A. P. Krapcho

发表

SYNTHETIC APPLICATIONS OF DEALKOXYCARBONYLATIONS OF MALONATE ESTERS, β-KETO ESTERS, α-CYANO ESTERS AND RELATED COMPOUNDS IN DIPOLAR APROTIC MEDIA. PART II

A. P. Krapcho, 1983 .

Facile acidic hydrolysis and displacement reactions of 2‐chloro‐and 2,9‐dichloro‐1,10‐phenanthroline

A. P. Krapcho, S. Sparapani, 2008 .

IMPROVED SYNTHESIS OF 2-CHLORO- AND 2, 9-DICHLORO-1, 10-PHENANTHROLINES

A. P. Krapcho, Jennifer Brett Lanza, 2007 .

Characterization of anthracenediones and their photoaffinity analogs.

M. Hacker, K. Chou, D. Horn, 2002, Biochemical pharmacology.

Mono-Protected Diamines. N-tert-Butoxycarbonyl-α,ω-Alkanediamines from α,ω-Alkanediamines

A. P. Krapcho, C. Kuell, A. Krapcho, 1990 .

Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8- and 9-aza regioisomers.

S. Moro, G. Capranico, M. Palumbo, 2004, Biochemical pharmacology.

Bis-phenanthroline derivatives as suitable scaffolds for effective G-quadruplex recognition.

M. Palumbo, C. Sissi, C. Musetti, 2010, Dalton transactions.

Displacement reactions of 2-chloro- and 2,9-dichloro-1,10-phenanthroline: synthesis of a sulfur-bridged bis-1,10-phenanthroline macrocycle and a 2,2'-amino-substituted-bis-1,10-phenanthroline

A. P. Krapcho, S. Sparapani, J. Seitz, 2009 .

The Krapcho Dealkoxycarbonylation Reaction of Esters with α‐Electron‐Withdrawing Substituents

E. Ciganek, A. P. Krapcho, A. Krapcho, 2013 .

Synthetic applications and mechanism studies of the decarbalkoxylations of geminal diesters and related systems effected in dimethyl sulfoxide by water and/or by water with added salts

A. Lovey, E. Jahngen, A. P. Krapcho, 1978 .

Sequence selectivity of topoisomerase II DNA cleavage stimulated by mitoxantrone derivatives: relationships to drug DNA binding and cellular effects.

F. Zunino, G. Capranico, M. Palumbo, 1993, Molecular pharmacology.

The synthesis of 6,9‐bis[(aminoalkyl)amino] substituted benzo[g]quinoxaline‐, benzo[g]quinazoline‐ and benzo‐[g]phthalazine‐5,10‐diones via regiospecific displacements

M. Hacker, A. P. Krapcho, K. Rosner, 1993 .

Unexpected Displacements of Chloride by Bromide Found During Sandmeyer Reactions of 3- or 5-Amino-2-Chloropyridines

S. Haydar, A. P. Krapcho, A. Krapcho, 1998 .

USES OF SODIUM CHLORITE AND SODIUM BROMATE IN ORGANIC SYNTHESIS. A REVIEW

A. P. Krapcho, A. Krapcho, 2006 .

SYNTHESIS OF CARBOCYCLIC SPIRO COMPOUNDS VIA REARRANGEMENT ROUTES

A. P. Krapcho, 1976 .

General preparative route to benzo[g]quinolines (1-azaanthracenes)

A. P. Krapcho, T. Gilmor, A. Krapcho, 1999 .

Synthetic applications of dealkoxycarbonylations of malonate esters, β-keto esters, α-cyano esters and related compounds in dipolar aprotic media - Part II.

