access to various arylketones and heterocycles

J. Peyrat, J. Brion, M. Alami, 2010 .

Platinum oxide catalyzed silylation of aryl halides with triethylsilane: an efficient synthetic route to functionalized aryltriethylsilanes.

J. Brion, M. Alami, Abdallah Hamze, 2006, Organic letters.

Recent advances in the synthesis of pyrido[1,2-a]indoles.

M. Alami, Abdallah Hamze, O. Provot, 2021, Organic & biomolecular chemistry.

Rapid microwave assisted hydration of internal arylalkynes in the presence of PTSA : an efficient regioselective access to carbonyl compounds

J. Peyrat, J. Brion, M. Alami, 2006 .

DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

J. Bignon, C. Mousset, J. Brion, 2008 .

PtO2/PTSA system catalyzed regioselective hydration of internal arylalkynes bearing electron withdrawing groups

M. Alami, Abdallah Hamze, O. Provot, 2018, RSC advances.

Palladium‐Catalyzed Coupling of 3‐Halo‐Substituted Coumarins, Chromenes, and Quinolones with Various Nitrogen‐Containing Nucleophiles

S. Messaoudi, J. Brion, M. Alami, 2011 .

Highly diastereomer selective acylation of 2,5-dialkylpyrrolidines. A versatile route to trans-2,5-disubstituted cyclic amino alcohols

J. Celerier, G. Lhommet, O. Provot, 1993 .

Csp2-N bond formation via ligand-free Pd-catalyzed oxidative coupling reaction of N-tosylhydrazones and indole derivatives.

G. Frison, J. Brion, M. Alami, 2013, The Journal of organic chemistry.

DIASTEREOSELECTIVE SYNTHESIS OF CIS-3- AND 3,5-ALKYLPYRROLIZIDINES

J. Celerier, G. Lhommet, O. Provot, 1998 .

Copper-catalyzed sulfonylation of N-tosylhydrazones followed by a one-pot C-N bond formation.

C. Tran, M. Alami, Abdallah Hamze, 2021, Organic & biomolecular chemistry.

A One‐Pot Three‐Step Synthesis of Z‐Trisubstituted Olefins from Arylalkynes and Their Cyclization into 4‐Aryl‐2H‐chromenes

J. Brion, M. Alami, Abdallah Hamze, 2012 .

Palladium-catalyzed coupling of N-tosylhydrazones with ortho substituted aryl halides: synthesis of 4-arylchromenes and related heterocycles

J. Brion, M. Alami, Abdallah Hamze, 2011 .

Expeditious synthesis of 1,1-diarylethylenes related to isocombretastatin A-4 (isoCA-4) via palladium-catalyzed arylation of N-tosylhydrazones with aryl triflates

J. Brion, M. Alami, Abdallah Hamze, 2009 .

Disproportionation reaction of diarylmethylisopropyl ethers: a versatile access to diarylmethanes from diarylcarbinols speeded up by the use of microwave irradiation

A. Giraud, J. Peyrat, J. Brion, 2006 .

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

J. Bignon, J. Rodrigo, J. Dubois, 2015, European journal of medicinal chemistry.

One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.

J. Bignon, J. Dubois, M. Alami, 2018, The Journal of organic chemistry.

Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3

A. Giraud, J. Peyrat, J. Brion, 2006 .

Desulfurization of Thioketals into Methylene and Methyl Derivatives: Nickel or not Nickel?

M. Alami, O. Provot, Ling-zhi Yuan, 2017 .

Synthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuinesSynthesis and Anticancer Properties of Oxazepines Related to Azaisoerianin and IsoCoQuines.