A. P. Krapcho, A. Paul Krapcho, 1982 .

Formation of Isocyanides during the Thermal Decomposition of Sodium Trichloroacetate in the Presence of Arylamines

A. P. Krapcho, 1962 .

Synthesis of 1,4-Dihydropyridines by Regioselective Additions of Benzylic Zinc Bromides to Pyridinium Salts and Their Aromatizations to 4-Benzylpyridines

A. P. Krapcho, A. Hammach, D. Waterhouse, 1997 .

Synthesis of regioisomeric 6,9-(chlorofluoro)-substituted benzo[g]quinoline-5,10-diones, benzo[g] isoquinoline-5,10-diones and 6-chloro-9-fluorobenzo[g]quinoxaline-5,10-dione

C. Gallagher, A. P. Krapcho, A. Hammach, 1997 .

Synthesis of 2,9‐diacyl‐1, 10‐phenanthrolines

A. P. Krapcho, Akbar Ali, 2004 .

Stereochemistry of decarbalkoxylation of cyclic geminal diesters effected by water and lithium chloride in dimethyl sulfoxide

A. P. Krapcho, J. Weimaster, 1980 .

Solvolysis studies of cycloalkylcarbinyl tosylates. Effect of adjacent ring size on the rates and products. Ionization constant determinations of cycloalkanecarboxylic acids

A. P. Krapcho, R. G. Johanson, 1971 .

6,9-Bis[(aminoalkyl)amino]benzo[g]isoquinoline-5,10-diones. A novel class of chromophore-modified antitumor anthracene-9,10-diones: synthesis and antitumor evaluations.

J. Polsenberg, M. Hacker, C. Gallagher, 1994, Journal of medicinal chemistry.

A synthetic route to highly substituted ketones. Acylations of .alpha. anions of carboxylic acid salts with acid chlorides

A. Lovey, E. Jahngen, A. P. Krapcho, 1977 .

Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles).

G. Pezzoni, M. Hacker, C. Gallagher, 1998, Journal of medicinal chemistry.

Convenient Synthetic Routes to 1,4-Difluoroanthracene-9,10-Dione

A. P. Krapcho, Z. Getahun, 1985 .

Synthesis of Carbocyclic Spiro Compounds via Cycloaddition Routes

A. P. Krapcho, 1978 .

Kinetics of the Metal-Ammonia-Alcohol Reductions of Benzene and Substituted Benzenes1

A. P. Krapcho, A. Bothner, A. Krapcho, 1959 .

Synthesis of regioisomeric 2,5-bis-substituted-aza-benzothiopyranoindazoles

S. Haydar, A. P. Krapcho, A. Krapcho, 2001 .

DNA-interactive anticancer aza-anthrapyrazoles: biophysical and biochemical studies relevant to the mechanism of action.

S. Moro, B. Gatto, F. Zunino, 2001, Molecular pharmacology.

N-tert-butoxycarbonyl-N-substituted hydrazines in SNAr displacements. Synthetic pathways to N-1-substituted anthrapyrazoles, aza-anthrapyrazoles and aza-benzothiopyranoindazoles

A. P. Krapcho, E. Menta, A. Oliva, 2000 .

SYNTHESIS OF HYDROXY-SUBSTITUTED AZA-ANALOGUES OF ANTITUMOR ANTHRAPYRAZOLES

M. Hacker, A. P. Krapcho, A. Hammach, 1998 .

The decarbethoxylation of geminal dicarbethoxy compounds.

B. Grenon, A. P. Krapcho, G. A. Glynn, 1967, Tetrahedron letters.

A stereospecific synthesis of 2-isopropylidene-cis,cis-4,8-dimethyl-6-keto-cis-decahydroazulene

A. P. Krapcho, B. P. Mundy, 1970 .

Synthesis of Carbocyclic Spiro Compounds via Intramolecular Alkylation Routes

A. P. Krapcho, A. Krapcho, 1974 .

Sodium Trimethyl Silanoate. A Hydroxyl Synthon for Fluoride SNAr Type Displacements from Anthracene-9,10-diones, Benz[g]isoquinoline-5–10-diones and Nitrobenzenes

A. P. Krapcho, D. Waterhouse, A. Krapcho, 1998 .

Synthesis of regioisomeric difluoro- and 8-chloro-9- fluorobenz [g] isoquinoline-5,10-diones and SNAr displacements studies by diamines: bis(aminoalkyl)aminobenz[g] isoquinoline-5,10-diones

A. P. Krapcho, M. Ellis, 1998 .

General synthetic route to benz[g]isoquinolines (2‐azaanthracenes)

A. P. Krapcho, T. Gilmor, 1998 .

The synthesis of 6,9-difluorobenzo[g]quinoline-5,10-dione. Displacements of the fluorides by diamines which lead to 6,9-bis[(aminoalkyl)amino]benzo[g]quinoline-5,10-diones

J. Polsenberg, M. Hacker, A. P. Krapcho, 1993 .

Synthesis and antineoplastic evaluations of 5,8-bis[(aminoalkyl)amino]-1-azaanthracene-9,10-diones.

M. Hacker, A. P. Krapcho, J. McCormack, 1985, Journal of medicinal chemistry.

Synthesis of 1,4-Dihydropyridines (IV) by Regioselective Additions of Benzylic Zinc Bromides to Pyridinium Salts and Their Aromatizations to 4-Benzylpyridines (V).

A. P. Krapcho, A. Hammach, D. Waterhouse, 1997 .

CARBENE INTERMEDIATE IN THE WURTZ REACTION. α-ELIMINATION OF HYDROGEN CHLORIDE FROM NEOPENTYL CHLORIDE

A. P. Krapcho, P. Skell, 1961 .

KINETICS OF THE METAL-AMMONIA-ALCOHOL REDUCTION OF BENZENE

A. Bothner‐By, A. P. Krapcho, 1960 .

Decarbalkoxylations of geminal diesters, β-keto esters and α-cyano esters effected by sodium chloride in dimethyl sulpoxide

A. Lovey, A. P. Krapcho, A. Krapcho, 1973 .

Specific introduction of an isopropylidene group in the synthesis of the monoterpene terpinolene and the sesquiterpene (+-)-.alpha.-curcumene

E. Jahngen, A. P. Krapcho, 1974 .

General Synthetic Pathway to Oxygenated 3-Methylbenz[g]isoquinoline-5,10-diones

A. P. Krapcho, D. Waterhouse, 1999 .

Heterosubstituted Anthracene‐9,10‐dione Analogues. The Synthesis and Antitumor Evaluation of 5,8‐Bis((aminoalkyl)amino)naphtho(2,3‐b) thiophene‐4,9‐diones.

M. Hacker, A. P. Krapcho, M. Petry, 1991 .

Synthesis and antitumor evaluations of symmetrically and unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and 1,4-bis[(aminoalkyl)amino]-5,8-dihydroxyanthracene-9,10-diones.

C. Manzotti, G. Pezzoni, M. Hacker, 1991, Journal of medicinal chemistry.

Heterosubstituted anthracene-9,10-dione analogues. The synthesis and antitumor evaluation of 5,8-bis[(aminoalkyl)amino]naphtho[2,3-b] thiophene-4,9-diones.

M. Hacker, A. P. Krapcho, M. Petry, 1990, Journal of medicinal chemistry.

Decarbalkoxylations of geminal diesters and β-keto esters in wet dimethyl sulfoxide. Effect of added sodium chloride on the decarbalkoxylation rates of mono- and di-substituted Malonate esters

A. Lovey, E. Jahngen, A. P. Krapcho, 1974 .

Diazoniapentaphenes. Synthesis from pyridine-2-carboxaldehyde and structural verifications

S. A. Cadamuro, A. P. Krapcho, 2004 .

Physicochemical properties, cytotoxic activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones.

F. Zunino, G. Capranico, M. Palumbo, 1997, Biochemical pharmacology.

Synthesis of unsymmetrical 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones for antineoplastic evaluation

D. Phinney, A. P. Krapcho, K. Shaw, 1984 .

Synthesis and Antitumor Evaluations of Symmetrically and Unsymmetrically Substituted 1,4-Bis((aminoalkyl)amino)anthracene-9,10- diones and 1,4-Bis((aminoalkyl)amino)-5,8-dihydroxyanthracene-9,10- diones.