J. Bignon, J. Dubois, M. Alami, 2020, ChemMedChem.

Synthesis and Biological Activities of Pyrazino[1,2-a]indole and Pyrazino[1,2-a]indol-1-one Derivatives

C. Tran, M. Alami, Abdallah Hamze, 2021, Pharmaceuticals.

Trifluoromethylketones chemistry: efficient access to silyl enol ethers or silyl carbinols using lithium diisopropylamide

O. Provot, J. Berrien, J. Mayrargue, 1997 .

Metal-Catalyzed Synthesis of 1,1-Diarylethylene Scaffolds

M. Alami, Abdallah Hamze, O. Provot, 2017 .

Synthesis of ortho/ortho'-substituted 1,1-diarylethylenes through cross-coupling reactions of sterically encumbered hydrazones and aryl halides.

J. Brion, M. Alami, Abdallah Hamze, 2013, The Journal of organic chemistry.

DMSO–PdI2 as a powerful oxidizing couple of alkynes into benzils: one-pot synthesis of nitrogen-containing five- or six-membered heterocycles

J. Bignon, C. Mousset, J. Brion, 2008 .

Hydrostannation of Alkynes

M. Alami, Abdallah Hamze, O. Provot, 2019, ACS Catalysis.

Recent Progress on the Mild Deprotection of Dithioketals, Dithioacetals, and Oxathiolanes

J. Pozzo, Abdallah Hamze, O. Provot, 2022, European Journal of Organic Chemistry.

Chlorotrimethylsilane and Sodium Iodide: A Remarkable Metal‐Free Association for the Desulfurization of Benzylic Dithioketals under Mild Conditions

M. Alami, O. Provot, Ling-zhi Yuan, 2018 .

N-Methylpyrrolidin-2-one hydrotribromide (MPHT) a mild reagent for selective bromination of carbonyl compounds: synthesis of substituted 2-bromo-1-naphtols

J. Brion, M. Alami, O. Provot, 2005 .

Chlorotrimethylsilane and Sodium Iodide: A Useful Combination for the Regioselective Deoxygenation of Arylalkyl-α-Diketones

M. Alami, Abdallah Hamze, O. Provot, 2017 .

Selective Metal-Free Deoxygenation of Unsymmetrical 1,2-Dicarbonyl Compounds by Chlorotrimethylsilane and Sodium Iodide.

J. Brion, M. Alami, Abdallah Hamze, 2016, Organic letters.

Lactim Ether Chemistry: A Versatile One-Step β-Enamino Lactone Synthesis

J. Celerier, G. Lhommet, O. Provot, 1993 .

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes.

J. Brion, M. Alami, Abdallah Hamze, 2009, The Journal of organic chemistry.

Platinum chloride/Xphos-catalyzed regioselective hydrosilylation of functionalized terminal arylalkynes

J. Brion, M. Alami, Abdallah Hamze, 2008 .

Platinum oxide catalyzed hydrosilylation of unsymmetrical internal aryl alkynes under ortho-substituent regiocontrol.

J. Brion, M. Alami, Abdallah Hamze, 2005, Organic letters.

Regioselective Hydrostannation of Highly Hindered Arylalkynes under Ortho Directing Effects

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

J. Bignon, C. Lenoir, J. Dubois, 2017, European journal of medicinal chemistry.

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity

J. Bignon, J. Dubois, S. Messaoudi, 2015, ChemMedChem.

The Metabolic Fate of isoCombretastatin A‐4 in Human Liver Microsomes: Identification, Synthesis and Biological Evaluation of Metabolites

J. Bignon, J. Dubois, S. Messaoudi, 2011, ChemMedChem.

Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2009, Journal of medicinal chemistry.

p-Toluenesulfonic Acid-Promoted Selective Functionalization of Unsymmetrical Arylalkynes: A Regioselective Access to Various Arylketones and Heterocycles.

J. Peyrat, J. Brion, M. Alami, 2010 .

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

J. Bignon, J. Dubois, M. Alami, 2019, European journal of medicinal chemistry.

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.