C. Manzotti, G. Pezzoni, M. Hacker, 1991 .

Topoisomerase II DNA cleavage stimulation, DNA binding activity, cytotoxicity, and physico-chemical properties of 2-aza- and 2-aza-oxide-anthracenedione derivatives.

G. Capranico, M. Palumbo, N. Carenini, 1995, Molecular pharmacology.

Synthesis and antitumor activities of 5-methyl-1- and 2-[[2-dimethylaminoethyl]amino]-aza-thiopyranoindazoles.

M. Hacker, S. Haydar, A. P. Krapcho, 2000, Bioorganic & medicinal chemistry letters.

Experimental and theoretical study of tautomerism in 1,4-bis[methoxyamino]anthracene-9,10-diones and their reduced forms

J. O. Morley, A. P. Krapcho, D. S. Cummings, 1996 .

Synthesis of 4‐hydroxy‐6,9‐difluorobenz[g]isoquinoline‐5,10‐diones and conversions to 4‐hydroxy‐6,9‐bis[(aminoalkyl)amino]‐benz[g]isoquinoline‐5,10‐diones

M. Hacker, C. Gallagher, A. P. Krapcho, 1995 .

Stereochemistry of alkylation of carboxylic acid salt and ester .alpha. anions derived from cyclic systems

A. P. Krapcho, E. Dundulis, 1980 .

Trianions (α-anions of dilithio malonates). C-alkylations of monosubstituted malonic acids.

A. P. Krapcho, D. S. Kashdan, 1975 .

α-Carbalkoxylations of carboxylic acids. A general synthetic route to monoesters of malonic acids.

E. Jahngen, A. P. Krapcho, D. S. Kashdan, 1974 .

General synthetic route to malonamic acids and 3-thiomalonamic acids. Amidations and thioamidations of .alpha. anions of carboxylate salts with alkyl and aryl isocyanates and isothiocyanates

A. P. Krapcho, W. Stephens, 1980 .

General synthetic route to cycloalkylidenecycloalkanes. Reactions of .alpha.-anions of cycloalkanecarboxylic acid salts with cycloalkanones

E. Jahngen, A. P. Krapcho, 1974 .

THE EFFECT OF SOLVENT ON THE REGIOSELECTIVITY OF CYCLOADDITION OF DIAZOMETHANE TO THE THIONE GROUP IN ADAMANTANETHIONE

E. Jahngen, A. P. Krapcho, M. P. Silvon, 1974 .

Reactions of diazo compounds with tetrasubstituted 1,3-cyclobutanediones and the corresponding dithiones. Isolation of bis-.DELTA.3-1,3,4-thiadiazolines from the dipolar addition of diazomethane to the dithiones and their thermal decomposition into diepisulfides

A. P. Krapcho, B. Abegaz, M. P. Silvon, 1971 .

GENERAL SYNTHETIC ROUTE TO MALONAMIC ACIDS AND 3-THIOMALONAMIC ACIDS. AMIDATIONS AND THIOAMIDATIONS OF α ANIONS OF CARBOXYLATE SALTS WITH ALKYL AND ARYL ISOCYANATES AND ISOTHIOCYANATES

A. P. Krapcho, W. Stephens, 1980 .

Rate decelerations in the acetolysis of substituted cyclopentyl tosylates

B. Grenon, D. Horn, A. P. Krapcho, 1979 .

Ionic Reactions in the Spiran Series. II. Effect of Variation of the Size of the Ring Bearing the Leaving Group on the Solvolytic Rates of Neopentyl-Type Tosylates of the Spiran Series

J. McCullough, A. P. Krapcho, K. V. Nahabedian, 1965 .

Recent synthetic applications of the dealkoxycarbonylation reaction. Part 1. Dealkoxycarbonylations of malonate esters

A. P. Krapcho, A. Krapcho, 2007 .

Correlation of DNA reactivity and cytotoxicity of a new class of anticancer agents: aza-anthracenediones.

M. Hacker, A. P. Krapcho, L. Hazlehurst, 1995, Cancer letters.

Comparison of aza-anthracenedione-induced DNA damage and cytotoxicity in experimental tumor cells.

M. Hacker, A. P. Krapcho, L. Hazlehurst, 1995, Biochemical pharmacology.

The Synthesis of 5,8-Difluoronaphtho(2,3-c)thiophene-4,9-dione and Its Facile Conversion to 2-(2-(Dimethylamino)ethyl)-5-(2-(dimethylamino)ethylamino)-8-fluoronaphtho(2,3-c)pyrrole-4,9-dione.

A. P. Krapcho, M. Petry, 1990 .

Synthesis and antitumor activities of unsymmetrically substituted 1,4-bis[(aminoalkyl)amino]anthracene-9,10-diones and related systems.

M. Hacker, D. Phinney, A. P. Krapcho, 1986, Journal of medicinal chemistry.

Effect of G-Quadruplex Polymorphism on the Recognition of Telomeric DNA by a Metal Complex

M. Palumbo, C. Sissi, C. Musetti, 2013, PloS one.

Perylene side chains modulate G-quadruplex conformation in biologically relevant DNA sequences.

B. Gatto, M. Palumbo, L. Lucatello, 2008, Bioorganic & medicinal chemistry.

Synthesis and rearrangements of dihydro-1,4-oxazepine and dihydro-1,4-thiazepine derivatives

A. P. Krapcho, K. Shaw, 1983 .

Syntheses of trispirocyclopropanes via triple photodecarbonylations of polymethyleneketene trimers

F. J. Waller, A. P. Krapcho, 1972 .

Synthesis of cis,cis-4,8-dimethyl-cis-2,6-dioxadecahydroazulene

A. P. Krapcho, B. P. Mundy, 1965 .

Anthracene-9,10-Diones and Aza Bioisosteres as Antitumor Agents

G. Pezzoni, M. Hacker, L. Hazelhurst, 1995, Current Medicinal Chemistry.

The Synthesis of 1,4-Difluoro-5,8-Dihydroxyanthracene-9,10-Dione and Ipso Substitutions of the Fluorides by Diamines Leading to 1,4-Bis-[(Aminoalkyl)Amino]-5,8-Dihydroxyanthracene-9,10-Diones

A. P. Krapcho, Z. Getahun, K. J. Avery, 1990 .

PROTONATED CYCLOPROPANE INTERMEDIATES IN THE NEOPENTYL CARBONIUM ION SYSTEM

A. P. Krapcho, P. Skell, I. Starer, 1960 .

Facile de-tert-butoxycarbonylations of .beta.-keto esters and mixed malonate esters using water in dimethyl sulfoxide

A. P. Krapcho, G. Gadamasetti, 1987 .

Facile De-tert-butoxycarbonylations of β-Keto Esters and Mixed Malonate Esters Using Water in Dimethyl Sulfoxide.

A. P. Krapcho, G. Gadamasetti, 1987 .

MODIFIED SYNTHETIC ROUTE TO 2-HYDROXYIMINO-N-ARYLACETAMIDES

A. P. Krapcho, Sergio A. Cadarmro, 2004 .

Modified Synthetic Route to 2-Hydroxyimino-N-arylacetamides.

S. A. Cadamuro, A. P. Krapcho, 2004 .

Synthesis and reactions of 1,10-phenanthroline-2(1H)-thione: a facile synthesis of 2,2′-thiobis-1,10-phenanthroline

M. Boxer, A. P. Krapcho, S. Sparapani, 2007 .

Potassium permanganate oxidations of terminal olefins and acetylenes to carboxylic acids of one less carbon

J. R. Larson, A. P. Krapcho, J. M. Eldridge, 1977 .

Mono-(BOC)-Protected Diamines. Synthesis of tert-Butyl-N-alkyl-N-(2-aminoethyl)carbamates and tert-Butyl-N-[2-(alkylamino)ethyl] Carbamates

A. P. Krapcho, M. Maresch, J. Lunn, 1993 .