J. Wdzieczak‐Bakala, J. Bignon, C. Lenoir, 2013, European journal of medicinal chemistry.

Synthesis and functionalization of 3-bromo-2-(2-chlorovinyl)benzothiophenes as molecular tools

M. Alami, O. Provot, Guangkuan Zhao, 2017 .

Synthetic approach to enyne and enediyne analogues of anticancer agents

A. Giraud, J. Peyrat, J. Brion, 2005 .

Discovery of Isoerianin Analogues as Promising Anticancer Agents

J. Wdzieczak‐Bakala, J. Bignon, J. Dubois, 2011, ChemMedChem.

Compounds cytotoxic inhibitors of tubulin polymerization

J. Bignon, J. Dubois, S. Messaoudi, 2014 .

Excimer Fluorescence of a new Bisanthracene as Probe of Viscosity in Polysiloxanes

J. Pozzo, O. Provot, A. Ferraro, 2001 .

Alkylating properties of synthetic trioxanes related to artemisinin

B. Meunier, A. Robert, O. Provot, 2000 .

One‐Pot Hydrosilylation—Protodesilylation of Functionalized Diarylalkynes: A Highly Selective Access to (Z)‐Stilbenes. Application to the Synthesis of Combretastatin A‐4.

A. Giraud, J. Brion, M. Alami, 2008 .

Rh(III)-Catalyzed Direct Access to 2,3-Substituted β-N-Glycosyl Indoles Through C-H Activation/annulation Coupling of β-N-Aryl Glycosides with Substituted Internal Alkynes

Mingxiang Zhu, S. Messaoudi, M. Alami, 2019 .

Anticancer properties of indole derivatives as IsoCombretastatin A-4 analogues.

M. Diederich, J. Bignon, Laura Gallego-Yerga, 2021, European journal of medicinal chemistry.

Diastereoselective Synthesis of a Simplified Analogue of Artemisinin with a Substituted Ring Junction

O. Provot, J. Mayrargue, M. Hamzaoui, 1996 .

MPHT-Promoted Bromocyclization of ortho-Substituted Arylalkynes: Application to the Synthesis of 2-Substituted 3-Bromobenzofurans and -Benzo[b]thiophenes

J. Brion, M. Alami, Abdallah Hamze, 2010 .

Erratum to “Synthesis and in vitro Trichomonacidal activities of some new dialkylperoxides and 1,2,4-trioxanes”

L. Cointeaux, C. Bories, P. Loiseau, 2002 .

Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.

B. Meunier, F. Gay, M. Daniš, 2003, Organic & biomolecular chemistry.

Synthesis of Dihydro‐5H‐benzo[c]‐fluorenes, Dihydroindeno[c]‐Chromenes and Thiochromenes via Intramolecular Cyclization and their Effect on Human Leukemia Cells

J. Bignon, C. Tran, Abdallah Hamze, 2022, Advanced Synthesis & Catalysis.

Iron-Catalyzed Coupling Reaction Between 1,1-Dichloro-1-alkenes and Grignard Reagents.

R. Hocquemiller, B. Figadère, X. Franck, 2005 .

Palladium-catalyzed Markovnikov terminal arylalkynes hydrostannation: application to the synthesis of 1,1-diarylethylenes.

J. Brion, M. Alami, Abdallah Hamze, 2009, Journal of Organic Chemistry.

Synthesis, Biological Evaluation of 1,1‐Diarylethylenes as a Novel Class of Antimitotic Agents

J. Wdzieczak‐Bakala, J. Bignon, A. Giraud, 2009, ChemMedChem.

Regiocontrol of the palladium-catalyzed tin hydride addition to Z-enynols: remarkable Z-directing effects.

J. Brion, M. Alami, Abdallah Hamze, 2007, The Journal of organic chemistry.

Synthesis of 4-trifluoromethyl-1,2,4-trioxanes, simplified analogues of artemisinin

O. Provot, J. Mayrargue, H. Moskowitz, 1998 .